JP2017533899A5 - - Google Patents
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- Publication number
- JP2017533899A5 JP2017533899A5 JP2017518817A JP2017518817A JP2017533899A5 JP 2017533899 A5 JP2017533899 A5 JP 2017533899A5 JP 2017518817 A JP2017518817 A JP 2017518817A JP 2017518817 A JP2017518817 A JP 2017518817A JP 2017533899 A5 JP2017533899 A5 JP 2017533899A5
- Authority
- JP
- Japan
- Prior art keywords
- type
- dose
- soak
- poliovirus
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims description 84
- 239000000427 antigen Substances 0.000 claims description 48
- 102000036639 antigens Human genes 0.000 claims description 48
- 108091007433 antigens Proteins 0.000 claims description 48
- 239000000203 mixture Substances 0.000 claims description 44
- 230000002779 inactivation Effects 0.000 claims description 43
- 241000991587 Enterovirus C Species 0.000 claims description 37
- 241000274177 Juniperus sabina Species 0.000 claims description 35
- 238000000034 method Methods 0.000 claims description 33
- 229940029583 inactivated polio vaccine Drugs 0.000 claims description 31
- 229960005486 vaccine Drugs 0.000 claims description 29
- 229940037003 alum Drugs 0.000 claims description 21
- 239000002671 adjuvant Substances 0.000 claims description 18
- 241000700605 Viruses Species 0.000 claims description 16
- 239000002245 particle Substances 0.000 claims description 16
- 241000588650 Neisseria meningitidis Species 0.000 claims description 15
- 239000007983 Tris buffer Substances 0.000 claims description 15
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 claims description 15
- 239000008363 phosphate buffer Substances 0.000 claims description 13
- 238000001179 sorption measurement Methods 0.000 claims description 13
- 230000009467 reduction Effects 0.000 claims description 11
- 230000002829 reductive effect Effects 0.000 claims description 11
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims description 10
- 238000004519 manufacturing process Methods 0.000 claims description 10
- 239000000872 buffer Substances 0.000 claims description 9
- 230000007812 deficiency Effects 0.000 claims description 9
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 8
- 201000005702 Pertussis Diseases 0.000 claims description 8
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 claims description 7
- 230000002776 aggregation Effects 0.000 claims description 5
- 238000004220 aggregation Methods 0.000 claims description 5
- 229960003983 diphtheria toxoid Drugs 0.000 claims description 5
- 229960000814 tetanus toxoid Drugs 0.000 claims description 5
- 241000606768 Haemophilus influenzae Species 0.000 claims description 4
- 241000709727 Human poliovirus 3 Species 0.000 claims description 4
- ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical compound O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 claims description 4
- 208000002672 hepatitis B Diseases 0.000 claims description 4
- 241000709701 Human poliovirus 1 Species 0.000 claims description 3
- 241000709704 Human poliovirus 2 Species 0.000 claims description 3
- 241000193998 Streptococcus pneumoniae Species 0.000 claims description 3
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims description 3
- 229910052782 aluminium Inorganic materials 0.000 claims description 3
- 239000007853 buffer solution Substances 0.000 claims description 3
- 230000000415 inactivating effect Effects 0.000 claims description 3
- 229940031000 streptococcus pneumoniae Drugs 0.000 claims description 3
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 claims description 2
- 239000007995 HEPES buffer Substances 0.000 claims description 2
- 239000007993 MOPS buffer Substances 0.000 claims description 2
- 101100388690 Plasmodium falciparum (isolate K1 / Thailand) MEF-1 gene Proteins 0.000 claims description 2
- 241000293871 Salmonella enterica subsp. enterica serovar Typhi Species 0.000 claims description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 2
- 244000052769 pathogen Species 0.000 claims description 2
- 229940031418 trivalent vaccine Drugs 0.000 claims description 2
- 241000709661 Enterovirus Species 0.000 claims 11
- 230000000087 stabilizing effect Effects 0.000 claims 3
- 229940047650 haemophilus influenzae Drugs 0.000 claims 2
- 208000006454 hepatitis Diseases 0.000 claims 2
- 231100000283 hepatitis Toxicity 0.000 claims 2
- 229940031348 multivalent vaccine Drugs 0.000 claims 1
- 230000001717 pathogenic effect Effects 0.000 claims 1
- 229910019142 PO4 Inorganic materials 0.000 description 9
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 9
- 239000010452 phosphate Substances 0.000 description 9
- 238000009472 formulation Methods 0.000 description 8
- 208000000474 Poliomyelitis Diseases 0.000 description 7
- 229910017119 AlPO Inorganic materials 0.000 description 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 238000009295 crossflow filtration Methods 0.000 description 4
- 239000003085 diluting agent Substances 0.000 description 4
- 230000008029 eradication Effects 0.000 description 4
- 238000001914 filtration Methods 0.000 description 4
- 230000028993 immune response Effects 0.000 description 4
- 230000003053 immunization Effects 0.000 description 4
- 238000002649 immunization Methods 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 239000004471 Glycine Substances 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- -1 carboxylatophenoxy Chemical group 0.000 description 3
- 239000000839 emulsion Substances 0.000 description 3
- 239000013020 final formulation Substances 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 3
- 230000005847 immunogenicity Effects 0.000 description 3
- 230000006872 improvement Effects 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 238000007918 intramuscular administration Methods 0.000 description 3
- 238000000746 purification Methods 0.000 description 3
- 210000002966 serum Anatomy 0.000 description 3
- 239000003656 tris buffered saline Substances 0.000 description 3
- 238000002965 ELISA Methods 0.000 description 2
- 206010014611 Encephalitis venezuelan equine Diseases 0.000 description 2
- 241000282412 Homo Species 0.000 description 2
- 208000002687 Venezuelan Equine Encephalomyelitis Diseases 0.000 description 2
- 201000009145 Venezuelan equine encephalitis Diseases 0.000 description 2
- 230000000890 antigenic effect Effects 0.000 description 2
- 230000002238 attenuated effect Effects 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 238000004113 cell culture Methods 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 229940001442 combination vaccine Drugs 0.000 description 2
- 229940028617 conventional vaccine Drugs 0.000 description 2
- 238000004132 cross linking Methods 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 238000011026 diafiltration Methods 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 229960003971 influenza vaccine Drugs 0.000 description 2
- 238000004255 ion exchange chromatography Methods 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 238000007920 subcutaneous administration Methods 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 210000003501 vero cell Anatomy 0.000 description 2
- GMRQFYUYWCNGIN-UHFFFAOYSA-N 1,25-Dihydroxy-vitamin D3' Natural products C1CCC2(C)C(C(CCCC(C)(C)O)C)CCC2C1=CC=C1CC(O)CC(O)C1=C GMRQFYUYWCNGIN-UHFFFAOYSA-N 0.000 description 1
- UAIUNKRWKOVEES-UHFFFAOYSA-N 3,3',5,5'-tetramethylbenzidine Chemical compound CC1=C(N)C(C)=CC(C=2C=C(C)C(N)=C(C)C=2)=C1 UAIUNKRWKOVEES-UHFFFAOYSA-N 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 241000282693 Cercopithecidae Species 0.000 description 1
- 241000699800 Cricetinae Species 0.000 description 1
- 206010025323 Lymphomas Diseases 0.000 description 1
- 241000829100 Macaca mulatta polyomavirus 1 Species 0.000 description 1
- 102000018697 Membrane Proteins Human genes 0.000 description 1
- 108010052285 Membrane Proteins Proteins 0.000 description 1
- 241000711408 Murine respirovirus Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 102100029740 Poliovirus receptor Human genes 0.000 description 1
- 229940124867 Poliovirus vaccine Drugs 0.000 description 1
- 241000711798 Rabies lyssavirus Species 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 241000700157 Rattus norvegicus Species 0.000 description 1
- 101000874347 Streptococcus agalactiae IgA FC receptor Proteins 0.000 description 1
- 206010053614 Type III immune complex mediated reaction Diseases 0.000 description 1
- 108010067390 Viral Proteins Proteins 0.000 description 1
- 239000000556 agonist Substances 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 150000001450 anions Chemical class 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 208000002352 blister Diseases 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 229960005084 calcitriol Drugs 0.000 description 1
- GMRQFYUYWCNGIN-NKMMMXOESA-N calcitriol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C GMRQFYUYWCNGIN-NKMMMXOESA-N 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000004440 column chromatography Methods 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000007123 defense Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 206010013023 diphtheria Diseases 0.000 description 1
- 238000011143 downstream manufacturing Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 208000005252 hepatitis A Diseases 0.000 description 1
- DOUYETYNHWVLEO-UHFFFAOYSA-N imiquimod Chemical compound C1=CC=CC2=C3N(CC(C)C)C=NC3=C(N)N=C21 DOUYETYNHWVLEO-UHFFFAOYSA-N 0.000 description 1
- 229960002751 imiquimod Drugs 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 206010022000 influenza Diseases 0.000 description 1
- 239000007972 injectable composition Substances 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 201000007270 liver cancer Diseases 0.000 description 1
- 208000014018 liver neoplasm Diseases 0.000 description 1
- 238000003760 magnetic stirring Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 231100000189 neurotoxic Toxicity 0.000 description 1
- 230000002887 neurotoxic effect Effects 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 125000004433 nitrogen atom Chemical group N* 0.000 description 1
- 231100000590 oncogenic Toxicity 0.000 description 1
- 230000002246 oncogenic effect Effects 0.000 description 1
- 229940127241 oral polio vaccine Drugs 0.000 description 1
- 230000001769 paralizing effect Effects 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 210000004180 plasmocyte Anatomy 0.000 description 1
- 229960001539 poliomyelitis vaccine Drugs 0.000 description 1
- 108010048507 poliovirus receptor Proteins 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 150000003141 primary amines Chemical group 0.000 description 1
- 229940021993 prophylactic vaccine Drugs 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 206010041823 squamous cell carcinoma Diseases 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- 241000701161 unidentified adenovirus Species 0.000 description 1
- 229960004854 viral vaccine Drugs 0.000 description 1
- 210000002845 virion Anatomy 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN3180/MUM/2014 | 2014-10-07 | ||
| IN3180MU2014 | 2014-10-07 | ||
| PCT/IN2015/000376 WO2016063291A1 (en) | 2014-10-07 | 2015-10-06 | Improved methods for enterovirus inactivation, adjuvant adsorption and dose reduced vaccine compositions obtained thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020142117A Division JP7063957B2 (ja) | 2014-10-07 | 2020-08-25 | エンテロウイルス不活化およびアジュバント吸着のための改良された方法、ならびに、それから得られる投与量減量ワクチン組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017533899A JP2017533899A (ja) | 2017-11-16 |
| JP2017533899A5 true JP2017533899A5 (enExample) | 2018-11-22 |
| JP6755243B2 JP6755243B2 (ja) | 2020-09-16 |
Family
ID=55300742
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017518817A Active JP6755243B2 (ja) | 2014-10-07 | 2015-10-06 | エンテロウイルス不活化およびアジュバント吸着のための改良された方法、ならびに、それから得られる投与量減量ワクチン組成物 |
| JP2020142117A Active JP7063957B2 (ja) | 2014-10-07 | 2020-08-25 | エンテロウイルス不活化およびアジュバント吸着のための改良された方法、ならびに、それから得られる投与量減量ワクチン組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020142117A Active JP7063957B2 (ja) | 2014-10-07 | 2020-08-25 | エンテロウイルス不活化およびアジュバント吸着のための改良された方法、ならびに、それから得られる投与量減量ワクチン組成物 |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US10485862B2 (enExample) |
| EP (2) | EP3204494B1 (enExample) |
| JP (2) | JP6755243B2 (enExample) |
| KR (2) | KR102510744B1 (enExample) |
| CN (2) | CN113368227A (enExample) |
| AU (2) | AU2015334495B2 (enExample) |
| CA (1) | CA2963897C (enExample) |
| CU (1) | CU24510B1 (enExample) |
| CY (1) | CY1123078T1 (enExample) |
| DK (1) | DK3204494T3 (enExample) |
| EA (1) | EA201700187A1 (enExample) |
| ES (1) | ES2803578T3 (enExample) |
| HU (1) | HUE049104T2 (enExample) |
| LT (1) | LT3204494T (enExample) |
| MX (1) | MX388525B (enExample) |
| MY (1) | MY204389A (enExample) |
| PE (1) | PE20171132A1 (enExample) |
| PH (1) | PH12017500627A1 (enExample) |
| PL (1) | PL3204494T3 (enExample) |
| PT (1) | PT3204494T (enExample) |
| SG (2) | SG11201702838SA (enExample) |
| SI (1) | SI3204494T1 (enExample) |
| UA (1) | UA125788C2 (enExample) |
| WO (1) | WO2016063291A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3204494B1 (en) * | 2014-10-07 | 2020-04-01 | Serum Institute Of India Private Limited | Improved methods for poliovirus inactivation, adjuvant adsorption |
| AU2017261706B2 (en) | 2016-05-10 | 2024-10-31 | Najit Technologies, Inc. | Inactivating pathogens and producing highly immunogenic inactivated vaccines using a dual oxidation process |
| AU2017316768B2 (en) * | 2016-08-26 | 2024-04-11 | Serum Institute Of India Private Limited | Multivalent vaccine composition |
| TWI711700B (zh) * | 2017-07-10 | 2020-12-01 | 印度商印度血清研究公司 | 使腸病毒去活化之改良方法、佐劑吸附及所獲得之劑量減少的疫苗組成物 |
| CA3081586A1 (en) | 2017-11-03 | 2019-05-09 | Takeda Vaccines, Inc. | Zika vaccines and immunogenic compositions, and methods of using the same |
| CN116983398A (zh) | 2017-11-30 | 2023-11-03 | 武田疫苗股份有限公司 | 寨卡疫苗和免疫原性组合物以及其使用方法 |
| EP3749757A4 (en) * | 2018-02-07 | 2021-11-24 | Bharat Biotech International Limited | PROCESS FOR PURIFICATION AND INACTIVATION OF ENTERVIRUSES AND VACCINE COMPOSITIONS OBTAINED THEREOF |
| CN109550046B (zh) * | 2018-12-21 | 2020-08-25 | 北京民海生物科技有限公司 | 一种吸附无细胞百白破-脊髓灰质炎-b型流感嗜血杆菌联合疫苗及其制备方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2259415A1 (en) * | 1996-07-02 | 1998-01-08 | Connaught Laboratories Limited | Multivalent dtp-polio vaccines |
| EP1793852A1 (en) * | 2004-08-27 | 2007-06-13 | Panacea Biotec Ltd. | Inactivated poliomyelitis vaccine derived from sabin strain of polio virus |
| CN1647822A (zh) * | 2005-02-06 | 2005-08-03 | 北京生物制品研究所 | 脊髓灰质炎灭活疫苗及其制备方法 |
| EA015964B1 (ru) * | 2006-09-07 | 2012-01-30 | Глаксосмитклайн Байолоджикалс С.А. | Вакцина |
| CN100540662C (zh) * | 2006-12-06 | 2009-09-16 | 云南沃森生物技术有限公司 | 一种混合床凝胶过滤层析技术用于病毒性疫苗纯化的方法 |
| WO2010036226A1 (en) * | 2008-09-26 | 2010-04-01 | George Nelson | Process for treatment of rheumatoid arthritis, tremors/parkinson's disease and multiple sclerosis |
| CN102655879B (zh) * | 2009-12-16 | 2016-03-09 | 印度血清研究所 | 疫苗组合物 |
| US20140112950A1 (en) * | 2011-03-02 | 2014-04-24 | Manmohan Singh | Combination vaccines with lower doses of antigen and/or adjuvant |
| GB201105981D0 (en) * | 2011-04-08 | 2011-05-18 | Glaxosmithkline Biolog Sa | Novel process |
| EP3204494B1 (en) * | 2014-10-07 | 2020-04-01 | Serum Institute Of India Private Limited | Improved methods for poliovirus inactivation, adjuvant adsorption |
-
2015
- 2015-10-06 EP EP15831237.1A patent/EP3204494B1/en active Active
- 2015-10-06 KR KR1020217004836A patent/KR102510744B1/ko active Active
- 2015-10-06 SG SG11201702838SA patent/SG11201702838SA/en unknown
- 2015-10-06 DK DK15831237.1T patent/DK3204494T3/da active
- 2015-10-06 SI SI201531223T patent/SI3204494T1/sl unknown
- 2015-10-06 LT LTEP15831237.1T patent/LT3204494T/lt unknown
- 2015-10-06 KR KR1020177012227A patent/KR102219638B1/ko active Active
- 2015-10-06 PT PT158312371T patent/PT3204494T/pt unknown
- 2015-10-06 PE PE2017000562A patent/PE20171132A1/es unknown
- 2015-10-06 PL PL15831237T patent/PL3204494T3/pl unknown
- 2015-10-06 US US15/517,225 patent/US10485862B2/en active Active
- 2015-10-06 CN CN202110677385.5A patent/CN113368227A/zh active Pending
- 2015-10-06 CN CN201580066368.0A patent/CN106999569B/zh active Active
- 2015-10-06 JP JP2017518817A patent/JP6755243B2/ja active Active
- 2015-10-06 UA UAA201704367A patent/UA125788C2/uk unknown
- 2015-10-06 HU HUE15831237A patent/HUE049104T2/hu unknown
- 2015-10-06 AU AU2015334495A patent/AU2015334495B2/en active Active
- 2015-10-06 WO PCT/IN2015/000376 patent/WO2016063291A1/en not_active Ceased
- 2015-10-06 EA EA201700187A patent/EA201700187A1/ru unknown
- 2015-10-06 CA CA2963897A patent/CA2963897C/en active Active
- 2015-10-06 MX MX2017004534A patent/MX388525B/es unknown
- 2015-10-06 CU CU2017000044A patent/CU24510B1/es unknown
- 2015-10-06 SG SG10202010814RA patent/SG10202010814RA/en unknown
- 2015-10-06 EP EP20154738.7A patent/EP3663396A1/en active Pending
- 2015-10-06 MY MYPI2017703783A patent/MY204389A/en unknown
- 2015-10-06 ES ES15831237T patent/ES2803578T3/es active Active
-
2017
- 2017-04-05 PH PH12017500627A patent/PH12017500627A1/en unknown
-
2020
- 2020-06-25 CY CY20201100591T patent/CY1123078T1/el unknown
- 2020-08-25 JP JP2020142117A patent/JP7063957B2/ja active Active
-
2021
- 2021-11-18 AU AU2021269395A patent/AU2021269395B2/en active Active
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