JP2014530226A5 - - Google Patents
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- JP2014530226A5 JP2014530226A5 JP2014535044A JP2014535044A JP2014530226A5 JP 2014530226 A5 JP2014530226 A5 JP 2014530226A5 JP 2014535044 A JP2014535044 A JP 2014535044A JP 2014535044 A JP2014535044 A JP 2014535044A JP 2014530226 A5 JP2014530226 A5 JP 2014530226A5
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- Prior art keywords
- pharmaceutical composition
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- antibody
- tnf
- Prior art date
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- 239000008194 pharmaceutical composition Substances 0.000 claims 23
- 239000005557 antagonist Substances 0.000 claims 9
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims 6
- 229960000485 methotrexate Drugs 0.000 claims 6
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 6
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims 4
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 4
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- UETNIIAIRMUTSM-UHFFFAOYSA-N Jacareubin Natural products CC1(C)OC2=CC3Oc4c(O)c(O)ccc4C(=O)C3C(=C2C=C1)O UETNIIAIRMUTSM-UHFFFAOYSA-N 0.000 claims 3
- XXSMGPRMXLTPCZ-UHFFFAOYSA-N hydroxychloroquine Chemical compound ClC1=CC=C2C(NC(C)CCCN(CCO)CC)=CC=NC2=C1 XXSMGPRMXLTPCZ-UHFFFAOYSA-N 0.000 claims 3
- 229960004171 hydroxychloroquine Drugs 0.000 claims 3
- VHOGYURTWQBHIL-UHFFFAOYSA-N leflunomide Chemical compound O1N=CC(C(=O)NC=2C=CC(=CC=2)C(F)(F)F)=C1C VHOGYURTWQBHIL-UHFFFAOYSA-N 0.000 claims 3
- 229960000681 leflunomide Drugs 0.000 claims 3
- NCEXYHBECQHGNR-QZQOTICOSA-N sulfasalazine Chemical compound C1=C(O)C(C(=O)O)=CC(\N=N\C=2C=CC(=CC=2)S(=O)(=O)NC=2N=CC=CC=2)=C1 NCEXYHBECQHGNR-QZQOTICOSA-N 0.000 claims 3
- 229960001940 sulfasalazine Drugs 0.000 claims 3
- NCEXYHBECQHGNR-UHFFFAOYSA-N sulfasalazine Natural products C1=C(O)C(C(=O)O)=CC(N=NC=2C=CC(=CC=2)S(=O)(=O)NC=2N=CC=CC=2)=C1 NCEXYHBECQHGNR-UHFFFAOYSA-N 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 108010008165 Etanercept Proteins 0.000 claims 2
- 101001076408 Homo sapiens Interleukin-6 Proteins 0.000 claims 2
- 229960002964 adalimumab Drugs 0.000 claims 2
- 229960003115 certolizumab pegol Drugs 0.000 claims 2
- 229960000403 etanercept Drugs 0.000 claims 2
- 229960001743 golimumab Drugs 0.000 claims 2
- 102000052611 human IL6 Human genes 0.000 claims 2
- 229960000598 infliximab Drugs 0.000 claims 2
- 108020003175 receptors Proteins 0.000 claims 2
- 102000005962 receptors Human genes 0.000 claims 2
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161545864P | 2011-10-11 | 2011-10-11 | |
| US61/545,864 | 2011-10-11 | ||
| EP12305889 | 2012-07-20 | ||
| EP12305889.3 | 2012-07-20 | ||
| PCT/EP2012/070052 WO2013053751A1 (en) | 2011-10-11 | 2012-10-10 | Compositions for the treatment of rheumatoid arthritis and methods of using same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017064130A Division JP6336171B2 (ja) | 2011-10-11 | 2017-03-29 | 関節リウマチを治療するための組成物およびこれを用いる方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014530226A JP2014530226A (ja) | 2014-11-17 |
| JP2014530226A5 true JP2014530226A5 (enExample) | 2015-12-03 |
| JP6122018B2 JP6122018B2 (ja) | 2017-04-26 |
Family
ID=48081395
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014535044A Active JP6122018B2 (ja) | 2011-10-11 | 2012-10-10 | 関節リウマチを治療するための組成物およびこれを用いる方法 |
| JP2017064130A Active JP6336171B2 (ja) | 2011-10-11 | 2017-03-29 | 関節リウマチを治療するための組成物およびこれを用いる方法 |
| JP2018086193A Active JP6983717B2 (ja) | 2011-10-11 | 2018-04-27 | 関節リウマチを治療するための組成物およびこれを用いる方法 |
| JP2020088567A Active JP7025477B2 (ja) | 2011-10-11 | 2020-05-21 | 関節リウマチを治療するための組成物およびこれを用いる方法 |
| JP2024039618A Pending JP2024069453A (ja) | 2011-10-11 | 2024-03-14 | 関節リウマチを治療するための組成物およびこれを用いる方法 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017064130A Active JP6336171B2 (ja) | 2011-10-11 | 2017-03-29 | 関節リウマチを治療するための組成物およびこれを用いる方法 |
| JP2018086193A Active JP6983717B2 (ja) | 2011-10-11 | 2018-04-27 | 関節リウマチを治療するための組成物およびこれを用いる方法 |
| JP2020088567A Active JP7025477B2 (ja) | 2011-10-11 | 2020-05-21 | 関節リウマチを治療するための組成物およびこれを用いる方法 |
| JP2024039618A Pending JP2024069453A (ja) | 2011-10-11 | 2024-03-14 | 関節リウマチを治療するための組成物およびこれを用いる方法 |
Country Status (31)
| Country | Link |
|---|---|
| US (3) | US10927435B2 (enExample) |
| EP (1) | EP2766039B1 (enExample) |
| JP (5) | JP6122018B2 (enExample) |
| KR (3) | KR20220035272A (enExample) |
| CN (2) | CN104105505A (enExample) |
| AR (1) | AR088289A1 (enExample) |
| AU (1) | AU2012323062B2 (enExample) |
| BR (1) | BR112014008764A8 (enExample) |
| CA (1) | CA2851751A1 (enExample) |
| CL (1) | CL2014000926A1 (enExample) |
| CO (1) | CO6950482A2 (enExample) |
| DK (1) | DK2766039T3 (enExample) |
| ES (1) | ES2660112T3 (enExample) |
| HU (1) | HUE036561T2 (enExample) |
| IL (1) | IL232001A0 (enExample) |
| LT (1) | LT2766039T (enExample) |
| MA (1) | MA35620B1 (enExample) |
| MX (3) | MX353126B (enExample) |
| MY (1) | MY177212A (enExample) |
| NO (1) | NO2766039T3 (enExample) |
| PH (1) | PH12014500784B1 (enExample) |
| PL (1) | PL2766039T3 (enExample) |
| PT (1) | PT2766039T (enExample) |
| RS (1) | RS56973B1 (enExample) |
| RU (1) | RU2664697C2 (enExample) |
| SG (3) | SG11201401373RA (enExample) |
| SI (1) | SI2766039T1 (enExample) |
| TR (1) | TR201802387T4 (enExample) |
| TW (1) | TWI589299B (enExample) |
| UY (1) | UY34387A (enExample) |
| WO (1) | WO2013053751A1 (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO3672B1 (ar) | 2008-12-15 | 2020-08-27 | Regeneron Pharma | أجسام مضادة بشرية عالية التفاعل الكيماوي بالنسبة لإنزيم سبتيليسين كنفرتيز بروبروتين / كيكسين نوع 9 (pcsk9). |
| JO3417B1 (ar) | 2010-01-08 | 2019-10-20 | Regeneron Pharma | الصيغ المستقرة التي تحتوي على الأجسام المضادة لمضاد مستقبل( interleukin-6 (il-6r |
| DK2668212T3 (en) | 2011-01-28 | 2018-07-02 | Saonofi Biotechnology | HUMAN ANTIBODIES AGAINST PCSK9 FOR USE IN PROCEDURES FOR TREATING PARTICULAR GROUPS OF PERSONS |
| AR087305A1 (es) | 2011-07-28 | 2014-03-12 | Regeneron Pharma | Formulaciones estabilizadas que contienen anticuerpos anti-pcsk9, metodo de preparacion y kit |
| TWI589299B (zh) * | 2011-10-11 | 2017-07-01 | 再生元醫藥公司 | 用於治療類風濕性關節炎之組成物及其使用方法 |
| US9943594B2 (en) | 2011-10-11 | 2018-04-17 | Sanofi Biotechnology | Methods for the treatment of rheumatoid arthritis |
| CA2899746A1 (en) * | 2013-01-31 | 2014-06-26 | Alfred E. Tiefenbacher (Gmbh & Co. Kg) | Pharmaceutical composition comprising leflunomide |
| RU2701684C2 (ru) | 2013-10-31 | 2019-09-30 | Ридженерон Фармасьютикалз, Инк. | Анализ конкурентного связывания с лигандом для обнаружения нейтрализирующих антител |
| PT3071230T (pt) * | 2013-11-22 | 2020-06-26 | Regeneron Pharma | Composições para o tratamento da artrite reumatoide e métodos de utilização das mesmas |
| CA2930615C (en) * | 2013-11-22 | 2023-04-04 | Sanofi Biotechnology | Compositions for the treatment of rheumatoid arthritis and methods of using same |
| WO2016044343A1 (en) * | 2014-09-16 | 2016-03-24 | Sanofi Biotechnology | Compositions for improving the health related quality of life of rheumatoid arthritis patients |
| TW201628649A (zh) | 2014-10-09 | 2016-08-16 | 再生元醫藥公司 | 減少醫藥調配物中微可見顆粒之方法 |
| CA2995645A1 (en) | 2015-08-18 | 2017-02-23 | Regeneron Pharmaceuticals, Inc. | Anti-pcsk9 inhibitory antibodies for treating patients with hyperlipidemia undergoing lipoprotein apheresis |
| WO2017079443A1 (en) | 2015-11-03 | 2017-05-11 | Sanofi Biotechnology | Compositions comprising il6r antibodies for the treatment of uveitis and macular edema and methods of using same |
| KR101895950B1 (ko) * | 2015-12-18 | 2018-09-06 | (주)한국비엠아이 | 골관절염 치료를 위한 친수화된 설파살라진 및 히알루론산을 포함하는 조성물 및 이의제조방법 |
| EP3216461A1 (en) * | 2016-03-07 | 2017-09-13 | Sanofi Biotechnology | Compositions and methods for treating rheumatoid arthritis |
| CA3016880A1 (en) * | 2016-03-07 | 2017-09-14 | Sanofi Biotechnology | Compositions and methods for treating rheumatoid arthritis |
| CN107456455B (zh) * | 2016-06-06 | 2021-09-24 | 海南先声药业有限公司 | 一种预防或治疗炎性疾病的药物组合物 |
| CA3031742A1 (en) | 2016-08-16 | 2018-02-22 | Regeneron Pharmaceuticals, Inc. | Methods for quantitating individual antibodies from a mixture |
| EP4071469B1 (en) | 2016-10-25 | 2025-04-09 | Regeneron Pharmaceuticals, Inc. | Methods for chromatography data analysis |
| CA3073935A1 (en) | 2017-09-19 | 2019-03-28 | Regeneron Pharmaceuticals, Inc. | Methods of reducing particle formation and compositions formed thereby |
| EA039731B1 (ru) * | 2017-12-13 | 2022-03-04 | Ридженерон Фармасьютикалз, Инк. | Устройства и системы для управления опорой слоя сорбента хроматографической колонки и связанные с ними способы |
| WO2019136219A1 (en) * | 2018-01-05 | 2019-07-11 | Attillaps Holdings | Treating autoimmune disorders with acetylcholinesterase inhibitors |
| CN108597083A (zh) * | 2018-04-28 | 2018-09-28 | 江苏食品药品职业技术学院 | 一种酒店旅游自助服务系统 |
| TWI814812B (zh) | 2018-05-02 | 2023-09-11 | 美商里珍納龍藥品有限公司 | 用於評估生化過濾器的適合性的方法 |
| JP7634993B2 (ja) * | 2018-06-19 | 2025-02-25 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 抗因子ＸＩＩ／ＸＩＩａ抗体およびその使用 |
| TW202448568A (zh) | 2018-07-02 | 2024-12-16 | 美商里珍納龍藥品有限公司 | 自混合物製備多肽之系統及方法 |
| CN109013990A (zh) * | 2018-08-04 | 2018-12-18 | 安徽盛美金属科技有限公司 | 一种加热铝合金锻压件坯料的装置 |
| KR20210049871A (ko) | 2018-08-29 | 2021-05-06 | 리제너론 파아마슈티컬스, 인크. | 류마티스성 관절염을 갖는 대상체를 치료하기 위한 방법 및 조성물 |
| CN109858649A (zh) * | 2019-01-04 | 2019-06-07 | 珠海格力电器股份有限公司 | 预订酒店方法和装置、酒店管理方法和装置 |
| TWI860325B (zh) | 2019-01-31 | 2024-11-01 | 法商賽諾菲生物技術公司 | 用於治療幼年原發性關節炎之組成物及方法 |
| BR112021021077A2 (pt) | 2019-04-24 | 2021-12-14 | E Zilberstein Moshe | Métodos de diagnóstico e tratamento de artrite reumatoide |
| MX2021014892A (es) | 2019-06-04 | 2022-06-27 | Sanofi Biotechnology | Composiciones y metodos para el tratamiento del dolor en sujetos con artritis reumatoide. |
| KR102453140B1 (ko) | 2021-09-07 | 2022-10-11 | 배호진 | 블록체인을 이용한 후원자 보상 방법 및 장치 |
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