JP2015525237A5 - - Google Patents
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- Publication number
- JP2015525237A5 JP2015525237A5 JP2015518318A JP2015518318A JP2015525237A5 JP 2015525237 A5 JP2015525237 A5 JP 2015525237A5 JP 2015518318 A JP2015518318 A JP 2015518318A JP 2015518318 A JP2015518318 A JP 2015518318A JP 2015525237 A5 JP2015525237 A5 JP 2015525237A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- acid sequence
- composition
- seq
- modified
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 31
- 102220232872 rs1085307474 Human genes 0.000 claims description 22
- 102220295859 rs139273474 Human genes 0.000 claims description 22
- 150000001413 amino acids Chemical class 0.000 claims description 14
- 239000000203 mixture Substances 0.000 claims description 13
- 102220466271 Protein Jade-1_H98A_mutation Human genes 0.000 claims description 12
- 108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 claims 8
- 102000003298 tumor necrosis factor receptor Human genes 0.000 claims 8
- 208000005494 xerophthalmia Diseases 0.000 claims 7
- 230000002265 prevention Effects 0.000 claims 6
- 230000004048 modification Effects 0.000 claims 3
- 238000012986 modification Methods 0.000 claims 3
- 241000588724 Escherichia coli Species 0.000 claims 2
- 239000003889 eye drop Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000000699 topical effect Effects 0.000 claims 2
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 1
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 1
- 206010048222 Xerosis Diseases 0.000 claims 1
- 210000005252 bulbus oculi Anatomy 0.000 claims 1
- 239000003885 eye ointment Substances 0.000 claims 1
- 229930182817 methionine Natural products 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20120066527 | 2012-06-21 | ||
| KR10-2012-0066527 | 2012-06-21 | ||
| PCT/KR2013/000983 WO2013191352A1 (en) | 2012-06-21 | 2013-02-07 | New uses of modified human tumor necrosis factor receptor-1 polypeptide |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015525237A JP2015525237A (ja) | 2015-09-03 |
| JP2015525237A5 true JP2015525237A5 (enExample) | 2016-04-28 |
| JP6087429B2 JP6087429B2 (ja) | 2017-03-01 |
Family
ID=49768924
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015518318A Active JP6087429B2 (ja) | 2012-06-21 | 2013-02-07 | 変形されたヒト腫瘍壊死因子受容体−１ポリペプチドの新規用途 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9580490B2 (enExample) |
| JP (1) | JP6087429B2 (enExample) |
| KR (1) | KR101514238B1 (enExample) |
| CN (1) | CN104394881B (enExample) |
| BR (1) | BR112014031923B1 (enExample) |
| WO (1) | WO2013191352A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6884755B2 (ja) | 2015-05-01 | 2021-06-09 | オーエヌエル セラピューティクス，インコーポレーテッド | ペプチド組成物および使用方法 |
| WO2017221128A1 (en) * | 2016-06-20 | 2017-12-28 | Novartis Ag | Methods of treating dry eye disease using tnf alpha antagonists |
| US20240059768A1 (en) * | 2021-01-14 | 2024-02-22 | Hanall Biopharma Co., Ltd. | A stable ophthalmic composition comprising tanfanercept, which is free of stabilizer or substantially free of stabilizer |
| KR20230131213A (ko) * | 2021-01-14 | 2023-09-12 | 한올바이오파마주식회사 | 탄파너셉트 안과용 조성물을 이용한 안구건조증의 치료 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU1521000A (en) | 1998-11-06 | 2000-05-29 | Schepens Eye Research Institute, Inc., The | Local use of soluble tumor necrosis receptor i (stnfri) for prophylaxis and treatment of corneal transplant rejection and other disorders of the eye |
| US6177077B1 (en) | 1999-02-24 | 2001-01-23 | Edward L. Tobinick | TNT inhibitors for the treatment of neurological disorders |
| US6379666B1 (en) | 1999-02-24 | 2002-04-30 | Edward L. Tobinick | TNF inhibitors for the treatment of neurological, retinal and muscular disorders |
| US6204270B1 (en) | 1999-11-12 | 2001-03-20 | Eyal S. Ron | Ophthalmic and mucosal preparations |
| PL218992B1 (pl) | 2002-07-19 | 2015-02-27 | Abbott Biotech Ltd | Neutralizujące o wysokim powinowactwie izolowane ludzkie przeciwciało anty-TNFα, zastosowanie tego przeciwciała, kryształ zawierający ludzkie przeciwciało anty-TNFα i preparat zawierający ten kryształ |
| US20090098136A1 (en) * | 2007-10-15 | 2009-04-16 | Alcon Research, Ltd. | Use of tnf receptor antagonists for treating dry eye |
| CN101591388A (zh) * | 2008-05-30 | 2009-12-02 | 上海复旦张江生物医药股份有限公司 | 一种可溶性tnf受体突变体 |
| EP2492281B1 (en) * | 2009-10-19 | 2018-04-11 | HanAll Biopharma Co., Ltd. | Modified human tumor necrosis factor receptor-1 polypeptide or fragment thereof, and method for preparing same |
| KR101273893B1 (ko) | 2010-09-13 | 2013-06-14 | 한올바이오파마주식회사 | 변형된 인간 종양 괴사 인자 수용체-1 폴리펩티드 또는 그의 절편 및 그의 제조방법 |
| CN103370334B (zh) * | 2010-12-23 | 2016-06-22 | 韩诺生物制药株式会社 | 修饰的人肿瘤坏死因子受体-i多肽或其片段及其制备方法 |
-
2013
- 2013-02-07 WO PCT/KR2013/000983 patent/WO2013191352A1/en not_active Ceased
- 2013-02-07 KR KR1020130014076A patent/KR101514238B1/ko active Active
- 2013-02-07 JP JP2015518318A patent/JP6087429B2/ja active Active
- 2013-02-07 US US14/404,001 patent/US9580490B2/en active Active
- 2013-02-07 CN CN201380032597.1A patent/CN104394881B/zh active Active
- 2013-02-07 BR BR112014031923-5A patent/BR112014031923B1/pt active IP Right Grant
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