SG10202010814RA - Improved methods for enterovirus inactivation, adjuvant adsorption and dose reduced vaccine compositions obtained thereof - Google Patents

Improved methods for enterovirus inactivation, adjuvant adsorption and dose reduced vaccine compositions obtained thereof

Info

Publication number
SG10202010814RA
SG10202010814RA SG10202010814RA SG10202010814RA SG10202010814RA SG 10202010814R A SG10202010814R A SG 10202010814RA SG 10202010814R A SG10202010814R A SG 10202010814RA SG 10202010814R A SG10202010814R A SG 10202010814RA SG 10202010814R A SG10202010814R A SG 10202010814RA
Authority
SG
Singapore
Prior art keywords
improved methods
vaccine compositions
compositions obtained
dose reduced
reduced vaccine
Prior art date
Application number
SG10202010814RA
Inventor
Rajeev Mhalasakant Dhere
Sambhaji Shankar Pisal
Jagdish Kamalaji Zade
Rajendra Narayan Sabale
Original Assignee
Serum Institute Of India Pvt Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Serum Institute Of India Pvt Ltd filed Critical Serum Institute Of India Pvt Ltd
Publication of SG10202010814RA publication Critical patent/SG10202010814RA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • A61K39/125Picornaviridae, e.g. calicivirus
    • A61K39/13Poliovirus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/39Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/04Inactivation or attenuation; Producing viral sub-units
    • C12N7/045Pseudoviral particles; Non infectious pseudovirions, e.g. genetically engineered
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/04Inactivation or attenuation; Producing viral sub-units
    • C12N7/06Inactivation or attenuation by chemical treatment
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525Virus
    • A61K2039/5252Virus inactivated (killed)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525Virus
    • A61K2039/5254Virus avirulent or attenuated
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/545Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505Inorganic adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/57Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/575Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/70Multivalent vaccine
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011Details
    • C12N2770/32011Picornaviridae
    • C12N2770/32311Enterovirus
    • C12N2770/32334Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011Details
    • C12N2770/32011Picornaviridae
    • C12N2770/32611Poliovirus
    • C12N2770/32634Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011Details
    • C12N2770/32011Picornaviridae
    • C12N2770/32611Poliovirus
    • C12N2770/32661Methods of inactivation or attenuation
    • C12N2770/32663Methods of inactivation or attenuation by chemical treatment
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011Details
    • C12N2770/32011Picornaviridae
    • C12N2770/32611Poliovirus
    • C12N2770/32671Demonstrated in vivo effect
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SG10202010814RA 2014-10-07 2015-10-06 Improved methods for enterovirus inactivation, adjuvant adsorption and dose reduced vaccine compositions obtained thereof SG10202010814RA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IN3180MU2014 2014-10-07

Publications (1)

Publication Number Publication Date
SG10202010814RA true SG10202010814RA (en) 2020-12-30

Family

ID=55300742

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10202010814RA SG10202010814RA (en) 2014-10-07 2015-10-06 Improved methods for enterovirus inactivation, adjuvant adsorption and dose reduced vaccine compositions obtained thereof
SG11201702838SA SG11201702838SA (en) 2014-10-07 2015-10-06 Improved methods for enterovirus inactivation, adjuvant adsorption and dose reduced vaccine compositions obtained thereof

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG11201702838SA SG11201702838SA (en) 2014-10-07 2015-10-06 Improved methods for enterovirus inactivation, adjuvant adsorption and dose reduced vaccine compositions obtained thereof

Country Status (24)

Country Link
US (1) US10485862B2 (en)
EP (2) EP3204494B1 (en)
JP (2) JP6755243B2 (en)
KR (2) KR102219638B1 (en)
CN (2) CN113368227A (en)
AU (2) AU2015334495B2 (en)
BR (1) BR112017007089A2 (en)
CA (1) CA2963897C (en)
CU (1) CU24510B1 (en)
CY (1) CY1123078T1 (en)
DK (1) DK3204494T3 (en)
EA (1) EA201700187A1 (en)
ES (1) ES2803578T3 (en)
HU (1) HUE049104T2 (en)
LT (1) LT3204494T (en)
MX (1) MX2017004534A (en)
PE (1) PE20171132A1 (en)
PH (1) PH12017500627A1 (en)
PL (1) PL3204494T3 (en)
PT (1) PT3204494T (en)
SG (2) SG10202010814RA (en)
SI (1) SI3204494T1 (en)
UA (1) UA125788C2 (en)
WO (1) WO2016063291A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6755243B2 (en) * 2014-10-07 2020-09-16 セラム インスティチュート オブ インディア プライベイト リミテッド Improved methods for enterovirus inactivation and adjuvant adsorption, and the resulting dose-reducing vaccine compositions.
EP3454895B1 (en) * 2016-05-10 2024-03-27 Najit Technologies, Inc. Inorganic polyatomic oxyanions for protecting against antigenic damage during pathogen inactivation for vaccine production
EP3503917B1 (en) * 2016-08-26 2024-07-03 Serum Institute Of India Private Limited Multivalent vaccine composition
TWI711700B (en) * 2017-07-10 2020-12-01 印度商印度血清研究公司 Improved methods for enterovirus inactivation, adjuvant adsorption and dose reduced vaccine compositions obtained thereof
MX2020004543A (en) 2017-11-03 2020-09-18 Takeda Vaccines Inc Zika vaccines and immunogenic compositions, and methods of using the same.
MX2020004633A (en) 2017-11-30 2020-09-28 Takeda Vaccines Inc Method for inactivating zika virus and related methods.
WO2019155492A1 (en) * 2018-02-07 2019-08-15 Bharat Biotech International Limited A process for enterovirus purification and inactivation and vaccine compositions obtained thereof
CN109550046B (en) * 2018-12-21 2020-08-25 北京民海生物科技有限公司 Combined vaccine for adsorbing acellular pertussis-poliomyelitis-b haemophilus influenzae and preparation method thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1762246A1 (en) * 1996-07-02 2007-03-14 Sanofi Pasteur Limited Multivalent DTP-Polio vaccines
EP1793852A1 (en) * 2004-08-27 2007-06-13 Panacea Biotec Ltd. Inactivated poliomyelitis vaccine derived from sabin strain of polio virus
CN1647822A (en) * 2005-02-06 2005-08-03 北京生物制品研究所 Poliomyelitis inactivated vaccine and its preparing method
AU2007293673B2 (en) 2006-09-07 2013-06-27 Glaxosmithkline Biologicals S.A. Vaccine
CN100540662C (en) * 2006-12-06 2009-09-16 云南沃森生物技术有限公司 A kind of mixed bed gel filtration chromatography is used for the method for purifying viral vaccine
WO2010036226A1 (en) * 2008-09-26 2010-04-01 George Nelson Process for treatment of rheumatoid arthritis, tremors/parkinson's disease and multiple sclerosis
CN102655879B (en) * 2009-12-16 2016-03-09 印度血清研究所 Vaccine combination
EP2680885B8 (en) * 2011-03-02 2018-07-25 GlaxoSmithKline Biologicals SA Combination vaccines with lower doses of antigen and/or adjuvant
GB201105981D0 (en) * 2011-04-08 2011-05-18 Glaxosmithkline Biolog Sa Novel process
JP6755243B2 (en) 2014-10-07 2020-09-16 セラム インスティチュート オブ インディア プライベイト リミテッド Improved methods for enterovirus inactivation and adjuvant adsorption, and the resulting dose-reducing vaccine compositions.

Also Published As

Publication number Publication date
JP2020203906A (en) 2020-12-24
CA2963897C (en) 2023-08-22
ES2803578T3 (en) 2021-01-28
EP3204494A1 (en) 2017-08-16
JP6755243B2 (en) 2020-09-16
PL3204494T3 (en) 2020-09-21
PT3204494T (en) 2020-07-10
MX2017004534A (en) 2017-10-11
CA2963897A1 (en) 2016-04-28
US20170348411A1 (en) 2017-12-07
KR102510744B1 (en) 2023-03-15
KR20170063947A (en) 2017-06-08
AU2015334495A1 (en) 2017-05-25
PH12017500627A1 (en) 2017-09-25
EP3663396A1 (en) 2020-06-10
CN113368227A (en) 2021-09-10
WO2016063291A1 (en) 2016-04-28
EP3204494B1 (en) 2020-04-01
AU2021269395A1 (en) 2021-12-16
KR20210021148A (en) 2021-02-24
LT3204494T (en) 2020-07-10
AU2015334495B2 (en) 2021-08-19
JP2017533899A (en) 2017-11-16
JP7063957B2 (en) 2022-05-09
CY1123078T1 (en) 2021-10-29
SG11201702838SA (en) 2017-05-30
NZ731341A (en) 2023-11-24
BR112017007089A2 (en) 2017-12-26
KR102219638B1 (en) 2021-02-23
US10485862B2 (en) 2019-11-26
HUE049104T2 (en) 2020-08-28
PE20171132A1 (en) 2017-08-09
CU24510B1 (en) 2021-05-12
AU2021269395B2 (en) 2024-05-23
CN106999569A (en) 2017-08-01
UA125788C2 (en) 2022-06-08
DK3204494T3 (en) 2020-07-06
SI3204494T1 (en) 2020-08-31
CU20170044A7 (en) 2018-09-05
CN106999569B (en) 2021-06-29
EA201700187A1 (en) 2017-12-29

Similar Documents

Publication Publication Date Title
ZA201904717B (en) Therapeutic hpv18 vaccines
IL247309A0 (en) Compositions for the inactivation of virus replication and methods of making and using the same
ZA201700952B (en) Indoles for use in influenza virus infection
SG11201702838SA (en) Improved methods for enterovirus inactivation, adjuvant adsorption and dose reduced vaccine compositions obtained thereof
ZA201608487B (en) Dual adjuvant vaccine compositions, preparation and uses
IL273932A (en) Viral treatment and prophylaxis methods
HK1215864A1 (en) Cannula for catgut-embedding therapy
IL251108A0 (en) Compositions and methods for treating acute radiation syndrome
EP3166637A4 (en) Compositions and methods for treating dengue virus infection
PL3331359T3 (en) Agricultural adjuvant compositions and methods for using such compositions
IL251101A0 (en) Vaccine compositions comprising tryptophan 2,3-dioxygenase or fragments thereof
PL3106459T3 (en) Pyrrole-substituted indolone derivative, preparation method therefor, composition comprising same and use thereof
PL3223846T3 (en) Adjuvant compositions and related methods
EP3166957A4 (en) Sulfated-glycolipids as adjuvants for vaccines
PL3142641T3 (en) Formulations for treatment of hyperthyroidism
IL250553A0 (en) Means and methods for targeted x-ray therapy
PT3297666T (en) Molecular adjuvant and vaccine
GB201521083D0 (en) Compositions for treatment and methods thereof
GB201406755D0 (en) Indigestion, angled adjustable bed
GB201419559D0 (en) Therapeutic compositions and methods
SG10201400823PA (en) Therapeutic methods and compositions for treating diabetes
GB201411371D0 (en) Immunogenic composition
GB201411306D0 (en) Immunogenic composition
GB201405857D0 (en) Immunogenic formulations