BR112017007089A2 - métodos melhorados para a inativação de enterovírus, adsorção de adjuvante e composições de vacina reduzidas por dose daí obtidas - Google Patents

métodos melhorados para a inativação de enterovírus, adsorção de adjuvante e composições de vacina reduzidas por dose daí obtidas

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Publication number
BR112017007089A2
BR112017007089A2 BR112017007089A BR112017007089A BR112017007089A2 BR 112017007089 A2 BR112017007089 A2 BR 112017007089A2 BR 112017007089 A BR112017007089 A BR 112017007089A BR 112017007089 A BR112017007089 A BR 112017007089A BR 112017007089 A2 BR112017007089 A2 BR 112017007089A2
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BR
Brazil
Prior art keywords
improved methods
dose
obtained therefrom
vaccine compositions
compositions obtained
Prior art date
Application number
BR112017007089A
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English (en)
Inventor
Kamalaji Zade Jagdish
Mhalasakant Dhere Rajeev
Narayan SABALE Rajendra
Shankar Pisal Sambhaji
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Serum Institute Of India Pvt Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Serum Institute Of India Pvt Ltd filed Critical Serum Institute Of India Pvt Ltd
Publication of BR112017007089A2 publication Critical patent/BR112017007089A2/pt

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/125—Picornaviridae, e.g. calicivirus
    • A61K39/13—Poliovirus
    • C—CHEMISTRY; METALLURGY
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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/04—Inactivation or attenuation; Producing viral sub-units
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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/04—Inactivation or attenuation; Producing viral sub-units
    • C12N7/06—Inactivation or attenuation by chemical treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5252—Virus inactivated (killed)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2039/70—Multivalent vaccine
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    • C12N2770/32011—Picornaviridae
    • C12N2770/32311—Enterovirus
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    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32611—Poliovirus
    • C12N2770/32634—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32611—Poliovirus
    • C12N2770/32661—Methods of inactivation or attenuation
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    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32611—Poliovirus
    • C12N2770/32671—Demonstrated in vivo effect
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
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  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
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  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Epidemiology (AREA)
  • Mycology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

a presente invenção é direcionada a métodos melhorados de inativação de enterovírus através de formaldeído na presença de tampão de trometamina que resulta em uma recuperação máxima do antígeno d. a subsequente adsorção de dita sipv em hidróxido de alumínio fornece composições de sipv de dose significativamente reduzidas.
BR112017007089A 2014-10-07 2015-10-06 métodos melhorados para a inativação de enterovírus, adsorção de adjuvante e composições de vacina reduzidas por dose daí obtidas BR112017007089A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN3180MU2014 2014-10-07
PCT/IN2015/000376 WO2016063291A1 (en) 2014-10-07 2015-10-06 Improved methods for enterovirus inactivation, adjuvant adsorption and dose reduced vaccine compositions obtained thereof

Publications (1)

Publication Number Publication Date
BR112017007089A2 true BR112017007089A2 (pt) 2017-12-26

Family

ID=55300742

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112017007089A BR112017007089A2 (pt) 2014-10-07 2015-10-06 métodos melhorados para a inativação de enterovírus, adsorção de adjuvante e composições de vacina reduzidas por dose daí obtidas

Country Status (24)

Country Link
US (1) US10485862B2 (pt)
EP (2) EP3204494B1 (pt)
JP (2) JP6755243B2 (pt)
KR (2) KR102219638B1 (pt)
CN (2) CN106999569B (pt)
AU (2) AU2015334495B2 (pt)
BR (1) BR112017007089A2 (pt)
CA (1) CA2963897C (pt)
CU (1) CU24510B1 (pt)
CY (1) CY1123078T1 (pt)
DK (1) DK3204494T3 (pt)
EA (1) EA201700187A1 (pt)
ES (1) ES2803578T3 (pt)
HU (1) HUE049104T2 (pt)
LT (1) LT3204494T (pt)
MX (1) MX2017004534A (pt)
PE (1) PE20171132A1 (pt)
PH (1) PH12017500627A1 (pt)
PL (1) PL3204494T3 (pt)
PT (1) PT3204494T (pt)
SG (2) SG10202010814RA (pt)
SI (1) SI3204494T1 (pt)
UA (1) UA125788C2 (pt)
WO (1) WO2016063291A1 (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102219638B1 (ko) * 2014-10-07 2021-02-23 세럼 인스티튜트 오브 인디아 프라이비트 리미티드 엔테로바이러스 불활화 및 보강제 흡착 방법과 이로부터 수득되는 저용량 백신 조성물
ES2929274T3 (es) 2016-05-10 2022-11-28 Najit Tech Inc Inactivación de patógenos y producción de vacunas inactivadas altamente inmunógenas utilizando un proceso de oxidación dual
BR112019003419A2 (pt) * 2016-08-26 2019-05-21 Serum Institute Of India Private Limited composição de vacina multivalente
TWI711700B (zh) * 2017-07-10 2020-12-01 印度商印度血清研究公司 使腸病毒去活化之改良方法、佐劑吸附及所獲得之劑量減少的疫苗組成物
EP3703741A1 (en) 2017-11-03 2020-09-09 Takeda Vaccines, Inc. Zika vaccines and immunogenic compositions, and methods of using the same
BR112020009960A2 (pt) 2017-11-30 2020-11-10 Takeda Vaccines, Inc. método para a inativação de vírus zika e métodos relacionados
SG11202007503WA (en) * 2018-02-07 2020-09-29 Bharat Biotech Int Ltd A process for enterovirus purification and inactivation and vaccine compositions obtained thereof
CN109550046B (zh) * 2018-12-21 2020-08-25 北京民海生物科技有限公司 一种吸附无细胞百白破-脊髓灰质炎-b型流感嗜血杆菌联合疫苗及其制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
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PL187935B1 (pl) * 1996-07-02 2004-11-30 Connaught Lab Multiwalentna kompozycja immunogenna i jej zastosowanie
MX2007002372A (es) * 2004-08-27 2007-05-08 Panacea Biotec Ltd Vacuna para la poliomielitis inactivada derivada de la cepa sabin del virus de la polio.
CN1647822A (zh) * 2005-02-06 2005-08-03 北京生物制品研究所 脊髓灰质炎灭活疫苗及其制备方法
AU2007293672B2 (en) * 2006-09-07 2013-06-27 Glaxosmithkline Biologicals S.A. Vaccine
CN100540662C (zh) * 2006-12-06 2009-09-16 云南沃森生物技术有限公司 一种混合床凝胶过滤层析技术用于病毒性疫苗纯化的方法
WO2010036226A1 (en) * 2008-09-26 2010-04-01 George Nelson Process for treatment of rheumatoid arthritis, tremors/parkinson's disease and multiple sclerosis
BR112012014689B1 (pt) 2009-12-16 2019-11-12 Serum Institute Of India Private Limited composição imunogênica
ES2681698T3 (es) * 2011-03-02 2018-09-14 Glaxosmithkline Biologicals Sa Vacunas de combinación con menores dosis de antígeno y/o adyuvante
GB201105981D0 (en) * 2011-04-08 2011-05-18 Glaxosmithkline Biolog Sa Novel process
KR102219638B1 (ko) 2014-10-07 2021-02-23 세럼 인스티튜트 오브 인디아 프라이비트 리미티드 엔테로바이러스 불활화 및 보강제 흡착 방법과 이로부터 수득되는 저용량 백신 조성물

Also Published As

Publication number Publication date
JP6755243B2 (ja) 2020-09-16
EP3663396A1 (en) 2020-06-10
PL3204494T3 (pl) 2020-09-21
SI3204494T1 (sl) 2020-08-31
AU2021269395A1 (en) 2021-12-16
SG10202010814RA (en) 2020-12-30
CN106999569A (zh) 2017-08-01
EP3204494B1 (en) 2020-04-01
DK3204494T3 (da) 2020-07-06
KR102510744B1 (ko) 2023-03-15
CN106999569B (zh) 2021-06-29
KR102219638B1 (ko) 2021-02-23
PE20171132A1 (es) 2017-08-09
AU2015334495A1 (en) 2017-05-25
KR20170063947A (ko) 2017-06-08
JP2017533899A (ja) 2017-11-16
US20170348411A1 (en) 2017-12-07
CU20170044A7 (es) 2018-09-05
KR20210021148A (ko) 2021-02-24
EP3204494A1 (en) 2017-08-16
US10485862B2 (en) 2019-11-26
CY1123078T1 (el) 2021-10-29
MX2017004534A (es) 2017-10-11
WO2016063291A1 (en) 2016-04-28
ES2803578T3 (es) 2021-01-28
JP2020203906A (ja) 2020-12-24
PH12017500627A1 (en) 2017-09-25
EA201700187A1 (ru) 2017-12-29
LT3204494T (lt) 2020-07-10
CA2963897C (en) 2023-08-22
NZ731341A (en) 2023-11-24
JP7063957B2 (ja) 2022-05-09
CA2963897A1 (en) 2016-04-28
CU24510B1 (es) 2021-05-12
CN113368227A (zh) 2021-09-10
AU2021269395B2 (en) 2024-05-23
SG11201702838SA (en) 2017-05-30
PT3204494T (pt) 2020-07-10
UA125788C2 (uk) 2022-06-08
AU2015334495B2 (en) 2021-08-19
HUE049104T2 (hu) 2020-08-28

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