KR102035877B1 - 우울증이 있는 대상체를 위한 치료 양생법 선택을 위한 검정법 및 치료 방법 - Google Patents

우울증이 있는 대상체를 위한 치료 양생법 선택을 위한 검정법 및 치료 방법 Download PDF

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KR102035877B1
KR102035877B1 KR1020147016192A KR20147016192A KR102035877B1 KR 102035877 B1 KR102035877 B1 KR 102035877B1 KR 1020147016192 A KR1020147016192 A KR 1020147016192A KR 20147016192 A KR20147016192 A KR 20147016192A KR 102035877 B1 KR102035877 B1 KR 102035877B1
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folic acid
depression
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KR20140100524A (ko
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마우리치오 파바
조지 파라코스타스
주니어 해롤드 오 코치
데이비드 크론레이지
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알파시그마 에스.피.에이.
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KR1020147016192A 2011-11-14 2012-11-14 우울증이 있는 대상체를 위한 치료 양생법 선택을 위한 검정법 및 치료 방법 Expired - Fee Related KR102035877B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161559541P 2011-11-14 2011-11-14
US61/559,541 2011-11-14
PCT/US2012/065084 WO2013074676A2 (en) 2011-11-14 2012-11-14 Assays and methods for selecting a treatment regimen for a subject with depression

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KR20140100524A KR20140100524A (ko) 2014-08-14
KR102035877B1 true KR102035877B1 (ko) 2019-10-23

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US (2) US9540691B2 (enExample)
EP (1) EP2780467B1 (enExample)
JP (1) JP6285865B2 (enExample)
KR (1) KR102035877B1 (enExample)
CN (1) CN104053785A (enExample)
AU (1) AU2012340015B2 (enExample)
BR (1) BR112014011491A2 (enExample)
CA (1) CA2855640C (enExample)
IL (1) IL232407B (enExample)
IN (1) IN2014DN04226A (enExample)
MX (1) MX354547B (enExample)
RU (1) RU2622082C2 (enExample)
WO (1) WO2013074676A2 (enExample)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2855640C (en) 2011-11-14 2020-03-10 The General Hospital Corporation Assays and methods for selecting a treatment regimen for a subject with depression
KR20150131147A (ko) * 2013-03-12 2015-11-24 네스텍 소시에테아노님 우울증을 갖는 대상을 위해 치료 섭생법을 선별하기 위한 검정법 및 방법
MX371392B (es) 2013-03-15 2020-01-28 Janssen Pharmaceutica Nv Composicion farmaceutica de clorhidrato de s-ketamina.
US9610302B2 (en) * 2013-12-05 2017-04-04 Buriva, LLC. Composition containing phospholipid-DHA and B vitamins
US20150250813A1 (en) * 2013-12-05 2015-09-10 Buriva, LLC Dietary supplement containing phospholipid-dha, folate, and n-acetyl-l-cysteine
US9549937B2 (en) * 2013-12-05 2017-01-24 Burvia, LLC. Composition containing phospholipid-DHA and folate
JP2017512204A (ja) * 2014-03-05 2017-05-18 武田薬品工業株式会社 うつ病および大うつ病性障害を治療するための方法
WO2015136446A1 (en) * 2014-03-11 2015-09-17 Nestec S.A. Methods for selecting antidepressant drug therapy to treat depression
KR101588119B1 (ko) * 2014-05-16 2016-01-25 동아대학교 산학협력단 Slc6a3 유전자의 다형성 소위성과 이를 이용한 dna 타이핑 키트 및 상기 유전자 관련 질병의 진단키트
EP3179993B1 (en) * 2014-08-13 2021-01-20 Janssen Pharmaceutica NV Esketamine for use in a method for the treatment of depression
CA2961208A1 (en) 2014-09-15 2016-03-24 Janssen Pharmaceutica Nv Val66met (snp rs6265) genotype specific dosing regimens and methods for the treatment of depression
CN105671130A (zh) * 2014-11-18 2016-06-15 武汉白原科技有限公司 一种心理性格检测试剂盒和方法
US20160203591A1 (en) * 2015-01-09 2016-07-14 Umm Al-Qura University System and process for monitoring the quality of food in a refrigerator
CN104655705B (zh) * 2015-02-12 2017-03-08 江苏省原子医学研究所 一种用毛细管电泳快速检测生物样本中儿茶酚氧甲基转移酶comt活性的方法
CN104789668A (zh) * 2015-04-10 2015-07-22 浙江博惠生物科技有限公司 一种叶酸代谢能力评估的检测位点rs1801394的检测PCR扩增引物和单碱基延伸引物
WO2016168685A1 (en) * 2015-04-17 2016-10-20 Mayo Foundation For Medical Education And Research Modulating the aryl hydrocarbon receptor system to treat major depressive disorder
WO2016176458A1 (en) * 2015-04-28 2016-11-03 Proove Biosciences, Inc. System and method for processing genotype information relating to opiod risk
US20160332962A1 (en) 2015-05-13 2016-11-17 Janssen Pharmaceutica Nv (s)-csa salt of s-ketamine, (r)-csa salt of s-ketamine and processes for the preparation of s-ketamine
CA2987292A1 (en) * 2015-05-25 2016-12-01 Hunan Skyworld Biotechnologies Co. Ltd. Use of fluorescence for the quick and easy determination of s-adenosylmethionine, s-adenosylhomocysteine and homocysteine
WO2017218632A1 (en) 2016-06-14 2017-12-21 Board Of Regents, The University Of Texas System Methods of detecting anti-folic acid antibodies and uses thereof
CN110023752B (zh) * 2016-09-26 2021-06-29 精密医药控股私人有限公司 精神分裂症和分裂情感性精神病的诊断、预后和治疗
CN107245527A (zh) * 2017-07-25 2017-10-13 重庆京因生物科技有限责任公司 Mtrr基因多态性快速检测的引物、分子信标、试剂盒及其检测方法
US11399575B2 (en) * 2017-08-02 2022-08-02 Glaxosmithkline Consumer Healthcare Holdings (Us) Llc Wearable device and application for behavioral support
US20200009081A1 (en) 2017-09-13 2020-01-09 Janssen Pharmaceutica N.V. Delivery Of Esketamine For The Treatment Of Depression
BR112020012473A2 (pt) 2017-12-22 2020-11-24 Janssen Pharmaceuticals, Inc. escetamina para o tratamento da depressão
CN108251522B (zh) * 2018-04-09 2020-11-27 江苏硕世生物科技股份有限公司 人类mthfr和mtrr基因检测试剂盒及其用途
CN108642138B (zh) * 2018-05-02 2021-11-30 广东药科大学 一种检测叶酸代谢相关基因遗传信息的方法及试剂盒
US11681348B2 (en) 2018-05-03 2023-06-20 L. Pierre de Rochemont High speed / low power server farms and server networks
KR20210042895A (ko) 2018-06-05 2021-04-20 피에르 엘. 드 로쉬몽 높은 피크 대역폭 i/o 채널들을 갖는 모듈
CN108823299A (zh) * 2018-06-11 2018-11-16 苏州艾达康医疗科技有限公司 一种抑郁症用药相关基因的检测方法及试剂盒
EP3846940A4 (en) * 2018-09-03 2022-07-27 Visby Medical, Inc. DEVICES AND METHODS FOR TESTING ANTIBIOTIC SUSCEPTIBILITY
AU2020231172A1 (en) 2019-03-05 2021-09-23 Janssen Pharmaceuticals, Inc. Esketamine for the treatment of depression
AU2020275413A1 (en) 2019-05-14 2021-12-23 Cedars-Sinai Medical Center TL1A patient selection methods, systems, and devices
CN110148461B (zh) * 2019-06-26 2021-09-21 周建勋 用于多参数测量的模块切换系统
CN110693507A (zh) * 2019-08-30 2020-01-17 中国民用航空飞行学院 一种民航飞行学员心理健康测试和心理援助系统
CN111351945B (zh) * 2020-03-18 2021-04-23 东南大学 维生素d结合蛋白作为标志物在精神疾病抑郁症诊断中的应用
US20220165379A1 (en) * 2020-11-24 2022-05-26 Genomind, Inc. Methods and systems for reporting patient- and drug-specific medical data
CN116103385B (zh) * 2021-11-11 2024-11-15 深圳理工大学 一种预测抑郁障碍患者对治疗反应的基因诊断试剂盒和系统
CN116298233A (zh) * 2022-03-16 2023-06-23 昱言科技(北京)有限公司 用于诊断双相障碍的生物标记物
WO2023220213A1 (en) * 2022-05-11 2023-11-16 Higgins Evelyn Methods for providing a personalized therapeutic treatment regime for addictions

Family Cites Families (93)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US548257A (en) 1895-10-22 Hay rake and loader
US3837376A (en) 1971-06-01 1974-09-24 Metropolitan Pathology Labor I Blood serum collection tube and method
US4336185A (en) 1976-03-02 1982-06-22 Rohm And Haas Company Folic acid derivatives
US4120448A (en) 1977-06-08 1978-10-17 Baxter Travenol Laboratories, Inc. Centrifugal liquid processing apparatus with automatically positioned collection port
US4656035A (en) 1984-12-21 1987-04-07 University Of Tennessee Research Corporation Method of separating blood platelets
US4946773A (en) 1985-12-23 1990-08-07 President And Fellows Of Harvard College Detection of base pair mismatches using RNAase A
US5322770A (en) 1989-12-22 1994-06-21 Hoffman-Laroche Inc. Reverse transcription with thermostable DNA polymerases - high temperature reverse transcription
US5202231A (en) 1987-04-01 1993-04-13 Drmanac Radoje T Method of sequencing of genomes by hybridization of oligonucleotide probes
US6270961B1 (en) 1987-04-01 2001-08-07 Hyseq, Inc. Methods and apparatus for DNA sequencing and DNA identification
IL86724A (en) 1987-06-19 1995-01-24 Siska Diagnostics Inc Methods and kits for amplification and testing of nucleic acid sequences
ATE92538T1 (de) 1988-01-21 1993-08-15 Genentech Inc Verstaerkung und nachweis von nukleinsaeuresequenzen.
CA1340807C (en) 1988-02-24 1999-11-02 Lawrence T. Malek Nucleic acid amplification process
AU3694689A (en) 1988-04-28 1989-11-24 Mark H. Skolnick Amplified sequence polymorphisms (asps)
US5130238A (en) 1988-06-24 1992-07-14 Cangene Corporation Enhanced nucleic acid amplification process
US5925525A (en) 1989-06-07 1999-07-20 Affymetrix, Inc. Method of identifying nucleotide differences
GB2236186B (en) 1989-08-22 1994-01-05 Finnigan Mat Gmbh Process and device for laser desorption of analyte molecular ions, especially of biomolecules
US5045694A (en) 1989-09-27 1991-09-03 The Rockefeller University Instrument and method for the laser desorption of ions in mass spectrometry
US6013431A (en) 1990-02-16 2000-01-11 Molecular Tool, Inc. Method for determining specific nucleotide variations by primer extension in the presence of mixture of labeled nucleotides and terminators
US5846710A (en) 1990-11-02 1998-12-08 St. Louis University Method for the detection of genetic diseases and gene sequence variations by single nucleotide primer extension
EP0834576B1 (en) 1990-12-06 2002-01-16 Affymetrix, Inc. (a Delaware Corporation) Detection of nucleic acid sequences
US5169766A (en) 1991-06-14 1992-12-08 Life Technologies, Inc. Amplification of nucleic acid molecules
US5994069A (en) 1996-01-24 1999-11-30 Third Wave Technologies, Inc. Detection of nucleic acids by multiple sequential invasive cleavages
ATE242485T1 (de) 1993-05-28 2003-06-15 Baylor College Medicine Verfahren und massenspektrometer zur desorption und ionisierung von analyten
US5858659A (en) 1995-11-29 1999-01-12 Affymetrix, Inc. Polymorphism detection
US6136540A (en) 1994-10-03 2000-10-24 Ikonisys Inc. Automated fluorescence in situ hybridization detection of genetic abnormalities
US5952172A (en) 1993-12-10 1999-09-14 California Institute Of Technology Nucleic acid mediated electron transfer
US5851770A (en) 1994-04-25 1998-12-22 Variagenics, Inc. Detection of mismatches by resolvase cleavage using a magnetic bead support
US6566065B1 (en) 1994-05-26 2003-05-20 Mcgill University Method of diagnosing schizophrenia by detecting a mutation in the (MTHFR) gene
GB9410620D0 (en) 1994-05-26 1994-07-13 Univ Mcgill cDNA for human mehylenetetrahydrofolate reductase
US6379897B1 (en) 2000-11-09 2002-04-30 Nanogen, Inc. Methods for gene expression monitoring on electronic microarrays
US5849483A (en) 1994-07-28 1998-12-15 Ig Laboratories, Inc. High throughput screening method for sequences or genetic alterations in nucleic acids
US5866337A (en) 1995-03-24 1999-02-02 The Trustees Of Columbia University In The City Of New York Method to detect mutations in a nucleic acid using a hybridization-ligation procedure
US5704888A (en) 1995-04-14 1998-01-06 Cobe Laboratories, Inc. Intermittent collection of mononuclear cells in a centrifuge apparatus
US5968740A (en) 1995-07-24 1999-10-19 Affymetrix, Inc. Method of Identifying a Base in a Nucleic Acid
US6264970B1 (en) 1996-06-26 2001-07-24 Takeda Chemical Industries, Ltd. Sustained-release preparation
US5928870A (en) 1997-06-16 1999-07-27 Exact Laboratories, Inc. Methods for the detection of loss of heterozygosity
GB9620209D0 (en) 1996-09-27 1996-11-13 Cemu Bioteknik Ab Method of sequencing DNA
US6465611B1 (en) 1997-02-25 2002-10-15 Corixa Corporation Compounds for immunotherapy of prostate cancer and methods for their use
NZ516848A (en) 1997-06-20 2004-03-26 Ciphergen Biosystems Inc Retentate chromatography apparatus with applications in biology and medicine
AU9381598A (en) 1997-09-10 1999-03-29 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Method of amplifying dna and rna mismatch cleavage products
CA2329665C (en) * 1998-04-24 2007-09-04 Scarista Limited Treatment of depression and pharmaceutical preparations therefor
US6406921B1 (en) 1998-07-14 2002-06-18 Zyomyx, Incorporated Protein arrays for high-throughput screening
AU764866B2 (en) 1998-10-01 2003-09-04 Novartis Ag New sustained release oral formulations
US6395481B1 (en) 1999-02-16 2002-05-28 Arch Development Corp. Methods for detection of promoter polymorphism in a UGT gene promoter
US7429466B2 (en) 2000-01-24 2008-09-30 Hypromatrix, Inc Methods and arrays for detecting biological molecules
EP1257664A4 (en) 2000-01-28 2006-04-05 Althea Technologies Inc METHOD FOR THE ANALYSIS OF GENE EXPRESSION
EP1946783B1 (en) 2000-03-09 2011-09-07 CaridianBCT, Inc. Extracorporeal blood processing apparatus
WO2001080896A2 (en) 2000-04-21 2001-11-01 Arch Development Corporation Flavopiridol drug combinations and methods with reduced side effects
DE10022510A1 (de) 2000-05-10 2001-11-15 Basf Ag Zusammensetzungen enthaltend Folsäure und reduziertes Folat
US6355433B1 (en) 2000-06-02 2002-03-12 Dna Sciences, Inc. Determination of nucleotide sequence variations through limited primer extension
EP1304324B1 (en) 2000-07-18 2007-10-03 Dainippon Sumitomo Pharma Co., Ltd. Serotonin reuptake inhibitors
AU2002240066A1 (en) 2001-01-26 2002-08-06 University Of Chicago Determination of ugt2b7 gene polymorphisms for predicting ugt2b7 substrate toxicity and for optimising drug dosage
US6720003B2 (en) 2001-02-16 2004-04-13 Andrx Corporation Serotonin reuptake inhibitor formulations
US20030077616A1 (en) 2001-04-19 2003-04-24 Ciphergen Biosystems, Inc. Biomolecule characterization using mass spectrometry and affinity tags
US20030100476A1 (en) 2001-05-11 2003-05-29 Weinberger Daniel R. Effect of COMT genotype on frontal lobe function
US7074901B2 (en) 2001-05-25 2006-07-11 Serono Genetics Institute S.A. Isolated human vCOL16A1 polypeptide and fragments thereof
US7112408B2 (en) 2001-06-08 2006-09-26 The Brigham And Women's Hospital, Inc. Detection of ovarian cancer based upon alpha-haptoglobin levels
US20030013208A1 (en) 2001-07-13 2003-01-16 Milagen, Inc. Information enhanced antibody arrays
JP2005500543A (ja) 2001-08-13 2005-01-06 ビヨンド ジェノミクス, インコーポレイテッド 生物学的系をプロファイリングするための方法およびシステム
UA81749C2 (uk) 2001-10-04 2008-02-11 Х. Луннбек А/С Фенілпіперазинові похідні як інгібітори зворотного захоплення серотоніну
AU2003207989A1 (en) 2002-02-21 2003-09-09 Idgene Pharmaceuticals Ltd. Association of snps in the comt locus and neighboring loci with schizophrenia, bipolar disorder, breast cancer and colorectal cancer
US7241281B2 (en) 2002-04-08 2007-07-10 Thermogenesis Corporation Blood component separation method and apparatus
US20030215858A1 (en) 2002-04-08 2003-11-20 Baylor College Of Medicine Enhanced gene expression system
US20030194711A1 (en) 2002-04-10 2003-10-16 Matthew Zapala System and method for analyzing gene expression data
US20030199001A1 (en) 2002-04-23 2003-10-23 Pitt Aldo M. Sample preparation of biological fluids for proteomic applications
US20030205538A1 (en) 2002-05-03 2003-11-06 Randel Dorian Methods and apparatus for isolating platelets from blood
CA2415154C (en) 2002-12-24 2009-06-16 Biovail Laboratories Inc. Modified release formulations of selective serotonin re-uptake inhibitors
US20040203034A1 (en) 2003-01-03 2004-10-14 The University Of Chicago Optimization of cancer treatment with irinotecan
SI1610791T1 (sl) 2003-03-31 2011-05-31 Titan Pharmaceuticals Inc Implantibilna polimerna naprava za zadržano sproščanje dopaminskega agonista
US20050054688A1 (en) 2003-08-08 2005-03-10 Pfizer Inc Selective serotonin reuptake inhibitors in the treatment of disease
US20050069936A1 (en) 2003-09-26 2005-03-31 Cornelius Diamond Diagnostic markers of depression treatment and methods of use thereof
EP1732610A2 (en) 2004-03-26 2006-12-20 Baylor University Targeted serotonin reuptake inhibitors
JP2005312435A (ja) 2004-03-29 2005-11-10 Kazuhito Rokutan うつ病の評価方法
US20060216737A1 (en) 2005-03-10 2006-09-28 John Bodeau Methods for multiplex amplification
WO2007022248A2 (en) 2005-08-16 2007-02-22 Sloan Kettering Institute For Cancer Research Methods of detection of cancer using peptide profiles
WO2007067263A2 (en) 2005-12-06 2007-06-14 The General Hospital Corporation Diagnostic methods for pain sensitivity and chronicity and for tetrahydrobiopterin-related disorders
US20080064702A1 (en) 2006-09-08 2008-03-13 Charalambos Antoniades Use of folates for the prevention and treatment of vascular diseases
US8268347B1 (en) 2006-10-24 2012-09-18 Aradigm Corporation Dual action, inhaled formulations providing both an immediate and sustained release profile
US20100273153A1 (en) 2006-11-29 2010-10-28 Boris Tabakoff Genetic diagnosis of depression
WO2008086579A1 (en) 2007-01-19 2008-07-24 Queensland University Of Technology Diagnostic methods and agents
US7947662B2 (en) 2008-02-20 2011-05-24 Gnosis S.P.A. Folates, compositions and uses thereof
US20090307181A1 (en) 2008-03-19 2009-12-10 Brandon Colby Genetic analysis
US8344115B2 (en) 2008-04-21 2013-01-01 Chan-Sui Pang, legal representative Immunoassay for specific determination of S-adenosylmethionine and analogs thereof in biological samples
WO2009155585A1 (en) 2008-06-21 2009-12-23 Blumy Kenneth N utragenomics
WO2010060189A1 (en) 2008-11-03 2010-06-03 Newlab Clinical Research Inc. Allele-allele interactions of mthfr gene variants, and uses thereof in predicting disease risk
US20100304391A1 (en) * 2009-05-29 2010-12-02 Lombard Jay L Methods for assessment and treatment of depression via utilization of single nucleotide polymorphisms analysis
CA2776173A1 (en) 2009-09-30 2011-04-07 Nicholas Marini Cofactors and methods of use for individuals
US20140088035A1 (en) * 2010-12-03 2014-03-27 The General Hospital Corporation Treating schizophrenia
KR20120092993A (ko) 2011-02-14 2012-08-22 지엘팜텍 주식회사 티아넵틴 또는 이의 약제학적으로 허용되는 염을 포함하는 경구투여용 서방성 정제
BR112013024863A2 (pt) 2011-03-28 2016-12-20 Yissum Res Dev Co formulação injetável de liberação sustentada
CA2876169C (en) 2011-06-21 2023-01-24 Global Healthcare Focus, Llc Methods of preventing or treating disease states related to certain metabolic abnormalities
CA2855640C (en) * 2011-11-14 2020-03-10 The General Hospital Corporation Assays and methods for selecting a treatment regimen for a subject with depression
US20160058766A1 (en) * 2011-11-14 2016-03-03 Nestec S.A. Assays and methods for selecting a treatment regimen for a subject with depression

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
J Clin Psychiatry, 70, Suppl 5, pp. 12-17 (2009)*

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