JP2014503523A5 - - Google Patents
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- Publication number
- JP2014503523A5 JP2014503523A5 JP2013543774A JP2013543774A JP2014503523A5 JP 2014503523 A5 JP2014503523 A5 JP 2014503523A5 JP 2013543774 A JP2013543774 A JP 2013543774A JP 2013543774 A JP2013543774 A JP 2013543774A JP 2014503523 A5 JP2014503523 A5 JP 2014503523A5
- Authority
- JP
- Japan
- Prior art keywords
- active ingredient
- layer
- therapeutic system
- transdermal therapeutic
- release
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000004480 active ingredient Substances 0.000 claims 40
- 230000001225 therapeutic effect Effects 0.000 claims 36
- 239000010410 layer Substances 0.000 claims 35
- 229920000642 polymer Polymers 0.000 claims 21
- 239000012790 adhesive layer Substances 0.000 claims 13
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 13
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 13
- 229920002367 Polyisobutene Polymers 0.000 claims 12
- 239000000203 mixture Substances 0.000 claims 11
- XSVMFMHYUFZWBK-NSHDSACASA-N Rivastigmine Chemical group CCN(C)C(=O)OC1=CC=CC([C@H](C)N(C)C)=C1 XSVMFMHYUFZWBK-NSHDSACASA-N 0.000 claims 10
- 239000012528 membrane Substances 0.000 claims 10
- 229960004136 rivastigmine Drugs 0.000 claims 10
- 239000011247 coating layer Substances 0.000 claims 9
- 239000011159 matrix material Substances 0.000 claims 9
- 229920001083 polybutene Polymers 0.000 claims 9
- 239000003963 antioxidant agent Substances 0.000 claims 6
- 230000003078 antioxidant effect Effects 0.000 claims 6
- 229920001577 copolymer Polymers 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 5
- 239000012453 solvate Substances 0.000 claims 5
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims 4
- 239000006185 dispersion Substances 0.000 claims 4
- 238000001035 drying Methods 0.000 claims 4
- 235000010384 tocopherol Nutrition 0.000 claims 4
- 229960001295 tocopherol Drugs 0.000 claims 4
- 229930003799 tocopherol Natural products 0.000 claims 4
- 239000011732 tocopherol Substances 0.000 claims 4
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims 4
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 claims 3
- 239000004698 Polyethylene Substances 0.000 claims 3
- CZBZUDVBLSSABA-UHFFFAOYSA-N butylated hydroxyanisole Chemical compound COC1=CC=C(O)C(C(C)(C)C)=C1.COC1=CC=C(O)C=C1C(C)(C)C CZBZUDVBLSSABA-UHFFFAOYSA-N 0.000 claims 3
- 238000010030 laminating Methods 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 229920000058 polyacrylate Polymers 0.000 claims 3
- -1 polyethylene Polymers 0.000 claims 3
- 229920000573 polyethylene Polymers 0.000 claims 3
- 239000010409 thin film Substances 0.000 claims 3
- 239000004821 Contact adhesive Substances 0.000 claims 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 2
- 239000000853 adhesive Substances 0.000 claims 2
- 230000001070 adhesive effect Effects 0.000 claims 2
- 230000015556 catabolic process Effects 0.000 claims 2
- 238000006731 degradation reaction Methods 0.000 claims 2
- 239000010408 film Substances 0.000 claims 2
- 229920001296 polysiloxane Polymers 0.000 claims 2
- 230000000087 stabilizing effect Effects 0.000 claims 2
- 229920003048 styrene butadiene rubber Polymers 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 239000004322 Butylated hydroxytoluene Substances 0.000 claims 1
- 206010012289 Dementia Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 claims 1
- 235000010354 butylated hydroxytoluene Nutrition 0.000 claims 1
- 229940095259 butylated hydroxytoluene Drugs 0.000 claims 1
- 239000000470 constituent Substances 0.000 claims 1
- 239000004446 fluoropolymer coating Substances 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000377 silicon dioxide Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10194968.3A EP2468274B1 (de) | 2010-12-14 | 2010-12-14 | Transdermales therapeutisches System zur Verabreichung eines Wirkstoffs |
| EP10194968.3 | 2010-12-14 | ||
| PCT/EP2011/072812 WO2012080365A1 (de) | 2010-12-14 | 2011-12-14 | Transdermales therapeutisches system zur verabreichung eines wirkstoffs |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014503523A JP2014503523A (ja) | 2014-02-13 |
| JP2014503523A5 true JP2014503523A5 (enExample) | 2015-02-05 |
| JP6043296B2 JP6043296B2 (ja) | 2016-12-14 |
Family
ID=43836835
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013543774A Active JP6043296B2 (ja) | 2010-12-14 | 2011-12-14 | 有効成分を投与するための経皮治療システム |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US10660863B2 (enExample) |
| EP (2) | EP2468274B1 (enExample) |
| JP (1) | JP6043296B2 (enExample) |
| KR (1) | KR101842309B1 (enExample) |
| CN (3) | CN107412202A (enExample) |
| AU (2) | AU2011343363B2 (enExample) |
| BR (1) | BR112013014616B1 (enExample) |
| CA (2) | CA3065240C (enExample) |
| CY (2) | CY1116638T1 (enExample) |
| DK (2) | DK2468274T3 (enExample) |
| EA (1) | EA026520B1 (enExample) |
| ES (2) | ES2545094T3 (enExample) |
| HK (1) | HK1243336A1 (enExample) |
| HR (2) | HRP20201880T1 (enExample) |
| HU (2) | HUE027916T2 (enExample) |
| LT (1) | LT2651410T (enExample) |
| MX (1) | MX345344B (enExample) |
| MY (1) | MY183873A (enExample) |
| PL (2) | PL2468274T3 (enExample) |
| PT (2) | PT2468274E (enExample) |
| RS (2) | RS54173B1 (enExample) |
| SI (2) | SI2468274T1 (enExample) |
| SM (2) | SMT202000638T1 (enExample) |
| WO (1) | WO2012080365A1 (enExample) |
| ZA (1) | ZA201303965B (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102012000369A1 (de) * | 2012-01-11 | 2013-07-11 | Alfred E. Tiefenbacher (Gmbh & Co. Kg) | Transdermales therapeutisches System mit Cholinesterase-Hemmer |
| DE102012016317A1 (de) * | 2012-08-14 | 2014-02-20 | Jenabatteries GmbH | Redox-Flow-Zelle zur Speicherung elektrischer Energie |
| US20150196515A1 (en) * | 2012-08-15 | 2015-07-16 | Dow Coming Corporation | Multi-Layer Drug Delivery System |
| WO2014111790A2 (en) * | 2013-01-15 | 2014-07-24 | Zydus Technologies Limited | Stable transdermal pharmaceutical drug delivery system comprising rivastigmine |
| US20240082065A1 (en) * | 2016-07-08 | 2024-03-14 | Moteah Williams | Waterproof and transparent wound barrier and method of manufacturing same |
| JP6864968B2 (ja) | 2016-08-22 | 2021-04-28 | 救急薬品工業株式会社 | 貼付剤 |
| JP7193863B2 (ja) * | 2017-07-19 | 2022-12-21 | 帝國製薬株式会社 | リバスチグミン含有経皮吸収型製剤 |
| DE102018120505A1 (de) * | 2017-10-20 | 2019-04-25 | Amw Gmbh | Verhinderung der Kristallisation von Wirkstoffen in transdermalen Darreichungssystemen |
| DE102017127433A1 (de) * | 2017-11-21 | 2019-05-23 | Lts Lohmann Therapie-Systeme Ag | TTS auf Basis von klebenden Weichmacher-Polymer-Matrices |
| EP3764998A1 (en) * | 2018-03-13 | 2021-01-20 | LTS Lohmann Therapie-Systeme AG | Transdermal therapeutic system comprising a silicone acrylic hybrid polymer |
| WO2019220697A1 (ja) * | 2018-05-17 | 2019-11-21 | パナソニックＩｐマネジメント株式会社 | 生体貼付け用選択透過膜、経皮吸収キットおよび美容方法 |
| ES2923891T3 (es) | 2018-08-08 | 2022-10-03 | Danapak Flexibles As | Películas y láminas mejoradas para usarse en el envase de compuestos reactivos |
| KR102823139B1 (ko) | 2018-08-31 | 2025-06-19 | 에스케이케미칼 주식회사 | 장기 투여용 리바스티그민 패취 |
| KR102710072B1 (ko) | 2018-08-31 | 2024-09-24 | 에스케이케미칼 주식회사 | 장기 투여용 리바스티그민 패취 |
| CA3146086A1 (en) * | 2019-07-09 | 2021-01-14 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system comprising an active agent-containing layer comprising an acrylic polymer and a skin contact layer comprising a silicone gel adhesive |
| CN113616625B (zh) * | 2021-08-26 | 2023-05-30 | 大连科翔科技开发有限公司 | 一种卡巴拉汀的长效透皮贴剂 |
| DE102021128912A1 (de) * | 2021-11-05 | 2023-05-11 | Lts Lohmann Therapie-Systeme Ag. | Okklusives pflaster mit flexibler backing |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU201906B (en) | 1987-03-04 | 1991-01-28 | Sandoz Ag | Process for producing phenyl-carbamate derivative and acid additional salts and pharmaceutical compositions containing them |
| KR950702811A (ko) * | 1992-08-25 | 1995-08-23 | 더블유. 클레어리 게리 | 프린트 경피약제투여장치(Printed Transdermal Drug Delivery Device) |
| JPH0912448A (ja) * | 1995-04-28 | 1997-01-14 | Read Chem Kk | 薬物放出制御型経皮吸収製剤 |
| GB9800526D0 (en) | 1998-01-12 | 1998-03-11 | Ciba Geigy Ag | Organic compounds |
| US6348210B1 (en) * | 1998-11-13 | 2002-02-19 | Alza Corporation | Methods for transdermal drug administration |
| DE19918106A1 (de) * | 1999-04-22 | 2000-10-26 | Lohmann Therapie Syst Lts | Transdermales therapeutisches System mit neutralisierten Acrylathaftklebern |
| DE10033853A1 (de) | 2000-07-12 | 2002-01-31 | Hexal Ag | Transdermales therapeutisches System mit hochdispersem Siliziumdioxid |
| DE10103860B4 (de) * | 2001-01-30 | 2004-12-23 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches System für die Verabreichung carboxylgruppenhaltiger, nichtsteroidaler Antiphlogistika, sowie Verfahren zu seiner Herstellung |
| DE10141650C1 (de) * | 2001-08-24 | 2002-11-28 | Lohmann Therapie Syst Lts | Transdermales Therapeutisches System mit Fentanyl bzw. verwandten Substanzen |
| DE10141652B4 (de) | 2001-08-24 | 2011-04-07 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches System auf der Basis von Polyacrylat-Haftklebern ohne funktionelle Gruppen und seine Verwendung |
| DE602005021909D1 (de) * | 2004-10-21 | 2010-07-29 | Durect Corp | Transdermale verabreichungssysteme |
| US8252319B2 (en) * | 2004-10-21 | 2012-08-28 | Durect Corporation | Transdermal delivery system for sufentanil |
| TWI389709B (zh) * | 2005-12-01 | 2013-03-21 | Novartis Ag | 經皮治療系統 |
| US7943812B2 (en) * | 2005-12-30 | 2011-05-17 | Colopast A/S | Layered adhesive construct having a mouldable layer as skin contact surface |
| CN101304735A (zh) * | 2006-01-12 | 2008-11-12 | Lts勒曼治疗系统股份公司 | 用于挥发性和/或热不稳定的物质的经皮治疗体系 |
| WO2007129427A1 (ja) | 2006-05-08 | 2007-11-15 | Teikoku Seiyaku Co., Ltd. | 抗認知症薬物の経皮吸収製剤 |
| US9248104B2 (en) * | 2006-08-17 | 2016-02-02 | Core Tech Solutions, Inc. | Transdermal methods and systems for treating Alzheimer's disease |
| DE102006054731B4 (de) * | 2006-11-21 | 2013-02-28 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches System zur Verabreichung des Wirkstoffs Buprenorphin und Verwendung desselben in der Schmerztherapie |
| WO2009009651A1 (en) * | 2007-07-10 | 2009-01-15 | Agile Therapeutics, Inc. | Dermal delivery device with ultrasonic weld |
| WO2009026135A2 (en) | 2007-08-17 | 2009-02-26 | Alza Corporation | Controlled transdermal bisoprolol delivery system |
| ES2661767T3 (es) * | 2008-02-27 | 2018-04-03 | Hisamitsu Pharmaceutical Co., Inc. | Parche adhesivo para la piel y producto envasado |
| US20090291127A1 (en) * | 2008-05-21 | 2009-11-26 | Jianye Wen | Transdermal anti-dementia active agent formulations and methods for using the same |
| JP2010126450A (ja) * | 2008-11-25 | 2010-06-10 | Lintec Corp | 経皮吸収貼付剤 |
| CN102711744B (zh) * | 2009-12-22 | 2014-06-25 | 阿西诺股份公司 | 用于施用利凡斯的明和其衍生物的透皮治疗系统 |
-
2010
- 2010-12-14 RS RS20150562A patent/RS54173B1/sr unknown
- 2010-12-14 EP EP10194968.3A patent/EP2468274B1/de active Active
- 2010-12-14 PT PT101949683T patent/PT2468274E/pt unknown
- 2010-12-14 SI SI201031006T patent/SI2468274T1/sl unknown
- 2010-12-14 HU HUE10194968A patent/HUE027916T2/en unknown
- 2010-12-14 PL PL10194968T patent/PL2468274T3/pl unknown
- 2010-12-14 DK DK10194968.3T patent/DK2468274T3/en active
- 2010-12-14 ES ES10194968.3T patent/ES2545094T3/es active Active
-
2011
- 2011-12-14 MX MX2013005581A patent/MX345344B/es active IP Right Grant
- 2011-12-14 JP JP2013543774A patent/JP6043296B2/ja active Active
- 2011-12-14 WO PCT/EP2011/072812 patent/WO2012080365A1/de not_active Ceased
- 2011-12-14 CN CN201710451001.1A patent/CN107412202A/zh active Pending
- 2011-12-14 SM SM20200638T patent/SMT202000638T1/it unknown
- 2011-12-14 EP EP11799413.7A patent/EP2651410B1/de active Active
- 2011-12-14 HU HUE11799413A patent/HUE052137T2/hu unknown
- 2011-12-14 DK DK11799413.7T patent/DK2651410T3/da active
- 2011-12-14 ES ES11799413T patent/ES2836483T3/es active Active
- 2011-12-14 CN CN201180059614.1A patent/CN103269698B/zh active Active
- 2011-12-14 MY MYPI2013001975A patent/MY183873A/en unknown
- 2011-12-14 PT PT117994137T patent/PT2651410T/pt unknown
- 2011-12-14 CA CA3065240A patent/CA3065240C/en active Active
- 2011-12-14 CA CA2817461A patent/CA2817461C/en active Active
- 2011-12-14 CN CN202110438860.3A patent/CN113244199A/zh active Pending
- 2011-12-14 EA EA201300704A patent/EA026520B1/ru not_active IP Right Cessation
- 2011-12-14 KR KR1020137016047A patent/KR101842309B1/ko active Active
- 2011-12-14 AU AU2011343363A patent/AU2011343363B2/en active Active
- 2011-12-14 LT LTEP11799413.7T patent/LT2651410T/lt unknown
- 2011-12-14 RS RS20201478A patent/RS61155B1/sr unknown
- 2011-12-14 PL PL11799413T patent/PL2651410T3/pl unknown
- 2011-12-14 BR BR112013014616-8A patent/BR112013014616B1/pt active IP Right Grant
- 2011-12-14 HR HRP20201880TT patent/HRP20201880T1/hr unknown
- 2011-12-14 SI SI201131933T patent/SI2651410T1/sl unknown
- 2011-12-14 US US13/994,242 patent/US10660863B2/en active Active
-
2013
- 2013-05-30 ZA ZA2013/03965A patent/ZA201303965B/en unknown
-
2015
- 2015-07-31 SM SM201500184T patent/SMT201500184B/xx unknown
- 2015-08-19 HR HRP20150881TT patent/HRP20150881T1/hr unknown
- 2015-08-25 CY CY20151100738T patent/CY1116638T1/el unknown
-
2017
- 2017-08-11 AU AU2017213569A patent/AU2017213569B2/en active Active
-
2018
- 2018-02-28 HK HK18102858.7A patent/HK1243336A1/zh unknown
-
2020
- 2020-04-28 US US16/860,210 patent/US20200289426A1/en not_active Abandoned
- 2020-11-25 CY CY20201101121T patent/CY1123712T1/el unknown
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