JP6755243B2 - エンテロウイルス不活化およびアジュバント吸着のための改良された方法、ならびに、それから得られる投与量減量ワクチン組成物 - Google Patents
エンテロウイルス不活化およびアジュバント吸着のための改良された方法、ならびに、それから得られる投与量減量ワクチン組成物 Download PDFInfo
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- JP6755243B2 JP6755243B2 JP2017518817A JP2017518817A JP6755243B2 JP 6755243 B2 JP6755243 B2 JP 6755243B2 JP 2017518817 A JP2017518817 A JP 2017518817A JP 2017518817 A JP2017518817 A JP 2017518817A JP 6755243 B2 JP6755243 B2 JP 6755243B2
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- poliovirus
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- neisseria meningitidis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/125—Picornaviridae, e.g. calicivirus
- A61K39/13—Poliovirus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C12N7/04—Inactivation or attenuation; Producing viral sub-units
- C12N7/045—Pseudoviral particles; Non infectious pseudovirions, e.g. genetically engineered
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C12N7/04—Inactivation or attenuation; Producing viral sub-units
- C12N7/06—Inactivation or attenuation by chemical treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5252—Virus inactivated (killed)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/32011—Picornaviridae
- C12N2770/32311—Enterovirus
- C12N2770/32334—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/32011—Picornaviridae
- C12N2770/32611—Poliovirus
- C12N2770/32634—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/32011—Picornaviridae
- C12N2770/32611—Poliovirus
- C12N2770/32661—Methods of inactivation or attenuation
- C12N2770/32663—Methods of inactivation or attenuation by chemical treatment
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/32011—Picornaviridae
- C12N2770/32611—Poliovirus
- C12N2770/32671—Demonstrated in vivo effect
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN3180/MUM/2014 | 2014-10-07 | ||
| IN3180MU2014 | 2014-10-07 | ||
| PCT/IN2015/000376 WO2016063291A1 (en) | 2014-10-07 | 2015-10-06 | Improved methods for enterovirus inactivation, adjuvant adsorption and dose reduced vaccine compositions obtained thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020142117A Division JP7063957B2 (ja) | 2014-10-07 | 2020-08-25 | エンテロウイルス不活化およびアジュバント吸着のための改良された方法、ならびに、それから得られる投与量減量ワクチン組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017533899A JP2017533899A (ja) | 2017-11-16 |
| JP2017533899A5 JP2017533899A5 (enExample) | 2018-11-22 |
| JP6755243B2 true JP6755243B2 (ja) | 2020-09-16 |
Family
ID=55300742
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017518817A Active JP6755243B2 (ja) | 2014-10-07 | 2015-10-06 | エンテロウイルス不活化およびアジュバント吸着のための改良された方法、ならびに、それから得られる投与量減量ワクチン組成物 |
| JP2020142117A Active JP7063957B2 (ja) | 2014-10-07 | 2020-08-25 | エンテロウイルス不活化およびアジュバント吸着のための改良された方法、ならびに、それから得られる投与量減量ワクチン組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020142117A Active JP7063957B2 (ja) | 2014-10-07 | 2020-08-25 | エンテロウイルス不活化およびアジュバント吸着のための改良された方法、ならびに、それから得られる投与量減量ワクチン組成物 |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US10485862B2 (enExample) |
| EP (2) | EP3204494B1 (enExample) |
| JP (2) | JP6755243B2 (enExample) |
| KR (2) | KR102510744B1 (enExample) |
| CN (2) | CN113368227A (enExample) |
| AU (2) | AU2015334495B2 (enExample) |
| CA (1) | CA2963897C (enExample) |
| CU (1) | CU24510B1 (enExample) |
| CY (1) | CY1123078T1 (enExample) |
| DK (1) | DK3204494T3 (enExample) |
| EA (1) | EA201700187A1 (enExample) |
| ES (1) | ES2803578T3 (enExample) |
| HU (1) | HUE049104T2 (enExample) |
| LT (1) | LT3204494T (enExample) |
| MX (1) | MX388525B (enExample) |
| MY (1) | MY204389A (enExample) |
| PE (1) | PE20171132A1 (enExample) |
| PH (1) | PH12017500627A1 (enExample) |
| PL (1) | PL3204494T3 (enExample) |
| PT (1) | PT3204494T (enExample) |
| SG (2) | SG11201702838SA (enExample) |
| SI (1) | SI3204494T1 (enExample) |
| UA (1) | UA125788C2 (enExample) |
| WO (1) | WO2016063291A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20171132A1 (es) * | 2014-10-07 | 2017-08-09 | Serum Inst Of India Private Ltd | Metodos mejorados para la inactivacion de enterovirus y la adsorcion sobre coadyuvantes, y composiciones de vacunas con dosis reducidas obtenidas de estos |
| WO2017197034A1 (en) | 2016-05-10 | 2017-11-16 | Najit Technologies, Inc. | Inorganic polyatomic oxyanions for protecting against antigenic damage during pathogen inactivation for vaccine production |
| SG11201900365WA (en) * | 2016-08-26 | 2019-02-27 | Serum Institute Of India Pvt Ltd | Multivalent vaccine composition |
| TWI711700B (zh) * | 2017-07-10 | 2020-12-01 | 印度商印度血清研究公司 | 使腸病毒去活化之改良方法、佐劑吸附及所獲得之劑量減少的疫苗組成物 |
| US11648304B2 (en) | 2017-11-03 | 2023-05-16 | Takeda Vaccines, Inc. | Zika vaccines and immunogenic compositions, and methods of using the same |
| KR20200090893A (ko) | 2017-11-30 | 2020-07-29 | 다케다 백신즈 인코포레이티드 | 지카 바이러스를 비활성화시키기 위한 방법, 및 관련 방법들 |
| SG11202007503WA (en) | 2018-02-07 | 2020-09-29 | Bharat Biotech Int Ltd | A process for enterovirus purification and inactivation and vaccine compositions obtained thereof |
| CN109550046B (zh) * | 2018-12-21 | 2020-08-25 | 北京民海生物科技有限公司 | 一种吸附无细胞百白破-脊髓灰质炎-b型流感嗜血杆菌联合疫苗及其制备方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TR199802783T2 (xx) * | 1996-07-02 | 1999-03-22 | Connaught Laboratories Limited | �ok de�erli DTP polyo a��lar. |
| MX2007002372A (es) * | 2004-08-27 | 2007-05-08 | Panacea Biotec Ltd | Vacuna para la poliomielitis inactivada derivada de la cepa sabin del virus de la polio. |
| CN1647822A (zh) * | 2005-02-06 | 2005-08-03 | 北京生物制品研究所 | 脊髓灰质炎灭活疫苗及其制备方法 |
| CN103357003A (zh) * | 2006-09-07 | 2013-10-23 | 葛兰素史密丝克莱恩生物有限公司 | 疫苗 |
| CN100540662C (zh) * | 2006-12-06 | 2009-09-16 | 云南沃森生物技术有限公司 | 一种混合床凝胶过滤层析技术用于病毒性疫苗纯化的方法 |
| WO2010036226A1 (en) * | 2008-09-26 | 2010-04-01 | George Nelson | Process for treatment of rheumatoid arthritis, tremors/parkinson's disease and multiple sclerosis |
| CN102655879B (zh) * | 2009-12-16 | 2016-03-09 | 印度血清研究所 | 疫苗组合物 |
| US20140112950A1 (en) * | 2011-03-02 | 2014-04-24 | Manmohan Singh | Combination vaccines with lower doses of antigen and/or adjuvant |
| GB201105981D0 (en) * | 2011-04-08 | 2011-05-18 | Glaxosmithkline Biolog Sa | Novel process |
| PE20171132A1 (es) * | 2014-10-07 | 2017-08-09 | Serum Inst Of India Private Ltd | Metodos mejorados para la inactivacion de enterovirus y la adsorcion sobre coadyuvantes, y composiciones de vacunas con dosis reducidas obtenidas de estos |
-
2015
- 2015-10-06 PE PE2017000562A patent/PE20171132A1/es unknown
- 2015-10-06 AU AU2015334495A patent/AU2015334495B2/en active Active
- 2015-10-06 MY MYPI2017703783A patent/MY204389A/en unknown
- 2015-10-06 EP EP15831237.1A patent/EP3204494B1/en active Active
- 2015-10-06 WO PCT/IN2015/000376 patent/WO2016063291A1/en not_active Ceased
- 2015-10-06 CN CN202110677385.5A patent/CN113368227A/zh active Pending
- 2015-10-06 DK DK15831237.1T patent/DK3204494T3/da active
- 2015-10-06 LT LTEP15831237.1T patent/LT3204494T/lt unknown
- 2015-10-06 CU CU2017000044A patent/CU24510B1/es unknown
- 2015-10-06 EA EA201700187A patent/EA201700187A1/ru unknown
- 2015-10-06 HU HUE15831237A patent/HUE049104T2/hu unknown
- 2015-10-06 PL PL15831237T patent/PL3204494T3/pl unknown
- 2015-10-06 US US15/517,225 patent/US10485862B2/en active Active
- 2015-10-06 SI SI201531223T patent/SI3204494T1/sl unknown
- 2015-10-06 JP JP2017518817A patent/JP6755243B2/ja active Active
- 2015-10-06 KR KR1020217004836A patent/KR102510744B1/ko active Active
- 2015-10-06 KR KR1020177012227A patent/KR102219638B1/ko active Active
- 2015-10-06 MX MX2017004534A patent/MX388525B/es unknown
- 2015-10-06 SG SG11201702838SA patent/SG11201702838SA/en unknown
- 2015-10-06 CA CA2963897A patent/CA2963897C/en active Active
- 2015-10-06 CN CN201580066368.0A patent/CN106999569B/zh active Active
- 2015-10-06 SG SG10202010814RA patent/SG10202010814RA/en unknown
- 2015-10-06 UA UAA201704367A patent/UA125788C2/uk unknown
- 2015-10-06 PT PT158312371T patent/PT3204494T/pt unknown
- 2015-10-06 EP EP20154738.7A patent/EP3663396A1/en active Pending
- 2015-10-06 ES ES15831237T patent/ES2803578T3/es active Active
-
2017
- 2017-04-05 PH PH12017500627A patent/PH12017500627A1/en unknown
-
2020
- 2020-06-25 CY CY20201100591T patent/CY1123078T1/el unknown
- 2020-08-25 JP JP2020142117A patent/JP7063957B2/ja active Active
-
2021
- 2021-11-18 AU AU2021269395A patent/AU2021269395B2/en active Active
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