JP2015145400A5 - - Google Patents
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- JP2015145400A5 JP2015145400A5 JP2015075148A JP2015075148A JP2015145400A5 JP 2015145400 A5 JP2015145400 A5 JP 2015145400A5 JP 2015075148 A JP2015075148 A JP 2015075148A JP 2015075148 A JP2015075148 A JP 2015075148A JP 2015145400 A5 JP2015145400 A5 JP 2015145400A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- terminal
- polysialic acid
- epo
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06117830 | 2006-07-25 | ||
| EP06117830.7 | 2006-07-25 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013160269A Division JP5941440B2 (ja) | 2006-07-25 | 2013-08-01 | ポリサッカライドによるタンパク質のn末端誘導体化 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015145400A JP2015145400A (ja) | 2015-08-13 |
| JP2015145400A5 true JP2015145400A5 (enExample) | 2016-03-03 |
| JP6055506B2 JP6055506B2 (ja) | 2016-12-27 |
Family
ID=37397314
Family Applications (14)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009521337A Expired - Fee Related JP5096466B2 (ja) | 2006-07-25 | 2007-07-25 | N末端ポリシアリル化 |
| JP2009521336A Expired - Fee Related JP5419689B2 (ja) | 2006-07-25 | 2007-07-25 | 顆粒球コロニー刺激因子の誘導体化 |
| JP2009521342A Pending JP2009544680A (ja) | 2006-07-25 | 2007-07-25 | ポリサッカライドによるタンパク質のn末端誘導体化 |
| JP2009521343A Pending JP2009544681A (ja) | 2006-07-25 | 2007-07-25 | エリスロポエチンの多糖誘導体 |
| JP2012205475A Expired - Fee Related JP5586669B2 (ja) | 2006-07-25 | 2012-09-19 | N末端ポリシアリル化 |
| JP2012287324A Active JP5542195B2 (ja) | 2006-07-25 | 2012-12-28 | エリスロポエチンの多糖誘導体 |
| JP2013022825A Expired - Fee Related JP5420091B2 (ja) | 2006-07-25 | 2013-02-08 | ポリサッカライドによるタンパク質のn末端誘導体化 |
| JP2013160269A Active JP5941440B2 (ja) | 2006-07-25 | 2013-08-01 | ポリサッカライドによるタンパク質のn末端誘導体化 |
| JP2014025061A Active JP6165079B2 (ja) | 2006-07-25 | 2014-02-13 | エリスロポエチンの多糖誘導体 |
| JP2014154037A Active JP5912152B2 (ja) | 2006-07-25 | 2014-07-29 | N末端ポリシアリル化 |
| JP2015075148A Expired - Fee Related JP6055506B2 (ja) | 2006-07-25 | 2015-04-01 | ポリサッカライドによるタンパク質のn末端誘導体化 |
| JP2016020557A Expired - Fee Related JP6243456B2 (ja) | 2006-07-25 | 2016-02-05 | ポリサッカライドによるタンパク質のn末端誘導体化 |
| JP2016149090A Expired - Fee Related JP6203342B2 (ja) | 2006-07-25 | 2016-07-29 | エリスロポエチンの多糖誘導体 |
| JP2017157728A Expired - Fee Related JP6581157B2 (ja) | 2006-07-25 | 2017-08-18 | エリスロポエチンの多糖誘導体 |
Family Applications Before (10)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009521337A Expired - Fee Related JP5096466B2 (ja) | 2006-07-25 | 2007-07-25 | N末端ポリシアリル化 |
| JP2009521336A Expired - Fee Related JP5419689B2 (ja) | 2006-07-25 | 2007-07-25 | 顆粒球コロニー刺激因子の誘導体化 |
| JP2009521342A Pending JP2009544680A (ja) | 2006-07-25 | 2007-07-25 | ポリサッカライドによるタンパク質のn末端誘導体化 |
| JP2009521343A Pending JP2009544681A (ja) | 2006-07-25 | 2007-07-25 | エリスロポエチンの多糖誘導体 |
| JP2012205475A Expired - Fee Related JP5586669B2 (ja) | 2006-07-25 | 2012-09-19 | N末端ポリシアリル化 |
| JP2012287324A Active JP5542195B2 (ja) | 2006-07-25 | 2012-12-28 | エリスロポエチンの多糖誘導体 |
| JP2013022825A Expired - Fee Related JP5420091B2 (ja) | 2006-07-25 | 2013-02-08 | ポリサッカライドによるタンパク質のn末端誘導体化 |
| JP2013160269A Active JP5941440B2 (ja) | 2006-07-25 | 2013-08-01 | ポリサッカライドによるタンパク質のn末端誘導体化 |
| JP2014025061A Active JP6165079B2 (ja) | 2006-07-25 | 2014-02-13 | エリスロポエチンの多糖誘導体 |
| JP2014154037A Active JP5912152B2 (ja) | 2006-07-25 | 2014-07-29 | N末端ポリシアリル化 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016020557A Expired - Fee Related JP6243456B2 (ja) | 2006-07-25 | 2016-02-05 | ポリサッカライドによるタンパク質のn末端誘導体化 |
| JP2016149090A Expired - Fee Related JP6203342B2 (ja) | 2006-07-25 | 2016-07-29 | エリスロポエチンの多糖誘導体 |
| JP2017157728A Expired - Fee Related JP6581157B2 (ja) | 2006-07-25 | 2017-08-18 | エリスロポエチンの多糖誘導体 |
Country Status (10)
| Country | Link |
|---|---|
| US (22) | US10300144B2 (enExample) |
| EP (6) | EP3299033A1 (enExample) |
| JP (14) | JP5096466B2 (enExample) |
| KR (1) | KR101400105B1 (enExample) |
| CN (2) | CN101511391B (enExample) |
| AT (1) | ATE467642T1 (enExample) |
| DE (1) | DE602007006492D1 (enExample) |
| ES (5) | ES2581902T3 (enExample) |
| RU (1) | RU2432175C2 (enExample) |
| WO (4) | WO2008012528A1 (enExample) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2294535T3 (es) | 2003-08-12 | 2008-04-01 | Lipoxen Technologies Limited | Derivados del acido polisialico. |
| KR101113726B1 (ko) | 2003-08-12 | 2012-02-27 | 리폭센 테크놀로지즈 리미티드 | 단백질 유도 및 컨쥬게이션용 시알산 유도체 |
| EP3299033A1 (en) * | 2006-07-25 | 2018-03-28 | Lipoxen Technologies Limited | N-terminal polysialylation |
| CN105838699A (zh) | 2006-12-15 | 2016-08-10 | 巴克斯艾尔塔公司 | 具有延长的体内半衰期的因子VIIa-聚唾液酸结合物 |
| PL2115010T3 (pl) | 2007-02-28 | 2012-07-31 | Lipoxen Tech Limited | Zmniejszanie zawartości endotoksyny w kwasach polisialowych |
| BRPI0815324A2 (pt) | 2007-08-20 | 2015-07-14 | Protalix Ltd | "conjugado protêico que contém sacarídeos, processo de separação do conjugado protêico que contém sacarídeos, composição farmacêutica do conjugado protêico que contém sacarídeos, uso do conjugado protêico que contém sacarídeos e composto do conjugado protêico que contém sacarídeos" |
| RU2391354C1 (ru) * | 2008-10-15 | 2010-06-10 | Учреждение Российской академии наук Институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова РАН, Российская Федерация, от имени которой выступает Федеральное агентство по науке и инновациям | Комплекс биологически активного рекомбинантного белка с полисиаловой кислотой |
| WO2010089756A2 (en) * | 2008-10-20 | 2010-08-12 | Usv Limited | An improved process for pegylation of proteins |
| WO2010051335A1 (en) * | 2008-10-31 | 2010-05-06 | Amgen Inc. | Materials and methods relating to stem cell mobilization by multi-pegylated granulocyte colony stimulating factor |
| AU2010208305A1 (en) | 2009-01-28 | 2011-09-08 | Smartcells, Inc. | Synthetic conjugates and uses thereof |
| RU2011135730A (ru) | 2009-01-28 | 2013-03-10 | Смартселлз, Инк. | Кристаллические инсулин-коньюгаты |
| KR101635689B1 (ko) | 2009-01-28 | 2016-07-01 | 스마트쎌스, 인크. | 제어 약물 전달을 위한 접합체 기재 시스템 |
| US8846103B2 (en) | 2009-01-28 | 2014-09-30 | Smartcells, Inc. | Exogenously triggered controlled release materials and uses thereof |
| US8569231B2 (en) | 2009-03-20 | 2013-10-29 | Smartcells, Inc. | Soluble non-depot insulin conjugates and uses thereof |
| US8623345B2 (en) | 2009-03-20 | 2014-01-07 | Smartcells | Terminally-functionalized conjugates and uses thereof |
| EP2459226B1 (en) * | 2009-07-27 | 2016-06-29 | Lipoxen Technologies Limited | Glycopolysialylation of proteins other than blood coagulation proteins |
| US8642737B2 (en) | 2010-07-26 | 2014-02-04 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
| EP2459224B1 (en) | 2009-07-27 | 2016-06-01 | Baxalta GmbH | Blood coagulation protein conjugates |
| US8809501B2 (en) | 2009-07-27 | 2014-08-19 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
| PL2459224T3 (pl) * | 2009-07-27 | 2017-08-31 | Baxalta GmbH | Koniugaty białka związanego z krzepnięciem krwi |
| US9194011B2 (en) | 2009-11-17 | 2015-11-24 | Protalix Ltd. | Stabilized alpha-galactosidase and uses thereof |
| CN101787117B (zh) * | 2010-02-08 | 2012-05-23 | 江南大学 | 聚乙二醇-聚唾液酸嵌段共聚物的制备方法及应用 |
| KR20130115086A (ko) * | 2010-05-17 | 2013-10-21 | 세빅스 인코포레이티드 | 페길화된 c-펩티드 |
| US20120034631A1 (en) * | 2010-06-11 | 2012-02-09 | Wojciak Jonathan Michael | Anti-lysophospholipid antibody design using antibody structures |
| WO2012015692A2 (en) | 2010-07-28 | 2012-02-02 | Smartcells, Inc. | Recombinantly expressed insulin polypeptides and uses thereof |
| WO2012015691A2 (en) | 2010-07-28 | 2012-02-02 | Smartcells, Inc. | Recombinant lectins, binding-site modified lectins and uses thereof |
| AU2011282977A1 (en) | 2010-07-28 | 2013-02-21 | Smartcells, Inc. | Drug-ligand conjugates, synthesis thereof, and intermediates thereto |
| ES2774190T3 (es) | 2011-01-20 | 2020-07-17 | Protalix Ltd | Composiciones de alfa-galactosidasa |
| EP2780030A4 (en) | 2011-11-17 | 2015-11-18 | Cebix Ab | PEGYLATED C-PEPTIDE |
| TW201605470A (zh) | 2013-10-04 | 2016-02-16 | 默沙東藥廠 | 葡萄糖反應性胰島素結合物 |
| WO2015130963A2 (en) | 2014-02-27 | 2015-09-03 | Xenetic Biosciences, Inc. | Compositions and methods for administering insulin or insulin-like protein to the brain |
| JP2019218265A (ja) * | 2016-09-14 | 2019-12-26 | 生化学工業株式会社 | ペプチドの血中滞留性を増強させる方法 |
| WO2018197545A1 (en) * | 2017-04-25 | 2018-11-01 | Lipoxen Technologies Limited | Methods of treating multiple myeloma cancers expressing high levels of epo-receptor using psa-epo |
| WO2018197547A1 (en) | 2017-04-25 | 2018-11-01 | Lipoxen Technologies Limited | Methods of treating diseases related to net formation with parenteral administration of polysialylated dnase i |
| WO2020099513A1 (en) * | 2018-11-13 | 2020-05-22 | Lipoxen Technologies Limited | Glycopolysialylation of blinatumomab |
| WO2020163269A1 (en) * | 2019-02-04 | 2020-08-13 | Xenetic Biosciences, Inc. | Methods of using glycopolysialylated therapeutic proteins |
| PE20220098A1 (es) | 2019-07-08 | 2022-01-24 | Gi Innovation Inc | Dimero polipeptido con alto contenido en acido sialico, que comprende el dominio extracelular de la subunidad alfa del receptor fc de ige, y composicion farmaceutica que comprende el mismo |
| CN116249552A (zh) * | 2020-08-11 | 2023-06-09 | 隆延生物科技(上海)有限公司 | 一种液体制剂及其应用 |
| CN114966021B (zh) * | 2022-05-19 | 2025-03-04 | 山东博科生物产业有限公司 | 一种稳定的脂蛋白相关磷脂酶a2测定试剂盒 |
Family Cites Families (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| DE2930542A1 (de) | 1979-07-27 | 1981-02-12 | Hoechst Ag | Neue insulinderivate und verfahren zu ihrer herstellung |
| US5308617A (en) * | 1988-08-10 | 1994-05-03 | Halzyme Ltd. | Protein heparin conjugates |
| US7217689B1 (en) * | 1989-10-13 | 2007-05-15 | Amgen Inc. | Glycosylation analogs of erythropoietin |
| KR100221066B1 (ko) | 1989-10-13 | 1999-10-01 | 스튜어트 엘.왓트 | 에리트로포이에틴 유사체와 그를 포함하는 제약학적 조성물 |
| GB9112212D0 (en) | 1991-06-06 | 1991-07-24 | Gregoriadis Gregory | Pharmaceutical compositions |
| US5846951A (en) * | 1991-06-06 | 1998-12-08 | The School Of Pharmacy, University Of London | Pharmaceutical compositions |
| EP0550108B1 (en) | 1991-12-30 | 1998-03-18 | Akzo Nobel N.V. | Sustained release thyroactive composition |
| JP2747967B2 (ja) * | 1993-07-23 | 1998-05-06 | 雪印乳業株式会社 | シアル酸粉末 |
| US20030053982A1 (en) | 1994-09-26 | 2003-03-20 | Kinstler Olaf B. | N-terminally chemically modified protein compositions and methods |
| US5824784A (en) * | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
| DK1003525T3 (da) * | 1997-08-05 | 2003-03-24 | Bioniche Life Sciences Inc | Præparat og fremgangsmåde til regulering af celleproliferation og celledød |
| AU2794199A (en) | 1998-02-26 | 1999-09-15 | Robertas Bunevicius | Thyroid hormone replacement using sustained release triiodothyronine |
| RU2141531C1 (ru) | 1999-05-26 | 1999-11-20 | Российское акционерное общество открытого типа "Биопрепарат" | Способ получения рекомбинантного инсулина человека |
| US6323311B1 (en) * | 1999-09-22 | 2001-11-27 | University Of Utah Research Foundation | Synthesis of insulin derivatives |
| WO2001087922A2 (en) | 2000-05-16 | 2001-11-22 | Lipoxen Technologies Limited | Derivatisation of proteins in aqueous solution |
| ES2257412T3 (es) | 2000-05-18 | 2006-08-01 | Therics, Inc. | Encapsulacion de un nucleo toxico en una region no toxica en una forma de dosificacion oral. |
| US7118737B2 (en) * | 2000-09-08 | 2006-10-10 | Amylin Pharmaceuticals, Inc. | Polymer-modified synthetic proteins |
| ATE421535T1 (de) | 2000-10-16 | 2009-02-15 | Chugai Pharmaceutical Co Ltd | Peg-modifiziertes erythropoietin |
| AU2002233230B2 (en) | 2000-12-20 | 2007-02-01 | F. Hoffmann-La Roche Ag | Erythropoietin conjugates |
| KR100401296B1 (ko) | 2000-12-27 | 2003-10-11 | 드림바이오젠 주식회사 | 수식물질에 의해 수식된 단백질 변이체 및 이것의 제조방법 |
| US7125843B2 (en) * | 2001-10-19 | 2006-10-24 | Neose Technologies, Inc. | Glycoconjugates including more than one peptide |
| ES2561985T3 (es) * | 2001-10-10 | 2016-03-01 | Ratiopharm Gmbh | Remodelación y glicoconjugación de anticuerpos |
| WO2003055526A2 (en) | 2001-12-21 | 2003-07-10 | Maxygen Aps | Erythropoietin conjugates |
| ITPD20010302A1 (it) | 2001-12-28 | 2003-06-28 | Bbs Riva Spa | Dispositivo idraulico per pompare e / p intercettare metallo allo stato fuso |
| US6763226B1 (en) | 2002-07-31 | 2004-07-13 | Computer Science Central, Inc. | Multifunctional world wide walkie talkie, a tri-frequency cellular-satellite wireless instant messenger computer and network for establishing global wireless volp quality of service (qos) communications, unified messaging, and video conferencing via the internet |
| EP1400533A1 (en) * | 2002-09-11 | 2004-03-24 | Fresenius Kabi Deutschland GmbH | HASylated polypeptides, especially HASylated erythropoietin |
| EP1681303B1 (en) | 2002-09-11 | 2013-09-04 | Fresenius Kabi Deutschland GmbH | HASylated polypeptides, especially HASylated erythropoietin |
| AU2003255406B2 (en) * | 2002-09-11 | 2009-09-10 | Fresenius Kabi Deutschland Gmbh | Hydroxyalkyl starch derivatives |
| CN101514223B (zh) | 2003-04-11 | 2017-03-01 | 安特里阿比奥有限公司 | 位点特异性蛋白质偶联物的制备方法 |
| WO2004101619A1 (ja) * | 2003-05-15 | 2004-11-25 | Shionogi Co., Ltd. | 機能的糖ペプチドの合理的設計および合成 |
| US7074755B2 (en) | 2003-05-17 | 2006-07-11 | Centocor, Inc. | Erythropoietin conjugate compounds with extended half-lives |
| US7550593B2 (en) | 2003-07-03 | 2009-06-23 | Cipla Limited | Process for the preparation of finasteride Form I |
| EP1651547B1 (en) | 2003-08-05 | 2006-11-22 | Dematic Corp. | Motorized roller transverse drive |
| BRPI0413309B8 (pt) | 2003-08-06 | 2021-05-25 | The Government Of The Us Secretary Department Of Health And Human Services | método para a preparação de uma vacina conjugada de polissacarídeo-proteína |
| PL1660134T3 (pl) * | 2003-08-08 | 2011-05-31 | Fresenius Kabi Deutschland Gmbh | Koniugaty hydroksyalkiloskrobi i G-CSF |
| KR101113726B1 (ko) * | 2003-08-12 | 2012-02-27 | 리폭센 테크놀로지즈 리미티드 | 단백질 유도 및 컨쥬게이션용 시알산 유도체 |
| ES2294535T3 (es) * | 2003-08-12 | 2008-04-01 | Lipoxen Technologies Limited | Derivados del acido polisialico. |
| US20070254834A1 (en) * | 2003-11-24 | 2007-11-01 | Defrees Shawn | Glycopegylated Erythropoietin |
| US7956032B2 (en) | 2003-12-03 | 2011-06-07 | Novo Nordisk A/S | Glycopegylated granulocyte colony stimulating factor |
| CN1897812B (zh) | 2003-12-03 | 2011-08-17 | 生物种属学股份公司 | 糖聚乙二醇化的粒细胞集落刺激因子 |
| DE202005021885U1 (de) * | 2004-03-11 | 2011-03-03 | Fresenius Kabi Deutschland Gmbh | Hydroxyalkylstärke-Protein-Konjugate, durch reduktive Aminierung hergestellt |
| FR2868071B1 (fr) * | 2004-03-26 | 2006-06-09 | Biomerieux Sa | Reactifs de marquage, procedes de synthese de tels reactifs et procedes de detection de molecules biologiques |
| DE102004030392A1 (de) | 2004-06-23 | 2006-01-19 | Endress + Hauser Flowtec Ag, Reinach | Meßwandler vom Vibrationstyp |
| WO2006014148A2 (fr) | 2004-08-04 | 2006-02-09 | Sergey Alexandrovich Orlov | Procede permettant d'organiser un processus de jeu a action intermittente |
| GB2416993A (en) | 2004-08-11 | 2006-02-15 | Dinesh Verma | Opthalmic prosthesis |
| US7875708B2 (en) * | 2004-08-12 | 2011-01-25 | Lipoxen Technologies Limited | Sialic acid derivatives |
| JP5026266B2 (ja) | 2004-08-12 | 2012-09-12 | リポクセン テクノロジーズ リミテッド | 分別 |
| US9029331B2 (en) | 2005-01-10 | 2015-05-12 | Novo Nordisk A/S | Glycopegylated granulocyte colony stimulating factor |
| TWI376234B (en) * | 2005-02-01 | 2012-11-11 | Msd Oss Bv | Conjugates of a polypeptide and an oligosaccharide |
| CN101160326B (zh) | 2005-02-23 | 2013-04-10 | 利普生技术有限公司 | 用于蛋白质衍生和缀合的活化的唾液酸衍生物 |
| JP3989936B2 (ja) * | 2005-04-07 | 2007-10-10 | 進 須永 | 抗腫瘍剤及び新規dnアーゼ |
| WO2007047997A2 (en) | 2005-10-19 | 2007-04-26 | Smartcells, Inc. | Methods for reducing the mitogenicity of lectin compositions |
| EP3299033A1 (en) * | 2006-07-25 | 2018-03-28 | Lipoxen Technologies Limited | N-terminal polysialylation |
| WO2011007865A1 (ja) | 2009-07-16 | 2011-01-20 | 花王株式会社 | 食後血中インスリン濃度上昇抑制剤 |
| TWI593708B (zh) | 2011-09-26 | 2017-08-01 | 諾華公司 | 治療代謝病症之融合蛋白質 |
-
2007
- 2007-07-25 EP EP17188428.1A patent/EP3299033A1/en not_active Withdrawn
- 2007-07-25 EP EP07789051.5A patent/EP2043693B1/en not_active Not-in-force
- 2007-07-25 US US12/375,010 patent/US10300144B2/en active Active
- 2007-07-25 CN CN2007800337418A patent/CN101511391B/zh not_active Expired - Fee Related
- 2007-07-25 DE DE602007006492T patent/DE602007006492D1/de active Active
- 2007-07-25 EP EP07766361.5A patent/EP2043616B1/en not_active Not-in-force
- 2007-07-25 JP JP2009521337A patent/JP5096466B2/ja not_active Expired - Fee Related
- 2007-07-25 ES ES07789051.5T patent/ES2581902T3/es active Active
- 2007-07-25 ES ES13163525.2T patent/ES2647528T3/es active Active
- 2007-07-25 WO PCT/GB2007/002821 patent/WO2008012528A1/en not_active Ceased
- 2007-07-25 KR KR1020097003805A patent/KR101400105B1/ko not_active Expired - Fee Related
- 2007-07-25 JP JP2009521336A patent/JP5419689B2/ja not_active Expired - Fee Related
- 2007-07-25 JP JP2009521342A patent/JP2009544680A/ja active Pending
- 2007-07-25 ES ES07766363.1T patent/ES2581983T3/es active Active
- 2007-07-25 US US12/375,006 patent/US8299015B2/en active Active
- 2007-07-25 EP EP07789047A patent/EP2041167B1/en not_active Not-in-force
- 2007-07-25 EP EP13163525.2A patent/EP2630972B1/en not_active Not-in-force
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