JP2015504666A5 - - Google Patents
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- JP2015504666A5 JP2015504666A5 JP2014550526A JP2014550526A JP2015504666A5 JP 2015504666 A5 JP2015504666 A5 JP 2015504666A5 JP 2014550526 A JP2014550526 A JP 2014550526A JP 2014550526 A JP2014550526 A JP 2014550526A JP 2015504666 A5 JP2015504666 A5 JP 2015504666A5
- Authority
- JP
- Japan
- Prior art keywords
- position corresponding
- polypeptide
- amino acid
- modified
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 108090000765 processed proteins & peptides Proteins 0.000 claims 51
- 229920001184 polypeptide Polymers 0.000 claims 50
- 102000004196 processed proteins & peptides Human genes 0.000 claims 50
- 102100021102 Hyaluronidase PH-20 Human genes 0.000 claims 43
- 101150055528 SPAM1 gene Proteins 0.000 claims 43
- 125000003275 alpha amino acid group Chemical group 0.000 claims 37
- 238000006467 substitution reaction Methods 0.000 claims 32
- 239000003814 drug Substances 0.000 claims 14
- 239000008194 pharmaceutical composition Substances 0.000 claims 13
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims 12
- RLSSMJSEOOYNOY-UHFFFAOYSA-N m-cresol Chemical compound CC1=CC=CC(O)=C1 RLSSMJSEOOYNOY-UHFFFAOYSA-N 0.000 claims 10
- 150000001413 amino acids Chemical class 0.000 claims 9
- 239000003755 preservative agent Substances 0.000 claims 9
- 230000002335 preservative effect Effects 0.000 claims 9
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 7
- 229940079593 drug Drugs 0.000 claims 7
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 claims 6
- 206010028980 Neoplasm Diseases 0.000 claims 5
- 230000021615 conjugation Effects 0.000 claims 5
- 230000000694 effects Effects 0.000 claims 5
- 229940124597 therapeutic agent Drugs 0.000 claims 5
- 229920002683 Glycosaminoglycan Polymers 0.000 claims 4
- 108010003272 Hyaluronate lyase Proteins 0.000 claims 4
- 102000001974 Hyaluronidases Human genes 0.000 claims 4
- 102000004877 Insulin Human genes 0.000 claims 4
- 108090001061 Insulin Proteins 0.000 claims 4
- 239000002246 antineoplastic agent Substances 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 4
- 208000035475 disorder Diseases 0.000 claims 4
- 229960002773 hyaluronidase Drugs 0.000 claims 4
- 229940125396 insulin Drugs 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims 3
- 125000000539 amino acid group Chemical group 0.000 claims 3
- 229940127089 cytotoxic agent Drugs 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 230000004048 modification Effects 0.000 claims 3
- 238000012986 modification Methods 0.000 claims 3
- -1 α-adrenergic Substances 0.000 claims 3
- 208000024172 Cardiovascular disease Diseases 0.000 claims 2
- 208000035484 Cellulite Diseases 0.000 claims 2
- 208000019693 Lung disease Diseases 0.000 claims 2
- 208000022873 Ocular disease Diseases 0.000 claims 2
- 206010030113 Oedema Diseases 0.000 claims 2
- 206010049752 Peau d'orange Diseases 0.000 claims 2
- 238000009825 accumulation Methods 0.000 claims 2
- UCTWMZQNUQWSLP-UHFFFAOYSA-N adrenaline Chemical compound CNCC(O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-UHFFFAOYSA-N 0.000 claims 2
- 235000019445 benzyl alcohol Nutrition 0.000 claims 2
- 229940034794 benzylparaben Drugs 0.000 claims 2
- 210000004556 brain Anatomy 0.000 claims 2
- 230000036232 cellulite Effects 0.000 claims 2
- 206010012601 diabetes mellitus Diseases 0.000 claims 2
- 210000003722 extracellular fluid Anatomy 0.000 claims 2
- KIUKXJAPPMFGSW-MNSSHETKSA-N hyaluronan Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)C1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H](C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-MNSSHETKSA-N 0.000 claims 2
- 229920002674 hyaluronan Polymers 0.000 claims 2
- 229940099552 hyaluronan Drugs 0.000 claims 2
- 229940100630 metacresol Drugs 0.000 claims 2
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical group COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims 2
- 230000035515 penetration Effects 0.000 claims 2
- 230000002062 proliferating effect Effects 0.000 claims 2
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 claims 2
- 102220182705 rs191061766 Human genes 0.000 claims 2
- XUHRVZXFBWDCFB-QRTDKPMLSA-N (3R)-4-[[(3S,6S,9S,12R,15S,18R,21R,24R,27R,28R)-12-(3-amino-3-oxopropyl)-6-[(2S)-butan-2-yl]-3-(2-carboxyethyl)-18-(hydroxymethyl)-28-methyl-9,15,21,24-tetrakis(2-methylpropyl)-2,5,8,11,14,17,20,23,26-nonaoxo-1-oxa-4,7,10,13,16,19,22,25-octazacyclooctacos-27-yl]amino]-3-[[(2R)-2-[[(3S)-3-hydroxydecanoyl]amino]-4-methylpentanoyl]amino]-4-oxobutanoic acid Chemical compound CCCCCCC[C@H](O)CC(=O)N[C@H](CC(C)C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H]1[C@@H](C)OC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CO)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC1=O)[C@@H](C)CC XUHRVZXFBWDCFB-QRTDKPMLSA-N 0.000 claims 1
- XWBADQOPXPRKBX-FMIVXFBMSA-N 1-n,1-n-diethyl-4-n-[6-methoxy-2-[(e)-2-(4-nitrophenyl)ethenyl]quinolin-4-yl]pentane-1,4-diamine Chemical compound N=1C2=CC=C(OC)C=C2C(NC(C)CCCN(CC)CC)=CC=1\C=C\C1=CC=C([N+]([O-])=O)C=C1 XWBADQOPXPRKBX-FMIVXFBMSA-N 0.000 claims 1
- 239000005541 ACE inhibitor Substances 0.000 claims 1
- 241000224489 Amoeba Species 0.000 claims 1
- 102000015081 Blood Coagulation Factors Human genes 0.000 claims 1
- 108010039209 Blood Coagulation Factors Proteins 0.000 claims 1
- 229940127291 Calcium channel antagonist Drugs 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 229920002307 Dextran Polymers 0.000 claims 1
- 108060003951 Immunoglobulin Proteins 0.000 claims 1
- 239000000150 Sympathomimetic Substances 0.000 claims 1
- 102000008068 Tensins Human genes 0.000 claims 1
- 108010088950 Tensins Proteins 0.000 claims 1
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 239000002160 alpha blocker Substances 0.000 claims 1
- 230000003444 anaesthetic effect Effects 0.000 claims 1
- 229940035676 analgesics Drugs 0.000 claims 1
- 239000000730 antalgic agent Substances 0.000 claims 1
- 230000002456 anti-arthritic effect Effects 0.000 claims 1
- 230000000844 anti-bacterial effect Effects 0.000 claims 1
- 230000000843 anti-fungal effect Effects 0.000 claims 1
- 230000001387 anti-histamine Effects 0.000 claims 1
- 230000003276 anti-hypertensive effect Effects 0.000 claims 1
- 229940124599 anti-inflammatory drug Drugs 0.000 claims 1
- 230000002141 anti-parasite Effects 0.000 claims 1
- 229940035678 anti-parkinson drug Drugs 0.000 claims 1
- 230000001754 anti-pyretic effect Effects 0.000 claims 1
- 229940124350 antibacterial drug Drugs 0.000 claims 1
- 229940125681 anticonvulsant agent Drugs 0.000 claims 1
- 239000001961 anticonvulsive agent Substances 0.000 claims 1
- 239000000935 antidepressant agent Substances 0.000 claims 1
- 229940005513 antidepressants Drugs 0.000 claims 1
- 229940121375 antifungal agent Drugs 0.000 claims 1
- 239000000739 antihistaminic agent Substances 0.000 claims 1
- 239000003430 antimalarial agent Substances 0.000 claims 1
- 239000003096 antiparasitic agent Substances 0.000 claims 1
- 239000002221 antipyretic Substances 0.000 claims 1
- 239000003716 antitrichomonal agent Substances 0.000 claims 1
- 239000003443 antiviral agent Substances 0.000 claims 1
- 239000003899 bactericide agent Substances 0.000 claims 1
- 230000003385 bacteriostatic effect Effects 0.000 claims 1
- 230000003115 biocidal effect Effects 0.000 claims 1
- 239000003139 biocide Substances 0.000 claims 1
- 239000003114 blood coagulation factor Substances 0.000 claims 1
- 229940019700 blood coagulation factors Drugs 0.000 claims 1
- 229940124630 bronchodilator Drugs 0.000 claims 1
- 239000000480 calcium channel blocker Substances 0.000 claims 1
- 230000021523 carboxylation Effects 0.000 claims 1
- 238000006473 carboxylation reaction Methods 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 229940044683 chemotherapy drug Drugs 0.000 claims 1
- 239000003433 contraceptive agent Substances 0.000 claims 1
- 230000002254 contraceptive effect Effects 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000000850 decongestant Substances 0.000 claims 1
- 229940039227 diagnostic agent Drugs 0.000 claims 1
- 239000000032 diagnostic agent Substances 0.000 claims 1
- 239000002934 diuretic Substances 0.000 claims 1
- 230000001882 diuretic effect Effects 0.000 claims 1
- 230000002526 effect on cardiovascular system Effects 0.000 claims 1
- 239000003792 electrolyte Substances 0.000 claims 1
- 230000013595 glycosylation Effects 0.000 claims 1
- 238000006206 glycosylation reaction Methods 0.000 claims 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
- 230000033444 hydroxylation Effects 0.000 claims 1
- 238000005805 hydroxylation reaction Methods 0.000 claims 1
- 230000003345 hyperglycaemic effect Effects 0.000 claims 1
- 230000000147 hypnotic effect Effects 0.000 claims 1
- 102000018358 immunoglobulin Human genes 0.000 claims 1
- 239000000411 inducer Substances 0.000 claims 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 claims 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 claims 1
- 229960002216 methylparaben Drugs 0.000 claims 1
- 210000003205 muscle Anatomy 0.000 claims 1
- 239000003158 myorelaxant agent Substances 0.000 claims 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 1
- 229940023490 ophthalmic product Drugs 0.000 claims 1
- 239000000734 parasympathomimetic agent Substances 0.000 claims 1
- 230000001499 parasympathomimetic effect Effects 0.000 claims 1
- 229940005542 parasympathomimetics Drugs 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000026731 phosphorylation Effects 0.000 claims 1
- 238000006366 phosphorylation reaction Methods 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 claims 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 claims 1
- 229960003415 propylparaben Drugs 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 239000003368 psychostimulant agent Substances 0.000 claims 1
- 239000000932 sedative agent Substances 0.000 claims 1
- 229940125723 sedative agent Drugs 0.000 claims 1
- 230000009450 sialylation Effects 0.000 claims 1
- 150000003384 small molecules Chemical class 0.000 claims 1
- 230000001975 sympathomimetic effect Effects 0.000 claims 1
- 229940064707 sympathomimetics Drugs 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
- 108700012359 toxins Proteins 0.000 claims 1
- 239000003204 tranquilizing agent Substances 0.000 claims 1
- 230000002936 tranquilizing effect Effects 0.000 claims 1
- 229940088594 vitamin Drugs 0.000 claims 1
- 239000011782 vitamin Substances 0.000 claims 1
- 229930003231 vitamin Natural products 0.000 claims 1
- 235000013343 vitamin Nutrition 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161631313P | 2011-12-30 | 2011-12-30 | |
| US61/631,313 | 2011-12-30 | ||
| US201261796208P | 2012-11-01 | 2012-11-01 | |
| US61/796,208 | 2012-11-01 | ||
| PCT/US2012/072182 WO2013102144A2 (en) | 2011-12-30 | 2012-12-28 | Ph20 polypeptede variants, formulations and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016247708A Division JP6422933B2 (ja) | 2011-12-30 | 2016-12-21 | Ｐｈ２０ポリペプチド変異体、その製剤および使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015504666A JP2015504666A (ja) | 2015-02-16 |
| JP2015504666A5 true JP2015504666A5 (enExample) | 2015-03-26 |
| JP6067746B2 JP6067746B2 (ja) | 2017-01-25 |
Family
ID=47595052
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014550526A Active JP6067746B2 (ja) | 2011-12-30 | 2012-12-28 | Ｐｈ２０ポリペプチド変異体、その製剤および使用 |
| JP2016247708A Active JP6422933B2 (ja) | 2011-12-30 | 2016-12-21 | Ｐｈ２０ポリペプチド変異体、その製剤および使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016247708A Active JP6422933B2 (ja) | 2011-12-30 | 2016-12-21 | Ｐｈ２０ポリペプチド変異体、その製剤および使用 |
Country Status (23)
| Country | Link |
|---|---|
| US (28) | US9447401B2 (enExample) |
| EP (2) | EP3130347B1 (enExample) |
| JP (2) | JP6067746B2 (enExample) |
| CN (1) | CN104244968B (enExample) |
| AU (2) | AU2012362141B2 (enExample) |
| BR (1) | BR112014016195A2 (enExample) |
| CA (1) | CA2861919C (enExample) |
| CY (1) | CY1122532T1 (enExample) |
| DK (2) | DK3130347T3 (enExample) |
| EA (1) | EA030252B9 (enExample) |
| ES (2) | ES2749620T3 (enExample) |
| HR (1) | HRP20192249T1 (enExample) |
| HU (1) | HUE047849T2 (enExample) |
| IL (5) | IL298330B1 (enExample) |
| LT (1) | LT3130347T (enExample) |
| MX (2) | MX361727B (enExample) |
| PL (1) | PL3130347T3 (enExample) |
| PT (1) | PT3130347T (enExample) |
| RS (1) | RS59703B1 (enExample) |
| SG (2) | SG11201403714TA (enExample) |
| SI (1) | SI3130347T1 (enExample) |
| SM (1) | SMT201900630T1 (enExample) |
| WO (1) | WO2013102144A2 (enExample) |
Families Citing this family (77)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0408116B1 (pt) | 2003-03-05 | 2022-09-20 | Halozyme, Inc | Polipeptídeos de hialuronidase solúveis conjugados a polímero, composições farmacêuticas compreendendo polipeptídeos ph20 solúveis, seus usos e processo de preparação, e ácidos nucléicos que codificam polipeptídeos de hialuronidase solúveis |
| NZ601248A (en) | 2008-04-14 | 2014-06-27 | Halozyme Inc | Modified hyaluronidases and uses in treating hyaluronan-associated diseases and conditions |
| TWI394580B (zh) | 2008-04-28 | 2013-05-01 | Halozyme Inc | 超快起作用胰島素組成物 |
| AU2009333918B2 (en) | 2008-12-09 | 2014-06-05 | Halozyme, Inc. | Extended soluble PH20 polypeptides and uses thereof |
| WO2011034604A2 (en) | 2009-09-17 | 2011-03-24 | Baxter Healthcare, S.A. | Stable co-formulation of hyaluronidase and immunoglobulin, and methods of use thereof |
| DK2595624T3 (en) | 2010-07-20 | 2018-03-26 | Halozyme Inc | Methods of treating or preventing adverse side effects associated with administration of an anti-hyaluronan agent |
| WO2012174478A2 (en) * | 2011-06-17 | 2012-12-20 | Halozyme, Inc. | Stable formulations of a hyaluronan-degrading enzyme |
| US9993529B2 (en) | 2011-06-17 | 2018-06-12 | Halozyme, Inc. | Stable formulations of a hyaluronan-degrading enzyme |
| EA030440B1 (ru) | 2011-10-24 | 2018-08-31 | Галозим, Инк. | Сопровождающая диагностика для терапии антигиалуронановым агентом и способы ее применения |
| EP3130347B1 (en) | 2011-12-30 | 2019-09-18 | Halozyme, Inc. | Ph20 polypeptide variants, formulations and uses thereof |
| BR112014024848A2 (pt) | 2012-04-04 | 2017-07-11 | Halozyme Inc | terapia de combinação com um agente antihialuronano e um taxano direcionamento ao tumor |
| US9278124B2 (en) | 2012-10-16 | 2016-03-08 | Halozyme, Inc. | Hypoxia and hyaluronan and markers thereof for diagnosis and monitoring of diseases and conditions and related methods |
| CA2889552C (fr) | 2012-11-13 | 2023-10-10 | Adocia | Formulation a action rapide d'insuline comprenant un compose anionique substitue |
| TW201534726A (zh) * | 2013-07-03 | 2015-09-16 | Halozyme Inc | 熱穩定ｐｈ２０玻尿酸酶變異體及其用途 |
| HUP1300646A2 (en) * | 2013-11-12 | 2015-05-28 | Druggability Technologies Ip Holdco Jersey Ltd | Complexes of fulvestrant and its derivatives, process for the preparation thereof and pharmaceutical compositions containing them |
| CN103819578B (zh) * | 2013-11-22 | 2016-05-11 | 青岛九龙生物医药有限公司 | 一种加氢氧化钠法提高硫酸软骨素收率的方法 |
| US9480731B2 (en) * | 2013-12-12 | 2016-11-01 | Medy-Tox, Inc. | Long lasting effect of new botulinum toxin formulations |
| US9603927B2 (en) | 2014-02-28 | 2017-03-28 | Janssen Biotech, Inc. | Combination therapies with anti-CD38 antibodies |
| US9732154B2 (en) | 2014-02-28 | 2017-08-15 | Janssen Biotech, Inc. | Anti-CD38 antibodies for treatment of acute lymphoblastic leukemia |
| WO2015175668A1 (en) * | 2014-05-13 | 2015-11-19 | Eagle Pharmaceuticals, Inc. | Aqueous buffer-free bivalirudin compositions |
| WO2016033555A1 (en) | 2014-08-28 | 2016-03-03 | Halozyme, Inc. | Combination therapy with a hyaluronan-degrading enzyme and an immune checkpoint inhibitor |
| CN108064282A (zh) | 2014-10-14 | 2018-05-22 | 哈洛齐梅公司 | 腺苷脱氨酶-2(ada2)、其变体的组合物及使用其的方法 |
| AU2015358615B2 (en) | 2014-12-04 | 2021-08-05 | Janssen Biotech, Inc. | Anti-CD38 antibodies for treatment of acute myeloid leukemia |
| TW201630622A (zh) | 2014-12-16 | 2016-09-01 | 美國禮來大藥廠 | 速效胰島素組合物 |
| HK1253242A1 (zh) | 2015-05-20 | 2019-06-14 | Janssen Biotech, Inc. | 用於治疗轻链淀粉样变性及其它cd38阳性血液恶性肿瘤的抗cd38抗体 |
| EP3302465A1 (en) | 2015-06-05 | 2018-04-11 | Vertex Pharmaceuticals Incorporated | Triazoles for the treatment of demyelinating diseases |
| JO3749B1 (ar) | 2015-08-27 | 2021-01-31 | Lilly Co Eli | تركيبات إنسولين سريعة المفعول |
| AU2016350717B2 (en) | 2015-11-03 | 2023-08-10 | Janssen Biotech, Inc. | Subcutaneous formulations of anti-CD38 antibodies and their uses |
| CN105727267B (zh) * | 2016-02-05 | 2020-05-26 | 苏州康聚生物科技有限公司 | 一种重组人透明质酸酶冻干制剂及其制备方法和应用 |
| GB201607918D0 (en) * | 2016-05-06 | 2016-06-22 | Arecor Ltd | Novel formulations |
| WO2017201635A1 (zh) * | 2016-05-23 | 2017-11-30 | 蔡胜和 | 透明质酸酶的细胞表达及其在实体瘤细胞治疗中的应用 |
| JP2019527678A (ja) | 2016-06-28 | 2019-10-03 | ユーエムセー・ユトレヒト・ホールディング・ベー・フェー | ＣＤ３８に特異的に結合する抗体によるＩｇＥ媒介疾患の治療 |
| US10685790B2 (en) * | 2016-06-29 | 2020-06-16 | Innocell Aps | Supercapacitor and a method for expanding the voltage range of an aqueous electrolyte suprcapacitor |
| TWI773686B (zh) | 2016-09-13 | 2022-08-11 | 美商愛力根公司 | 非蛋白梭菌毒素組成物 |
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