ATE359829T1 - Wasserlösliche polymerkonjugate von retinoesäure - Google Patents
Wasserlösliche polymerkonjugate von retinoesäureInfo
- Publication number
- ATE359829T1 ATE359829T1 AT02792256T AT02792256T ATE359829T1 AT E359829 T1 ATE359829 T1 AT E359829T1 AT 02792256 T AT02792256 T AT 02792256T AT 02792256 T AT02792256 T AT 02792256T AT E359829 T1 ATE359829 T1 AT E359829T1
- Authority
- AT
- Austria
- Prior art keywords
- retinoic acid
- conjugates
- water soluble
- soluble polymer
- polymer conjugates
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Otolaryngology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Preparation (AREA)
- Polyethers (AREA)
- Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33504301P | 2001-10-30 | 2001-10-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE359829T1 true ATE359829T1 (de) | 2007-05-15 |
Family
ID=23310007
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02792256T ATE359829T1 (de) | 2001-10-30 | 2002-10-30 | Wasserlösliche polymerkonjugate von retinoesäure |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20030161791A1 (de) |
| EP (1) | EP1453545B1 (de) |
| JP (1) | JP2005507934A (de) |
| KR (1) | KR20050042013A (de) |
| AT (1) | ATE359829T1 (de) |
| CA (1) | CA2464346A1 (de) |
| DE (1) | DE60219677T2 (de) |
| ES (1) | ES2284959T3 (de) |
| MX (1) | MXPA04004025A (de) |
| WO (1) | WO2003037385A1 (de) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA04003597A (es) | 2001-10-18 | 2004-07-30 | Nektar Therapeutics Al Corp | Conjugados polimericos de antagonistas opiaceos. |
| KR100836036B1 (ko) * | 2002-02-20 | 2008-06-09 | (주)아모레퍼시픽 | 신규 레티노이드 유도체 및 이의 제조방법 |
| CA2788505C (en) * | 2003-02-26 | 2018-09-04 | Nektar Therapeutics | Polymer-factor viii moiety conjugates |
| DE10326303A1 (de) * | 2003-06-11 | 2004-12-30 | Celares Gmbh | Reagenzien zur Modifikation von Biopharmazeutika, deren Herstellung und Anwendung |
| US7482376B2 (en) * | 2003-07-03 | 2009-01-27 | 3-Dimensional Pharmaceuticals, Inc. | Conjugated complement cascade inhibitors |
| EP2626083A1 (de) | 2003-09-17 | 2013-08-14 | Nektar Therapeutics | Multi-Arm Polymerprodrogen |
| US8394365B2 (en) | 2003-09-17 | 2013-03-12 | Nektar Therapeutics | Multi-arm polymer prodrugs |
| US8637650B2 (en) | 2003-11-05 | 2014-01-28 | Genovoxx Gmbh | Macromolecular nucleotide compounds and methods for using the same |
| US20060182692A1 (en) * | 2003-12-16 | 2006-08-17 | Fishburn C S | Chemically modified small molecules |
| US7786133B2 (en) * | 2003-12-16 | 2010-08-31 | Nektar Therapeutics | Chemically modified small molecules |
| EP4005601A1 (de) * | 2004-12-22 | 2022-06-01 | Nitto Denko Corporation | Wirkstoffträger und wirkstoffträgerkit zur hemmung von fibrose |
| JP2009221164A (ja) | 2008-03-17 | 2009-10-01 | Nitto Denko Corp | 肺線維症処置剤 |
| US9393315B2 (en) * | 2011-06-08 | 2016-07-19 | Nitto Denko Corporation | Compounds for targeting drug delivery and enhancing siRNA activity |
| US20120269886A1 (en) | 2004-12-22 | 2012-10-25 | Nitto Denko Corporation | Therapeutic agent for pulmonary fibrosis |
| US20090209508A1 (en) * | 2005-05-16 | 2009-08-20 | Universite De Geneve | Compounds for Photochemotherapy |
| DE102005041570A1 (de) * | 2005-09-01 | 2007-03-22 | Celares Gmbh | Hoch verzweigte Reagenzien zur Modifaktion von Biopharmazeutika, deren Herstellung und Anwendung |
| JP5342834B2 (ja) * | 2008-09-05 | 2013-11-13 | 日東電工株式会社 | 骨髄線維症処置剤 |
| US9572886B2 (en) * | 2005-12-22 | 2017-02-21 | Nitto Denko Corporation | Agent for treating myelofibrosis |
| US7671067B2 (en) | 2006-02-09 | 2010-03-02 | Enzon Pharmaceuticals, Inc. | Treatment of non-hodgkin's lymphomas with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamtothecin |
| US7462627B2 (en) | 2006-02-09 | 2008-12-09 | Enzon Pharmaceuticals, Inc. | Multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin for treatment of breast, colorectal, pancreatic, ovarian and lung cancers |
| AU2007325631B9 (en) | 2006-11-30 | 2014-01-30 | Nektar Therapeutics | Method for preparing a polymer conjugate |
| KR100829890B1 (ko) | 2007-02-08 | 2008-05-16 | 주식회사 바이오폴리메드 | 신규한 레티놀 유도체, 이의 제조방법 및 이를 포함하는주름 개선용 화장료 조성물 |
| WO2008098178A2 (en) | 2007-02-09 | 2008-08-14 | Enzon Pharmaceuticals, Inc. | Treatment of resistant or refractory cancers with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin |
| TWI407971B (zh) | 2007-03-30 | 2013-09-11 | Nitto Denko Corp | Cancer cells and tumor-related fibroblasts |
| US20080312174A1 (en) * | 2007-06-05 | 2008-12-18 | Nitto Denko Corporation | Water soluble crosslinked polymers |
| CA2698812A1 (en) * | 2007-09-14 | 2009-03-19 | Nitto Denko Corporation | Drug carriers |
| US8536213B2 (en) | 2007-11-16 | 2013-09-17 | Nektar Therapeutics | Oligomer-dantrolene conjugates and related compounds |
| US8883211B2 (en) * | 2008-07-10 | 2014-11-11 | Serina Therapeutics, Inc. | Polyoxazolines with inert terminating groups, polyoxazolines prepared from protected initiating groups and related compounds |
| CN102159247A (zh) * | 2008-07-30 | 2011-08-17 | 日东电工株式会社 | 药物载体 |
| KR101671537B1 (ko) | 2008-08-11 | 2016-11-01 | 넥타르 테라퓨틱스 | 다분지형 중합체 알카노에이트 컨쥬게이트 |
| MX2011003063A (es) | 2008-09-23 | 2011-04-21 | Nektar Therapeutics | Composiciones y metodos para lograr concentraciones terapeuticas de farmaco sostenidas en un individuo. |
| US9315860B2 (en) | 2009-10-26 | 2016-04-19 | Genovoxx Gmbh | Conjugates of nucleotides and method for the application thereof |
| JP5950428B2 (ja) | 2010-08-05 | 2016-07-13 | 日東電工株式会社 | 線維化組織から正常組織を再生するための組成物 |
| US20160015656A2 (en) * | 2010-08-05 | 2016-01-21 | Nitto Denko Corporation | Composition for regenerating normal tissue from fibrotic tissue |
| NZ609874A (en) | 2010-09-30 | 2014-10-31 | Astrazeneca Ab | Crystalline naloxol-peg conjugate |
| US20130331443A1 (en) | 2010-12-22 | 2013-12-12 | Nektar Therapeutics | Multi-arm polymeric prodrug conjugates of taxane-based compounds |
| US10894087B2 (en) | 2010-12-22 | 2021-01-19 | Nektar Therapeutics | Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds |
| US10196637B2 (en) | 2011-06-08 | 2019-02-05 | Nitto Denko Corporation | Retinoid-lipid drug carrier |
| TWI658830B (zh) | 2011-06-08 | 2019-05-11 | 日東電工股份有限公司 | Ｈｓｐ47表現調控強化用類視色素脂質體 |
| US9011903B2 (en) | 2011-06-08 | 2015-04-21 | Nitto Denko Corporation | Cationic lipids for therapeutic agent delivery formulations |
| EP2998289B1 (de) * | 2011-06-08 | 2019-08-07 | Nitto Denko Corporation | Verbindungen für die gezielte wirkstofffreisetzung und verbesserung der sirna-wirkung |
| US10226536B2 (en) | 2011-11-28 | 2019-03-12 | Case Western Reserve University | Polysaccharide therapeutic conjugates |
| JP6340162B2 (ja) | 2012-12-20 | 2018-06-06 | 日東電工株式会社 | アポトーシス誘導剤 |
| CN104414973A (zh) * | 2013-08-21 | 2015-03-18 | 复旦大学 | 一种视黄酸和紫杉醇共递药的胶束给药系统及其制备方法 |
| CN106164089B (zh) | 2014-04-02 | 2020-11-03 | 日东电工株式会社 | 靶向分子及其用途 |
| CN106133024B (zh) | 2014-04-07 | 2019-07-05 | 日东电工株式会社 | 用于疏水性药物递送的新颖的基于聚合物的助水溶物 |
| US10471118B2 (en) * | 2014-05-30 | 2019-11-12 | Case Western Reserve University | Retinylamine derivitives for treatment of ocular disorders |
| US11129845B2 (en) | 2014-06-18 | 2021-09-28 | Case Western Reserve University | Compositions and methods for the delivery of nucleic acids |
| US10925980B2 (en) | 2014-08-04 | 2021-02-23 | Case Western Reserve University | Molecular probes and methods of use |
| CN104399084B (zh) * | 2014-11-29 | 2017-08-25 | 沈阳药科大学 | Peg化维甲酸及其自组装胶束在药物传递中的应用 |
| EP3302438A4 (de) * | 2015-05-29 | 2019-01-09 | Sun Pharmaceutical Industries Ltd | Orale pharmazeutische zusammensetzung aus isotretinoin |
| US11407786B2 (en) | 2015-06-18 | 2022-08-09 | Case Western Reserve University | Compositions and methods for the delivery of nucleic acids |
| US12060318B2 (en) | 2015-10-09 | 2024-08-13 | Case Western Reserve University | Compositions and methods for the delivery of nucleic acids |
| WO2018175340A1 (en) * | 2017-03-20 | 2018-09-27 | Sienna Biopharmaceuticals, Inc. | Reduced exposure conjugates modulating therapeutic targets |
| KR102093209B1 (ko) | 2017-05-11 | 2020-03-25 | (주)케어젠 | 이소트레티노인과 펩타이드의 결합체 |
| US20210261814A1 (en) * | 2018-07-20 | 2021-08-26 | Hercules Llc | Water soluble or dispersible composition |
| CN110124049B (zh) * | 2019-04-29 | 2023-09-22 | 大连医科大学 | 聚乙二醇化芬维a胺前体药物及其用途 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4371673A (en) * | 1980-07-21 | 1983-02-01 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Water soluble forms of retinoids |
| DK498487A (da) * | 1986-10-06 | 1988-04-07 | Hoffmann La Roche | Hidtil ukendte retinoider |
| DE3815221C2 (de) * | 1988-05-04 | 1995-06-29 | Gradinger F Hermes Pharma | Verwendung einer Retinol- und/oder Retinsäureester enthaltenden pharmazeutischen Zubereitung zur Inhalation zur Einwirkung auf die Schleimhäute des Tracheo-Bronchialtraktes einschließlich der Lungenalveolen |
| US5210133A (en) * | 1992-06-15 | 1993-05-11 | Siltech Inc. | Silicone polyester polymers as delivery systems |
| US5618850A (en) * | 1995-03-09 | 1997-04-08 | Focal, Inc. | Hydroxy-acid cosmetics |
| HU226646B1 (en) * | 1996-03-12 | 2009-05-28 | Pg Txl Company | Water soluble pharmaceutical compositions containing taxane derivatives |
| US6515022B2 (en) * | 1996-04-19 | 2003-02-04 | Sloan-Kettering Institute For Cancer Research | Use of inhaled retinoids in the treatment of lung diseases |
| WO1997039745A1 (en) * | 1996-04-19 | 1997-10-30 | Sloan-Kettering Institute For Cancer Research | Use of inhaled retinoids in the prevention of cancer |
| US6090800A (en) * | 1997-05-06 | 2000-07-18 | Imarx Pharmaceutical Corp. | Lipid soluble steroid prodrugs |
| FR2763853B1 (fr) * | 1997-05-28 | 2000-01-07 | Oreal | Association d'un retinoide avec un polymere polyamine |
| US5998486A (en) * | 1997-07-08 | 1999-12-07 | Georgetown University School Of Medicine | Treatment of emphysema with retinoic acid or other retinoids by inducing formation of gas-exchange units (alveoli) |
| TR200001228T2 (tr) * | 1997-11-12 | 2001-01-22 | F.Hoffmann-La Roche Ag | T yardımcı hücre tür 2 kökenli bağışıklık hastalıklarının retinoit antagonistlerle tedavisi |
| DE10012151A1 (de) * | 2000-03-13 | 2001-09-27 | Gsf Forschungszentrum Umwelt | Mittel zur Behandlung von Erkrankungen des Tracheo-Brochialtraktes, insbesondere der COPD |
| US6339107B1 (en) * | 2000-08-02 | 2002-01-15 | Syntex (U.S.A.) Llc | Methods for treatment of Emphysema using 13-cis retinoic acid |
-
2002
- 2002-10-30 JP JP2003539725A patent/JP2005507934A/ja active Pending
- 2002-10-30 EP EP02792256A patent/EP1453545B1/de not_active Expired - Lifetime
- 2002-10-30 DE DE60219677T patent/DE60219677T2/de not_active Expired - Fee Related
- 2002-10-30 AT AT02792256T patent/ATE359829T1/de not_active IP Right Cessation
- 2002-10-30 CA CA002464346A patent/CA2464346A1/en not_active Abandoned
- 2002-10-30 KR KR1020047006369A patent/KR20050042013A/ko not_active Application Discontinuation
- 2002-10-30 ES ES02792256T patent/ES2284959T3/es not_active Expired - Lifetime
- 2002-10-30 US US10/284,077 patent/US20030161791A1/en not_active Abandoned
- 2002-10-30 WO PCT/US2002/036421 patent/WO2003037385A1/en active IP Right Grant
- 2002-10-30 MX MXPA04004025A patent/MXPA04004025A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20050042013A (ko) | 2005-05-04 |
| CA2464346A1 (en) | 2003-05-08 |
| EP1453545A1 (de) | 2004-09-08 |
| ES2284959T3 (es) | 2007-11-16 |
| JP2005507934A (ja) | 2005-03-24 |
| EP1453545B1 (de) | 2007-04-18 |
| US20030161791A1 (en) | 2003-08-28 |
| WO2003037385A1 (en) | 2003-05-08 |
| MXPA04004025A (es) | 2004-07-08 |
| DE60219677D1 (de) | 2007-05-31 |
| DE60219677T2 (de) | 2008-05-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |