AU2012340015B2 - Assays for selecting a treatment regimen for a subject with depression and methods for treatment - Google Patents

Assays for selecting a treatment regimen for a subject with depression and methods for treatment Download PDF

Info

Publication number
AU2012340015B2
AU2012340015B2 AU2012340015A AU2012340015A AU2012340015B2 AU 2012340015 B2 AU2012340015 B2 AU 2012340015B2 AU 2012340015 A AU2012340015 A AU 2012340015A AU 2012340015 A AU2012340015 A AU 2012340015A AU 2012340015 B2 AU2012340015 B2 AU 2012340015B2
Authority
AU
Australia
Prior art keywords
seq
folate
depression
allele
containing compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2012340015A
Other languages
English (en)
Other versions
AU2012340015A1 (en
Inventor
Maurizio Fava
Harold O. Koch Jr.
David KRONLAGE
George PAPAKOSTAS
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alfasigma SpA
Original Assignee
Alfasigma SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alfasigma SpA filed Critical Alfasigma SpA
Publication of AU2012340015A1 publication Critical patent/AU2012340015A1/en
Assigned to NESTEC S.A. reassignment NESTEC S.A. Request for Assignment Assignors: NESTEC S.A., THE GENERAL HOSPITAL CORPORATION
Application granted granted Critical
Publication of AU2012340015B2 publication Critical patent/AU2012340015B2/en
Assigned to ALFASIGMA S.P.A. reassignment ALFASIGMA S.P.A. Request for Assignment Assignors: NESTEC S.A.
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cell Biology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AU2012340015A 2011-11-14 2012-11-14 Assays for selecting a treatment regimen for a subject with depression and methods for treatment Ceased AU2012340015B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161559541P 2011-11-14 2011-11-14
US61/559,541 2011-11-14
PCT/US2012/065084 WO2013074676A2 (en) 2011-11-14 2012-11-14 Assays and methods for selecting a treatment regimen for a subject with depression

Publications (2)

Publication Number Publication Date
AU2012340015A1 AU2012340015A1 (en) 2014-05-22
AU2012340015B2 true AU2012340015B2 (en) 2017-09-21

Family

ID=47279072

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2012340015A Ceased AU2012340015B2 (en) 2011-11-14 2012-11-14 Assays for selecting a treatment regimen for a subject with depression and methods for treatment

Country Status (13)

Country Link
US (2) US9540691B2 (enExample)
EP (1) EP2780467B1 (enExample)
JP (1) JP6285865B2 (enExample)
KR (1) KR102035877B1 (enExample)
CN (1) CN104053785A (enExample)
AU (1) AU2012340015B2 (enExample)
BR (1) BR112014011491A2 (enExample)
CA (1) CA2855640C (enExample)
IL (1) IL232407B (enExample)
IN (1) IN2014DN04226A (enExample)
MX (1) MX354547B (enExample)
RU (1) RU2622082C2 (enExample)
WO (1) WO2013074676A2 (enExample)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102035877B1 (ko) 2011-11-14 2019-10-23 알파시그마 에스.피.에이. 우울증이 있는 대상체를 위한 치료 양생법 선택을 위한 검정법 및 치료 방법
MX2015012520A (es) * 2013-03-12 2016-01-12 Nestec Sa Ensayos y metodos para seleccionar un regimen de tratamiento para un sujeto con depresion.
US20140275278A1 (en) 2013-03-15 2014-09-18 Janssen Pharmaceutica Nv Pharmaceutical composition of s-ketamine hydrochloride
US9610302B2 (en) * 2013-12-05 2017-04-04 Buriva, LLC. Composition containing phospholipid-DHA and B vitamins
US9549937B2 (en) * 2013-12-05 2017-01-24 Burvia, LLC. Composition containing phospholipid-DHA and folate
US20150250813A1 (en) * 2013-12-05 2015-09-10 Buriva, LLC Dietary supplement containing phospholipid-dha, folate, and n-acetyl-l-cysteine
US20170137880A1 (en) * 2014-03-05 2017-05-18 Takeda Pharmaceutical Company Limited Method for treating depression and major depressive disorder
WO2015136446A1 (en) * 2014-03-11 2015-09-17 Nestec S.A. Methods for selecting antidepressant drug therapy to treat depression
KR101588119B1 (ko) * 2014-05-16 2016-01-25 동아대학교 산학협력단 Ｓｌｃ6ａ3 유전자의 다형성 소위성과 이를 이용한 ｄｎａ 타이핑 키트 및 상기 유전자 관련 질병의 진단키트
EP3179993B1 (en) * 2014-08-13 2021-01-20 Janssen Pharmaceutica NV Esketamine for use in a method for the treatment of depression
CA2961208A1 (en) 2014-09-15 2016-03-24 Janssen Pharmaceutica Nv Val66met (snp rs6265) genotype specific dosing regimens and methods for the treatment of depression
CN105671130A (zh) * 2014-11-18 2016-06-15 武汉白原科技有限公司 一种心理性格检测试剂盒和方法
US20160203591A1 (en) * 2015-01-09 2016-07-14 Umm Al-Qura University System and process for monitoring the quality of food in a refrigerator
CN104655705B (zh) * 2015-02-12 2017-03-08 江苏省原子医学研究所 一种用毛细管电泳快速检测生物样本中儿茶酚氧甲基转移酶comt活性的方法
CN104789668A (zh) * 2015-04-10 2015-07-22 浙江博惠生物科技有限公司 一种叶酸代谢能力评估的检测位点rs1801394的检测PCR扩增引物和单碱基延伸引物
WO2016168685A1 (en) * 2015-04-17 2016-10-20 Mayo Foundation For Medical Education And Research Modulating the aryl hydrocarbon receptor system to treat major depressive disorder
WO2016176458A1 (en) * 2015-04-28 2016-11-03 Proove Biosciences, Inc. System and method for processing genotype information relating to opiod risk
US20160332962A1 (en) 2015-05-13 2016-11-17 Janssen Pharmaceutica Nv (s)-csa salt of s-ketamine, (r)-csa salt of s-ketamine and processes for the preparation of s-ketamine
CA2987292A1 (en) * 2015-05-25 2016-12-01 Hunan Skyworld Biotechnologies Co. Ltd. Use of fluorescence for the quick and easy determination of s-adenosylmethionine, s-adenosylhomocysteine and homocysteine
WO2017218632A1 (en) * 2016-06-14 2017-12-21 Board Of Regents, The University Of Texas System Methods of detecting anti-folic acid antibodies and uses thereof
EP3516389A4 (en) * 2016-09-26 2020-09-02 Precision Medicine Holdings Pty Ltd DIAGNOSIS, PROGNOSIS AND TREATMENT OF SCHIZOPHRENIA AND SCHIZOAFFECTIVE PSYCHOSIS
CN107245527A (zh) * 2017-07-25 2017-10-13 重庆京因生物科技有限责任公司 Mtrr基因多态性快速检测的引物、分子信标、试剂盒及其检测方法
US11399575B2 (en) * 2017-08-02 2022-08-02 Glaxosmithkline Consumer Healthcare Holdings (Us) Llc Wearable device and application for behavioral support
US20200009081A1 (en) 2017-09-13 2020-01-09 Janssen Pharmaceutica N.V. Delivery Of Esketamine For The Treatment Of Depression
MX2020006650A (es) 2017-12-22 2020-11-06 Janssen Pharmaceuticals Inc Esketamina para el tratamiento de la depresión.
CN108251522B (zh) * 2018-04-09 2020-11-27 江苏硕世生物科技股份有限公司 人类mthfr和mtrr基因检测试剂盒及其用途
CN108642138B (zh) * 2018-05-02 2021-11-30 广东药科大学 一种检测叶酸代谢相关基因遗传信息的方法及试剂盒
KR20210043491A (ko) 2018-05-03 2021-04-21 피에르 엘. 드 로쉬몽 고속/저 전력 서버 팜들 및 서버 네트워크들
WO2019236734A1 (en) 2018-06-05 2019-12-12 De Rochemont L Pierre Module with high peak bandwidth i/o channels
CN108823299A (zh) * 2018-06-11 2018-11-16 苏州艾达康医疗科技有限公司 一种抑郁症用药相关基因的检测方法及试剂盒
JP2021534804A (ja) * 2018-09-03 2021-12-16 ビスビュー メディカル，インコーポレイテッド 抗生物質感受性検査のための装置および方法
WO2020178653A1 (en) 2019-03-05 2020-09-10 Janssen Pharmaceuticals, Inc. Esketamine for the treatment of depression
CN114375339A (zh) 2019-05-14 2022-04-19 普罗米修斯生物科学公司 Tl1a患者选择方法、系统和装置
CN110148461B (zh) * 2019-06-26 2021-09-21 周建勋 用于多参数测量的模块切换系统
CN110693507A (zh) * 2019-08-30 2020-01-17 中国民用航空飞行学院 一种民航飞行学员心理健康测试和心理援助系统
CN111351945B (zh) * 2020-03-18 2021-04-23 东南大学 维生素d结合蛋白作为标志物在精神疾病抑郁症诊断中的应用
US20220165379A1 (en) * 2020-11-24 2022-05-26 Genomind, Inc. Methods and systems for reporting patient- and drug-specific medical data
CN116103385B (zh) * 2021-11-11 2024-11-15 深圳理工大学 一种预测抑郁障碍患者对治疗反应的基因诊断试剂盒和系统
KR102925724B1 (ko) * 2022-01-17 2026-02-10 서울대학교산학협력단 게놈-대사체 통합 분석 기반의 만성신장질환 분석 장치 및 방법
KR102925722B1 (ko) * 2022-01-17 2026-02-10 서울대학교산학협력단 멀티오믹스 기반의 신경계 질환 분석 장치 및 방법
CN116298233A (zh) * 2022-03-16 2023-06-23 昱言科技(北京)有限公司 用于诊断双相障碍的生物标记物
WO2023220213A1 (en) * 2022-05-11 2023-11-16 Higgins Evelyn Methods for providing a personalized therapeutic treatment regime for addictions
CN120847438B (zh) * 2025-07-16 2026-02-03 江西众康中药饮片有限公司 药材辨识系统及方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012128799A2 (en) * 2010-12-03 2012-09-27 General Hospital Corporation, The Treating schizophrenia

Family Cites Families (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US548257A (en) 1895-10-22 Hay rake and loader
US3837376A (en) 1971-06-01 1974-09-24 Metropolitan Pathology Labor I Blood serum collection tube and method
US4336185A (en) 1976-03-02 1982-06-22 Rohm And Haas Company Folic acid derivatives
US4120448A (en) 1977-06-08 1978-10-17 Baxter Travenol Laboratories, Inc. Centrifugal liquid processing apparatus with automatically positioned collection port
US4656035A (en) 1984-12-21 1987-04-07 University Of Tennessee Research Corporation Method of separating blood platelets
US4946773A (en) 1985-12-23 1990-08-07 President And Fellows Of Harvard College Detection of base pair mismatches using RNAase A
US5322770A (en) 1989-12-22 1994-06-21 Hoffman-Laroche Inc. Reverse transcription with thermostable DNA polymerases - high temperature reverse transcription
US6270961B1 (en) 1987-04-01 2001-08-07 Hyseq, Inc. Methods and apparatus for DNA sequencing and DNA identification
US5202231A (en) 1987-04-01 1993-04-13 Drmanac Radoje T Method of sequencing of genomes by hybridization of oligonucleotide probes
IL86724A (en) 1987-06-19 1995-01-24 Siska Diagnostics Inc Methods and kits for amplification and testing of nucleic acid sequences
JP2846018B2 (ja) 1988-01-21 1999-01-13 ジェネンテク，インコーポレイテッド 核酸配列の増幅および検出
CA1340807C (en) 1988-02-24 1999-11-02 Lawrence T. Malek Nucleic acid amplification process
AU3694689A (en) 1988-04-28 1989-11-24 Mark H. Skolnick Amplified sequence polymorphisms (asps)
US5130238A (en) 1988-06-24 1992-07-14 Cangene Corporation Enhanced nucleic acid amplification process
US5925525A (en) 1989-06-07 1999-07-20 Affymetrix, Inc. Method of identifying nucleotide differences
GB2236186B (en) 1989-08-22 1994-01-05 Finnigan Mat Gmbh Process and device for laser desorption of analyte molecular ions, especially of biomolecules
US5045694A (en) 1989-09-27 1991-09-03 The Rockefeller University Instrument and method for the laser desorption of ions in mass spectrometry
US6013431A (en) 1990-02-16 2000-01-11 Molecular Tool, Inc. Method for determining specific nucleotide variations by primer extension in the presence of mixture of labeled nucleotides and terminators
US5846710A (en) 1990-11-02 1998-12-08 St. Louis University Method for the detection of genetic diseases and gene sequence variations by single nucleotide primer extension
WO1992010588A1 (en) 1990-12-06 1992-06-25 Affymax Technologies N.V. Sequencing by hybridization of a target nucleic acid to a matrix of defined oligonucleotides
US5169766A (en) 1991-06-14 1992-12-08 Life Technologies, Inc. Amplification of nucleic acid molecules
US5994069A (en) 1996-01-24 1999-11-30 Third Wave Technologies, Inc. Detection of nucleic acids by multiple sequential invasive cleavages
WO1994028418A1 (en) 1993-05-28 1994-12-08 Baylor College Of Medicine Method and apparatus for desorption and ionization of analytes
US5858659A (en) 1995-11-29 1999-01-12 Affymetrix, Inc. Polymorphism detection
US6136540A (en) 1994-10-03 2000-10-24 Ikonisys Inc. Automated fluorescence in situ hybridization detection of genetic abnormalities
US5952172A (en) 1993-12-10 1999-09-14 California Institute Of Technology Nucleic acid mediated electron transfer
US5851770A (en) 1994-04-25 1998-12-22 Variagenics, Inc. Detection of mismatches by resolvase cleavage using a magnetic bead support
GB9410620D0 (en) 1994-05-26 1994-07-13 Univ Mcgill cDNA for human mehylenetetrahydrofolate reductase
US6566065B1 (en) 1994-05-26 2003-05-20 Mcgill University Method of diagnosing schizophrenia by detecting a mutation in the (MTHFR) gene
US6379897B1 (en) 2000-11-09 2002-04-30 Nanogen, Inc. Methods for gene expression monitoring on electronic microarrays
US5849483A (en) 1994-07-28 1998-12-15 Ig Laboratories, Inc. High throughput screening method for sequences or genetic alterations in nucleic acids
US5866337A (en) 1995-03-24 1999-02-02 The Trustees Of Columbia University In The City Of New York Method to detect mutations in a nucleic acid using a hybridization-ligation procedure
US5704888A (en) 1995-04-14 1998-01-06 Cobe Laboratories, Inc. Intermittent collection of mononuclear cells in a centrifuge apparatus
US5968740A (en) 1995-07-24 1999-10-19 Affymetrix, Inc. Method of Identifying a Base in a Nucleic Acid
US6264970B1 (en) 1996-06-26 2001-07-24 Takeda Chemical Industries, Ltd. Sustained-release preparation
US5928870A (en) 1997-06-16 1999-07-27 Exact Laboratories, Inc. Methods for the detection of loss of heterozygosity
GB9620209D0 (en) 1996-09-27 1996-11-13 Cemu Bioteknik Ab Method of sequencing DNA
US6465611B1 (en) 1997-02-25 2002-10-15 Corixa Corporation Compounds for immunotherapy of prostate cancer and methods for their use
NZ516848A (en) 1997-06-20 2004-03-26 Ciphergen Biosystems Inc Retentate chromatography apparatus with applications in biology and medicine
AU9381598A (en) 1997-09-10 1999-03-29 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Method of amplifying dna and rna mismatch cleavage products
ES2292238T3 (es) * 1998-04-24 2008-03-01 Scarista Limited Tratamiento de la depresion y preparaciones farmaceuticas para el mismo.
US6406921B1 (en) 1998-07-14 2002-06-18 Zyomyx, Incorporated Protein arrays for high-throughput screening
CN1406126A (zh) 1998-10-01 2003-03-26 诺瓦提斯公司 新型缓释口服制剂
US6395481B1 (en) 1999-02-16 2002-05-28 Arch Development Corp. Methods for detection of promoter polymorphism in a UGT gene promoter
US7429466B2 (en) 2000-01-24 2008-09-30 Hypromatrix, Inc Methods and arrays for detecting biological molecules
WO2001055454A1 (en) 2000-01-28 2001-08-02 Althea Technologies, Inc. Methods for analysis of gene expression
EP1231956A2 (en) 2000-03-09 2002-08-21 Gambro, Inc. Extracorporeal blood processing method and apparatus
WO2001080896A2 (en) 2000-04-21 2001-11-01 Arch Development Corporation Flavopiridol drug combinations and methods with reduced side effects
DE10022510A1 (de) 2000-05-10 2001-11-15 Basf Ag Zusammensetzungen enthaltend Folsäure und reduziertes Folat
US6355433B1 (en) 2000-06-02 2002-03-12 Dna Sciences, Inc. Determination of nucleotide sequence variations through limited primer extension
JP5079202B2 (ja) 2000-07-18 2012-11-21 大日本住友製薬株式会社 セロトニン再取り込み阻害剤
AU2002240066A1 (en) 2001-01-26 2002-08-06 University Of Chicago Determination of ugt2b7 gene polymorphisms for predicting ugt2b7 substrate toxicity and for optimising drug dosage
US6720003B2 (en) 2001-02-16 2004-04-13 Andrx Corporation Serotonin reuptake inhibitor formulations
WO2002086168A1 (en) 2001-04-19 2002-10-31 Ciphergen Biosystems, Inc. Biomolecule characterization using mass spectrometry and affinity tags
US20030100476A1 (en) 2001-05-11 2003-05-29 Weinberger Daniel R. Effect of COMT genotype on frontal lobe function
AU2001286171B2 (en) 2001-05-25 2008-01-10 Serono Genetics Institute S.A. Human CDNAs and proteins and uses thereof
US7112408B2 (en) 2001-06-08 2006-09-26 The Brigham And Women's Hospital, Inc. Detection of ovarian cancer based upon alpha-haptoglobin levels
US20030013208A1 (en) 2001-07-13 2003-01-16 Milagen, Inc. Information enhanced antibody arrays
EP1425695A2 (en) 2001-08-13 2004-06-09 Beyong Genomics, Inc. Method and system for profiling biological systems
UA81749C2 (uk) 2001-10-04 2008-02-11 Х. Луннбек А/С Фенілпіперазинові похідні як інгібітори зворотного захоплення серотоніну
WO2003070082A2 (en) 2002-02-21 2003-08-28 Idgene Pharmaceuticals Ltd. Association of snps in the comt locus and neighboring loci with schizophrenia, bipolar disorder, breast cancer and colorectal cancer
US20030215858A1 (en) 2002-04-08 2003-11-20 Baylor College Of Medicine Enhanced gene expression system
US7241281B2 (en) 2002-04-08 2007-07-10 Thermogenesis Corporation Blood component separation method and apparatus
US20030194711A1 (en) 2002-04-10 2003-10-16 Matthew Zapala System and method for analyzing gene expression data
WO2003091735A1 (en) 2002-04-23 2003-11-06 Millipore Corporation Sample preparation of biological fluids for proteomic applications
US20030205538A1 (en) 2002-05-03 2003-11-06 Randel Dorian Methods and apparatus for isolating platelets from blood
CA2415154C (en) 2002-12-24 2009-06-16 Biovail Laboratories Inc. Modified release formulations of selective serotonin re-uptake inhibitors
US20040203034A1 (en) 2003-01-03 2004-10-14 The University Of Chicago Optimization of cancer treatment with irinotecan
CA2520613C (en) 2003-03-31 2012-12-04 Titan Pharmaceuticals, Inc. Implantable polymeric device for sustained release of dopamine agonist
US20050054688A1 (en) 2003-08-08 2005-03-10 Pfizer Inc Selective serotonin reuptake inhibitors in the treatment of disease
US20050069936A1 (en) 2003-09-26 2005-03-31 Cornelius Diamond Diagnostic markers of depression treatment and methods of use thereof
US7893261B2 (en) 2004-03-26 2011-02-22 Baylor University Serotonin reuptake inhibitors
JP2005312435A (ja) 2004-03-29 2005-11-10 Kazuhito Rokutan うつ病の評価方法
US20060216737A1 (en) 2005-03-10 2006-09-28 John Bodeau Methods for multiplex amplification
WO2007022248A2 (en) 2005-08-16 2007-02-22 Sloan Kettering Institute For Cancer Research Methods of detection of cancer using peptide profiles
US20070254288A1 (en) 2005-12-06 2007-11-01 The General Hospital Corporation Diagnostic methods for pain sensitivity and chronicity and for tetrahydrobiopterin-related disorders
US20080064702A1 (en) 2006-09-08 2008-03-13 Charalambos Antoniades Use of folates for the prevention and treatment of vascular diseases
US8268347B1 (en) 2006-10-24 2012-09-18 Aradigm Corporation Dual action, inhaled formulations providing both an immediate and sustained release profile
WO2008066769A2 (en) 2006-11-29 2008-06-05 Lohocla Research Corporation Genetic diagnosis of depression
WO2008086579A1 (en) 2007-01-19 2008-07-24 Queensland University Of Technology Diagnostic methods and agents
US7947662B2 (en) 2008-02-20 2011-05-24 Gnosis S.P.A. Folates, compositions and uses thereof
EP2227780A4 (en) 2008-03-19 2011-08-03 Existence Genetics Llc GENETIC ANALYSIS
WO2009131643A1 (en) 2008-04-21 2009-10-29 Monabio, Inc. Immunoassay for specific determination of s-adenosymethionine and analogs thereof in biological samples
AU2009259887A1 (en) 2008-06-21 2009-12-23 B. William Downs DNA-directed customization of analgesic compounds as a therapeutic modality
US20100112589A1 (en) 2008-11-03 2010-05-06 Xie Yagang Allele-allele interactions of mthfr gene variants, and uses thereof in predicting disease risk
US20100304391A1 (en) * 2009-05-29 2010-12-02 Lombard Jay L Methods for assessment and treatment of depression via utilization of single nucleotide polymorphisms analysis
EP2482677A1 (en) 2009-09-30 2012-08-08 The Regents of The University of California Cofactors and methods for use for individuals
KR20120092993A (ko) 2011-02-14 2012-08-22 지엘팜텍 주식회사 티아넵틴 또는 이의 약제학적으로 허용되는 염을 포함하는 경구투여용 서방성 정제
WO2012131678A1 (en) 2011-03-28 2012-10-04 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Sustained-release injectable formulation
CA2876169C (en) 2011-06-21 2023-01-24 Global Healthcare Focus, Llc Methods of preventing or treating disease states related to certain metabolic abnormalities
KR102035877B1 (ko) * 2011-11-14 2019-10-23 알파시그마 에스.피.에이. 우울증이 있는 대상체를 위한 치료 양생법 선택을 위한 검정법 및 치료 방법
US20160058766A1 (en) * 2011-11-14 2016-03-03 Nestec S.A. Assays and methods for selecting a treatment regimen for a subject with depression

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012128799A2 (en) * 2010-12-03 2012-09-27 General Hospital Corporation, The Treating schizophrenia

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
FAVA MAURIZIO ET AL, "Folate in depression:efficacy safety differences in formulations,and clinical issues", THE JOURNAL OF CLINICAL PSYCHIATRY, 2009, vol. 70, supp 5, pages 12-17 *
ROBERTS SEREN HAF ET AL, "Folate Augmentation of Treatment - Evaluation for Depression (FolATED): protocol of a randomised controlled trial", BMC PSYCHIATRY, 2007, vol. 7, page 65 *
S J LEWIS ET AL, "Folic acid supplementation during pregnancy may protect against depression 21 months after pregnancy, an effect modified by MTHFR C677T genotype", EUROPEAN JOURNAL OF CLINICAL NUTRITION, vol. 66, pages 97 - 103 *
Slopien et al., "Polymorphic variants of genes encoding MTHFR, MTR, and MTHFD1 and the risk of depression in postmenopausal women in Poland" Maturitas (2008) Vol 61, pages 252-255 *

Also Published As

Publication number Publication date
EP2780467A2 (en) 2014-09-24
NZ624231A (en) 2016-10-28
WO2013074676A2 (en) 2013-05-23
CA2855640A1 (en) 2013-05-23
US20130172361A1 (en) 2013-07-04
KR20140100524A (ko) 2014-08-14
MX354547B (es) 2018-03-09
WO2013074676A3 (en) 2013-08-15
JP6285865B2 (ja) 2018-02-28
US9540691B2 (en) 2017-01-10
JP2015508281A (ja) 2015-03-19
HK1202590A1 (en) 2015-10-02
RU2014124121A (ru) 2015-12-27
AU2012340015A1 (en) 2014-05-22
EP2780467B1 (en) 2018-10-17
US20130267523A1 (en) 2013-10-10
BR112014011491A2 (pt) 2017-05-09
US9546401B2 (en) 2017-01-17
RU2622082C2 (ru) 2017-06-09
IL232407B (en) 2019-03-31
IL232407A0 (en) 2014-06-30
IN2014DN04226A (enExample) 2015-05-22
CA2855640C (en) 2020-03-10
KR102035877B1 (ko) 2019-10-23
MX2014005786A (es) 2014-08-27
CN104053785A (zh) 2014-09-17

Similar Documents

Publication Publication Date Title
US9540691B2 (en) Assays and methods for selecting a treatment regimen for a subject with depression
Aquilante et al. Influence of coagulation factor, vitamin K epoxide reductase complex subunit 1, and cytochrome P450 2C9 gene polymorphisms on warfarin dose requirements
TW201437635A (zh) 選擇用於患憂鬱症個體之療法之分析及方法
Yoshino et al. GCH1 mutations in dopa-responsive dystonia and Parkinson’s disease
Claes et al. The kynurenine pathway in major depression: haplotype analysis of three related functional candidate genes
Nibali et al. Vitamin D receptor polymorphism (− 1056 Taq‐I) interacts with smoking for the presence and progression of periodontitis
US20180275149A1 (en) Method for predicting a subject's response to valproic acid therapy
Serretti et al. A preliminary investigation of the influence of CREB1 gene on treatment resistance in major depression
US20100130599A1 (en) CYP2C9*8 Alleles Correlate With Decreased Warfarin Metabolism And Increased Warfarin Sensitivity
WO2015136446A1 (en) Methods for selecting antidepressant drug therapy to treat depression
Giusti et al. Early-onset ischaemic stroke: analysis of 58 polymorphisms in 17 genes involved in methionine metabolism
Mischoulon et al. Prevalence of MTHFR C677T and MS A2756G polymorphisms in major depressive disorder, and their impact on response to fluoxetine treatment
US20080118918A1 (en) Compositions and Methods For Determining and Predicting Treatment Responses For Depression and Anxiety
HK1202590B (en) Assays and methods for selecting a treatment regimen for a subject with depression and methods for treatment
US20140088035A1 (en) Treating schizophrenia
NZ624231B2 (en) Assays and methods for selecting a treatment regimen for a subject with depression
US20160058766A1 (en) Assays and methods for selecting a treatment regimen for a subject with depression
Mu et al. Association between angiotensin-converting enzyme gene insertion/deletion polymorphism and cognition impairment in patients with schizophrenia
US20160002733A1 (en) Assessing risk for encephalopathy induced by 5-fluorouracil or capecitabine
WO2009125851A1 (ja) 糖尿病患者のフェニルアラニン誘導体系薬物有効性検出方法
Riva Genetic polymorphism of catechol-O-methyltransferase and levodopa pharmacokinetic-pharmacodynamic pattern in patients with Parkinson's disease
US20140187593A1 (en) Diagnostic test and treatment for a neurological disorder

Legal Events

Date Code Title Description
PC1 Assignment before grant (sect. 113)

Owner name: NESTEC S.A.

Free format text: FORMER APPLICANT(S): THE GENERAL HOSPITAL CORPORATION; NESTEC S.A.

PC1 Assignment before grant (sect. 113)

Owner name: ALFASIGMA S.P.A.

Free format text: FORMER APPLICANT(S): NESTEC S.A.

FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired