JP2014518557A5 - - Google Patents
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- JP2014518557A5 JP2014518557A5 JP2014506615A JP2014506615A JP2014518557A5 JP 2014518557 A5 JP2014518557 A5 JP 2014518557A5 JP 2014506615 A JP2014506615 A JP 2014506615A JP 2014506615 A JP2014506615 A JP 2014506615A JP 2014518557 A5 JP2014518557 A5 JP 2014518557A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- vaccine
- virus
- immunogen
- silk fibroin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000000203 mixture Substances 0.000 claims description 46
- 230000002238 attenuated effect Effects 0.000 claims description 13
- 108010022355 Fibroins Proteins 0.000 claims description 12
- 229960005486 vaccine Drugs 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 11
- 244000052769 pathogen Species 0.000 claims description 8
- 239000007787 solid Substances 0.000 claims description 8
- 208000037386 Typhoid Diseases 0.000 claims description 5
- 239000002245 particle Substances 0.000 claims description 5
- 201000008297 typhoid fever Diseases 0.000 claims description 5
- 230000003612 virological effect Effects 0.000 claims description 3
- 201000005505 Measles Diseases 0.000 claims description 2
- 208000005647 Mumps Diseases 0.000 claims description 2
- 241000187479 Mycobacterium tuberculosis Species 0.000 claims description 2
- 208000010805 mumps infectious disease Diseases 0.000 claims description 2
- 201000005404 rubella Diseases 0.000 claims description 2
- 241000700605 Viruses Species 0.000 claims 17
- 230000002163 immunogen Effects 0.000 claims 14
- 241000894006 Bacteria Species 0.000 claims 10
- 229940032046 DTaP vaccine Drugs 0.000 claims 6
- 239000013543 active substance Substances 0.000 claims 5
- 230000001580 bacterial effect Effects 0.000 claims 5
- 229960003971 influenza vaccine Drugs 0.000 claims 5
- 239000011159 matrix material Substances 0.000 claims 4
- 241000991587 Enterovirus C Species 0.000 claims 3
- 241000701806 Human papillomavirus Species 0.000 claims 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- 241000606768 Haemophilus influenzae Species 0.000 claims 2
- 241000700721 Hepatitis B virus Species 0.000 claims 2
- 229940124726 Japanese encephalitis vaccine Drugs 0.000 claims 2
- 229940124859 Rotavirus vaccine Drugs 0.000 claims 2
- 229940032047 Tdap vaccine Drugs 0.000 claims 2
- 239000000654 additive Substances 0.000 claims 2
- 230000000996 additive effect Effects 0.000 claims 2
- 230000004071 biological effect Effects 0.000 claims 2
- 239000002131 composite material Substances 0.000 claims 2
- 239000000835 fiber Substances 0.000 claims 2
- 208000002672 hepatitis B Diseases 0.000 claims 2
- SPSXSWRZQFPVTJ-ZQQKUFEYSA-N hepatitis b vaccine Chemical compound C([C@H](NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CCSC)C(=O)N[C@@H](CC1N=CN=C1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)OC(=O)CNC(=O)CNC(=O)[C@H](C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](N)CCCNC(N)=N)C1=CC=CC=C1 SPSXSWRZQFPVTJ-ZQQKUFEYSA-N 0.000 claims 2
- 229940124724 hepatitis-A vaccine Drugs 0.000 claims 2
- 229940124736 hepatitis-B vaccine Drugs 0.000 claims 2
- 239000000017 hydrogel Substances 0.000 claims 2
- 206010022000 influenza Diseases 0.000 claims 2
- 239000011859 microparticle Substances 0.000 claims 2
- 239000002105 nanoparticle Substances 0.000 claims 2
- 244000309711 non-enveloped viruses Species 0.000 claims 2
- 229940124733 pneumococcal vaccine Drugs 0.000 claims 2
- 229960001539 poliomyelitis vaccine Drugs 0.000 claims 2
- 229960003127 rabies vaccine Drugs 0.000 claims 2
- 239000003381 stabilizer Substances 0.000 claims 2
- 239000010409 thin film Substances 0.000 claims 2
- 239000003053 toxin Substances 0.000 claims 2
- 231100000765 toxin Toxicity 0.000 claims 2
- 108700012359 toxins Proteins 0.000 claims 2
- 239000013603 viral vector Substances 0.000 claims 2
- 229940124965 ACAM2000 Drugs 0.000 claims 1
- 229940124962 ActHIB Drugs 0.000 claims 1
- 229940124963 Afluria Drugs 0.000 claims 1
- 241000193738 Bacillus anthracis Species 0.000 claims 1
- 101100394745 Bacillus subtilis (strain 168) hepT gene Proteins 0.000 claims 1
- 229940124899 Biothrax Drugs 0.000 claims 1
- 229940124900 Boostrix Drugs 0.000 claims 1
- 241000588832 Bordetella pertussis Species 0.000 claims 1
- 201000006082 Chickenpox Diseases 0.000 claims 1
- 229940124888 DECAVAC Drugs 0.000 claims 1
- 229940124902 Daptacel Drugs 0.000 claims 1
- 229940124884 Engerix-B Drugs 0.000 claims 1
- 241000710781 Flaviviridae Species 0.000 claims 1
- 229940124895 FluMist Drugs 0.000 claims 1
- 229940124896 Fluarix Drugs 0.000 claims 1
- 229940124893 Fluvirin Drugs 0.000 claims 1
- 229940124894 Fluzone Drugs 0.000 claims 1
- 229940124897 Gardasil Drugs 0.000 claims 1
- 229940124914 Havrix Drugs 0.000 claims 1
- 241000700586 Herpesviridae Species 0.000 claims 1
- 229940124913 IPOL Drugs 0.000 claims 1
- 229940124915 Infanrix Drugs 0.000 claims 1
- 229940124956 Ixiaro Drugs 0.000 claims 1
- 229940124918 JE-Vax Drugs 0.000 claims 1
- 229940124919 Kinrix Drugs 0.000 claims 1
- GXCLGNHLZMTTQJ-ZOULSWATSA-N L-alpha-D-Hepp-(1->3)-L-alpha-D-Hepp Chemical compound O[C@@H]1[C@@H]([C@@H](O)CO)O[C@H](O)[C@@H](O)[C@H]1O[C@@H]1[C@@H](O)[C@@H](O)[C@H](O)[C@@H]([C@@H](O)CO)O1 GXCLGNHLZMTTQJ-ZOULSWATSA-N 0.000 claims 1
- 241000712079 Measles morbillivirus Species 0.000 claims 1
- 229940124904 Menactra Drugs 0.000 claims 1
- 241000711386 Mumps virus Species 0.000 claims 1
- 241000588653 Neisseria Species 0.000 claims 1
- 241000588650 Neisseria meningitidis Species 0.000 claims 1
- 241000712464 Orthomyxoviridae Species 0.000 claims 1
- 241000711504 Paramyxoviridae Species 0.000 claims 1
- 229940124908 Pediarix Drugs 0.000 claims 1
- 101100338762 Pedobacter heparinus (strain ATCC 13125 / DSM 2366 / CIP 104194 / JCM 7457 / NBRC 12017 / NCIMB 9290 / NRRL B-14731 / HIM 762-3) hepB gene Proteins 0.000 claims 1
- 229940124909 PedvaxHIB Drugs 0.000 claims 1
- 229940124910 Pentacel Drugs 0.000 claims 1
- 201000005702 Pertussis Diseases 0.000 claims 1
- 229940124876 ProQuad Drugs 0.000 claims 1
- 229940124875 RabAvert Drugs 0.000 claims 1
- 241000711798 Rabies lyssavirus Species 0.000 claims 1
- 241000702263 Reovirus sp. Species 0.000 claims 1
- 241000725643 Respiratory syncytial virus Species 0.000 claims 1
- 241000712907 Retroviridae Species 0.000 claims 1
- 241000711931 Rhabdoviridae Species 0.000 claims 1
- 229940124878 RotaTeq Drugs 0.000 claims 1
- 229940124941 Rotarix Drugs 0.000 claims 1
- 241000702670 Rotavirus Species 0.000 claims 1
- 241000710799 Rubella virus Species 0.000 claims 1
- 241000193998 Streptococcus pneumoniae Species 0.000 claims 1
- 229930006000 Sucrose Natural products 0.000 claims 1
- 229940124929 TYPHIM Vi Drugs 0.000 claims 1
- 241000710924 Togaviridae Species 0.000 claims 1
- 229940124923 Tripedia Drugs 0.000 claims 1
- 229940124922 Twinrix Drugs 0.000 claims 1
- 206010046865 Vaccinia virus infection Diseases 0.000 claims 1
- 229940124937 Vaqta Drugs 0.000 claims 1
- 206010046980 Varicella Diseases 0.000 claims 1
- 229940124924 Varivax Drugs 0.000 claims 1
- 229940124928 YF-Vax Drugs 0.000 claims 1
- 241000710772 Yellow fever virus Species 0.000 claims 1
- 229940124925 Zostavax Drugs 0.000 claims 1
- 229940102614 adacel Drugs 0.000 claims 1
- 150000001720 carbohydrates Chemical class 0.000 claims 1
- 229960003983 diphtheria toxoid Drugs 0.000 claims 1
- 229960005097 diphtheria vaccines Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000001035 drying Methods 0.000 claims 1
- 230000005684 electric field Effects 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- 150000004676 glycans Chemical class 0.000 claims 1
- 229940047650 haemophilus influenzae Drugs 0.000 claims 1
- 229940045808 haemophilus influenzae type b Drugs 0.000 claims 1
- 229960004443 hemophilus influenzae b vaccines Drugs 0.000 claims 1
- 208000006454 hepatitis Diseases 0.000 claims 1
- 231100000283 hepatitis Toxicity 0.000 claims 1
- 229940026063 imovax Drugs 0.000 claims 1
- 150000002500 ions Chemical class 0.000 claims 1
- 229940014135 meningitis vaccine Drugs 0.000 claims 1
- 229940049548 pneumovax Drugs 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 229940114241 recombivax Drugs 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 230000000087 stabilizing effect Effects 0.000 claims 1
- 229940031000 streptococcus pneumoniae Drugs 0.000 claims 1
- 239000005720 sucrose Substances 0.000 claims 1
- 125000000185 sucrose group Chemical group 0.000 claims 1
- 235000000346 sugar Nutrition 0.000 claims 1
- 150000005846 sugar alcohols Chemical class 0.000 claims 1
- 150000008163 sugars Chemical group 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 claims 1
- 229960000814 tetanus toxoid Drugs 0.000 claims 1
- 229960002766 tetanus vaccines Drugs 0.000 claims 1
- 201000008827 tuberculosis Diseases 0.000 claims 1
- 241000712461 unidentified influenza virus Species 0.000 claims 1
- 208000007089 vaccinia Diseases 0.000 claims 1
- 229940021648 varicella vaccine Drugs 0.000 claims 1
- 229960001515 yellow fever vaccine Drugs 0.000 claims 1
- 229940051021 yellow-fever virus Drugs 0.000 claims 1
- 230000001717 pathogenic effect Effects 0.000 description 4
- 230000028993 immune response Effects 0.000 description 3
- 241000607479 Yersinia pestis Species 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000000227 grinding Methods 0.000 description 2
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 206010035148 Plague Diseases 0.000 description 1
- 208000003152 Yellow Fever Diseases 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 229940124590 live attenuated vaccine Drugs 0.000 description 1
- 229940023012 live-attenuated vaccine Drugs 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 229960002109 tuberculosis vaccine Drugs 0.000 description 1
- 244000000057 wild-type pathogen Species 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161477737P | 2011-04-21 | 2011-04-21 | |
| US61/477,737 | 2011-04-21 | ||
| PCT/US2012/034643 WO2012145739A1 (en) | 2011-04-21 | 2012-04-23 | Compositions and methods for stabilization of active agents |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017042342A Division JP2017137328A (ja) | 2011-04-21 | 2017-03-07 | 活性物質を安定化させるための組成物および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014518557A JP2014518557A (ja) | 2014-07-31 |
| JP2014518557A5 true JP2014518557A5 (enExample) | 2016-09-29 |
| JP6170906B2 JP6170906B2 (ja) | 2017-07-26 |
Family
ID=47041958
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014506615A Active JP6170906B2 (ja) | 2011-04-21 | 2012-04-23 | 活性物質を安定化させるための組成物および方法 |
| JP2017042342A Pending JP2017137328A (ja) | 2011-04-21 | 2017-03-07 | 活性物質を安定化させるための組成物および方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017042342A Pending JP2017137328A (ja) | 2011-04-21 | 2017-03-07 | 活性物質を安定化させるための組成物および方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US20140287043A1 (enExample) |
| EP (1) | EP2699266B1 (enExample) |
| JP (2) | JP6170906B2 (enExample) |
| CN (2) | CN105148285B (enExample) |
| AU (6) | AU2012245198B2 (enExample) |
| BR (1) | BR112013027057A2 (enExample) |
| CA (1) | CA2833879C (enExample) |
| IL (1) | IL228984A0 (enExample) |
| WO (1) | WO2012145739A1 (enExample) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102271724B (zh) | 2008-10-09 | 2015-10-14 | 塔夫茨大学信托人 | 含有甘油的改性丝膜 |
| US20140287043A1 (en) | 2011-04-21 | 2014-09-25 | Trustees Of Tufts College | Compositions and methods for stabilization of active agents |
| WO2013106822A1 (en) | 2012-01-12 | 2013-07-18 | Johnson Jed K | Nanofiber scaffolds for biological structures |
| JP2015510818A (ja) | 2012-03-20 | 2015-04-13 | トラスティーズ オブ タフツ カレッジ | 薬物送達のための絹リザーバー |
| WO2013155404A1 (en) | 2012-04-13 | 2013-10-17 | Trustees Of Tufts College | Methods and compositions for preparing a silk microsphere |
| US10653786B2 (en) | 2012-04-25 | 2020-05-19 | Trustees Of Tufts College | Silk microspheres and methods for surface lubrication |
| WO2014127309A1 (en) | 2013-02-15 | 2014-08-21 | Tufts University | Silk-based nanoimprinting |
| US11376329B2 (en) | 2013-03-15 | 2022-07-05 | Trustees Of Tufts College | Low molecular weight silk compositions and stabilizing silk compositions |
| WO2014197093A2 (en) | 2013-03-15 | 2014-12-11 | Tufts University | All water-based nanopatterning |
| AU2014233480B2 (en) * | 2013-03-15 | 2018-08-09 | Trustees Of Tufts College | Low molecular weight silk compositions and stabilizing silk compositions |
| AU2014240170B2 (en) * | 2013-03-15 | 2018-05-17 | Patheon Softgels Inc. | Silk-based capsules |
| WO2014144971A1 (en) | 2013-03-15 | 2014-09-18 | Tufts University | Silk water lithography |
| ITMI20131255A1 (it) * | 2013-07-26 | 2015-01-27 | Ct Tessile Serico Societa Co Nsortile Per A | Composizioni farmaceutiche nebulizzabili a base di fibroina per il trattamento di lesioni cutanee |
| CN105579059B (zh) * | 2013-09-03 | 2020-07-31 | 佐治亚科技研究公司 | 热稳定的疫苗配制物、工艺和包含疫苗配制物的微针 |
| CA2923753C (en) | 2013-09-19 | 2021-10-12 | Terumo Corporation | Polymer particles |
| BR112016005768B1 (pt) * | 2013-09-19 | 2021-09-21 | Microvention, Inc | Películas de polímero |
| KR20210153142A (ko) * | 2013-09-30 | 2021-12-16 | 실크 테라퓨틱스, 인코퍼레이티드 | 실크 단백질 단편 조성물 및 이로부터 제작된 물품 |
| EP3065719A4 (en) | 2013-11-08 | 2017-08-09 | Terumo Corporation | Polymer particles |
| ES2875330T3 (es) * | 2014-04-04 | 2021-11-10 | Nanofiber Solutions Llc | Composiciones de fibras biocompatibles electrohiladas |
| EA035551B1 (ru) | 2014-12-02 | 2020-07-06 | Силк Терапьютикс, Инк. | Изделие |
| US10213378B2 (en) * | 2015-03-10 | 2019-02-26 | Sporos Therapeutics, LLC | Single dose non-adjuvanted cutaneous tetanus vaccine and uses thereof |
| US9907880B2 (en) | 2015-03-26 | 2018-03-06 | Microvention, Inc. | Particles |
| CN104940981B (zh) * | 2015-05-21 | 2018-11-30 | 重庆市畜牧科学院 | 具有生物活性的外用敷料及其制备方法 |
| CN108135975A (zh) | 2015-07-14 | 2018-06-08 | 丝绸医疗公司 | 丝性能服装和产品及其制备方法 |
| CN105903027A (zh) * | 2016-05-31 | 2016-08-31 | 福建傲农生物科技集团股份有限公司 | 一种常温下长期保存抗生素的方法 |
| WO2017214187A1 (en) * | 2016-06-07 | 2017-12-14 | Aridis Pharmaceuticals, Inc. | Method for preparation of quick dissolving thin films containing bioactive material with enhanced thermal stability |
| CN106362223B (zh) * | 2016-08-26 | 2019-05-03 | 南通纺织丝绸产业技术研究院 | 多孔丝素蛋白微针给药装置及其制备方法 |
| GB201614799D0 (en) * | 2016-09-01 | 2016-10-19 | Glaxosmithkline Biologicals Sa | Compositions |
| US20190275136A1 (en) * | 2016-09-19 | 2019-09-12 | Vaxess Technologies, Inc. | Vaccine formulations with increased stability |
| CA3038642C (en) | 2016-09-28 | 2021-11-02 | Terumo Corporation | Polymer particles comprising polymerizable pharmaceutical agents |
| US10857262B2 (en) | 2016-10-31 | 2020-12-08 | Sofregen Medical, Inc. | Compositions comprising low molecular weight silk fibroin fragments and plasticizers |
| US10898608B2 (en) | 2017-02-02 | 2021-01-26 | Nanofiber Solutions, Llc | Methods of improving bone-soft tissue healing using electrospun fibers |
| US11390988B2 (en) | 2017-09-27 | 2022-07-19 | Evolved By Nature, Inc. | Silk coated fabrics and products and methods of preparing the same |
| WO2019094702A1 (en) | 2017-11-10 | 2019-05-16 | Cocoon Biotech Inc. | Ocular applications of silk-based products |
| SG11202007503WA (en) * | 2018-02-07 | 2020-09-29 | Bharat Biotech Int Ltd | A process for enterovirus purification and inactivation and vaccine compositions obtained thereof |
| EP3830576A2 (en) * | 2018-07-27 | 2021-06-09 | Vaxess Technologies, Inc. | Polymer-based biospecimen collection devices and uses thereof |
| CA3111273C (en) * | 2018-09-06 | 2024-03-26 | Bavarian Nordic A/S | Storage improved poxvirus compositions |
| MX2021006436A (es) | 2018-12-10 | 2021-09-14 | Cambridge Crops Inc | Composiciones y metodos para la extension de la vida util a base de polimero. |
| TWI691531B (zh) * | 2019-02-11 | 2020-04-21 | 南臺學校財團法人南臺科技大學 | 蠶絲蛋白膜的製造方法 |
| AU2020288624B2 (en) | 2019-06-04 | 2025-09-25 | Cocoon Biotech Inc. | Silk-based products, formulations, and methods of use |
| CN110627899A (zh) * | 2019-10-09 | 2019-12-31 | 山东天牧生物科技有限公司 | 一种呼肠孤病毒和细小病毒卵黄抗体锭及其制备方法 |
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| US20240117321A1 (en) * | 2021-03-02 | 2024-04-11 | Georgia Tech Research Corporation | Hydrogel materials and methods of making and transport using the same |
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| US11584784B2 (en) | 2021-05-21 | 2023-02-21 | Cambridge Crops, Inc. | Systems and methods for manufacturing a silk fibroin solution and powders containing silk fibroin |
| US11864569B2 (en) | 2021-08-16 | 2024-01-09 | Cambridge Crops, Inc. | Systems and methods for improving the performance of cereal using a silk fibroin solution and powders containing silk fibroin |
| CN116421734A (zh) * | 2021-12-30 | 2023-07-14 | 深圳复诺健生物科技有限公司 | 适用于溶瘤病毒的冻干保护剂及其应用 |
| US20250223571A1 (en) | 2022-03-30 | 2025-07-10 | Bioneedle Drug Delivery B.V. | A process for storing biologically active constructs in a biodegradable material |
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-
2012
- 2012-04-23 US US14/112,769 patent/US20140287043A1/en not_active Abandoned
- 2012-04-23 CN CN201510559840.6A patent/CN105148285B/zh active Active
- 2012-04-23 AU AU2012245198A patent/AU2012245198B2/en active Active
- 2012-04-23 CN CN201280030582.7A patent/CN103796683A/zh active Pending
- 2012-04-23 BR BR112013027057-8A patent/BR112013027057A2/pt not_active IP Right Cessation
- 2012-04-23 JP JP2014506615A patent/JP6170906B2/ja active Active
- 2012-04-23 EP EP12774253.4A patent/EP2699266B1/en active Active
- 2012-04-23 CA CA2833879A patent/CA2833879C/en active Active
- 2012-04-23 WO PCT/US2012/034643 patent/WO2012145739A1/en not_active Ceased
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2013
- 2013-10-21 IL IL228984A patent/IL228984A0/en unknown
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2017
- 2017-03-07 JP JP2017042342A patent/JP2017137328A/ja active Pending
- 2017-04-20 US US15/492,363 patent/US20170258889A1/en not_active Abandoned
- 2017-06-20 AU AU2017204162A patent/AU2017204162A1/en not_active Abandoned
- 2017-12-29 US US15/858,239 patent/US12280101B2/en active Active
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2018
- 2018-09-03 AU AU2018226377A patent/AU2018226377B2/en active Active
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2020
- 2020-05-18 AU AU2020203212A patent/AU2020203212A1/en not_active Abandoned
- 2020-08-13 AU AU2020217419A patent/AU2020217419A1/en not_active Abandoned
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2022
- 2022-09-20 AU AU2022235540A patent/AU2022235540A1/en not_active Abandoned
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