JP6285865B2 - うつ病を有する対象のための処置レジメンを選択するためのアッセイ及び方法 - Google Patents

うつ病を有する対象のための処置レジメンを選択するためのアッセイ及び方法 Download PDF

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JP6285865B2
JP6285865B2 JP2014541420A JP2014541420A JP6285865B2 JP 6285865 B2 JP6285865 B2 JP 6285865B2 JP 2014541420 A JP2014541420 A JP 2014541420A JP 2014541420 A JP2014541420 A JP 2014541420A JP 6285865 B2 JP6285865 B2 JP 6285865B2
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seq
folate
depression
snp
containing compound
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JP2015508281A5 (enExample
JP2015508281A (ja
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マウリツィオ ファーヴァー,
マウリツィオ ファーヴァー,
ジョージ パパコスタス,
ジョージ パパコスタス,
ジュニア, ハロルド オー. コッチ,
ジュニア, ハロルド オー. コッチ,
デーヴィッド クロンレージ,
デーヴィッド クロンレージ,
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アルファシグマ ソシエタ ペル アチオニ
アルファシグマ ソシエタ ペル アチオニ
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JP2014541420A 2011-11-14 2012-11-14 うつ病を有する対象のための処置レジメンを選択するためのアッセイ及び方法 Expired - Fee Related JP6285865B2 (ja)

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US201161559541P 2011-11-14 2011-11-14
US61/559,541 2011-11-14
PCT/US2012/065084 WO2013074676A2 (en) 2011-11-14 2012-11-14 Assays and methods for selecting a treatment regimen for a subject with depression

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JP2015508281A JP2015508281A (ja) 2015-03-19
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US (2) US9540691B2 (enExample)
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KR (1) KR102035877B1 (enExample)
CN (1) CN104053785A (enExample)
AU (1) AU2012340015B2 (enExample)
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11681348B2 (en) 2018-05-03 2023-06-20 L. Pierre de Rochemont High speed / low power server farms and server networks
US11901956B2 (en) 2018-06-05 2024-02-13 L. Pierre de Rochemont Module with high peak bandwidth I/O channels

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104053785A (zh) * 2011-11-14 2014-09-17 综合医院公司 为患有抑郁症的受试者选择治疗方案的测定法和方法
KR20150131147A (ko) * 2013-03-12 2015-11-24 네스텍 소시에테아노님 우울증을 갖는 대상을 위해 치료 섭생법을 선별하기 위한 검정법 및 방법
US20140274981A1 (en) 2013-03-15 2014-09-18 Janssen Pharmaceutica Nv Pharmaceutical composition of s-ketamine hydrochloride
US20150250813A1 (en) * 2013-12-05 2015-09-10 Buriva, LLC Dietary supplement containing phospholipid-dha, folate, and n-acetyl-l-cysteine
US9610302B2 (en) * 2013-12-05 2017-04-04 Buriva, LLC. Composition containing phospholipid-DHA and B vitamins
US9549937B2 (en) * 2013-12-05 2017-01-24 Burvia, LLC. Composition containing phospholipid-DHA and folate
AU2015227296A1 (en) * 2014-03-05 2016-09-08 Takeda Pharmaceutical Company Limited Method for treating depression and major depressive disorder
WO2015136446A1 (en) * 2014-03-11 2015-09-17 Nestec S.A. Methods for selecting antidepressant drug therapy to treat depression
KR101588119B1 (ko) * 2014-05-16 2016-01-25 동아대학교 산학협력단 Slc6a3 유전자의 다형성 소위성과 이를 이용한 dna 타이핑 키트 및 상기 유전자 관련 질병의 진단키트
US10098854B2 (en) 2014-08-13 2018-10-16 Janssen Pharmaceutica Nv Method for the treatment of depression
EP3193853A1 (en) 2014-09-15 2017-07-26 Janssen Pharmaceutica NV VAL66MET (SNP rs6265) GENOTYPE SPECIFIC DOSING REGIMENS AND METHODS FOR THE TREATMENT OF DEPRESSION
CN105671130A (zh) * 2014-11-18 2016-06-15 武汉白原科技有限公司 一种心理性格检测试剂盒和方法
US20160203591A1 (en) * 2015-01-09 2016-07-14 Umm Al-Qura University System and process for monitoring the quality of food in a refrigerator
CN104655705B (zh) * 2015-02-12 2017-03-08 江苏省原子医学研究所 一种用毛细管电泳快速检测生物样本中儿茶酚氧甲基转移酶comt活性的方法
CN104789668A (zh) * 2015-04-10 2015-07-22 浙江博惠生物科技有限公司 一种叶酸代谢能力评估的检测位点rs1801394的检测PCR扩增引物和单碱基延伸引物
US11122997B2 (en) 2015-04-17 2021-09-21 Mayo Foundation For Medical Education And Research Modulating the aryl hydrocarbon receptor system to treat major depressive disorder
US20180137235A1 (en) * 2015-04-28 2018-05-17 Proove Biosciences, Inc. System and method for processing genotype information relating to opioid risk
US20160332962A1 (en) 2015-05-13 2016-11-17 Janssen Pharmaceutica Nv (s)-csa salt of s-ketamine, (r)-csa salt of s-ketamine and processes for the preparation of s-ketamine
JP6974179B2 (ja) * 2015-05-25 2021-12-01 フーナン スカイワールド バイオテクノロジーズ コンパニー S−アデノシルメチオニン、s−アデノシルホモシステイン及びホモシステインを迅速かつ簡単に測定するための蛍光の使用
US11313868B2 (en) 2016-06-14 2022-04-26 Board Of Regents, The University Of Texas System Methods of detecting anti-folic acid antibodies and uses thereof
WO2018053605A1 (en) * 2016-09-26 2018-03-29 Precision Medicine Holdings Pty Ltd Diagnosis, prognosis and treatment for schizophrenia and schizoaffective psychosis
CN107245527A (zh) * 2017-07-25 2017-10-13 重庆京因生物科技有限责任公司 Mtrr基因多态性快速检测的引物、分子信标、试剂盒及其检测方法
US11399575B2 (en) * 2017-08-02 2022-08-02 Glaxosmithkline Consumer Healthcare Holdings (Us) Llc Wearable device and application for behavioral support
US20200009081A1 (en) 2017-09-13 2020-01-09 Janssen Pharmaceutica N.V. Delivery Of Esketamine For The Treatment Of Depression
SG11202005896WA (en) 2017-12-22 2020-07-29 Janssen Pharmaceuticals Inc Esketamine for the treatment of depression
CN108251522B (zh) * 2018-04-09 2020-11-27 江苏硕世生物科技股份有限公司 人类mthfr和mtrr基因检测试剂盒及其用途
CN108642138B (zh) * 2018-05-02 2021-11-30 广东药科大学 一种检测叶酸代谢相关基因遗传信息的方法及试剂盒
CN108823299A (zh) * 2018-06-11 2018-11-16 苏州艾达康医疗科技有限公司 一种抑郁症用药相关基因的检测方法及试剂盒
JP2021534804A (ja) * 2018-09-03 2021-12-16 ビスビュー メディカル,インコーポレイテッド 抗生物質感受性検査のための装置および方法
EP3934632A4 (en) 2019-03-05 2022-11-23 Janssen Pharmaceuticals, Inc. Esketamine for the treatment of depression
EP3969621A4 (en) 2019-05-14 2023-01-25 Prometheus Biosciences, Inc. TL1A PATIENT SELECTION METHODS, SYSTEMS AND DEVICES
CN110148461B (zh) * 2019-06-26 2021-09-21 周建勋 用于多参数测量的模块切换系统
CN110693507A (zh) * 2019-08-30 2020-01-17 中国民用航空飞行学院 一种民航飞行学员心理健康测试和心理援助系统
CN111351945B (zh) * 2020-03-18 2021-04-23 东南大学 维生素d结合蛋白作为标志物在精神疾病抑郁症诊断中的应用
AU2021244617A1 (en) 2020-03-26 2022-11-10 Migdalia FORT Ultraviolet radiation treatments
WO2022115277A1 (en) * 2020-11-24 2022-06-02 Genomind, Inc. Methods and systems for reporting patient-and drug-specific medical data
CN116103385B (zh) * 2021-11-11 2024-11-15 深圳理工大学 一种预测抑郁障碍患者对治疗反应的基因诊断试剂盒和系统
KR102925722B1 (ko) * 2022-01-17 2026-02-10 서울대학교산학협력단 멀티오믹스 기반의 신경계 질환 분석 장치 및 방법
KR102925724B1 (ko) * 2022-01-17 2026-02-10 서울대학교산학협력단 게놈-대사체 통합 분석 기반의 만성신장질환 분석 장치 및 방법
CN116298233A (zh) * 2022-03-16 2023-06-23 昱言科技(北京)有限公司 用于诊断双相障碍的生物标记物
WO2023220213A1 (en) * 2022-05-11 2023-11-16 Higgins Evelyn Methods for providing a personalized therapeutic treatment regime for addictions
CN120847438B (zh) * 2025-07-16 2026-02-03 江西众康中药饮片有限公司 药材辨识系统及方法

Family Cites Families (93)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US548257A (en) 1895-10-22 Hay rake and loader
US3837376A (en) 1971-06-01 1974-09-24 Metropolitan Pathology Labor I Blood serum collection tube and method
US4336185A (en) 1976-03-02 1982-06-22 Rohm And Haas Company Folic acid derivatives
US4120448A (en) 1977-06-08 1978-10-17 Baxter Travenol Laboratories, Inc. Centrifugal liquid processing apparatus with automatically positioned collection port
US4656035A (en) 1984-12-21 1987-04-07 University Of Tennessee Research Corporation Method of separating blood platelets
US4946773A (en) 1985-12-23 1990-08-07 President And Fellows Of Harvard College Detection of base pair mismatches using RNAase A
US5322770A (en) 1989-12-22 1994-06-21 Hoffman-Laroche Inc. Reverse transcription with thermostable DNA polymerases - high temperature reverse transcription
US5202231A (en) 1987-04-01 1993-04-13 Drmanac Radoje T Method of sequencing of genomes by hybridization of oligonucleotide probes
US6270961B1 (en) 1987-04-01 2001-08-07 Hyseq, Inc. Methods and apparatus for DNA sequencing and DNA identification
IL86724A (en) 1987-06-19 1995-01-24 Siska Diagnostics Inc Methods and kits for amplification and testing of nucleic acid sequences
EP0359789B1 (en) 1988-01-21 1993-08-04 Genentech, Inc. Amplification and detection of nucleic acid sequences
CA1340807C (en) 1988-02-24 1999-11-02 Lawrence T. Malek Nucleic acid amplification process
AU3694689A (en) 1988-04-28 1989-11-24 Mark H. Skolnick Amplified sequence polymorphisms (asps)
US5130238A (en) 1988-06-24 1992-07-14 Cangene Corporation Enhanced nucleic acid amplification process
US5925525A (en) 1989-06-07 1999-07-20 Affymetrix, Inc. Method of identifying nucleotide differences
GB2236186B (en) 1989-08-22 1994-01-05 Finnigan Mat Gmbh Process and device for laser desorption of analyte molecular ions, especially of biomolecules
US5045694A (en) 1989-09-27 1991-09-03 The Rockefeller University Instrument and method for the laser desorption of ions in mass spectrometry
US6013431A (en) 1990-02-16 2000-01-11 Molecular Tool, Inc. Method for determining specific nucleotide variations by primer extension in the presence of mixture of labeled nucleotides and terminators
US5846710A (en) 1990-11-02 1998-12-08 St. Louis University Method for the detection of genetic diseases and gene sequence variations by single nucleotide primer extension
DE69132905T2 (de) 1990-12-06 2002-08-01 Affymetrix, Inc. (N.D.Ges.D.Staates Delaware) Detektion von Nukleinsäuresequenzen
US5169766A (en) 1991-06-14 1992-12-08 Life Technologies, Inc. Amplification of nucleic acid molecules
US5994069A (en) 1996-01-24 1999-11-30 Third Wave Technologies, Inc. Detection of nucleic acids by multiple sequential invasive cleavages
PT700521E (pt) 1993-05-28 2003-10-31 Baylor College Medicine Metodo e espectrometro de massa para dessorcao e ionizacao de analitos
US5858659A (en) 1995-11-29 1999-01-12 Affymetrix, Inc. Polymorphism detection
US6136540A (en) 1994-10-03 2000-10-24 Ikonisys Inc. Automated fluorescence in situ hybridization detection of genetic abnormalities
US5952172A (en) 1993-12-10 1999-09-14 California Institute Of Technology Nucleic acid mediated electron transfer
US5851770A (en) 1994-04-25 1998-12-22 Variagenics, Inc. Detection of mismatches by resolvase cleavage using a magnetic bead support
US6566065B1 (en) 1994-05-26 2003-05-20 Mcgill University Method of diagnosing schizophrenia by detecting a mutation in the (MTHFR) gene
GB9410620D0 (en) 1994-05-26 1994-07-13 Univ Mcgill cDNA for human mehylenetetrahydrofolate reductase
US6379897B1 (en) 2000-11-09 2002-04-30 Nanogen, Inc. Methods for gene expression monitoring on electronic microarrays
US5849483A (en) 1994-07-28 1998-12-15 Ig Laboratories, Inc. High throughput screening method for sequences or genetic alterations in nucleic acids
US5866337A (en) 1995-03-24 1999-02-02 The Trustees Of Columbia University In The City Of New York Method to detect mutations in a nucleic acid using a hybridization-ligation procedure
US5704888A (en) 1995-04-14 1998-01-06 Cobe Laboratories, Inc. Intermittent collection of mononuclear cells in a centrifuge apparatus
US5968740A (en) 1995-07-24 1999-10-19 Affymetrix, Inc. Method of Identifying a Base in a Nucleic Acid
US6264970B1 (en) 1996-06-26 2001-07-24 Takeda Chemical Industries, Ltd. Sustained-release preparation
US5928870A (en) 1997-06-16 1999-07-27 Exact Laboratories, Inc. Methods for the detection of loss of heterozygosity
GB9620209D0 (en) 1996-09-27 1996-11-13 Cemu Bioteknik Ab Method of sequencing DNA
US6465611B1 (en) 1997-02-25 2002-10-15 Corixa Corporation Compounds for immunotherapy of prostate cancer and methods for their use
NZ516848A (en) 1997-06-20 2004-03-26 Ciphergen Biosystems Inc Retentate chromatography apparatus with applications in biology and medicine
CA2303206A1 (en) 1997-09-10 1999-03-18 University Of Maryland, Baltimore Method of amplifying dna and rna mismatch cleavage products
JP2002512965A (ja) * 1998-04-24 2002-05-08 スカリスタ リミティッド 鬱病の治療およびそのための薬学的調製物
US6406921B1 (en) 1998-07-14 2002-06-18 Zyomyx, Incorporated Protein arrays for high-throughput screening
IL141762A0 (en) 1998-10-01 2002-03-10 Novartis Ag New oral formulations
US6395481B1 (en) 1999-02-16 2002-05-28 Arch Development Corp. Methods for detection of promoter polymorphism in a UGT gene promoter
US7429466B2 (en) 2000-01-24 2008-09-30 Hypromatrix, Inc Methods and arrays for detecting biological molecules
US6618679B2 (en) 2000-01-28 2003-09-09 Althea Technologies, Inc. Methods for analysis of gene expression
US6730055B2 (en) 2000-03-09 2004-05-04 Gambro Inc. Extracorporeal blood processing methods and apparatus
AU2001253618A1 (en) 2000-04-21 2001-11-07 Arch Development Corporation Flavopiridol drug combinations and methods with reduced side effects
DE10022510A1 (de) 2000-05-10 2001-11-15 Basf Ag Zusammensetzungen enthaltend Folsäure und reduziertes Folat
US6355433B1 (en) 2000-06-02 2002-03-12 Dna Sciences, Inc. Determination of nucleotide sequence variations through limited primer extension
JP5079202B2 (ja) 2000-07-18 2012-11-21 大日本住友製薬株式会社 セロトニン再取り込み阻害剤
US20030099960A1 (en) 2001-01-26 2003-05-29 The University Of Chicago Compositions and methods for optimizing UGT2B7 substrate dosings and for predicting UGT2B7 substrate toxicity
US6720003B2 (en) 2001-02-16 2004-04-13 Andrx Corporation Serotonin reuptake inhibitor formulations
US20030077616A1 (en) 2001-04-19 2003-04-24 Ciphergen Biosystems, Inc. Biomolecule characterization using mass spectrometry and affinity tags
US20030100476A1 (en) 2001-05-11 2003-05-29 Weinberger Daniel R. Effect of COMT genotype on frontal lobe function
WO2002094864A2 (en) 2001-05-25 2002-11-28 Genset S.A. Human cdnas and proteins and uses thereof
US7112408B2 (en) 2001-06-08 2006-09-26 The Brigham And Women's Hospital, Inc. Detection of ovarian cancer based upon alpha-haptoglobin levels
US20030013208A1 (en) 2001-07-13 2003-01-16 Milagen, Inc. Information enhanced antibody arrays
JP2005500543A (ja) 2001-08-13 2005-01-06 ビヨンド ジェノミクス, インコーポレイテッド 生物学的系をプロファイリングするための方法およびシステム
UA81749C2 (uk) 2001-10-04 2008-02-11 Х. Луннбек А/С Фенілпіперазинові похідні як інгібітори зворотного захоплення серотоніну
WO2003070082A2 (en) 2002-02-21 2003-08-28 Idgene Pharmaceuticals Ltd. Association of snps in the comt locus and neighboring loci with schizophrenia, bipolar disorder, breast cancer and colorectal cancer
US20030215858A1 (en) 2002-04-08 2003-11-20 Baylor College Of Medicine Enhanced gene expression system
US7241281B2 (en) 2002-04-08 2007-07-10 Thermogenesis Corporation Blood component separation method and apparatus
US20030194711A1 (en) 2002-04-10 2003-10-16 Matthew Zapala System and method for analyzing gene expression data
US20030199001A1 (en) 2002-04-23 2003-10-23 Pitt Aldo M. Sample preparation of biological fluids for proteomic applications
US20030205538A1 (en) 2002-05-03 2003-11-06 Randel Dorian Methods and apparatus for isolating platelets from blood
CA2415154C (en) 2002-12-24 2009-06-16 Biovail Laboratories Inc. Modified release formulations of selective serotonin re-uptake inhibitors
US20040203034A1 (en) 2003-01-03 2004-10-14 The University Of Chicago Optimization of cancer treatment with irinotecan
SI1610791T1 (sl) 2003-03-31 2011-05-31 Titan Pharmaceuticals Inc Implantibilna polimerna naprava za zadržano sproščanje dopaminskega agonista
US20050054688A1 (en) 2003-08-08 2005-03-10 Pfizer Inc Selective serotonin reuptake inhibitors in the treatment of disease
US20050069936A1 (en) 2003-09-26 2005-03-31 Cornelius Diamond Diagnostic markers of depression treatment and methods of use thereof
US7893261B2 (en) 2004-03-26 2011-02-22 Baylor University Serotonin reuptake inhibitors
JP2005312435A (ja) 2004-03-29 2005-11-10 Kazuhito Rokutan うつ病の評価方法
WO2006099164A2 (en) 2005-03-10 2006-09-21 Applera Corporation Methods for multiplex amplification
WO2007022248A2 (en) 2005-08-16 2007-02-22 Sloan Kettering Institute For Cancer Research Methods of detection of cancer using peptide profiles
JP2009518035A (ja) 2005-12-06 2009-05-07 ザ ジェネラル ホスピタル コーポレイション 疼痛感受性および慢性化に関する診断法およびテトラヒドロビオプテリン関連障害に関する診断法
US20080064702A1 (en) 2006-09-08 2008-03-13 Charalambos Antoniades Use of folates for the prevention and treatment of vascular diseases
US8268347B1 (en) 2006-10-24 2012-09-18 Aradigm Corporation Dual action, inhaled formulations providing both an immediate and sustained release profile
WO2008066769A2 (en) 2006-11-29 2008-06-05 Lohocla Research Corporation Genetic diagnosis of depression
WO2008086579A1 (en) 2007-01-19 2008-07-24 Queensland University Of Technology Diagnostic methods and agents
US7947662B2 (en) 2008-02-20 2011-05-24 Gnosis S.P.A. Folates, compositions and uses thereof
US20090307181A1 (en) 2008-03-19 2009-12-10 Brandon Colby Genetic analysis
WO2009131643A1 (en) 2008-04-21 2009-10-29 Monabio, Inc. Immunoassay for specific determination of s-adenosymethionine and analogs thereof in biological samples
JP2011528321A (ja) 2008-06-21 2011-11-17 ケンバー,エルエルシー ニュートリゲノミクス方法および組成
US20100112589A1 (en) 2008-11-03 2010-05-06 Xie Yagang Allele-allele interactions of mthfr gene variants, and uses thereof in predicting disease risk
EP2435586A4 (en) * 2009-05-29 2012-12-26 Genomind Llc METHODS OF EVALUATION AND TREATMENT OF DEPRESSION VIA USE OF ANALYSIS OF SIMPLE NUCLEOTIDE POLYMORPHISMS
KR20120100964A (ko) 2009-09-30 2012-09-12 바이타패스 제네틱스 인코포레이티드 개인용 보조인자 및 사용 방법
US20140088035A1 (en) * 2010-12-03 2014-03-27 The General Hospital Corporation Treating schizophrenia
KR20120092993A (ko) 2011-02-14 2012-08-22 지엘팜텍 주식회사 티아넵틴 또는 이의 약제학적으로 허용되는 염을 포함하는 경구투여용 서방성 정제
BR112013024863A2 (pt) 2011-03-28 2016-12-20 Yissum Res Dev Co formulação injetável de liberação sustentada
MX2014000197A (es) 2011-06-21 2014-06-11 Global Healthcare Focus Llc Metodos para prevenir o tratar estados patologicos relacionados con ciertas anormalidades metabolicas.
US20160058766A1 (en) * 2011-11-14 2016-03-03 Nestec S.A. Assays and methods for selecting a treatment regimen for a subject with depression
CN104053785A (zh) 2011-11-14 2014-09-17 综合医院公司 为患有抑郁症的受试者选择治疗方案的测定法和方法

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US12578778B2 (en) 2018-05-03 2026-03-17 L. Pierre de Rochemont Hybrid computer module element X-(cross)-point memory
US12585320B2 (en) 2018-05-03 2026-03-24 L. Pierre de Rochemont Power management system for delivery from a power grid or primary electrical source to a server farm or other facility consuming electric power using an input power block with on or more modules, a resonant gate transistor and a low loss transfer stage with a ladder circuit
US11901956B2 (en) 2018-06-05 2024-02-13 L. Pierre de Rochemont Module with high peak bandwidth I/O channels
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US9540691B2 (en) 2017-01-10
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US20130172361A1 (en) 2013-07-04
US20130267523A1 (en) 2013-10-10
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US9546401B2 (en) 2017-01-17
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