JP2009544681A5 - - Google Patents
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- JP2009544681A5 JP2009544681A5 JP2009521343A JP2009521343A JP2009544681A5 JP 2009544681 A5 JP2009544681 A5 JP 2009544681A5 JP 2009521343 A JP2009521343 A JP 2009521343A JP 2009521343 A JP2009521343 A JP 2009521343A JP 2009544681 A5 JP2009544681 A5 JP 2009544681A5
- Authority
- JP
- Japan
- Prior art keywords
- epo
- polysaccharide
- protein
- compound
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06117830 | 2006-07-25 | ||
| PCT/GB2007/002841 WO2008012542A2 (en) | 2006-07-25 | 2007-07-25 | Polysaccharide derivatives of erythropoietin |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012287324A Division JP5542195B2 (ja) | 2006-07-25 | 2012-12-28 | エリスロポエチンの多糖誘導体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009544681A JP2009544681A (ja) | 2009-12-17 |
| JP2009544681A5 true JP2009544681A5 (enExample) | 2011-03-03 |
Family
ID=37397314
Family Applications (14)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009521337A Expired - Fee Related JP5096466B2 (ja) | 2006-07-25 | 2007-07-25 | Ｎ末端ポリシアリル化 |
| JP2009521336A Expired - Fee Related JP5419689B2 (ja) | 2006-07-25 | 2007-07-25 | 顆粒球コロニー刺激因子の誘導体化 |
| JP2009521342A Pending JP2009544680A (ja) | 2006-07-25 | 2007-07-25 | ポリサッカライドによるタンパク質のｎ末端誘導体化 |
| JP2009521343A Pending JP2009544681A (ja) | 2006-07-25 | 2007-07-25 | エリスロポエチンの多糖誘導体 |
| JP2012205475A Expired - Fee Related JP5586669B2 (ja) | 2006-07-25 | 2012-09-19 | Ｎ末端ポリシアリル化 |
| JP2012287324A Active JP5542195B2 (ja) | 2006-07-25 | 2012-12-28 | エリスロポエチンの多糖誘導体 |
| JP2013022825A Expired - Fee Related JP5420091B2 (ja) | 2006-07-25 | 2013-02-08 | ポリサッカライドによるタンパク質のｎ末端誘導体化 |
| JP2013160269A Active JP5941440B2 (ja) | 2006-07-25 | 2013-08-01 | ポリサッカライドによるタンパク質のｎ末端誘導体化 |
| JP2014025061A Active JP6165079B2 (ja) | 2006-07-25 | 2014-02-13 | エリスロポエチンの多糖誘導体 |
| JP2014154037A Active JP5912152B2 (ja) | 2006-07-25 | 2014-07-29 | Ｎ末端ポリシアリル化 |
| JP2015075148A Expired - Fee Related JP6055506B2 (ja) | 2006-07-25 | 2015-04-01 | ポリサッカライドによるタンパク質のｎ末端誘導体化 |
| JP2016020557A Expired - Fee Related JP6243456B2 (ja) | 2006-07-25 | 2016-02-05 | ポリサッカライドによるタンパク質のｎ末端誘導体化 |
| JP2016149090A Expired - Fee Related JP6203342B2 (ja) | 2006-07-25 | 2016-07-29 | エリスロポエチンの多糖誘導体 |
| JP2017157728A Expired - Fee Related JP6581157B2 (ja) | 2006-07-25 | 2017-08-18 | エリスロポエチンの多糖誘導体 |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009521337A Expired - Fee Related JP5096466B2 (ja) | 2006-07-25 | 2007-07-25 | Ｎ末端ポリシアリル化 |
| JP2009521336A Expired - Fee Related JP5419689B2 (ja) | 2006-07-25 | 2007-07-25 | 顆粒球コロニー刺激因子の誘導体化 |
| JP2009521342A Pending JP2009544680A (ja) | 2006-07-25 | 2007-07-25 | ポリサッカライドによるタンパク質のｎ末端誘導体化 |
Family Applications After (10)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012205475A Expired - Fee Related JP5586669B2 (ja) | 2006-07-25 | 2012-09-19 | Ｎ末端ポリシアリル化 |
| JP2012287324A Active JP5542195B2 (ja) | 2006-07-25 | 2012-12-28 | エリスロポエチンの多糖誘導体 |
| JP2013022825A Expired - Fee Related JP5420091B2 (ja) | 2006-07-25 | 2013-02-08 | ポリサッカライドによるタンパク質のｎ末端誘導体化 |
| JP2013160269A Active JP5941440B2 (ja) | 2006-07-25 | 2013-08-01 | ポリサッカライドによるタンパク質のｎ末端誘導体化 |
| JP2014025061A Active JP6165079B2 (ja) | 2006-07-25 | 2014-02-13 | エリスロポエチンの多糖誘導体 |
| JP2014154037A Active JP5912152B2 (ja) | 2006-07-25 | 2014-07-29 | Ｎ末端ポリシアリル化 |
| JP2015075148A Expired - Fee Related JP6055506B2 (ja) | 2006-07-25 | 2015-04-01 | ポリサッカライドによるタンパク質のｎ末端誘導体化 |
| JP2016020557A Expired - Fee Related JP6243456B2 (ja) | 2006-07-25 | 2016-02-05 | ポリサッカライドによるタンパク質のｎ末端誘導体化 |
| JP2016149090A Expired - Fee Related JP6203342B2 (ja) | 2006-07-25 | 2016-07-29 | エリスロポエチンの多糖誘導体 |
| JP2017157728A Expired - Fee Related JP6581157B2 (ja) | 2006-07-25 | 2017-08-18 | エリスロポエチンの多糖誘導体 |
Country Status (10)
| Country | Link |
|---|---|
| US (22) | US10300144B2 (enExample) |
| EP (6) | EP3299033A1 (enExample) |
| JP (14) | JP5096466B2 (enExample) |
| KR (1) | KR101400105B1 (enExample) |
| CN (2) | CN101511391B (enExample) |
| AT (1) | ATE467642T1 (enExample) |
| DE (1) | DE602007006492D1 (enExample) |
| ES (5) | ES2581902T3 (enExample) |
| RU (1) | RU2432175C2 (enExample) |
| WO (4) | WO2008012528A1 (enExample) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2294535T3 (es) | 2003-08-12 | 2008-04-01 | Lipoxen Technologies Limited | Derivados del acido polisialico. |
| KR101113726B1 (ko) | 2003-08-12 | 2012-02-27 | 리폭센 테크놀로지즈 리미티드 | 단백질 유도 및 컨쥬게이션용 시알산 유도체 |
| EP3299033A1 (en) * | 2006-07-25 | 2018-03-28 | Lipoxen Technologies Limited | N-terminal polysialylation |
| CN105838699A (zh) | 2006-12-15 | 2016-08-10 | 巴克斯艾尔塔公司 | 具有延长的体内半衰期的因子VIIa-聚唾液酸结合物 |
| PL2115010T3 (pl) | 2007-02-28 | 2012-07-31 | Lipoxen Tech Limited | Zmniejszanie zawartości endotoksyny w kwasach polisialowych |
| BRPI0815324A2 (pt) | 2007-08-20 | 2015-07-14 | Protalix Ltd | "conjugado protêico que contém sacarídeos, processo de separação do conjugado protêico que contém sacarídeos, composição farmacêutica do conjugado protêico que contém sacarídeos, uso do conjugado protêico que contém sacarídeos e composto do conjugado protêico que contém sacarídeos" |
| RU2391354C1 (ru) * | 2008-10-15 | 2010-06-10 | Учреждение Российской академии наук Институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова РАН, Российская Федерация, от имени которой выступает Федеральное агентство по науке и инновациям | Комплекс биологически активного рекомбинантного белка с полисиаловой кислотой |
| WO2010089756A2 (en) * | 2008-10-20 | 2010-08-12 | Usv Limited | An improved process for pegylation of proteins |
| WO2010051335A1 (en) * | 2008-10-31 | 2010-05-06 | Amgen Inc. | Materials and methods relating to stem cell mobilization by multi-pegylated granulocyte colony stimulating factor |
| AU2010208305A1 (en) | 2009-01-28 | 2011-09-08 | Smartcells, Inc. | Synthetic conjugates and uses thereof |
| RU2011135730A (ru) | 2009-01-28 | 2013-03-10 | Смартселлз, Инк. | Кристаллические инсулин-коньюгаты |
| KR101635689B1 (ko) | 2009-01-28 | 2016-07-01 | 스마트쎌스, 인크. | 제어 약물 전달을 위한 접합체 기재 시스템 |
| US8846103B2 (en) | 2009-01-28 | 2014-09-30 | Smartcells, Inc. | Exogenously triggered controlled release materials and uses thereof |
| US8569231B2 (en) | 2009-03-20 | 2013-10-29 | Smartcells, Inc. | Soluble non-depot insulin conjugates and uses thereof |
| US8623345B2 (en) | 2009-03-20 | 2014-01-07 | Smartcells | Terminally-functionalized conjugates and uses thereof |
| EP2459226B1 (en) * | 2009-07-27 | 2016-06-29 | Lipoxen Technologies Limited | Glycopolysialylation of proteins other than blood coagulation proteins |
| US8642737B2 (en) | 2010-07-26 | 2014-02-04 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
| EP2459224B1 (en) | 2009-07-27 | 2016-06-01 | Baxalta GmbH | Blood coagulation protein conjugates |
| US8809501B2 (en) | 2009-07-27 | 2014-08-19 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
| PL2459224T3 (pl) * | 2009-07-27 | 2017-08-31 | Baxalta GmbH | Koniugaty białka związanego z krzepnięciem krwi |
| US9194011B2 (en) | 2009-11-17 | 2015-11-24 | Protalix Ltd. | Stabilized alpha-galactosidase and uses thereof |
| CN101787117B (zh) * | 2010-02-08 | 2012-05-23 | 江南大学 | 聚乙二醇-聚唾液酸嵌段共聚物的制备方法及应用 |
| KR20130115086A (ko) * | 2010-05-17 | 2013-10-21 | 세빅스 인코포레이티드 | 페길화된 c-펩티드 |
| US20120034631A1 (en) * | 2010-06-11 | 2012-02-09 | Wojciak Jonathan Michael | Anti-lysophospholipid antibody design using antibody structures |
| WO2012015692A2 (en) | 2010-07-28 | 2012-02-02 | Smartcells, Inc. | Recombinantly expressed insulin polypeptides and uses thereof |
| WO2012015691A2 (en) | 2010-07-28 | 2012-02-02 | Smartcells, Inc. | Recombinant lectins, binding-site modified lectins and uses thereof |
| AU2011282977A1 (en) | 2010-07-28 | 2013-02-21 | Smartcells, Inc. | Drug-ligand conjugates, synthesis thereof, and intermediates thereto |
| ES2774190T3 (es) | 2011-01-20 | 2020-07-17 | Protalix Ltd | Composiciones de alfa-galactosidasa |
| EP2780030A4 (en) | 2011-11-17 | 2015-11-18 | Cebix Ab | PEGYLATED C-PEPTIDE |
| TW201605470A (zh) | 2013-10-04 | 2016-02-16 | 默沙東藥廠 | 葡萄糖反應性胰島素結合物 |
| WO2015130963A2 (en) | 2014-02-27 | 2015-09-03 | Xenetic Biosciences, Inc. | Compositions and methods for administering insulin or insulin-like protein to the brain |
| JP2019218265A (ja) * | 2016-09-14 | 2019-12-26 | 生化学工業株式会社 | ペプチドの血中滞留性を増強させる方法 |
| WO2018197545A1 (en) * | 2017-04-25 | 2018-11-01 | Lipoxen Technologies Limited | Methods of treating multiple myeloma cancers expressing high levels of epo-receptor using psa-epo |
| WO2018197547A1 (en) | 2017-04-25 | 2018-11-01 | Lipoxen Technologies Limited | Methods of treating diseases related to net formation with parenteral administration of polysialylated dnase i |
| WO2020099513A1 (en) * | 2018-11-13 | 2020-05-22 | Lipoxen Technologies Limited | Glycopolysialylation of blinatumomab |
| WO2020163269A1 (en) * | 2019-02-04 | 2020-08-13 | Xenetic Biosciences, Inc. | Methods of using glycopolysialylated therapeutic proteins |
| PE20220098A1 (es) | 2019-07-08 | 2022-01-24 | Gi Innovation Inc | Dimero polipeptido con alto contenido en acido sialico, que comprende el dominio extracelular de la subunidad alfa del receptor fc de ige, y composicion farmaceutica que comprende el mismo |
| CN116249552A (zh) * | 2020-08-11 | 2023-06-09 | 隆延生物科技（上海）有限公司 | 一种液体制剂及其应用 |
| CN114966021B (zh) * | 2022-05-19 | 2025-03-04 | 山东博科生物产业有限公司 | 一种稳定的脂蛋白相关磷脂酶a2测定试剂盒 |
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| EP3299033A1 (en) * | 2006-07-25 | 2018-03-28 | Lipoxen Technologies Limited | N-terminal polysialylation |
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-
2007
- 2007-07-25 EP EP17188428.1A patent/EP3299033A1/en not_active Withdrawn
- 2007-07-25 EP EP07789051.5A patent/EP2043693B1/en not_active Not-in-force
- 2007-07-25 US US12/375,010 patent/US10300144B2/en active Active
- 2007-07-25 CN CN2007800337418A patent/CN101511391B/zh not_active Expired - Fee Related
- 2007-07-25 DE DE602007006492T patent/DE602007006492D1/de active Active
- 2007-07-25 EP EP07766361.5A patent/EP2043616B1/en not_active Not-in-force
- 2007-07-25 JP JP2009521337A patent/JP5096466B2/ja not_active Expired - Fee Related
- 2007-07-25 ES ES07789051.5T patent/ES2581902T3/es active Active
- 2007-07-25 ES ES13163525.2T patent/ES2647528T3/es active Active
- 2007-07-25 WO PCT/GB2007/002821 patent/WO2008012528A1/en not_active Ceased
- 2007-07-25 KR KR1020097003805A patent/KR101400105B1/ko not_active Expired - Fee Related
- 2007-07-25 JP JP2009521336A patent/JP5419689B2/ja not_active Expired - Fee Related
- 2007-07-25 JP JP2009521342A patent/JP2009544680A/ja active Pending
- 2007-07-25 ES ES07766363.1T patent/ES2581983T3/es active Active
- 2007-07-25 US US12/375,006 patent/US8299015B2/en active Active
- 2007-07-25 EP EP07789047A patent/EP2041167B1/en not_active Not-in-force
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