JP2014529328A5 - - Google Patents
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- JP2014529328A5 JP2014529328A5 JP2014514909A JP2014514909A JP2014529328A5 JP 2014529328 A5 JP2014529328 A5 JP 2014529328A5 JP 2014514909 A JP2014514909 A JP 2014514909A JP 2014514909 A JP2014514909 A JP 2014514909A JP 2014529328 A5 JP2014529328 A5 JP 2014529328A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- retinoid
- group
- composition according
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161494840P | 2011-06-08 | 2011-06-08 | |
| US201161494710P | 2011-06-08 | 2011-06-08 | |
| US61/494,710 | 2011-06-08 | ||
| US61/494,840 | 2011-06-08 | ||
| PCT/US2012/041753 WO2012170952A2 (en) | 2011-06-08 | 2012-06-08 | Compounds for targeting drug delivery and enhancing sirna activity |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016006249A Division JP6232083B2 (ja) | 2011-06-08 | 2016-01-15 | 薬物送達を標的化しｓｉＲＮＡ活性を増強する化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014529328A JP2014529328A (ja) | 2014-11-06 |
| JP2014529328A5 true JP2014529328A5 (https=) | 2015-07-23 |
| JP5873553B2 JP5873553B2 (ja) | 2016-03-01 |
Family
ID=46317540
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014514909A Active JP5873553B2 (ja) | 2011-06-08 | 2012-06-08 | 薬物送達を標的化しｓｉＲＮＡ活性を増強する化合物 |
| JP2016006249A Active JP6232083B2 (ja) | 2011-06-08 | 2016-01-15 | 薬物送達を標的化しｓｉＲＮＡ活性を増強する化合物 |
| JP2017203199A Active JP6590888B2 (ja) | 2011-06-08 | 2017-10-20 | 薬物送達を標的化しｓｉＲＮＡ活性を増強する化合物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016006249A Active JP6232083B2 (ja) | 2011-06-08 | 2016-01-15 | 薬物送達を標的化しｓｉＲＮＡ活性を増強する化合物 |
| JP2017203199A Active JP6590888B2 (ja) | 2011-06-08 | 2017-10-20 | 薬物送達を標的化しｓｉＲＮＡ活性を増強する化合物 |
Country Status (20)
| Country | Link |
|---|---|
| EP (2) | EP2718261B1 (https=) |
| JP (3) | JP5873553B2 (https=) |
| KR (3) | KR102029654B1 (https=) |
| CN (3) | CN103857654B (https=) |
| AU (2) | AU2012267467B8 (https=) |
| CA (2) | CA2837101C (https=) |
| CY (2) | CY1117433T1 (https=) |
| DK (2) | DK2718261T3 (https=) |
| ES (2) | ES2743540T3 (https=) |
| HR (1) | HRP20191463T8 (https=) |
| HU (1) | HUE045821T2 (https=) |
| LT (1) | LT2998289T (https=) |
| PL (2) | PL2718261T3 (https=) |
| PT (1) | PT2998289T (https=) |
| RS (1) | RS59380B1 (https=) |
| RU (2) | RU2632888C2 (https=) |
| SI (1) | SI2998289T1 (https=) |
| SM (1) | SMT201900523T1 (https=) |
| TW (2) | TWI569814B (https=) |
| WO (1) | WO2012170952A2 (https=) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2635460C2 (ru) * | 2010-06-17 | 2017-11-13 | Нитто Денко Корпорейшн | Средство для лечения фиброза почек |
| US9011903B2 (en) | 2011-06-08 | 2015-04-21 | Nitto Denko Corporation | Cationic lipids for therapeutic agent delivery formulations |
| EP3485875A1 (en) * | 2011-11-04 | 2019-05-22 | Nitto Denko Corporation | Single use system for sterelily producing lipid-nucleic acid particles |
| US9579338B2 (en) | 2011-11-04 | 2017-02-28 | Nitto Denko Corporation | Method of producing lipid nanoparticles for drug delivery |
| HRP20181855T1 (hr) | 2012-06-08 | 2018-12-28 | Nitto Denko Corporation | Lipidi za formulacije namijenjene unosu terapijskog sredstva |
| JP6340162B2 (ja) | 2012-12-20 | 2018-06-06 | 日東電工株式会社 | アポトーシス誘導剤 |
| JP6076076B2 (ja) | 2012-12-21 | 2017-02-08 | 日東電工株式会社 | 組織再生促進剤 |
| AU2014348212C1 (en) | 2013-11-18 | 2018-11-29 | Arcturus Therapeutics, Inc. | Ionizable cationic lipid for RNA delivery |
| US9365610B2 (en) | 2013-11-18 | 2016-06-14 | Arcturus Therapeutics, Inc. | Asymmetric ionizable cationic lipid for RNA delivery |
| US9976142B2 (en) | 2014-04-02 | 2018-05-22 | Nitto Denko Corporation | Targeting molecule and a use thereof |
| WO2015194522A1 (ja) | 2014-06-17 | 2015-12-23 | 日東電工株式会社 | アポトーシス誘導剤 |
| EP2966068A1 (en) * | 2014-07-08 | 2016-01-13 | Incella GmbH | Synthesis and use of amino lipids |
| CN104174034A (zh) * | 2014-08-20 | 2014-12-03 | 南京大学 | 肝星状细胞靶向的基因药物输送载体及其制备方法和应用 |
| AU2015337909B2 (en) * | 2014-10-30 | 2018-12-13 | Delta-Fly Pharma, Inc. | New production method of lipoplex for local administration and antitumor drug using lipoplex |
| JP6637988B2 (ja) * | 2014-11-18 | 2020-01-29 | アークトゥルス セラピューティクス， インコーポレイテッド | Ｒｎａ送達のためのイオン化可能カチオン性脂質 |
| US11045488B2 (en) | 2014-12-26 | 2021-06-29 | Nitto Denko Corporation | RNA interference agents for GST-π gene modulation |
| US10264976B2 (en) | 2014-12-26 | 2019-04-23 | The University Of Akron | Biocompatible flavonoid compounds for organelle and cell imaging |
| US10167253B2 (en) * | 2015-06-24 | 2019-01-01 | Nitto Denko Corporation | Ionizable compounds and compositions and uses thereof |
| WO2017048789A1 (en) * | 2015-09-14 | 2017-03-23 | The Board Of Regents Of The University Of Texas System | Lipocationic dendrimers and uses thereof |
| CN105194689A (zh) * | 2015-10-10 | 2015-12-30 | 湖南中楚博生物科技有限公司 | 一种基于siRNA的双偶联复合物 |
| PL3458074T3 (pl) * | 2016-05-16 | 2024-11-12 | Board Of Regents Of The University Of Texas System | KOMPOZYCJA DO DOSTARCZANIA tRNA W POSTACI NANOCZĄSTEK I SPOSOBY ICH STOSOWANIA |
| CN109414408B (zh) * | 2016-05-16 | 2022-03-29 | 得克萨斯州大学系统董事会 | 阳离子磺酰胺氨基脂质和两亲性两性离子氨基脂质 |
| JP6833456B2 (ja) | 2016-11-02 | 2021-02-24 | 日東電工株式会社 | 皮膚線維症処置剤 |
| US10383952B2 (en) | 2016-12-21 | 2019-08-20 | Arcturus Therapeutics, Inc. | Ionizable cationic lipid for RNA delivery |
| US10526284B2 (en) | 2016-12-21 | 2020-01-07 | Arcturus Therapeutics, Inc. | Ionizable cationic lipid for RNA delivery |
| US11148998B2 (en) | 2017-05-23 | 2021-10-19 | The Regents Of The University Of Michigan | Dimethyl-nonatetraenyl-trimethyl-cyclohexyl compounds and uses thereof |
| MA49421A (fr) | 2017-06-15 | 2020-04-22 | Modernatx Inc | Formulations d'arn |
| WO2019027055A1 (ja) | 2017-08-04 | 2019-02-07 | 協和発酵キリン株式会社 | 核酸含有脂質ナノ粒子 |
| EP3675817A1 (en) | 2017-08-31 | 2020-07-08 | Modernatx, Inc. | Methods of making lipid nanoparticles |
| US11298371B2 (en) | 2017-10-11 | 2022-04-12 | Nitto Denko Corporation | Regulation of nucleic acid molecule expression |
| CN117105811B (zh) | 2017-11-06 | 2025-12-12 | 日东电工株式会社 | 用于递送生物活性分子的膜融合化合物 |
| CN112437674A (zh) * | 2018-04-11 | 2021-03-02 | 新墨西哥科技大学研究园公司 | 用于药物递送的脂质前药 |
| KR102591743B1 (ko) | 2018-06-08 | 2023-10-19 | 후지필름 가부시키가이샤 | 화합물 또는 그 염 및 지질 입자 |
| US12357580B2 (en) | 2018-06-19 | 2025-07-15 | The Board Of Regents Of The University Of Texas System | Lipid nanoparticle compositions for delivery of mRNA and long nucleic acids |
| WO2020051223A1 (en) | 2018-09-04 | 2020-03-12 | The Board Of Regents Of The University Of Texas System | Compositions and methods for organ specific delivery of nucleic acids |
| WO2020040185A1 (ja) * | 2018-08-22 | 2020-02-27 | 日東電工株式会社 | Ｈｓｐ４７の阻害物質を用いた、化学療法剤感受性の増強 |
| EP3846857A4 (en) | 2018-09-04 | 2022-10-12 | The Board Of Regents Of The University Of Texas System | COMPOSITIONS AND METHODS FOR ORGAN-SPECIFIC DELIVERY OF NUCLEIC ACIDS |
| WO2020061457A1 (en) | 2018-09-20 | 2020-03-26 | Modernatx, Inc. | Preparation of lipid nanoparticles and methods of administration thereof |
| CN110124049B (zh) * | 2019-04-29 | 2023-09-22 | 大连医科大学 | 聚乙二醇化芬维a胺前体药物及其用途 |
| WO2020246581A1 (ja) | 2019-06-07 | 2020-12-10 | 富士フイルム株式会社 | 脂質組成物 |
| KR102228271B1 (ko) | 2019-07-16 | 2021-03-17 | 한국과학기술연구원 | 항암활성을 갖는 면역조절 단백질-siRNA 복합체 |
| CN111248152A (zh) * | 2020-03-17 | 2020-06-09 | 上海市中医医院 | 一种肝硬化腹水动物模型及其构建方法 |
| BR112022021381A2 (pt) * | 2020-04-23 | 2022-12-06 | Purdue Research Foundation | Compostos para o tratamento de sars |
| KR102361479B1 (ko) * | 2020-06-18 | 2022-02-11 | 고려대학교 산학협력단 | ｓｉＲＮＡ의 생성 및 기능 증진 활성을 갖는 ＣＭＴＲ１의 신규용도 |
| BR112022026233A2 (pt) * | 2020-06-24 | 2023-01-17 | Bristol Myers Squibb Co | Processo para sintetizar lipídios catiônicos |
| US20230250053A1 (en) * | 2020-06-24 | 2023-08-10 | Bristol-Myers Squibb Company | Process for synthesizing targeting molecules |
| BR112022026344A2 (pt) * | 2020-06-24 | 2023-01-17 | Bristol Myers Squibb Co | Processo para a sintetização de lipídeos |
| EP4192432A1 (en) * | 2020-08-06 | 2023-06-14 | ModernaTX, Inc. | Methods of preparing lipid nanoparticles |
| JP7538334B2 (ja) | 2020-08-14 | 2024-08-21 | コリア・インスティテュート・オブ・サイエンス・アンド・テクノロジー | 抗癌活性を有する免疫調節タンパク質－ｓｉＲＮＡ複合体 |
| CN114391008B (zh) * | 2020-08-20 | 2024-05-03 | 苏州艾博生物科技有限公司 | 脂质化合物和脂质纳米颗粒组合物 |
| CN114306278A (zh) * | 2021-12-30 | 2022-04-12 | 上海纳米技术及应用国家工程研究中心有限公司 | 一种EV装载CPP-siRNA纳米颗粒的制备方法及其产品和应用 |
| CN114805113B (zh) * | 2022-01-22 | 2023-09-15 | 苏州天澜生物材料科技有限公司 | 一种安全高效的可降解脂质纳米颗粒及其制备方法和应用 |
| CN114522244B (zh) * | 2022-01-28 | 2023-09-01 | 浙江大学医学院附属第四医院 | 视黄酸修饰的lytac分子及其制备方法和应用 |
| US20250197865A1 (en) | 2022-03-03 | 2025-06-19 | Kyushu University, National University Corporation | Pharmaceutical composition for treatment or prevention of fibrotic disease |
| WO2024040194A1 (en) | 2022-08-17 | 2024-02-22 | Capstan Therapeutics, Inc. | Conditioning for in vivo immune cell engineering |
| WO2024160826A1 (en) * | 2023-01-31 | 2024-08-08 | BioNTech SE | Compositions and methods |
| EP4480943A1 (en) * | 2023-06-22 | 2024-12-25 | Oz Biosciences | New class of lipids for delivering active ingredients into cells |
| WO2025006799A1 (en) | 2023-06-27 | 2025-01-02 | Capstan Therapeutics, Inc. | Extracorporeal and ex vivo engineering of select cell populations from peripheral blood |
| CN117185942B (zh) * | 2023-07-04 | 2025-09-12 | 清华大学 | 一种可用于靶向肺部递送广谱中和抗体的脂质纳米颗粒及其制备方法与应用 |
| WO2025261607A1 (en) | 2024-06-21 | 2025-12-26 | BioNTech SE | Particles, compositions and methods |
| WO2026013203A1 (en) * | 2024-07-12 | 2026-01-15 | Dsm Ip Assets B.V. | Improved lipid nanoparticles |
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| TWI658830B (zh) * | 2011-06-08 | 2019-05-11 | 日東電工股份有限公司 | Ｈｓｐ47表現調控強化用類視色素脂質體 |
| JP6301742B2 (ja) * | 2014-06-05 | 2018-03-28 | ヨシモトポール株式会社 | 鋼管ポールおよびその設置方法 |
-
2012
- 2012-06-08 EP EP12728010.5A patent/EP2718261B1/en active Active
- 2012-06-08 ES ES15181729T patent/ES2743540T3/es active Active
- 2012-06-08 CA CA2837101A patent/CA2837101C/en active Active
- 2012-06-08 EP EP15181729.3A patent/EP2998289B1/en active Active
- 2012-06-08 TW TW101120844A patent/TWI569814B/zh active
- 2012-06-08 WO PCT/US2012/041753 patent/WO2012170952A2/en not_active Ceased
- 2012-06-08 DK DK12728010.5T patent/DK2718261T3/en active
- 2012-06-08 PL PL12728010T patent/PL2718261T3/pl unknown
- 2012-06-08 CN CN201280027912.7A patent/CN103857654B/zh active Active
- 2012-06-08 KR KR1020187034790A patent/KR102029654B1/ko active Active
- 2012-06-08 KR KR1020147000573A patent/KR102038300B1/ko active Active
- 2012-06-08 KR KR1020187034794A patent/KR102029657B1/ko active Active
- 2012-06-08 RS RSP20191142 patent/RS59380B1/sr unknown
- 2012-06-08 AU AU2012267467A patent/AU2012267467B8/en active Active
- 2012-06-08 CN CN201710081858.9A patent/CN107082747B/zh active Active
- 2012-06-08 PT PT15181729T patent/PT2998289T/pt unknown
- 2012-06-08 JP JP2014514909A patent/JP5873553B2/ja active Active
- 2012-06-08 LT LT15181729T patent/LT2998289T/lt unknown
- 2012-06-08 DK DK15181729.3T patent/DK2998289T3/da active
- 2012-06-08 ES ES12728010T patent/ES2570184T3/es active Active
- 2012-06-08 RU RU2013158456A patent/RU2632888C2/ru active
- 2012-06-08 RU RU2017135548A patent/RU2769872C2/ru active
- 2012-06-08 TW TW105140746A patent/TWI712422B/zh active
- 2012-06-08 SM SM20190523T patent/SMT201900523T1/it unknown
- 2012-06-08 PL PL15181729T patent/PL2998289T3/pl unknown
- 2012-06-08 SI SI201231655T patent/SI2998289T1/sl unknown
- 2012-06-08 HU HUE15181729A patent/HUE045821T2/hu unknown
- 2012-06-08 CN CN201710081577.3A patent/CN107043334B/zh active Active
- 2012-06-08 CA CA3094645A patent/CA3094645C/en active Active
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2016
- 2016-01-15 JP JP2016006249A patent/JP6232083B2/ja active Active
- 2016-03-31 CY CY20161100261T patent/CY1117433T1/el unknown
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2017
- 2017-05-09 AU AU2017203075A patent/AU2017203075B2/en active Active
- 2017-10-20 JP JP2017203199A patent/JP6590888B2/ja active Active
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2019
- 2019-08-13 HR HRP20191463TT patent/HRP20191463T8/hr unknown
- 2019-09-05 CY CY20191100937T patent/CY1123807T1/el unknown
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