CN109311988A - 一种BlyS抗体及其制备方法和应用 - Google Patents
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Classifications
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
-
- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- A—HUMAN NECESSITIES
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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Abstract
一种BLyS抗体及其制备方法和应用，所述BLyS抗体包括BLyS抗体的重链可变区重链CDR1、重链CDR2和重链CDR3中的一种或多种，和/或BLyS抗体的轻链可变区轻链CDR1、轻链CDR2和轻链CDR3中的一种或多种，其氨基酸序列如序列表所示。所述BLyS抗体具有高亲和力，能明显在蛋白水平和细胞水平有效封闭BLyS蛋白，阻止BLyS蛋白与受体的结合。所述BLyS抗体缺乏与人APRIL等同类蛋白抗原的交叉反应，并且具有良好的生物活性，其能抑制人BLyS诱导的小鼠B细胞的增殖，因此可运用于预防或治疗与BLyS表达或功能异常相关的疾病的药物的制备中。
Description
PCT国内申请，说明书已公开。
Claims (20)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2016105279960 | 2016-07-06 | ||
| CN201610527996 | 2016-07-06 | ||
| PCT/CN2017/091839 WO2018006824A1 (zh) | 2016-07-06 | 2017-07-05 | 一种BLyS抗体及其制备方法和应用 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109311988A true CN109311988A (zh) | 2019-02-05 |
Family
ID=60912362
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201780033470.XA Pending CN109311988A (zh) | 2016-07-06 | 2017-07-05 | 一种BlyS抗体及其制备方法和应用 |
| CN201710543744.1A Expired - Fee Related CN107586339B (zh) | 2016-07-06 | 2017-07-05 | 一种BLyS抗体及其制备方法和应用 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710543744.1A Expired - Fee Related CN107586339B (zh) | 2016-07-06 | 2017-07-05 | 一种BLyS抗体及其制备方法和应用 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20210347873A1 (zh) |
| EP (1) | EP3483181A4 (zh) |
| JP (1) | JP2019533423A (zh) |
| CN (2) | CN109311988A (zh) |
| WO (1) | WO2018006824A1 (zh) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114634575A (zh) * | 2020-12-16 | 2022-06-17 | 康诺亚生物医药科技（成都）有限公司 | 一种补体抑制剂的开发和应用 |
| WO2022223028A1 (zh) * | 2021-04-23 | 2022-10-27 | 上海君实生物医药科技股份有限公司 | 抗BLyS抗体、其药物组合物及其用途 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101678106A (zh) * | 2007-03-27 | 2010-03-24 | 津莫吉尼蒂克斯公司 | 用于治疗自身免疫疾病的BLyS抑制和/或APRIL抑制与免疫抑制剂的组合 |
| US20150218267A1 (en) * | 2014-01-31 | 2015-08-06 | Boehringer Ingelheim International Gmbh | Novel anti-baff antibodies |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000068378A1 (en) * | 1999-05-06 | 2000-11-16 | National Jewish Medical And Research Center | Tall-1 nucleic acid molecules, proteins, receptors and methods of use thereof |
| AU2002322301A1 (en) * | 2001-06-26 | 2003-03-03 | Gene Logic, Inc. | Methods for the diagnosis and treatment of cardiac tissue rejection |
| CA2467521A1 (en) * | 2001-11-16 | 2003-07-10 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to blys |
| US20110142836A1 (en) * | 2009-01-02 | 2011-06-16 | Olav Mella | B-cell depleting agents for the treatment of chronic fatigue syndrome |
| US20130028897A1 (en) * | 2009-04-27 | 2013-01-31 | Ali Naji | Methods for reducing the level of alloantibodies in a subject |
| CN103421113B (zh) * | 2012-05-22 | 2018-01-19 | 武汉华鑫康源生物医药有限公司 | 抗BLyS抗体 |
| US20170101466A1 (en) * | 2014-06-03 | 2017-04-13 | Masahisa Handa | Anti-blys antibodies |
| CN105061596B (zh) * | 2015-08-05 | 2019-01-29 | 江苏诺迈博生物医药科技有限公司 | 人b淋巴细胞刺激因子的单克隆抗体及其应用 |
-
2017
- 2017-07-05 EP EP17823636.0A patent/EP3483181A4/en not_active Withdrawn
- 2017-07-05 JP JP2018562628A patent/JP2019533423A/ja active Pending
- 2017-07-05 CN CN201780033470.XA patent/CN109311988A/zh active Pending
- 2017-07-05 WO PCT/CN2017/091839 patent/WO2018006824A1/zh unknown
- 2017-07-05 CN CN201710543744.1A patent/CN107586339B/zh not_active Expired - Fee Related
- 2017-07-05 US US16/315,519 patent/US20210347873A1/en not_active Abandoned
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101678106A (zh) * | 2007-03-27 | 2010-03-24 | 津莫吉尼蒂克斯公司 | 用于治疗自身免疫疾病的BLyS抑制和/或APRIL抑制与免疫抑制剂的组合 |
| US20150218267A1 (en) * | 2014-01-31 | 2015-08-06 | Boehringer Ingelheim International Gmbh | Novel anti-baff antibodies |
Non-Patent Citations (1)
| Title |
|---|
| GAO,H.G ET AL: "sBAFF mutants induce enutralizing antibodies against BAFF", 《FEBS LETTERS》 * |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3483181A4 (en) | 2020-04-22 |
| EP3483181A1 (en) | 2019-05-15 |
| WO2018006824A1 (zh) | 2018-01-11 |
| CN107586339B (zh) | 2023-01-20 |
| US20210347873A1 (en) | 2021-11-11 |
| CN107586339A (zh) | 2018-01-16 |
| JP2019533423A (ja) | 2019-11-21 |
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