JP2014221758A5 - - Google Patents
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- JP2014221758A5 JP2014221758A5 JP2014109818A JP2014109818A JP2014221758A5 JP 2014221758 A5 JP2014221758 A5 JP 2014221758A5 JP 2014109818 A JP2014109818 A JP 2014109818A JP 2014109818 A JP2014109818 A JP 2014109818A JP 2014221758 A5 JP2014221758 A5 JP 2014221758A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- mmp
- seq
- amino acid
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 24
- 102000004899 14-3-3 Proteins Human genes 0.000 claims 16
- 125000003275 alpha amino acid group Chemical group 0.000 claims 14
- 101710112812 14-3-3 protein Proteins 0.000 claims 7
- 108700020469 14-3-3 Proteins 0.000 claims 6
- 102000002274 Matrix Metalloproteinases Human genes 0.000 claims 6
- 108010000684 Matrix Metalloproteinases Proteins 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 102000001708 Protein Isoforms Human genes 0.000 claims 5
- 108010029485 Protein Isoforms Proteins 0.000 claims 5
- VKUYLANQOAKALN-UHFFFAOYSA-N 2-[benzyl-(4-methoxyphenyl)sulfonylamino]-n-hydroxy-4-methylpentanamide Chemical compound C1=CC(OC)=CC=C1S(=O)(=O)N(C(CC(C)C)C(=O)NO)CC1=CC=CC=C1 VKUYLANQOAKALN-UHFFFAOYSA-N 0.000 claims 4
- 101000723543 Homo sapiens 14-3-3 protein theta Proteins 0.000 claims 4
- 102000000380 Matrix Metalloproteinase 1 Human genes 0.000 claims 4
- 108010016113 Matrix Metalloproteinase 1 Proteins 0.000 claims 4
- 102100030416 Stromelysin-1 Human genes 0.000 claims 4
- 101710108790 Stromelysin-1 Proteins 0.000 claims 4
- 206010003246 arthritis Diseases 0.000 claims 3
- 102100027995 Collagenase 3 Human genes 0.000 claims 2
- 108050005238 Collagenase 3 Proteins 0.000 claims 2
- 102100030412 Matrix metalloproteinase-9 Human genes 0.000 claims 2
- 108010015302 Matrix metalloproteinase-9 Proteins 0.000 claims 2
- 102100030411 Neutrophil collagenase Human genes 0.000 claims 2
- 101710118230 Neutrophil collagenase Proteins 0.000 claims 2
- 102100028848 Stromelysin-2 Human genes 0.000 claims 2
- 101710108792 Stromelysin-2 Proteins 0.000 claims 2
- 102100028847 Stromelysin-3 Human genes 0.000 claims 2
- 108050005271 Stromelysin-3 Proteins 0.000 claims 2
- 238000009472 formulation Methods 0.000 claims 2
- 210000004408 hybridoma Anatomy 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 210000001258 synovial membrane Anatomy 0.000 claims 2
- 101000760084 Homo sapiens 14-3-3 protein eta Proteins 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US99052007P | 2007-11-27 | 2007-11-27 | |
| US60/990,520 | 2007-11-27 | ||
| US7712308P | 2008-06-30 | 2008-06-30 | |
| US61/077,123 | 2008-06-30 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010534332A Division JP5615181B2 (ja) | 2007-11-27 | 2008-11-26 | 関節炎の予防及び治療のための組成物及び方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017039151A Division JP2017149716A (ja) | 2007-11-27 | 2017-03-02 | 関節炎の予防及び治療のための組成物及び方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014221758A JP2014221758A (ja) | 2014-11-27 |
| JP2014221758A5 true JP2014221758A5 (enExample) | 2015-04-23 |
| JP6105516B2 JP6105516B2 (ja) | 2017-03-29 |
Family
ID=40677991
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010534331A Active JP5781764B2 (ja) | 2007-11-27 | 2008-11-26 | １４−３−３η抗体、並びに関節炎の診断及び治療のためのその使用 |
| JP2010534332A Active JP5615181B2 (ja) | 2007-11-27 | 2008-11-26 | 関節炎の予防及び治療のための組成物及び方法 |
| JP2014109818A Active JP6105516B2 (ja) | 2007-11-27 | 2014-05-28 | 関節炎の予防及び治療のための組成物及び方法 |
| JP2014236075A Active JP6054936B2 (ja) | 2007-11-27 | 2014-11-21 | １４−３−３η抗体、並びに関節炎の診断及び治療のためのその使用 |
| JP2017039151A Pending JP2017149716A (ja) | 2007-11-27 | 2017-03-02 | 関節炎の予防及び治療のための組成物及び方法 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010534331A Active JP5781764B2 (ja) | 2007-11-27 | 2008-11-26 | １４−３−３η抗体、並びに関節炎の診断及び治療のためのその使用 |
| JP2010534332A Active JP5615181B2 (ja) | 2007-11-27 | 2008-11-26 | 関節炎の予防及び治療のための組成物及び方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014236075A Active JP6054936B2 (ja) | 2007-11-27 | 2014-11-21 | １４−３−３η抗体、並びに関節炎の診断及び治療のためのその使用 |
| JP2017039151A Pending JP2017149716A (ja) | 2007-11-27 | 2017-03-02 | 関節炎の予防及び治療のための組成物及び方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (6) | US20110027269A1 (enExample) |
| EP (4) | EP3192808A1 (enExample) |
| JP (5) | JP5781764B2 (enExample) |
| KR (5) | KR101945394B1 (enExample) |
| CN (3) | CN101925364B (enExample) |
| AU (2) | AU2008329466B2 (enExample) |
| BR (2) | BRPI0819063A2 (enExample) |
| CA (2) | CA2706479C (enExample) |
| HK (1) | HK1253516A1 (enExample) |
| IL (3) | IL205907A0 (enExample) |
| WO (2) | WO2009067811A1 (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2407975T3 (es) * | 2006-05-09 | 2013-06-17 | The University Of British Columbia | Marcadores proteínicos de la artritis disueltos |
| BRPI0819063A2 (pt) | 2007-11-27 | 2020-08-18 | The University Of British Columbia | método para tratamento de artrite, anticorpo, hibridoma, antagonista de 14-3-3, usos de um antagonista de 14-3-3, composições farmacêuticas, método para redução da expressão de mmp no sinóvio de um paciente e usos de uma composição farmacêutica |
| DK2406633T3 (en) | 2009-03-11 | 2019-04-01 | Augurex Life Sciences Corp | COMPOSITIONS AND PROCEDURES FOR CHARACTERIZING ARTHRITIC CONDITIONS |
| US9474540B2 (en) | 2009-10-08 | 2016-10-25 | Ethicon-Endo-Surgery, Inc. | Laparoscopic device with compound angulation |
| US8562592B2 (en) | 2010-05-07 | 2013-10-22 | Ethicon Endo-Surgery, Inc. | Compound angle laparoscopic methods and devices |
| US9226760B2 (en) | 2010-05-07 | 2016-01-05 | Ethicon Endo-Surgery, Inc. | Laparoscopic devices with flexible actuation mechanisms |
| GB201016494D0 (en) * | 2010-09-30 | 2010-11-17 | Queen Mary Innovation Ltd | Polypeptide |
| WO2013056377A1 (en) * | 2011-10-21 | 2013-04-25 | Augurex Life Sciences Corporation | Antigens derived from citrullinated 14-3-3 and uses thereof in the diagnosis of rheumatoid arthritis |
| GB201200555D0 (en) * | 2012-01-13 | 2012-02-29 | Univ Birmingham | Peptide |
| CN103060360A (zh) * | 2013-01-04 | 2013-04-24 | 昆明理工大学 | 黑大豆14-3-3j蛋白基因的原核表达载体及其应用 |
| CN104099348B (zh) * | 2013-04-15 | 2017-03-29 | 上海市农业科学院 | 一种来源于耐高温菌的重金属结合蛋白基因及其抗重金属应用 |
| CN103555750B (zh) * | 2013-05-17 | 2015-04-08 | 温州医科大学附属第二医院 | 一种人子宫肌瘤14-3-3 γ高表达载体的构建方法及应用 |
| US20160116652A1 (en) * | 2013-06-20 | 2016-04-28 | Merck Patent Gmbh | Method for controlling the optical properties of uv filter layers |
| KR101489844B1 (ko) * | 2013-06-27 | 2015-02-06 | 강원대학교산학협력단 | 14-3-3 시그마 유전자 결손 마우스, 이를 이용한 인 비보 패혈증 연구모델 개발 방법 및 그 응용 |
| WO2015031645A1 (en) | 2013-08-28 | 2015-03-05 | Washington University | Monoclonal antibodies to human 14-3-3 epsilon and human 14-3-3 epsilon sv |
| US10583115B2 (en) | 2014-10-08 | 2020-03-10 | University Of South Australia | Modulators of 14-3-3 functionality and uses thereof |
| KR101946884B1 (ko) * | 2017-04-25 | 2019-02-13 | 고려대학교 산학협력단 | 대사체 분석을 이용한 베체트병의 진단방법 |
| JP2019054181A (ja) * | 2017-09-19 | 2019-04-04 | 東芝メモリ株式会社 | 半導体パッケージ |
| CN109596829A (zh) * | 2017-12-07 | 2019-04-09 | 南京医科大学 | 一种肝癌标志蛋白及其检测方法 |
| WO2019126737A1 (en) | 2017-12-21 | 2019-06-27 | Resolys Bio, Inc. | Compositions and methods of treatment of ehlers-danlos syndromes |
| CN108344865A (zh) * | 2018-01-05 | 2018-07-31 | 北京科美生物技术有限公司 | 检测14-3-3eta蛋白的均相免疫检测试剂盒及其应用 |
| CN110579597A (zh) * | 2018-05-23 | 2019-12-17 | 科美诊断技术股份有限公司 | 检测14-3-3 eta蛋白的非均相化学发光免疫检测试剂盒及其应用 |
| CN110579600B (zh) * | 2018-05-23 | 2023-12-26 | 科美诊断技术股份有限公司 | 通过生物标记物联检体外评估类风湿性关节炎是否存在的方法 |
| CN110726843A (zh) * | 2018-07-16 | 2020-01-24 | 科美诊断技术股份有限公司 | 检测14-3-3eta蛋白的化学发光免疫检测试剂盒及其应用 |
| WO2020102623A1 (en) * | 2018-11-15 | 2020-05-22 | The University Of Toledo | Materials and methods for the prevention of rheumatoid arthritis |
| MX2020014330A (es) | 2018-12-26 | 2021-03-09 | Caregen Co Ltd | Composicion para relajacion muscular. |
| WO2020138674A1 (ko) * | 2018-12-26 | 2020-07-02 | (주)케어젠 | 근육 이완용 조성물 |
| CN109593131B (zh) * | 2018-12-27 | 2021-09-03 | 南京医科大学 | 一种抗14-3-3η蛋白单克隆抗体及其用途 |
| CN109897109B (zh) * | 2019-01-30 | 2022-09-09 | 常州市第二人民医院 | 抗肿瘤标志蛋白单克隆抗体及其用途 |
| US11248325B2 (en) | 2019-11-19 | 2022-02-15 | Whirlpool Corporation | Laundry appliance having a processing belt |
| CN111606977B (zh) * | 2020-05-27 | 2021-11-09 | 福建农林大学 | 一种利用GF14f蛋白靶向多肽配体调控水稻弱势籽粒灌浆的方法 |
| WO2022022524A1 (en) * | 2020-07-27 | 2022-02-03 | Huazhong University Of Science & Technology | Prevention and/or treatment of a disease associated with stat3 |
| CN117024557B (zh) * | 2023-10-10 | 2024-01-30 | 天津外泌体科技有限公司 | 14-3-3蛋白theta异构体作为细胞外囊泡支架蛋白的应用和细胞外囊泡 |
| CN117899196B (zh) * | 2024-03-18 | 2024-06-04 | 中国人民解放军总医院第一医学中心 | 14-3-3zeta蛋白或YWHAZ基因在角膜损伤治疗中的应用 |
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-
2008
- 2008-11-26 BR BRPI0819063-1A patent/BRPI0819063A2/pt not_active Application Discontinuation
- 2008-11-26 AU AU2008329466A patent/AU2008329466B2/en active Active
- 2008-11-26 CN CN200880125674.7A patent/CN101925364B/zh active Active
- 2008-11-26 KR KR1020167029986A patent/KR101945394B1/ko active Active
- 2008-11-26 AU AU2008329529A patent/AU2008329529B2/en active Active
- 2008-11-26 EP EP17159003.7A patent/EP3192808A1/en not_active Ceased
- 2008-11-26 WO PCT/CA2008/002094 patent/WO2009067811A1/en not_active Ceased
- 2008-11-26 CN CN200880125676.6A patent/CN101952313B/zh active Active
- 2008-11-26 EP EP08855660A patent/EP2222704A4/en not_active Ceased
- 2008-11-26 KR KR1020107014289A patent/KR20100100912A/ko not_active Ceased
- 2008-11-26 CA CA2706479A patent/CA2706479C/en active Active
- 2008-11-26 US US12/745,229 patent/US20110027269A1/en not_active Abandoned
- 2008-11-26 KR KR1020187025773A patent/KR20180102215A/ko not_active Ceased
- 2008-11-26 WO PCT/CA2008/002154 patent/WO2009067820A1/en not_active Ceased
- 2008-11-26 CA CA2706476A patent/CA2706476C/en active Active
- 2008-11-26 CN CN201711119889.5A patent/CN107880122A/zh active Pending
- 2008-11-26 KR KR1020177027282A patent/KR20170116184A/ko not_active Ceased
- 2008-11-26 KR KR1020107014288A patent/KR20100099221A/ko not_active Ceased
- 2008-11-26 JP JP2010534331A patent/JP5781764B2/ja active Active
- 2008-11-26 EP EP17159000.3A patent/EP3192807A1/en active Pending
- 2008-11-26 US US12/745,235 patent/US9079947B2/en active Active
- 2008-11-26 EP EP08853323A patent/EP2224955A4/en not_active Ceased
- 2008-11-26 JP JP2010534332A patent/JP5615181B2/ja active Active
- 2008-11-26 BR BRPI0819066-6A patent/BRPI0819066A2/pt not_active Application Discontinuation
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2010
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- 2010-05-25 IL IL205948A patent/IL205948A/en active IP Right Grant
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2014
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2015
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2017
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- 2017-08-27 IL IL254157A patent/IL254157B/en active IP Right Grant
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2018
- 2018-10-05 HK HK18112716.8A patent/HK1253516A1/zh unknown
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2019
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2021
- 2021-05-03 US US17/306,913 patent/US12275779B2/en active Active
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