JP2013544499A5 - - Google Patents
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- Publication number
- JP2013544499A5 JP2013544499A5 JP2013530759A JP2013530759A JP2013544499A5 JP 2013544499 A5 JP2013544499 A5 JP 2013544499A5 JP 2013530759 A JP2013530759 A JP 2013530759A JP 2013530759 A JP2013530759 A JP 2013530759A JP 2013544499 A5 JP2013544499 A5 JP 2013544499A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- endopeptidase
- seq
- trypsin
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920001184 polypeptide Polymers 0.000 claims 28
- 102000004196 processed proteins & peptides Human genes 0.000 claims 28
- 108090000765 processed proteins & peptides Proteins 0.000 claims 28
- 102000005593 Endopeptidases Human genes 0.000 claims 10
- 108010059378 Endopeptidases Proteins 0.000 claims 10
- 238000000034 method Methods 0.000 claims 8
- 230000001810 trypsinlike Effects 0.000 claims 8
- 238000004519 manufacturing process Methods 0.000 claims 7
- 239000003531 protein hydrolysate Substances 0.000 claims 6
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 5
- 235000018102 proteins Nutrition 0.000 claims 5
- 102000004169 proteins and genes Human genes 0.000 claims 5
- 108090000623 proteins and genes Proteins 0.000 claims 5
- 108091026890 Coding region Proteins 0.000 claims 3
- 108010009736 Protein Hydrolysates Proteins 0.000 claims 3
- 108091033319 polynucleotide Proteins 0.000 claims 3
- 102000040430 polynucleotide Human genes 0.000 claims 3
- 239000002157 polynucleotide Substances 0.000 claims 3
- 241000894006 Bacteria Species 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 241001156739 Actinobacteria <phylum> Species 0.000 claims 1
- 102000014171 Milk Proteins Human genes 0.000 claims 1
- 108010011756 Milk Proteins Proteins 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 102000004142 Trypsin Human genes 0.000 claims 1
- 108090000631 Trypsin Proteins 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 238000003780 insertion Methods 0.000 claims 1
- 230000037431 insertion Effects 0.000 claims 1
- 235000021239 milk protein Nutrition 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10185793.6 | 2010-10-01 | ||
| EP10185793 | 2010-10-01 | ||
| PCT/EP2011/067167 WO2012042037A1 (en) | 2010-10-01 | 2011-09-30 | Polypeptides having endopeptidase activity and polynucleotides encoding same |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013544499A JP2013544499A (ja) | 2013-12-19 |
| JP2013544499A5 true JP2013544499A5 (enExample) | 2014-10-23 |
| JP5944908B2 JP5944908B2 (ja) | 2016-07-05 |
Family
ID=44720015
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013530759A Expired - Fee Related JP5944908B2 (ja) | 2010-10-01 | 2011-09-30 | エンドペプチダーゼ活性を有するポリペプチド及びそれをコードするポリヌクレオチド |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US9458446B2 (enExample) |
| EP (1) | EP2622071B1 (enExample) |
| JP (1) | JP5944908B2 (enExample) |
| CN (1) | CN103534349B (enExample) |
| BR (1) | BR112013004743A2 (enExample) |
| CA (1) | CA2809916A1 (enExample) |
| DK (1) | DK2622071T3 (enExample) |
| MX (1) | MX343295B (enExample) |
| RU (1) | RU2583293C2 (enExample) |
| WO (1) | WO2012042037A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2885931C (en) * | 2012-10-03 | 2023-01-10 | Agrivida, Inc. | Intein-modified proteases, their production and industrial applications |
| CA3107349A1 (en) * | 2018-07-23 | 2020-01-30 | Enclear Therapies, Inc. | Methods of treating neurological disorders |
| JP2022526671A (ja) | 2019-04-11 | 2022-05-25 | エンクリアー セラピーズ， インク． | 脳脊髄液の改善の方法ならびにそのためのデバイスおよびシステム |
| CN110283880A (zh) * | 2019-08-08 | 2019-09-27 | 天津科技大学 | 一种测定蛋白酶活力的新方法 |
| AU2021355470A1 (en) | 2020-09-29 | 2023-06-01 | Enclear Therapies, Inc. | Subarachnoid fluid management method and system |
| JP7766788B2 (ja) * | 2022-03-30 | 2025-11-10 | 森永乳業株式会社 | 乳タンパク質分解物の製造方法 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK122686D0 (da) | 1986-03-17 | 1986-03-17 | Novo Industri As | Fremstilling af proteiner |
| DK564086A (da) | 1986-11-25 | 1988-06-17 | Novo Industri As | Enzymatisk detergent-additiv |
| EP0321603A1 (fr) | 1987-12-23 | 1989-06-28 | Societe Des Produits Nestle S.A. | Procédé de préparation d'un hydrolysat de protéines de lactosérum et d'un aliment hypoallergéniques |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| PT97110B (pt) | 1990-03-23 | 1998-11-30 | Gist Brocades Nv | Processo para catalisar reaccoes acelaraveis por enzimas, mediante adicao ao meio reaccional de sementes de plantas transgenicas e para obtencao das referidas sementes |
| US6395966B1 (en) | 1990-08-09 | 2002-05-28 | Dekalb Genetics Corp. | Fertile transgenic maize plants containing a gene encoding the pat protein |
| IL99552A0 (en) | 1990-09-28 | 1992-08-18 | Ixsys Inc | Compositions containing procaryotic cells,a kit for the preparation of vectors useful for the coexpression of two or more dna sequences and methods for the use thereof |
| AU2468292A (en) | 1991-08-30 | 1993-04-05 | Teagasc, The Agriculture And Food Development Authority | Hypoallergenic whey protein hydrolysate |
| DE4343591A1 (de) | 1993-12-21 | 1995-06-22 | Evotec Biosystems Gmbh | Verfahren zum evolutiven Design und Synthese funktionaler Polymere auf der Basis von Formenelementen und Formencodes |
| US5605793A (en) | 1994-02-17 | 1997-02-25 | Affymax Technologies N.V. | Methods for in vitro recombination |
| CA2191718A1 (en) | 1994-06-03 | 1995-12-14 | Randy M. Berka | Phosphonyldipeptides useful in the treatment of cardiovascular diseases |
| WO1996000787A1 (en) | 1994-06-30 | 1996-01-11 | Novo Nordisk Biotech, Inc. | Non-toxic, non-toxigenic, non-pathogenic fusarium expression system and promoters and terminators for use therein |
| DK1396A (enExample) | 1996-01-09 | 1996-01-09 | Novo Nordisk As | |
| US5955310A (en) | 1998-02-26 | 1999-09-21 | Novo Nordisk Biotech, Inc. | Methods for producing a polypeptide in a bacillus cell |
| WO2000024883A1 (en) | 1998-10-26 | 2000-05-04 | Novozymes A/S | Constructing and screening a dna library of interest in filamentous fungal cells |
| CN100532561C (zh) | 1999-03-22 | 2009-08-26 | 诺沃奇梅兹有限公司 | 新的葡糖淀粉酶及编码它的核酸序列 |
| US7151204B2 (en) | 2001-01-09 | 2006-12-19 | Monsanto Technology Llc | Maize chloroplast aldolase promoter compositions and methods for use thereof |
| WO2004072279A2 (en) | 2003-02-07 | 2004-08-26 | Novozymes A/S | Proteases |
| CN101146908B (zh) * | 2005-03-22 | 2012-06-13 | 素出药株式会社 | 新型蛋白酶、生产该蛋白酶的微生物及其利用 |
| US9034402B2 (en) * | 2007-04-16 | 2015-05-19 | Solae, Llc | Protein hydrolysate compositions having improved sensory characteristics and physical properties |
| US8222372B2 (en) * | 2007-04-16 | 2012-07-17 | Novozymes A/S | Whey protein hydrolysate |
| SI2220107T1 (sl) * | 2007-11-12 | 2017-02-28 | Chreto Aps | Polipeptidi z dvojno afiniteto za čiščenje |
| FR2927336B1 (fr) | 2008-02-12 | 2010-05-21 | Cie Des Peches Saint Malo Sant | Hydrolysat de proteines de poissons presentant une activite de stimulation et de maintien du capital osseux, compositions nutraceutiques et pharmacologiques comprenant un tel hydrolysat et procede d'obtention |
| WO2010112546A1 (en) | 2009-04-02 | 2010-10-07 | Novozymes A/S | Process for making a milk-based protein hydrolysate |
-
2011
- 2011-09-30 DK DK11763735.5T patent/DK2622071T3/en active
- 2011-09-30 US US13/821,168 patent/US9458446B2/en not_active Expired - Fee Related
- 2011-09-30 MX MX2013003323A patent/MX343295B/es active IP Right Grant
- 2011-09-30 WO PCT/EP2011/067167 patent/WO2012042037A1/en not_active Ceased
- 2011-09-30 BR BR112013004743A patent/BR112013004743A2/pt not_active IP Right Cessation
- 2011-09-30 CN CN201180058129.2A patent/CN103534349B/zh not_active Expired - Fee Related
- 2011-09-30 JP JP2013530759A patent/JP5944908B2/ja not_active Expired - Fee Related
- 2011-09-30 RU RU2013120189/10A patent/RU2583293C2/ru not_active IP Right Cessation
- 2011-09-30 CA CA2809916A patent/CA2809916A1/en not_active Abandoned
- 2011-09-30 EP EP11763735.5A patent/EP2622071B1/en not_active Not-in-force
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