JP2023538144A5 - - Google Patents

Info

Publication number
JP2023538144A5
JP2023538144A5 JP2023512783A JP2023512783A JP2023538144A5 JP 2023538144 A5 JP2023538144 A5 JP 2023538144A5 JP 2023512783 A JP2023512783 A JP 2023512783A JP 2023512783 A JP2023512783 A JP 2023512783A JP 2023538144 A5 JP2023538144 A5 JP 2023538144A5
Authority
JP
Japan
Prior art keywords
unsubstituted
substituted
group
alkyl
ionizable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2023512783A
Other languages
English (en)
Japanese (ja)
Other versions
JP2023538144A (ja
JP7849049B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2021/047203 external-priority patent/WO2022040641A2/en
Publication of JP2023538144A publication Critical patent/JP2023538144A/ja
Publication of JP2023538144A5 publication Critical patent/JP2023538144A5/ja
Application granted granted Critical
Publication of JP7849049B2 publication Critical patent/JP7849049B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2023512783A 2020-08-21 2021-08-23 機能性のイオン化可能なリン脂質 Active JP7849049B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063068944P 2020-08-21 2020-08-21
US63/068,944 2020-08-21
PCT/US2021/047203 WO2022040641A2 (en) 2020-08-21 2021-08-23 Functional ionizable phospholipids

Publications (3)

Publication Number Publication Date
JP2023538144A JP2023538144A (ja) 2023-09-06
JP2023538144A5 true JP2023538144A5 (https=) 2024-11-05
JP7849049B2 JP7849049B2 (ja) 2026-04-21

Family

ID=80323210

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023512783A Active JP7849049B2 (ja) 2020-08-21 2021-08-23 機能性のイオン化可能なリン脂質

Country Status (7)

Country Link
US (1) US20230320994A1 (https=)
EP (1) EP4199934A4 (https=)
JP (1) JP7849049B2 (https=)
CN (1) CN117355335A (https=)
AU (1) AU2021327782A1 (https=)
CA (1) CA3189905A1 (https=)
WO (1) WO2022040641A2 (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2024511463A (ja) * 2021-03-22 2024-03-13 リコード セラピューティクス,インク. 細胞への標的送達のための組成物および方法
CA3213107A1 (en) 2021-03-23 2022-09-29 Mirko HENNIG Polynucleotide compositions, related formulations, and methods of use thereof
WO2023218420A1 (en) 2022-05-13 2023-11-16 Janssen Pharmaceuticals, Inc. Mrna compositions for inducing latent hiv-1 reversal
EP4385523A1 (en) * 2022-12-14 2024-06-19 Beijing Jitai Pharmaceutical Technology Co., Ltd. Lipid-based topical injection formulations
CN116211831A (zh) * 2022-12-14 2023-06-06 北京剂泰医药科技有限公司 脂质基质局部注射制剂
AU2023407378A1 (en) * 2022-12-23 2025-07-03 Turn Biotechnologies, Inc. Dual lipid structures
AU2024236558A1 (en) 2023-03-15 2025-10-09 Renagade Therapeutics Management Inc. Delivery of gene editing systems and methods of use thereof
AU2024234874A1 (en) 2023-03-15 2025-10-09 Renagade Therapeutics Management Inc. Lipid nanoparticles comprising coding rna molecules for use in gene editing and as vaccines and therapeutic agents
CN119997938A (zh) * 2023-06-05 2025-05-13 安徽医科大学第一附属医院 肺靶向纳米胶束、制备方法及应用
CN117180196B (zh) * 2023-08-09 2025-11-18 福建师范大学 一种抗原适配型的疫苗佐剂体系及其在制备新冠和猴痘疫苗中的应用
WO2025128871A2 (en) 2023-12-13 2025-06-19 Renagade Therapeutics Management Inc. Lipid nanoparticles comprising coding rna molecules for use in gene editing and as vaccines and therapeutic agents
WO2025155753A2 (en) 2024-01-17 2025-07-24 Renagade Therapeutics Management Inc. Improved gene editing system, guides, and methods
WO2025166238A1 (en) 2024-01-31 2025-08-07 Orna Therapeutics, Inc. Fast-shedding polyethylene glycol lipids
WO2025174765A1 (en) 2024-02-12 2025-08-21 Renagade Therapeutics Management Inc. Lipid nanoparticles comprising coding rna molecules for use in gene editing and as vaccines and therapeutic agents

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4774350A (en) * 1985-08-30 1988-09-27 Kao Corporation Phosphoric ester
DE4111105A1 (de) * 1991-04-05 1992-10-08 Max Planck Gesellschaft Neue erucyl-, brassidyl- und nervonylderivate
JPH06157560A (ja) * 1992-11-26 1994-06-03 Toyo Ink Mfg Co Ltd リン脂質系界面活性剤及びその製造方法
AU9263298A (en) 1997-08-18 1999-03-08 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Phospholipid analogue compounds
WO2003062290A1 (en) * 2002-01-16 2003-07-31 Biocompatibles Uk Limited Polymer conjugates
DE10207178A1 (de) 2002-02-19 2003-09-04 Novosom Ag Komponenten für die Herstellung amphoterer Liposomen
UA99434C2 (ru) * 2005-12-19 2012-08-27 Аетерна Центаріс Гмбх Применение производных алкилфосфолипидов со сниженной цитотоксичностью
DE102006028983A1 (de) 2006-06-23 2007-12-27 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Phosphorsäurediesteramide
JP5488121B2 (ja) 2010-03-31 2014-05-14 日油株式会社 経皮吸収促進及び/又は保湿性向上作用を示す剤、並びに化粧料
FR2966727B1 (fr) * 2010-11-03 2013-04-12 Oreal Utilisation comme antipelliculaire de polymeres phospholipidiques
FR2990206B1 (fr) * 2012-05-07 2014-06-06 Commissariat Energie Atomique Nouveaux composes bifonctionnels utiles comme ligands de l'uranium(vi), leurs procedes de synthese et leurs utilisations
US12415939B2 (en) * 2015-09-30 2025-09-16 The Regents Of The University Of California Nano-adhesive and surface primer compound and use thereof
PL3386484T3 (pl) * 2015-12-10 2022-07-25 Modernatx, Inc. Kompozycje i sposoby dostarczania środków terapeutycznych
CN109414408B (zh) 2016-05-16 2022-03-29 得克萨斯州大学系统董事会 阳离子磺酰胺氨基脂质和两亲性两性离子氨基脂质

Similar Documents

Publication Publication Date Title
JP2023538144A5 (https=)
Xiao et al. Emerging mRNA technologies: delivery strategies and biomedical applications
Kazemian et al. Lipid-nanoparticle-based delivery of CRISPR/Cas9 genome-editing components
JP7849049B2 (ja) 機能性のイオン化可能なリン脂質
Li et al. Nanoscale platforms for messenger RNA delivery
Huang et al. The roles of polymers in mRNA delivery
Kumar et al. Polymeric delivery of therapeutic nucleic acids
Navarro et al. Micelle-like nanoparticles as carriers for DNA and siRNA
Moss et al. Lipid nanoparticles for delivery of therapeutic RNA oligonucleotides
Tang et al. Ionizable lipid nanoparticles for mRNA delivery
Guan et al. Nanotechnologies in delivery of mRNA therapeutics using nonviral vector-based delivery systems
Lin et al. Targeting materials and strategies for RNA delivery
Romberg et al. Sheddable coatings for long-circulating nanoparticles
Kim et al. Efficient gene delivery by urocanic acid-modified chitosan
Hatakeyama et al. A pH-sensitive fusogenic peptide facilitates endosomal escape and greatly enhances the gene silencing of siRNA-containing nanoparticles in vitro and in vivo
Zhang et al. Cationic compounds used in lipoplexes and polyplexes for gene delivery
Draghici et al. Synthetic nucleic acid delivery systems: present and perspectives
Yang et al. Design, preparation and application of nucleic acid delivery carriers
Yuan et al. Recent advances of siRNA delivery by nanoparticles
KR102285326B1 (ko) Rna를 세포에 도입하기 위한 조성물
Dutta et al. Disulfide bridging strategies in viral and nonviral platforms for nucleic acid delivery
Jones et al. Hydrophobically modified dendrons: developing structure− activity relationships for DNA binding and gene transfection
Rouatbi et al. Pre-clinical non-viral vectors exploited for in vivo CRISPR/Cas9 gene editing: an overview
Tschiche et al. Nonviral gene delivery with dendritic self-assembling architectures
Wang et al. Recent progress in nucleic acid pulmonary delivery toward overcoming physiological barriers and improving transfection efficiency