CN113244199A - 用于施用活性物质的经皮治疗系统 - Google Patents
用于施用活性物质的经皮治疗系统 Download PDFInfo
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- CN113244199A CN113244199A CN202110438860.3A CN202110438860A CN113244199A CN 113244199 A CN113244199 A CN 113244199A CN 202110438860 A CN202110438860 A CN 202110438860A CN 113244199 A CN113244199 A CN 113244199A
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- rivastigmine
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- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
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- A—HUMAN NECESSITIES
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- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10194968.3A EP2468274B1 (de) | 2010-12-14 | 2010-12-14 | Transdermales therapeutisches System zur Verabreichung eines Wirkstoffs |
| EP10194968.3 | 2010-12-14 | ||
| CN201180059614.1A CN103269698B (zh) | 2010-12-14 | 2011-12-14 | 用于施用活性物质的经皮治疗系统 |
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| CN201180059614.1A Division CN103269698B (zh) | 2010-12-14 | 2011-12-14 | 用于施用活性物质的经皮治疗系统 |
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| CN201710451001.1A Pending CN107412202A (zh) | 2010-12-14 | 2011-12-14 | 用于施用活性物质的经皮治疗系统 |
| CN201180059614.1A Active CN103269698B (zh) | 2010-12-14 | 2011-12-14 | 用于施用活性物质的经皮治疗系统 |
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| CN201710451001.1A Pending CN107412202A (zh) | 2010-12-14 | 2011-12-14 | 用于施用活性物质的经皮治疗系统 |
| CN201180059614.1A Active CN103269698B (zh) | 2010-12-14 | 2011-12-14 | 用于施用活性物质的经皮治疗系统 |
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Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102012000369A1 (de) * | 2012-01-11 | 2013-07-11 | Alfred E. Tiefenbacher (Gmbh & Co. Kg) | Transdermales therapeutisches System mit Cholinesterase-Hemmer |
| DE102012016317A1 (de) | 2012-08-14 | 2014-02-20 | Jenabatteries GmbH | Redox-Flow-Zelle zur Speicherung elektrischer Energie |
| JP2015530375A (ja) * | 2012-08-15 | 2015-10-15 | ダウ コーニング コーポレーションＤｏｗ Ｃｏｒｎｉｎｇ Ｃｏｒｐｏｒａｔｉｏｎ | 多層薬物送達システム |
| WO2014111790A2 (en) * | 2013-01-15 | 2014-07-24 | Zydus Technologies Limited | Stable transdermal pharmaceutical drug delivery system comprising rivastigmine |
| US20240082065A1 (en) * | 2016-07-08 | 2024-03-14 | Moteah Williams | Waterproof and transparent wound barrier and method of manufacturing same |
| WO2018038022A1 (ja) | 2016-08-22 | 2018-03-01 | 救急薬品工業株式会社 | 貼付剤 |
| EP3656383A4 (en) * | 2017-07-19 | 2021-05-19 | Teikoku Seiyaku Co., Ltd. | RIVASTIGMIN-CONTAINING PERCUTICAL ABSORPTION PREPARATION |
| DE102018120506A1 (de) * | 2017-10-20 | 2019-04-25 | Amw Gmbh | Stabilisiertes transdermales Darreichungssystem |
| DE102017127433A1 (de) * | 2017-11-21 | 2019-05-23 | Lts Lohmann Therapie-Systeme Ag | TTS auf Basis von klebenden Weichmacher-Polymer-Matrices |
| CA3092757A1 (en) * | 2018-03-13 | 2019-09-19 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system comprising a silicone acrylic hybrid polymer |
| WO2019220697A1 (ja) * | 2018-05-17 | 2019-11-21 | パナソニックＩｐマネジメント株式会社 | 生体貼付け用選択透過膜、経皮吸収キットおよび美容方法 |
| DK3513965T3 (da) * | 2018-08-08 | 2022-07-25 | Danapak Flexibles As | Forbedrede film og laminater til anvendelse i pakning af reaktive forbindelser |
| KR102710072B1 (ko) | 2018-08-31 | 2024-09-24 | 에스케이케미칼 주식회사 | 장기 투여용 리바스티그민 패취 |
| KR102823139B1 (ko) | 2018-08-31 | 2025-06-19 | 에스케이케미칼 주식회사 | 장기 투여용 리바스티그민 패취 |
| JP7549642B2 (ja) * | 2019-07-09 | 2024-09-11 | エルテーエス ローマン テラピー－ジステーメ アーゲー | アクリルポリマーを含む活性剤含有層及びシリコーンゲル接着剤を含む皮膚接触層を含む経皮治療システム |
| CN113616625B (zh) * | 2021-08-26 | 2023-05-30 | 大连科翔科技开发有限公司 | 一种卡巴拉汀的长效透皮贴剂 |
| DE102021128912A1 (de) * | 2021-11-05 | 2023-05-11 | Lts Lohmann Therapie-Systeme Ag. | Okklusives pflaster mit flexibler backing |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040071764A1 (en) * | 2001-01-30 | 2004-04-15 | Stefan Bracht | Transdermal therapeutic system for administering non-steroidal antiphlogistic agents containing carboxyl groups, and a method for the production of the same |
| CN1713899A (zh) * | 2001-08-24 | 2005-12-28 | Lts勒曼治疗系统股份公司 | 含有芬太尼或其相关物质的透皮治疗体系 |
| US20070128263A1 (en) * | 2005-12-01 | 2007-06-07 | Gargiulo Paul M | Transdermal therapeutic system |
| CN101304735A (zh) * | 2006-01-12 | 2008-11-12 | Lts勒曼治疗系统股份公司 | 用于挥发性和/或热不稳定的物质的经皮治疗体系 |
| CN101528207A (zh) * | 2006-11-21 | 2009-09-09 | Lts勒曼治疗系统股份公司 | 用于活性物质丁丙诺啡的给药的透皮治疗系统 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL195004C (nl) | 1987-03-04 | 2003-11-04 | Novartis Ag | Fenylcarbamaat bevattend farmaceutisch preparaat. |
| EP0656771A4 (en) * | 1992-08-25 | 1996-07-31 | Cygnus Therapeutic Systems | DEVICE FOR TRANSDERMAL DRUG DELIVERY. |
| JPH0912448A (ja) * | 1995-04-28 | 1997-01-14 | Read Chem Kk | 薬物放出制御型経皮吸収製剤 |
| GB9800526D0 (en) * | 1998-01-12 | 1998-03-11 | Ciba Geigy Ag | Organic compounds |
| US6348210B1 (en) * | 1998-11-13 | 2002-02-19 | Alza Corporation | Methods for transdermal drug administration |
| DE19918106A1 (de) | 1999-04-22 | 2000-10-26 | Lohmann Therapie Syst Lts | Transdermales therapeutisches System mit neutralisierten Acrylathaftklebern |
| DE10033853A1 (de) | 2000-07-12 | 2002-01-31 | Hexal Ag | Transdermales therapeutisches System mit hochdispersem Siliziumdioxid |
| DE10141652B4 (de) | 2001-08-24 | 2011-04-07 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches System auf der Basis von Polyacrylat-Haftklebern ohne funktionelle Gruppen und seine Verwendung |
| US8252319B2 (en) * | 2004-10-21 | 2012-08-28 | Durect Corporation | Transdermal delivery system for sufentanil |
| SI1814531T1 (sl) * | 2004-10-21 | 2010-10-29 | Durect Corp | Transdermalni dostavni sistem |
| US7943812B2 (en) * | 2005-12-30 | 2011-05-17 | Colopast A/S | Layered adhesive construct having a mouldable layer as skin contact surface |
| MY149152A (en) * | 2006-05-08 | 2013-07-15 | Teikoku Seiyaku Kk | Percutaneous absorption preparations of antimentia drugs |
| US9248104B2 (en) | 2006-08-17 | 2016-02-02 | Core Tech Solutions, Inc. | Transdermal methods and systems for treating Alzheimer's disease |
| WO2009009651A1 (en) | 2007-07-10 | 2009-01-15 | Agile Therapeutics, Inc. | Dermal delivery device with ultrasonic weld |
| WO2009026135A2 (en) * | 2007-08-17 | 2009-02-26 | Alza Corporation | Controlled transdermal bisoprolol delivery system |
| JP5546013B2 (ja) * | 2008-02-27 | 2014-07-09 | 久光製薬株式会社 | 貼付剤及び包装体 |
| US20090291127A1 (en) * | 2008-05-21 | 2009-11-26 | Jianye Wen | Transdermal anti-dementia active agent formulations and methods for using the same |
| JP2010126450A (ja) * | 2008-11-25 | 2010-06-10 | Lintec Corp | 経皮吸収貼付剤 |
| KR101674240B1 (ko) * | 2009-12-22 | 2016-11-08 | 아시노 아게 | 리바스티그민 또는 그의 유도체 투여용 경피 치료 시스템 |
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2010
- 2010-12-14 DK DK10194968.3T patent/DK2468274T3/en active
- 2010-12-14 HU HUE10194968A patent/HUE027916T2/en unknown
- 2010-12-14 PL PL10194968T patent/PL2468274T3/pl unknown
- 2010-12-14 EP EP10194968.3A patent/EP2468274B1/de active Active
- 2010-12-14 RS RS20150562A patent/RS54173B1/sr unknown
- 2010-12-14 ES ES10194968.3T patent/ES2545094T3/es active Active
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2011
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- 2011-12-14 CN CN202110438860.3A patent/CN113244199A/zh active Pending
- 2011-12-14 EA EA201300704A patent/EA026520B1/ru not_active IP Right Cessation
- 2011-12-14 CN CN201710451001.1A patent/CN107412202A/zh active Pending
- 2011-12-14 HU HUE11799413A patent/HUE052137T2/hu unknown
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040071764A1 (en) * | 2001-01-30 | 2004-04-15 | Stefan Bracht | Transdermal therapeutic system for administering non-steroidal antiphlogistic agents containing carboxyl groups, and a method for the production of the same |
| CN1713899A (zh) * | 2001-08-24 | 2005-12-28 | Lts勒曼治疗系统股份公司 | 含有芬太尼或其相关物质的透皮治疗体系 |
| US20070128263A1 (en) * | 2005-12-01 | 2007-06-07 | Gargiulo Paul M | Transdermal therapeutic system |
| CN101304735A (zh) * | 2006-01-12 | 2008-11-12 | Lts勒曼治疗系统股份公司 | 用于挥发性和/或热不稳定的物质的经皮治疗体系 |
| CN101528207A (zh) * | 2006-11-21 | 2009-09-09 | Lts勒曼治疗系统股份公司 | 用于活性物质丁丙诺啡的给药的透皮治疗系统 |
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