CA2817461C - Transdermal therapeutic system for administering an active substance - Google Patents
Transdermal therapeutic system for administering an active substance Download PDFInfo
- Publication number
- CA2817461C CA2817461C CA2817461A CA2817461A CA2817461C CA 2817461 C CA2817461 C CA 2817461C CA 2817461 A CA2817461 A CA 2817461A CA 2817461 A CA2817461 A CA 2817461A CA 2817461 C CA2817461 C CA 2817461C
- Authority
- CA
- Canada
- Prior art keywords
- active substance
- layer
- polymer
- therapeutic system
- transdermal therapeutic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
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- 239000001856 Ethyl cellulose Substances 0.000 description 1
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- NHTMVDHEPJAVLT-UHFFFAOYSA-N Isooctane Chemical compound CC(C)CC(C)(C)C NHTMVDHEPJAVLT-UHFFFAOYSA-N 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 231100000233 OECD 428 Skin Absorption: In Vitro Method Toxicity 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 239000004820 Pressure-sensitive adhesive Substances 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 description 1
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- 239000000440 bentonite Substances 0.000 description 1
- 229910000278 bentonite Inorganic materials 0.000 description 1
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 1
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- 238000009792 diffusion process Methods 0.000 description 1
- JVSWJIKNEAIKJW-UHFFFAOYSA-N dimethyl-hexane Natural products CCCCCC(C)C JVSWJIKNEAIKJW-UHFFFAOYSA-N 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
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- 230000000694 effects Effects 0.000 description 1
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- WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical compound OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- BSCCSDNZEIHXOK-UHFFFAOYSA-N phenyl carbamate Chemical compound NC(=O)OC1=CC=CC=C1 BSCCSDNZEIHXOK-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA3065240A CA3065240C (en) | 2010-12-14 | 2011-12-14 | Transdermal therapeutic system for administering an active substance |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10194968.3A EP2468274B1 (de) | 2010-12-14 | 2010-12-14 | Transdermales therapeutisches System zur Verabreichung eines Wirkstoffs |
| EP10194968.3 | 2010-12-14 | ||
| PCT/EP2011/072812 WO2012080365A1 (de) | 2010-12-14 | 2011-12-14 | Transdermales therapeutisches system zur verabreichung eines wirkstoffs |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3065240A Division CA3065240C (en) | 2010-12-14 | 2011-12-14 | Transdermal therapeutic system for administering an active substance |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2817461A1 CA2817461A1 (en) | 2012-06-21 |
| CA2817461C true CA2817461C (en) | 2020-02-25 |
Family
ID=43836835
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2817461A Active CA2817461C (en) | 2010-12-14 | 2011-12-14 | Transdermal therapeutic system for administering an active substance |
| CA3065240A Active CA3065240C (en) | 2010-12-14 | 2011-12-14 | Transdermal therapeutic system for administering an active substance |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3065240A Active CA3065240C (en) | 2010-12-14 | 2011-12-14 | Transdermal therapeutic system for administering an active substance |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US10660863B2 (enExample) |
| EP (2) | EP2468274B1 (enExample) |
| JP (1) | JP6043296B2 (enExample) |
| KR (1) | KR101842309B1 (enExample) |
| CN (3) | CN107412202A (enExample) |
| AU (2) | AU2011343363B2 (enExample) |
| BR (1) | BR112013014616B1 (enExample) |
| CA (2) | CA2817461C (enExample) |
| CY (2) | CY1116638T1 (enExample) |
| DK (2) | DK2468274T3 (enExample) |
| EA (1) | EA026520B1 (enExample) |
| ES (2) | ES2545094T3 (enExample) |
| HK (1) | HK1243336A1 (enExample) |
| HR (2) | HRP20201880T1 (enExample) |
| HU (2) | HUE027916T2 (enExample) |
| LT (1) | LT2651410T (enExample) |
| MX (1) | MX345344B (enExample) |
| MY (1) | MY183873A (enExample) |
| PL (2) | PL2468274T3 (enExample) |
| PT (2) | PT2468274E (enExample) |
| RS (2) | RS54173B1 (enExample) |
| SI (2) | SI2468274T1 (enExample) |
| SM (2) | SMT202000638T1 (enExample) |
| WO (1) | WO2012080365A1 (enExample) |
| ZA (1) | ZA201303965B (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102012000369A1 (de) * | 2012-01-11 | 2013-07-11 | Alfred E. Tiefenbacher (Gmbh & Co. Kg) | Transdermales therapeutisches System mit Cholinesterase-Hemmer |
| DE102012016317A1 (de) | 2012-08-14 | 2014-02-20 | Jenabatteries GmbH | Redox-Flow-Zelle zur Speicherung elektrischer Energie |
| EP2884969A1 (en) * | 2012-08-15 | 2015-06-24 | Dow Corning Corporation | Multi - layer transdermal drug delivery system |
| WO2014111790A2 (en) * | 2013-01-15 | 2014-07-24 | Zydus Technologies Limited | Stable transdermal pharmaceutical drug delivery system comprising rivastigmine |
| US20240082065A1 (en) * | 2016-07-08 | 2024-03-14 | Moteah Williams | Waterproof and transparent wound barrier and method of manufacturing same |
| CN109640976B (zh) | 2016-08-22 | 2023-10-17 | 救急药品工业株式会社 | 贴附剂 |
| JP7193863B2 (ja) * | 2017-07-19 | 2022-12-21 | 帝國製薬株式会社 | リバスチグミン含有経皮吸収型製剤 |
| DE102018120505A1 (de) * | 2017-10-20 | 2019-04-25 | Amw Gmbh | Verhinderung der Kristallisation von Wirkstoffen in transdermalen Darreichungssystemen |
| DE102017127433A1 (de) * | 2017-11-21 | 2019-05-23 | Lts Lohmann Therapie-Systeme Ag | TTS auf Basis von klebenden Weichmacher-Polymer-Matrices |
| BR112020018300A2 (pt) * | 2018-03-13 | 2020-12-22 | Lts Lohmann Therapie-Systeme Ag | Sistema terapêutico transdérmico compreendendo um polímero híbrido de silicone e acrílico |
| JP7170285B2 (ja) * | 2018-05-17 | 2022-11-14 | パナソニックＩｐマネジメント株式会社 | 生体貼付け用選択透過膜、経皮吸収キットおよび美容方法 |
| EP3871877A1 (en) | 2018-08-08 | 2021-09-01 | Danapak Flexibles A/S | Improved films and laminates for use in packaging reactive compounds |
| KR102710072B1 (ko) | 2018-08-31 | 2024-09-24 | 에스케이케미칼 주식회사 | 장기 투여용 리바스티그민 패취 |
| KR102823139B1 (ko) | 2018-08-31 | 2025-06-19 | 에스케이케미칼 주식회사 | 장기 투여용 리바스티그민 패취 |
| CN114007595A (zh) * | 2019-07-09 | 2022-02-01 | 罗曼治疗系统股份公司 | 包括包含丙烯酸类聚合物的含活性剂层和包含硅酮凝胶粘合剂的皮肤接触层的透皮治疗系统 |
| CN113616625B (zh) * | 2021-08-26 | 2023-05-30 | 大连科翔科技开发有限公司 | 一种卡巴拉汀的长效透皮贴剂 |
| DE102021128912A1 (de) * | 2021-11-05 | 2023-05-11 | Lts Lohmann Therapie-Systeme Ag. | Okklusives pflaster mit flexibler backing |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU201906B (en) | 1987-03-04 | 1991-01-28 | Sandoz Ag | Process for producing phenyl-carbamate derivative and acid additional salts and pharmaceutical compositions containing them |
| EP0656771A4 (en) * | 1992-08-25 | 1996-07-31 | Cygnus Therapeutic Systems | DEVICE FOR TRANSDERMAL DRUG DELIVERY. |
| JPH0912448A (ja) * | 1995-04-28 | 1997-01-14 | Read Chem Kk | 薬物放出制御型経皮吸収製剤 |
| GB9800526D0 (en) | 1998-01-12 | 1998-03-11 | Ciba Geigy Ag | Organic compounds |
| US6348210B1 (en) * | 1998-11-13 | 2002-02-19 | Alza Corporation | Methods for transdermal drug administration |
| DE19918106A1 (de) * | 1999-04-22 | 2000-10-26 | Lohmann Therapie Syst Lts | Transdermales therapeutisches System mit neutralisierten Acrylathaftklebern |
| DE10033853A1 (de) | 2000-07-12 | 2002-01-31 | Hexal Ag | Transdermales therapeutisches System mit hochdispersem Siliziumdioxid |
| DE10103860B4 (de) * | 2001-01-30 | 2004-12-23 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches System für die Verabreichung carboxylgruppenhaltiger, nichtsteroidaler Antiphlogistika, sowie Verfahren zu seiner Herstellung |
| DE10141650C1 (de) * | 2001-08-24 | 2002-11-28 | Lohmann Therapie Syst Lts | Transdermales Therapeutisches System mit Fentanyl bzw. verwandten Substanzen |
| DE10141652B4 (de) | 2001-08-24 | 2011-04-07 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches System auf der Basis von Polyacrylat-Haftklebern ohne funktionelle Gruppen und seine Verwendung |
| US8252319B2 (en) * | 2004-10-21 | 2012-08-28 | Durect Corporation | Transdermal delivery system for sufentanil |
| CA2583642C (en) * | 2004-10-21 | 2013-06-25 | Durect Corporation | Transdermal delivery systems |
| TWI389709B (zh) * | 2005-12-01 | 2013-03-21 | Novartis Ag | 經皮治療系統 |
| WO2007076862A1 (en) * | 2005-12-30 | 2007-07-12 | Coloplast A/S | A layered adhesive construct having a mouldable layer as skin contact surface |
| CN101304735A (zh) * | 2006-01-12 | 2008-11-12 | Lts勒曼治疗系统股份公司 | 用于挥发性和/或热不稳定的物质的经皮治疗体系 |
| BRPI0621655A2 (pt) * | 2006-05-08 | 2011-12-20 | Teikoku Seiyaku Kk | preparação para a absorção percutánea de uma droga antidemência básica |
| US9248104B2 (en) * | 2006-08-17 | 2016-02-02 | Core Tech Solutions, Inc. | Transdermal methods and systems for treating Alzheimer's disease |
| DE102006054731B4 (de) * | 2006-11-21 | 2013-02-28 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches System zur Verabreichung des Wirkstoffs Buprenorphin und Verwendung desselben in der Schmerztherapie |
| US20100292660A1 (en) | 2007-07-10 | 2010-11-18 | Agis Kydonieus | Dermal delivery device with ultrasonic weld |
| WO2009026135A2 (en) * | 2007-08-17 | 2009-02-26 | Alza Corporation | Controlled transdermal bisoprolol delivery system |
| US9155725B2 (en) * | 2008-02-27 | 2015-10-13 | Hisamitsu Pharmaceutical Co., Inc. | Adhesive skin patch and packaged product |
| US20090291127A1 (en) * | 2008-05-21 | 2009-11-26 | Jianye Wen | Transdermal anti-dementia active agent formulations and methods for using the same |
| JP2010126450A (ja) * | 2008-11-25 | 2010-06-10 | Lintec Corp | 経皮吸収貼付剤 |
| WO2011076621A2 (de) * | 2009-12-22 | 2011-06-30 | Acino Ag | Transdermales therapeutisches system zur verabreichung von rivastigmin oder dessen derivaten |
-
2010
- 2010-12-14 ES ES10194968.3T patent/ES2545094T3/es active Active
- 2010-12-14 PT PT101949683T patent/PT2468274E/pt unknown
- 2010-12-14 EP EP10194968.3A patent/EP2468274B1/de active Active
- 2010-12-14 SI SI201031006T patent/SI2468274T1/sl unknown
- 2010-12-14 DK DK10194968.3T patent/DK2468274T3/en active
- 2010-12-14 HU HUE10194968A patent/HUE027916T2/en unknown
- 2010-12-14 RS RS20150562A patent/RS54173B1/sr unknown
- 2010-12-14 PL PL10194968T patent/PL2468274T3/pl unknown
-
2011
- 2011-12-14 ES ES11799413T patent/ES2836483T3/es active Active
- 2011-12-14 EA EA201300704A patent/EA026520B1/ru not_active IP Right Cessation
- 2011-12-14 MY MYPI2013001975A patent/MY183873A/en unknown
- 2011-12-14 EP EP11799413.7A patent/EP2651410B1/de active Active
- 2011-12-14 WO PCT/EP2011/072812 patent/WO2012080365A1/de not_active Ceased
- 2011-12-14 HU HUE11799413A patent/HUE052137T2/hu unknown
- 2011-12-14 PT PT117994137T patent/PT2651410T/pt unknown
- 2011-12-14 CA CA2817461A patent/CA2817461C/en active Active
- 2011-12-14 LT LTEP11799413.7T patent/LT2651410T/lt unknown
- 2011-12-14 CN CN201710451001.1A patent/CN107412202A/zh active Pending
- 2011-12-14 US US13/994,242 patent/US10660863B2/en active Active
- 2011-12-14 AU AU2011343363A patent/AU2011343363B2/en active Active
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- 2011-12-14 RS RS20201478A patent/RS61155B1/sr unknown
- 2011-12-14 SM SM20200638T patent/SMT202000638T1/it unknown
- 2011-12-14 JP JP2013543774A patent/JP6043296B2/ja active Active
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