CA2809916A1 - Polypeptides having endopeptidase activity and polynucleotides encoding same - Google Patents
Polypeptides having endopeptidase activity and polynucleotides encoding same Download PDFInfo
- Publication number
- CA2809916A1 CA2809916A1 CA2809916A CA2809916A CA2809916A1 CA 2809916 A1 CA2809916 A1 CA 2809916A1 CA 2809916 A CA2809916 A CA 2809916A CA 2809916 A CA2809916 A CA 2809916A CA 2809916 A1 CA2809916 A1 CA 2809916A1
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- CA
- Canada
- Prior art keywords
- polypeptide
- endopeptidase
- trypsin
- ala
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 108010082527 phosphinothricin N-acetyltransferase Proteins 0.000 description 1
- 230000026731 phosphorylation Effects 0.000 description 1
- 238000006366 phosphorylation reaction Methods 0.000 description 1
- 102000020233 phosphotransferase Human genes 0.000 description 1
- 238000005222 photoaffinity labeling Methods 0.000 description 1
- ZWLUXSQADUDCSB-UHFFFAOYSA-N phthalaldehyde Chemical compound O=CC1=CC=CC=C1C=O ZWLUXSQADUDCSB-UHFFFAOYSA-N 0.000 description 1
- 229940085127 phytase Drugs 0.000 description 1
- 239000003375 plant hormone Substances 0.000 description 1
- 230000037039 plant physiology Effects 0.000 description 1
- 238000002264 polyacrylamide gel electrophoresis Methods 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 230000001124 posttranscriptional effect Effects 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 108060006613 prolamin Proteins 0.000 description 1
- 229960002429 proline Drugs 0.000 description 1
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- 108010090894 prolylleucine Proteins 0.000 description 1
- 230000001902 propagating effect Effects 0.000 description 1
- 235000019833 protease Nutrition 0.000 description 1
- 230000007065 protein hydrolysis Effects 0.000 description 1
- 108060006633 protein kinase Proteins 0.000 description 1
- 238000001742 protein purification Methods 0.000 description 1
- 230000006337 proteolytic cleavage Effects 0.000 description 1
- 229940024999 proteolytic enzymes for treatment of wounds and ulcers Drugs 0.000 description 1
- 101150108007 prs gene Proteins 0.000 description 1
- 101150086435 prs1 gene Proteins 0.000 description 1
- 101150070305 prsA gene Proteins 0.000 description 1
- 238000000275 quality assurance Methods 0.000 description 1
- 238000010188 recombinant method Methods 0.000 description 1
- 230000006798 recombination Effects 0.000 description 1
- 238000005215 recombination Methods 0.000 description 1
- 230000022532 regulation of transcription, DNA-dependent Effects 0.000 description 1
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- 238000011160 research Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 108091008146 restriction endonucleases Proteins 0.000 description 1
- 238000010839 reverse transcription Methods 0.000 description 1
- 101150025220 sacB gene Proteins 0.000 description 1
- 235000019515 salmon Nutrition 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000012163 sequencing technique Methods 0.000 description 1
- 108010048818 seryl-histidine Proteins 0.000 description 1
- 108010048397 seryl-lysyl-leucine Proteins 0.000 description 1
- 108010026333 seryl-proline Proteins 0.000 description 1
- 238000002741 site-directed mutagenesis Methods 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 description 1
- 229940048086 sodium pyrophosphate Drugs 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 238000010563 solid-state fermentation Methods 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 229960002180 tetracycline Drugs 0.000 description 1
- 229930101283 tetracycline Natural products 0.000 description 1
- 235000019364 tetracycline Nutrition 0.000 description 1
- 150000003522 tetracyclines Chemical class 0.000 description 1
- 235000019818 tetrasodium diphosphate Nutrition 0.000 description 1
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 description 1
- 108010072986 threonyl-seryl-lysine Proteins 0.000 description 1
- 238000001890 transfection Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 102000003601 transglutaminase Human genes 0.000 description 1
- 230000014616 translation Effects 0.000 description 1
- 101150016309 trpC gene Proteins 0.000 description 1
- 108010029384 tryptophyl-histidine Proteins 0.000 description 1
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 1
- 229910052721 tungsten Inorganic materials 0.000 description 1
- 239000010937 tungsten Substances 0.000 description 1
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- 108010003137 tyrosyltyrosine Proteins 0.000 description 1
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- 108010009962 valyltyrosine Proteins 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
- 101150110790 xylB gene Proteins 0.000 description 1
- 210000005253 yeast cell Anatomy 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J3/00—Working-up of proteins for foodstuffs
- A23J3/30—Working-up of proteins for foodstuffs by hydrolysis
- A23J3/32—Working-up of proteins for foodstuffs by hydrolysis using chemical agents
- A23J3/34—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J3/00—Working-up of proteins for foodstuffs
- A23J3/30—Working-up of proteins for foodstuffs by hydrolysis
- A23J3/32—Working-up of proteins for foodstuffs by hydrolysis using chemical agents
- A23J3/34—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes
- A23J3/347—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes of proteins from microorganisms or unicellular algae
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/18—Peptides; Protein hydrolysates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Nutrition Science (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Mycology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Dairy Products (AREA)
- Peptides Or Proteins (AREA)
- General Preparation And Processing Of Foods (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10185793.6 | 2010-10-01 | ||
| EP10185793 | 2010-10-01 | ||
| PCT/EP2011/067167 WO2012042037A1 (en) | 2010-10-01 | 2011-09-30 | Polypeptides having endopeptidase activity and polynucleotides encoding same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2809916A1 true CA2809916A1 (en) | 2012-04-05 |
Family
ID=44720015
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2809916A Abandoned CA2809916A1 (en) | 2010-10-01 | 2011-09-30 | Polypeptides having endopeptidase activity and polynucleotides encoding same |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US9458446B2 (enExample) |
| EP (1) | EP2622071B1 (enExample) |
| JP (1) | JP5944908B2 (enExample) |
| CN (1) | CN103534349B (enExample) |
| BR (1) | BR112013004743A2 (enExample) |
| CA (1) | CA2809916A1 (enExample) |
| DK (1) | DK2622071T3 (enExample) |
| MX (1) | MX343295B (enExample) |
| RU (1) | RU2583293C2 (enExample) |
| WO (1) | WO2012042037A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2885931C (en) * | 2012-10-03 | 2023-01-10 | Agrivida, Inc. | Intein-modified proteases, their production and industrial applications |
| CA3107349A1 (en) * | 2018-07-23 | 2020-01-30 | Enclear Therapies, Inc. | Methods of treating neurological disorders |
| JP2022526671A (ja) | 2019-04-11 | 2022-05-25 | エンクリアー セラピーズ， インク． | 脳脊髄液の改善の方法ならびにそのためのデバイスおよびシステム |
| CN110283880A (zh) * | 2019-08-08 | 2019-09-27 | 天津科技大学 | 一种测定蛋白酶活力的新方法 |
| AU2021355470A1 (en) | 2020-09-29 | 2023-06-01 | Enclear Therapies, Inc. | Subarachnoid fluid management method and system |
| JP7766788B2 (ja) * | 2022-03-30 | 2025-11-10 | 森永乳業株式会社 | 乳タンパク質分解物の製造方法 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK122686D0 (da) | 1986-03-17 | 1986-03-17 | Novo Industri As | Fremstilling af proteiner |
| DK564086A (da) | 1986-11-25 | 1988-06-17 | Novo Industri As | Enzymatisk detergent-additiv |
| EP0321603A1 (fr) | 1987-12-23 | 1989-06-28 | Societe Des Produits Nestle S.A. | Procédé de préparation d'un hydrolysat de protéines de lactosérum et d'un aliment hypoallergéniques |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| PT97110B (pt) | 1990-03-23 | 1998-11-30 | Gist Brocades Nv | Processo para catalisar reaccoes acelaraveis por enzimas, mediante adicao ao meio reaccional de sementes de plantas transgenicas e para obtencao das referidas sementes |
| US6395966B1 (en) | 1990-08-09 | 2002-05-28 | Dekalb Genetics Corp. | Fertile transgenic maize plants containing a gene encoding the pat protein |
| IL99552A0 (en) | 1990-09-28 | 1992-08-18 | Ixsys Inc | Compositions containing procaryotic cells,a kit for the preparation of vectors useful for the coexpression of two or more dna sequences and methods for the use thereof |
| AU2468292A (en) | 1991-08-30 | 1993-04-05 | Teagasc, The Agriculture And Food Development Authority | Hypoallergenic whey protein hydrolysate |
| DE4343591A1 (de) | 1993-12-21 | 1995-06-22 | Evotec Biosystems Gmbh | Verfahren zum evolutiven Design und Synthese funktionaler Polymere auf der Basis von Formenelementen und Formencodes |
| US5605793A (en) | 1994-02-17 | 1997-02-25 | Affymax Technologies N.V. | Methods for in vitro recombination |
| CA2191718A1 (en) | 1994-06-03 | 1995-12-14 | Randy M. Berka | Phosphonyldipeptides useful in the treatment of cardiovascular diseases |
| WO1996000787A1 (en) | 1994-06-30 | 1996-01-11 | Novo Nordisk Biotech, Inc. | Non-toxic, non-toxigenic, non-pathogenic fusarium expression system and promoters and terminators for use therein |
| DK1396A (enExample) | 1996-01-09 | 1996-01-09 | Novo Nordisk As | |
| US5955310A (en) | 1998-02-26 | 1999-09-21 | Novo Nordisk Biotech, Inc. | Methods for producing a polypeptide in a bacillus cell |
| WO2000024883A1 (en) | 1998-10-26 | 2000-05-04 | Novozymes A/S | Constructing and screening a dna library of interest in filamentous fungal cells |
| CN100532561C (zh) | 1999-03-22 | 2009-08-26 | 诺沃奇梅兹有限公司 | 新的葡糖淀粉酶及编码它的核酸序列 |
| US7151204B2 (en) | 2001-01-09 | 2006-12-19 | Monsanto Technology Llc | Maize chloroplast aldolase promoter compositions and methods for use thereof |
| WO2004072279A2 (en) | 2003-02-07 | 2004-08-26 | Novozymes A/S | Proteases |
| CN101146908B (zh) * | 2005-03-22 | 2012-06-13 | 素出药株式会社 | 新型蛋白酶、生产该蛋白酶的微生物及其利用 |
| US9034402B2 (en) * | 2007-04-16 | 2015-05-19 | Solae, Llc | Protein hydrolysate compositions having improved sensory characteristics and physical properties |
| US8222372B2 (en) * | 2007-04-16 | 2012-07-17 | Novozymes A/S | Whey protein hydrolysate |
| SI2220107T1 (sl) * | 2007-11-12 | 2017-02-28 | Chreto Aps | Polipeptidi z dvojno afiniteto za čiščenje |
| FR2927336B1 (fr) | 2008-02-12 | 2010-05-21 | Cie Des Peches Saint Malo Sant | Hydrolysat de proteines de poissons presentant une activite de stimulation et de maintien du capital osseux, compositions nutraceutiques et pharmacologiques comprenant un tel hydrolysat et procede d'obtention |
| WO2010112546A1 (en) | 2009-04-02 | 2010-10-07 | Novozymes A/S | Process for making a milk-based protein hydrolysate |
-
2011
- 2011-09-30 DK DK11763735.5T patent/DK2622071T3/en active
- 2011-09-30 US US13/821,168 patent/US9458446B2/en not_active Expired - Fee Related
- 2011-09-30 MX MX2013003323A patent/MX343295B/es active IP Right Grant
- 2011-09-30 WO PCT/EP2011/067167 patent/WO2012042037A1/en not_active Ceased
- 2011-09-30 BR BR112013004743A patent/BR112013004743A2/pt not_active IP Right Cessation
- 2011-09-30 CN CN201180058129.2A patent/CN103534349B/zh not_active Expired - Fee Related
- 2011-09-30 JP JP2013530759A patent/JP5944908B2/ja not_active Expired - Fee Related
- 2011-09-30 RU RU2013120189/10A patent/RU2583293C2/ru not_active IP Right Cessation
- 2011-09-30 CA CA2809916A patent/CA2809916A1/en not_active Abandoned
- 2011-09-30 EP EP11763735.5A patent/EP2622071B1/en not_active Not-in-force
Also Published As
| Publication number | Publication date |
|---|---|
| DK2622071T3 (en) | 2016-03-07 |
| RU2013120189A (ru) | 2014-11-20 |
| US20130273203A1 (en) | 2013-10-17 |
| US9458446B2 (en) | 2016-10-04 |
| WO2012042037A1 (en) | 2012-04-05 |
| EP2622071A1 (en) | 2013-08-07 |
| BR112013004743A2 (pt) | 2016-06-07 |
| CN103534349A (zh) | 2014-01-22 |
| MX343295B (es) | 2016-11-01 |
| MX2013003323A (es) | 2013-06-24 |
| JP5944908B2 (ja) | 2016-07-05 |
| RU2583293C2 (ru) | 2016-05-10 |
| CN103534349B (zh) | 2017-07-21 |
| JP2013544499A (ja) | 2013-12-19 |
| EP2622071B1 (en) | 2015-12-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20160916 |
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| FZDE | Dead |
Effective date: 20181130 |