JP2017522886A5 - - Google Patents
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- Publication number
- JP2017522886A5 JP2017522886A5 JP2017504353A JP2017504353A JP2017522886A5 JP 2017522886 A5 JP2017522886 A5 JP 2017522886A5 JP 2017504353 A JP2017504353 A JP 2017504353A JP 2017504353 A JP2017504353 A JP 2017504353A JP 2017522886 A5 JP2017522886 A5 JP 2017522886A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- seq
- htt
- binding fragment
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14179004.8 | 2014-07-29 | ||
| EP14179004 | 2014-07-29 | ||
| PCT/EP2015/067327 WO2016016278A2 (en) | 2014-07-29 | 2015-07-29 | Human-derived anti-huntingtin (htt) antibodies and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020096056A Division JP7235939B2 (ja) | 2014-07-29 | 2020-06-02 | ヒト由来抗ハンチンチン(htt)抗体及びその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017522886A JP2017522886A (ja) | 2017-08-17 |
| JP2017522886A5 true JP2017522886A5 (OSRAM) | 2018-10-18 |
Family
ID=51225442
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017504353A Pending JP2017522886A (ja) | 2014-07-29 | 2015-07-29 | ヒト由来抗ハンチンチン(htt)抗体及びその使用 |
| JP2020096056A Active JP7235939B2 (ja) | 2014-07-29 | 2020-06-02 | ヒト由来抗ハンチンチン(htt)抗体及びその使用 |
| JP2023006564A Active JP7562168B2 (ja) | 2014-07-29 | 2023-01-19 | ヒト由来抗ハンチンチン(htt)抗体及びその使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020096056A Active JP7235939B2 (ja) | 2014-07-29 | 2020-06-02 | ヒト由来抗ハンチンチン(htt)抗体及びその使用 |
| JP2023006564A Active JP7562168B2 (ja) | 2014-07-29 | 2023-01-19 | ヒト由来抗ハンチンチン(htt)抗体及びその使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US10556946B2 (OSRAM) |
| EP (2) | EP4406549A3 (OSRAM) |
| JP (3) | JP2017522886A (OSRAM) |
| KR (1) | KR102643395B1 (OSRAM) |
| CN (2) | CN107074937B (OSRAM) |
| AU (3) | AU2015295441B2 (OSRAM) |
| CA (1) | CA2954738A1 (OSRAM) |
| EA (1) | EA201790165A1 (OSRAM) |
| IL (2) | IL250180A0 (OSRAM) |
| MX (3) | MX391037B (OSRAM) |
| WO (1) | WO2016016278A2 (OSRAM) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20140049T1 (hr) | 2007-01-05 | 2014-02-28 | University Of Zürich | Anti beta-amiloid antitijela i njihova upotreba |
| US10556946B2 (en) * | 2014-07-29 | 2020-02-11 | Neurimmunie Holding AG | Human derived anti-Huntingtin (HTT) antibodies and uses thereof |
| MA41115A (fr) | 2014-12-02 | 2017-10-10 | Biogen Int Neuroscience Gmbh | Procédé de traitement de la maladie d'alzheimer |
| EP4233901A3 (en) | 2017-08-22 | 2023-09-06 | Biogen MA Inc. | Pharmaceutical compositions containing anti-beta amyloid antibodies |
| TW202110878A (zh) * | 2019-05-16 | 2021-03-16 | 法商賽諾菲公司 | 在神經系統中表現抗原結合蛋白 |
| AU2020363372A1 (en) | 2019-10-07 | 2022-05-19 | University Of Virginia Patent Foundation | Modulating lymphatic vessels in neurological disease |
| EP4093426A1 (en) | 2020-01-24 | 2022-11-30 | University of Virginia Patent Foundation | Modulating lymphatic vessels in neurological disease |
| WO2022020680A1 (en) | 2020-07-23 | 2022-01-27 | Othair Prothena Limited | Anti-abeta antibodies |
| CN111909265B (zh) * | 2020-08-25 | 2022-02-11 | 中国人民解放军军事科学院军事医学研究院 | 一种结合破伤风毒素重链c端结构域的人源抗体及应用 |
| MX2023008744A (es) | 2021-01-29 | 2023-10-02 | Illimis Therapeutics Inc | Molecula de fusion que tiene actividad no inflamatoria inductora de la fagocitosis. |
| WO2023099788A1 (en) | 2021-12-03 | 2023-06-08 | Neurimmune Ag | Novel potency assay for antibody-based drugs and useful means therefor |
| CN114334076B (zh) * | 2021-12-23 | 2025-03-21 | 华中科技大学 | 一种药食同源中药玉竹的重金属概率风险评估方法及系统 |
| KR20250116724A (ko) * | 2022-12-07 | 2025-08-01 | 알케맙 테라퓨틱스 엘티디 | 항-헌팅틴 항체 |
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| US4741900A (en) | 1982-11-16 | 1988-05-03 | Cytogen Corporation | Antibody-metal ion complexes |
| DE3668186D1 (de) | 1985-04-01 | 1990-02-15 | Celltech Ltd | Transformierte myeloma-zell-linie und dieselbe verwendendes verfahren zur expression eines gens, das ein eukaryontisches polypeptid kodiert. |
| GB8601597D0 (en) | 1986-01-23 | 1986-02-26 | Wilson R H | Nucleotide sequences |
| JPS63502716A (ja) | 1986-03-07 | 1988-10-13 | マサチューセッツ・インステチュート・オブ・テクノロジー | 糖タンパク安定性の強化方法 |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| ATE120761T1 (de) | 1987-05-21 | 1995-04-15 | Creative Biomolecules Inc | Multifunktionelle proteine mit vorbestimmter zielsetzung. |
| US5892019A (en) | 1987-07-15 | 1999-04-06 | The United States Of America, As Represented By The Department Of Health And Human Services | Production of a single-gene-encoded immunoglobulin |
| GB8717430D0 (en) | 1987-07-23 | 1987-08-26 | Celltech Ltd | Recombinant dna product |
| JPH02503867A (ja) | 1988-04-15 | 1990-11-15 | プロテイン デザイン ラブズ インコーポレーテッド | Il‐2レセプター特異的キメラ抗体 |
| ATE120454T1 (de) | 1988-06-14 | 1995-04-15 | Cetus Oncology Corp | Kupplungsmittel und sterisch gehinderte, mit disulfid gebundene konjugate daraus. |
| IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
| US5225538A (en) | 1989-02-23 | 1993-07-06 | Genentech, Inc. | Lymphocyte homing receptor/immunoglobulin fusion proteins |
| US5116964A (en) | 1989-02-23 | 1992-05-26 | Genentech, Inc. | Hybrid immunoglobulins |
| IE63847B1 (en) | 1989-05-05 | 1995-06-14 | Res Dev Foundation | A novel antibody delivery system for biological response modifiers |
| ATE356869T1 (de) | 1990-01-12 | 2007-04-15 | Amgen Fremont Inc | Bildung von xenogenen antikörpern |
| US5314995A (en) | 1990-01-22 | 1994-05-24 | Oncogen | Therapeutic interleukin-2-antibody based fusion proteins |
| JP3319594B2 (ja) | 1990-03-20 | 2002-09-03 | ザ・トラスティーズ・オブ・コランビア・ユニバーシティー・イン・ザ・シティー・オブ・ニューヨーク | 定常領域の代わりに受容体結合性リガンドを有するキメラ抗体 |
| ATE218889T1 (de) | 1990-11-09 | 2002-06-15 | Stephen D Gillies | Cytokine immunokonjugate |
| IE922437A1 (en) | 1991-07-25 | 1993-01-27 | Idec Pharma Corp | Recombinant antibodies for human therapy |
| SG48760A1 (en) | 1992-07-24 | 2003-03-18 | Abgenix Inc | Generation of xenogenetic antibodies |
| WO1994009817A1 (en) | 1992-11-04 | 1994-05-11 | City Of Hope | Novel antibody construct |
| US5736137A (en) | 1992-11-13 | 1998-04-07 | Idec Pharmaceuticals Corporation | Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma |
| EP0669986B1 (en) | 1992-11-13 | 2003-04-09 | Idec Pharmaceuticals Corporation | Fully impaired consensus kozac sequences for mammalian expression |
| CA2116280A1 (en) | 1993-03-05 | 1994-09-06 | Marcy E. Macdonald | Huntingtin dna, protein and uses thereof |
| ATE390933T1 (de) | 1995-04-27 | 2008-04-15 | Amgen Fremont Inc | Aus immunisierten xenomäusen stammende menschliche antikörper gegen il-8 |
| AU2466895A (en) | 1995-04-28 | 1996-11-18 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| GB9524973D0 (en) | 1995-12-06 | 1996-02-07 | Lynxvale Ltd | Viral vectors |
| US6255455B1 (en) * | 1996-10-11 | 2001-07-03 | The Trustees Of The University Of Pennsylvania | Rh(D)-binding proteins and magnetically activated cell sorting method for production thereof |
| CN1175111C (zh) | 1997-03-14 | 2004-11-10 | 艾德药品公司 | 将基因整合至哺乳动物细胞特定位点的方法及所用载体 |
| EP0983303B1 (en) | 1997-05-21 | 2006-03-08 | Biovation Limited | Method for the production of non-immunogenic proteins |
| DE69834193T2 (de) | 1997-08-01 | 2007-04-19 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Verfahren zur bestimmung von amyloid-ähnlichen fibrillen oder proteinaggregaten |
| WO2000030680A1 (en) | 1998-11-23 | 2000-06-02 | Idec Pharmaceuticals Corporation | Tumor antigen-specific antibody-gp39 chimeric protein constructs |
| ES2278463T3 (es) | 1998-12-08 | 2007-08-01 | Biovation Limited | Metodo para reducir la inmunogenicidad de proteinas. |
| JP2003531570A (ja) * | 1999-07-27 | 2003-10-28 | アブジェニックス インク. | 神経障害に関連したポリペプチド蓄積を阻害する方法および組成物 |
| DE60126130T2 (de) | 2000-11-17 | 2007-10-18 | The University Of Rochester | In-vitro verfahren zur herstellung und identifizierung von immunglobulin moleküle in eukaryotischen zellen |
| AU2002327164A1 (en) | 2001-01-29 | 2002-12-09 | Idec Pharmaceuticals Corporation | Engineered tetravalent antibodies and methods of use |
| NZ545176A (en) | 2001-01-29 | 2008-05-30 | Biogen Idec Inc | Modified antibodies reactive with CD20 and methods of use |
| WO2002065136A2 (en) * | 2001-02-15 | 2002-08-22 | University Of Chicago | Yeast screens for agents affecting protein folding |
| US20030157641A1 (en) | 2001-11-16 | 2003-08-21 | Idec Pharmaceuticals Corporation | Polycistronic expression of antibodies |
| US7375194B2 (en) * | 2002-01-28 | 2008-05-20 | California Institute Of Technology | Antibodies that bind to an epitope on the Huntington's disease protein |
| US7589189B2 (en) * | 2003-05-14 | 2009-09-15 | Japan Science And Technology Agency | Inhibition of the expression of huntingtin gene |
| CN1871259A (zh) | 2003-08-22 | 2006-11-29 | 比奥根艾迪克Ma公司 | 具有改变的效应物功能的经改进的抗体和制备它的方法 |
| US20050226863A1 (en) | 2003-11-20 | 2005-10-13 | Massachusetts Institute Of Technology | Single-domain antibodies and uses thereof |
| PL2099826T3 (pl) * | 2007-01-05 | 2014-04-30 | Univ Zuerich | Przeciwciało przeciwko beta-amyloidowi i jego zastosowania |
| US20090304590A1 (en) * | 2007-05-29 | 2009-12-10 | Wyeth | Therapeutic compositions and methods |
| US8022268B2 (en) * | 2007-06-11 | 2011-09-20 | The University Of Zurich | Transgenic animal model for alzheimer's disease |
| PT2370466E (pt) | 2008-12-19 | 2015-09-21 | Univ Zuerich | Autoanticorpos humanos anti-alfa-sinucleína |
| EA031698B1 (ru) | 2010-10-11 | 2019-02-28 | Байоджен Интернэшнл Нейросайенз Гмбх | Человеческие анти-тау антитела |
| CN103380145B (zh) | 2010-12-17 | 2016-10-12 | 生物控股有限公司 | 人类抗-sod1抗体 |
| EP2678026B1 (en) | 2011-02-21 | 2016-05-18 | The University of Zurich | Ankyrin g for use in the treatment of neurodegenerative disorders |
| JP2014523745A (ja) * | 2011-07-20 | 2014-09-18 | メディミューン リミテッド | 抗cxcr4抗体及び使用方法 |
| PH12014500940A1 (en) | 2011-10-28 | 2019-06-26 | Biogen Int Neuroscience Gmbh | Tdp-43 specific binding molecules |
| WO2014193632A2 (en) * | 2013-05-29 | 2014-12-04 | Vybion, Inc. | Single chain intrabodies that alter huntingtin mutant degradation |
| EP3166966A1 (en) * | 2014-07-10 | 2017-05-17 | Affiris AG | Substances and methods for the use in prevention and/or treatment in huntington's disease |
| AU2015286606A1 (en) * | 2014-07-10 | 2017-01-12 | Affiris Ag | Substances and methods for the use in prevention and/or treatment in huntington's disease |
| US10556946B2 (en) | 2014-07-29 | 2020-02-11 | Neurimmunie Holding AG | Human derived anti-Huntingtin (HTT) antibodies and uses thereof |
-
2015
- 2015-07-29 US US15/323,784 patent/US10556946B2/en active Active
- 2015-07-29 CN CN201580040265.7A patent/CN107074937B/zh active Active
- 2015-07-29 CA CA2954738A patent/CA2954738A1/en active Pending
- 2015-07-29 JP JP2017504353A patent/JP2017522886A/ja active Pending
- 2015-07-29 EP EP24174406.9A patent/EP4406549A3/en active Pending
- 2015-07-29 CN CN202110774704.4A patent/CN113651887A/zh active Pending
- 2015-07-29 EA EA201790165A patent/EA201790165A1/ru unknown
- 2015-07-29 WO PCT/EP2015/067327 patent/WO2016016278A2/en not_active Ceased
- 2015-07-29 MX MX2017001285A patent/MX391037B/es unknown
- 2015-07-29 AU AU2015295441A patent/AU2015295441B2/en active Active
- 2015-07-29 KR KR1020177005723A patent/KR102643395B1/ko active Active
- 2015-07-29 EP EP15742303.9A patent/EP3174898A2/en not_active Withdrawn
-
2017
- 2017-01-18 IL IL250180A patent/IL250180A0/en unknown
- 2017-01-27 MX MX2022003706A patent/MX2022003706A/es unknown
- 2017-01-27 MX MX2022003704A patent/MX2022003704A/es unknown
-
2020
- 2020-02-07 US US16/784,645 patent/US11401325B2/en active Active
- 2020-06-02 JP JP2020096056A patent/JP7235939B2/ja active Active
- 2020-08-13 AU AU2020217427A patent/AU2020217427B2/en active Active
- 2020-08-16 IL IL276721A patent/IL276721A/en unknown
-
2022
- 2022-06-30 US US17/810,113 patent/US20220332808A1/en active Pending
-
2023
- 2023-01-19 JP JP2023006564A patent/JP7562168B2/ja active Active
-
2024
- 2024-01-17 AU AU2024200315A patent/AU2024200315A1/en active Pending
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