JP2014514321A - インスリン様増殖因子１受容体阻害剤 - Google Patents

インスリン様増殖因子１受容体阻害剤 Download PDF

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Publication number
JP2014514321A
JP2014514321A JP2014506536A JP2014506536A JP2014514321A JP 2014514321 A JP2014514321 A JP 2014514321A JP 2014506536 A JP2014506536 A JP 2014506536A JP 2014506536 A JP2014506536 A JP 2014506536A JP 2014514321 A JP2014514321 A JP 2014514321A
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JP
Japan
Prior art keywords
alkyl
group
phenoxymethyl
chloro
morpholinosulfonyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2014506536A
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English (en)
Japanese (ja)
Inventor
サララ・バーラチャンドラン
クリストファー・ジェイ・ディンスモア
アビジット・ロイチョウドゥーリ
ラジブ・シャルマ
ラム・アスレイ・ビシュワカルマ
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Merck Sharp and Dohme LLC
Original Assignee
Merck Sharp and Dohme LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp and Dohme LLC filed Critical Merck Sharp and Dohme LLC
Publication of JP2014514321A publication Critical patent/JP2014514321A/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2014506536A 2011-04-21 2012-04-19 インスリン様増殖因子１受容体阻害剤 Pending JP2014514321A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161477937P 2011-04-21 2011-04-21
US61/477,937 2011-04-21
PCT/US2012/034188 WO2012145471A1 (en) 2011-04-21 2012-04-19 Insulin-like growth factor-1 receptor inhibitors

Publications (1)

Publication Number Publication Date
JP2014514321A true JP2014514321A (ja) 2014-06-19

Family

ID=46026953

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2014506536A Pending JP2014514321A (ja) 2011-04-21 2012-04-19 インスリン様増殖因子１受容体阻害剤

Country Status (9)

Country Link
US (3) US20140046059A1 (https=)
EP (2) EP2699567A1 (https=)
JP (1) JP2014514321A (https=)
CN (1) CN103732592A (https=)
AU (2) AU2012245971A1 (https=)
CA (2) CA2833009A1 (https=)
IL (1) IL228810A0 (https=)
IN (1) IN2013MN02170A (https=)
WO (3) WO2012143879A1 (https=)

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JP6272897B2 (ja) 2012-11-29 2018-01-31 ケモセントリックス，インコーポレイティド Ｃｘｃｒ７アンタゴニスト
WO2014177915A1 (en) 2013-05-01 2014-11-06 Piramal Enterprises Limited Cancer combination therapy using imidazo[4,5-c]quinoline derivatives
CN104098498A (zh) * 2014-07-30 2014-10-15 天津市斯芬克司药物研发有限公司 一种吲唑类化合物及其制备方法
CN107003600A (zh) 2014-09-15 2017-08-01 德米特里·戈里洛夫斯基 包括观察大场景的多个数字照相机的系统
CN105218475A (zh) * 2015-10-15 2016-01-06 湖南华腾制药有限公司 1,2-吗啉盐酸盐的合成方法
EP3724178B1 (en) * 2017-12-15 2024-05-01 Inthera Bioscience AG 1-(piperidinocarbonylmethyl)-2-oxopiperazine derivatives for treating cancer
MX2021006915A (es) 2018-12-12 2021-08-24 Chemocentryx Inc Inhibidores de cxcr7 para el tratamiento de cancer.
BR112022003663A2 (pt) 2019-08-28 2022-05-24 Horizon Therapeutics Ireland Dac Método para tratar oftalmopatia tireoidiana (ted) em um indivíduo com ted; método para reduzir proptose em pelo menos 2 mm em um indivíduo com oftalmopatia tireoidiana (ted); método para tratar ou reduzir a gravidade de diplopia em um indivíduo com oftalmopatia tireoidiana (ted); método para tratar ou reduzir a gravidade de oftalmopatia tireoidiana (ted); método para reduzir proptose em um olho em um indivíduo com oftalmopatia tireoidiana (ted); método para reduzir pontuação de atividade clínica (cas) de oftalmopatia tireoidiana (ted); método para a) reduzir proptose em pelo menos 2 mm e b) reduzir a pontuação de atividade clínica (cas) em um indivíduo com oftalmopatia tireoidiana (ted); e método para melhorar a qualidade de vida em um indivíduo com oftalmopatia tireoidiana (ted)
CN113149941A (zh) * 2020-01-22 2021-07-23 中国科学院上海药物研究所 醚类化合物及其在防治糖尿病及代谢综合征中的药学用途
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US20140045847A1 (en) 2014-02-13
EP2699568A1 (en) 2014-02-26
IL228810A0 (en) 2013-12-31
AU2012245455A8 (en) 2013-11-07
US20140046059A1 (en) 2014-02-13
EP2699567A1 (en) 2014-02-26
AU2012245455A1 (en) 2013-10-31
CA2833009A1 (en) 2012-10-26
WO2012143879A1 (en) 2012-10-26
WO2012143874A1 (en) 2012-10-26
CN103732592A (zh) 2014-04-16
AU2012245971A8 (en) 2013-11-07

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