JP2014503178A5 - - Google Patents
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- JP2014503178A5 JP2014503178A5 JP2013532287A JP2013532287A JP2014503178A5 JP 2014503178 A5 JP2014503178 A5 JP 2014503178A5 JP 2013532287 A JP2013532287 A JP 2013532287A JP 2013532287 A JP2013532287 A JP 2013532287A JP 2014503178 A5 JP2014503178 A5 JP 2014503178A5
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- JP
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- Prior art keywords
- tau
- antibody
- seq
- binding fragment
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 208000002339 Frontotemporal Lobar Degeneration Diseases 0.000 claims description 2
- 101000891579 Homo sapiens Microtubule-associated protein tau Proteins 0.000 claims description 2
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- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 2
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims 1
- 229960001230 asparagine Drugs 0.000 claims 1
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- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 1
- 125000000404 glutamine group Chemical group N[C@@H](CCC(N)=O)C(=O)* 0.000 claims 1
- 230000000069 prophylactic effect Effects 0.000 claims 1
- 208000011990 Corticobasal Degeneration Diseases 0.000 description 1
- 206010044688 Trisomy 21 Diseases 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39175110P | 2010-10-11 | 2010-10-11 | |
| EP10013494.9 | 2010-10-11 | ||
| US61/391,751 | 2010-10-11 | ||
| EP10013494 | 2010-10-11 | ||
| PCT/IB2011/002786 WO2012049570A1 (en) | 2010-10-11 | 2011-10-11 | Human anti-tau antibodies |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016016975A Division JP6300842B2 (ja) | 2010-10-11 | 2016-02-01 | ヒト抗タウ抗体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014503178A JP2014503178A (ja) | 2014-02-13 |
| JP2014503178A5 true JP2014503178A5 (OSRAM) | 2014-10-16 |
Family
ID=43602869
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013532287A Pending JP2014503178A (ja) | 2010-10-11 | 2011-10-11 | ヒト抗タウ抗体 |
| JP2016016975A Expired - Fee Related JP6300842B2 (ja) | 2010-10-11 | 2016-02-01 | ヒト抗タウ抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016016975A Expired - Fee Related JP6300842B2 (ja) | 2010-10-11 | 2016-02-01 | ヒト抗タウ抗体 |
Country Status (23)
| Country | Link |
|---|---|
| US (6) | US20130295021A1 (OSRAM) |
| EP (1) | EP2627672B1 (OSRAM) |
| JP (2) | JP2014503178A (OSRAM) |
| CN (1) | CN103339146B (OSRAM) |
| AU (1) | AU2011315181B2 (OSRAM) |
| BR (1) | BR112013008765B8 (OSRAM) |
| CA (1) | CA2813493C (OSRAM) |
| CY (1) | CY1120951T1 (OSRAM) |
| DK (1) | DK2627672T3 (OSRAM) |
| EA (1) | EA031698B1 (OSRAM) |
| ES (1) | ES2686550T3 (OSRAM) |
| HR (1) | HRP20181320T8 (OSRAM) |
| IL (1) | IL225670B (OSRAM) |
| LT (1) | LT2627672T (OSRAM) |
| MX (1) | MX345092B (OSRAM) |
| NZ (1) | NZ609984A (OSRAM) |
| PL (1) | PL2627672T3 (OSRAM) |
| PT (1) | PT2627672T (OSRAM) |
| SG (1) | SG189174A1 (OSRAM) |
| SI (1) | SI2627672T1 (OSRAM) |
| TR (1) | TR201812636T4 (OSRAM) |
| WO (1) | WO2012049570A1 (OSRAM) |
| ZA (1) | ZA201303175B (OSRAM) |
Families Citing this family (91)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20140049T1 (hr) | 2007-01-05 | 2014-02-28 | University Of Zürich | Anti beta-amiloid antitijela i njihova upotreba |
| EA031698B1 (ru) | 2010-10-11 | 2019-02-28 | Байоджен Интернэшнл Нейросайенз Гмбх | Человеческие анти-тау антитела |
| CA2826286C (en) * | 2011-01-31 | 2021-09-21 | Intellect Neurosciences Inc. | Treatment of tauopathies |
| MY178142A (en) | 2011-12-20 | 2020-10-05 | Janssen Biotech Inc | Anti-phf-tau antibodies and their uses |
| MY171473A (en) | 2012-07-03 | 2019-10-15 | Univ Washington | Antibodies to tau |
| WO2014016737A1 (en) * | 2012-07-24 | 2014-01-30 | Pfizer Inc. | Novel chicken monoclonal antibodies against human phosphorylated tau and uses thereof |
| US9567395B2 (en) | 2012-08-16 | 2017-02-14 | Ipierian, Inc. | Methods of treating a tauopathy |
| US20140056901A1 (en) * | 2012-08-21 | 2014-02-27 | The Institute For Molecular Medicine | Anti-tau antibodies and compositions for and methods of making and using in treatment, diagnosis and monitoring of tauopathies |
| SG10201705104UA (en) * | 2012-12-21 | 2017-07-28 | Biogen Int Neuroscience Gmbh | Human anti-tau antibodies |
| US8980270B2 (en) | 2013-01-18 | 2015-03-17 | Ipierian, Inc. | Methods of treating a tauopathy |
| EP2970453B1 (en) * | 2013-03-13 | 2019-12-04 | Prothena Biosciences Limited | Tau immunotherapy |
| JP6568514B2 (ja) * | 2013-03-15 | 2019-08-28 | エーシー イミューン エス．エー． | 抗タウ抗体及び使用方法 |
| MX370723B (es) * | 2013-06-10 | 2019-12-20 | Ipierian Inc | Anticuerpos anti-tau y usos de los mismos en el tratamiento de una tauopatía. |
| GB201312226D0 (en) * | 2013-07-08 | 2013-08-21 | Adx Neurosciences | Improved antibodies |
| CN111569063A (zh) * | 2013-11-27 | 2020-08-25 | 伊皮埃里安股份有限公司 | 治疗tau病变的方法 |
| LT3083680T (lt) | 2013-12-20 | 2020-04-10 | F. Hoffmann-La Roche Ag | Humanizuoti anti-tau(ps422) antikūnai ir jų naudojimo būdai |
| NZ630610A (en) | 2014-02-14 | 2019-05-31 | Ipierian Inc | Tau peptides, anti-tau antibodies, and methods of use thereof |
| AR100978A1 (es) | 2014-06-26 | 2016-11-16 | Hoffmann La Roche | LANZADERAS CEREBRALES DE ANTICUERPO HUMANIZADO ANTI-Tau(pS422) Y USOS DE LAS MISMAS |
| ZA201608812B (en) | 2014-06-26 | 2019-08-28 | Janssen Vaccines & Prevention Bv | Antibodies and antigen-binding fragments that specifically bind to microtubule-associated protein tau |
| SG11201610446XA (en) * | 2014-06-26 | 2017-01-27 | Janssen Vaccines & Prevention Bv | Antibodies and antigen-binding fragments that specifically bind to microtubule-associated protein tau |
| TW202136296A (zh) | 2014-06-27 | 2021-10-01 | 美商Ｃ２Ｎ醫療診斷有限責任公司 | 人類化抗-tau抗體 |
| US10556946B2 (en) | 2014-07-29 | 2020-02-11 | Neurimmunie Holding AG | Human derived anti-Huntingtin (HTT) antibodies and uses thereof |
| BR112017006419A2 (pt) * | 2014-09-30 | 2017-12-19 | Univ Washington | medições cinéticas de tau |
| US10098973B2 (en) | 2014-10-10 | 2018-10-16 | National Research Council Of Canada | Anti-tau antibody and uses thereof |
| CN107428820B (zh) * | 2014-11-19 | 2022-03-22 | 阿克松神经系统科学公司 | 在阿尔茨海默氏病中的人源化tau抗体 |
| MA41115A (fr) | 2014-12-02 | 2017-10-10 | Biogen Int Neuroscience Gmbh | Procédé de traitement de la maladie d'alzheimer |
| WO2016137950A1 (en) * | 2015-02-24 | 2016-09-01 | Rpeptide, Llc | Anti-tau antibodies |
| TWI669314B (zh) | 2015-02-26 | 2019-08-21 | 美國禮來大藥廠 | 針對ｔａｕ之抗體及其用途 |
| WO2016164530A1 (en) * | 2015-04-07 | 2016-10-13 | University Of Maryland, College Park | Compositions and methods for high throughput protein sequencing |
| JP6793134B2 (ja) | 2015-06-05 | 2020-12-02 | ジェネンテック， インコーポレイテッド | 抗ｔａｕ抗体及び使用方法 |
| AR105089A1 (es) | 2015-06-24 | 2017-09-06 | Hoffmann La Roche | ANTICUERPOS ANTI-TAU(pS422) HUMANIZADOS Y MÉTODOS DE UTILIZACIÓN |
| US10344081B2 (en) | 2015-07-06 | 2019-07-09 | Ucb Biopharma Sprl | Tau-binding antibodies |
| JO3711B1 (ar) | 2015-07-13 | 2021-01-31 | H Lundbeck As | أجسام مضادة محددة لبروتين تاو وطرق استعمالها |
| GB201512203D0 (en) | 2015-07-13 | 2015-08-19 | Lundbeck & Co As H | Agents,uses and methods |
| CN105388302A (zh) * | 2015-12-22 | 2016-03-09 | 中国医学科学院输血研究所 | 一种人免疫球蛋白制品中Tau蛋白抗体含量的检测方法 |
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| US10906964B2 (en) | 2016-05-02 | 2021-02-02 | Prothena Biosciences Limited | Antibodies recognizing tau |
| SG11201808434WA (en) | 2016-05-02 | 2018-10-30 | Prothena Biosciences Ltd | Antibodies recognizing tau |
| PT3452507T (pt) | 2016-05-02 | 2022-12-20 | Prothena Biosciences Ltd | Imunoterapia anti-tau |
| CN109476730A (zh) | 2016-06-07 | 2019-03-15 | 生物基因国际神经科学有限责任公司 | 治疗阿尔茨海默病的方法 |
| GEP20217222B (en) | 2016-07-12 | 2021-02-10 | Lundbeck A/S H | Antibodies specific for hyperphosphorylated tau and methods of use thereof |
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| WO2018017370A1 (en) * | 2016-07-20 | 2018-01-25 | Anahit Ghochikyan | Humanized anti-tau antibodies and compositions for and methods of making and using in treatment, diagnosis and monitoring of tauopathies |
| MA45715A (fr) | 2016-07-25 | 2019-05-29 | Biogen Ma Inc | Anticorps anti-hspa5 (grp78) et leurs utilisations |
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| WO2018049219A1 (en) * | 2016-09-08 | 2018-03-15 | Regenerative Research Foundation | Bi-functional anti-tau polypeptides and use thereof |
| JP7217229B2 (ja) | 2016-11-15 | 2023-02-02 | ハー・ルンドベック・アクチエゼルスカベット | シヌクレイノパチーの治療のための薬剤、使用および方法 |
| CN110248959B (zh) | 2016-12-07 | 2023-06-30 | 基因泰克公司 | 抗tau抗体和使用方法 |
| MY198942A (en) | 2016-12-07 | 2023-10-03 | Genentech Inc | Anti-tau antibodies and methods of use |
| MA47163A (fr) | 2016-12-16 | 2019-11-06 | Biogen Ma Inc | Facteur 11 de différenciation de croissance activé protéolytiquement stabilisé |
| MA47499A (fr) * | 2017-02-17 | 2019-12-25 | Denali Therapeutics Inc | Anticorps anti-tau et leurs procédés d'utilisation |
| JOP20180014A1 (ar) | 2017-02-27 | 2019-01-30 | Teijin Pharma Ltd | جسم مضاد متوافق مع البشر لعلاج أو الوقاية من الاضطرابات الإدراكية، وعملية لإنتاجه، وعامل لعلاج أو الوقاية من الاضطرابات الإدراكية باستخدامه |
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| EP3724232B1 (en) | 2017-12-14 | 2024-12-04 | The University of Ottawa | Exosome packaging and targeted autophagy |
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| JP7623699B2 (ja) * | 2018-11-08 | 2025-01-29 | プロセナ バイオサイエンシーズ リミテッド | タウ認識抗体 |
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| EP4271708A1 (en) * | 2020-12-29 | 2023-11-08 | Neurimmune AG | Human anti-tau antibodies |
| CL2021001380A1 (es) | 2021-05-26 | 2022-01-14 | Corporacion Centro Int De Biomedicina Icc | Generación de un nuevo anticuerpo monoclonal sitio específico para la proteína tau y su uso como herramienta en biomarcadores específicos para la detección temprana de enfermedades neurodegenerativas y patologías involucradas con la proteína tau como alzheimer y otras demencias. |
| JP2024534151A (ja) | 2021-08-27 | 2024-09-18 | ジェネンテック， インコーポレイテッド | タウ病態の治療方法 |
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