JP2014039567A5 - - Google Patents

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JP2014039567A5
JP2014039567A5 JP2013247817A JP2013247817A JP2014039567A5 JP 2014039567 A5 JP2014039567 A5 JP 2014039567A5 JP 2013247817 A JP2013247817 A JP 2013247817A JP 2013247817 A JP2013247817 A JP 2013247817A JP 2014039567 A5 JP2014039567 A5 JP 2014039567A5
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locus
human
coding sequence
endogenous non
gene segment
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JP2013247817A
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JP5945263B2 (ja
JP2014039567A (ja
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Priority claimed from US09/732,234 external-priority patent/US6586251B2/en
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Claims (10)

  1. 1つの非ヒト種由来のコード配列または遺伝子セグメントの、異なる種由来のオルソログコード配列での置換を含むように所望の位置で改変された、内因性非ヒト遺伝子座。
  2. 前記非ヒト遺伝子座が哺乳動物遺伝子座である、請求項1に記載の内因性非ヒト遺伝子座。
  3. 前記哺乳動物遺伝子座がげっ歯類遺伝子座である、請求項2に記載の内因性非ヒト遺伝子座。
  4. 前記げっ歯類遺伝子座がマウス遺伝子座またはラット遺伝子座である、請求項3に記載の内因性非ヒト遺伝子座。
  5. 前記オルソログコード配列を持つ遺伝子セグメントがヒトである、請求項1に記載の内因性非ヒト遺伝子座。
  6. 前記オルソログコード配列を持つ遺伝子セグメントが少なくとも70kbである、請求項1に記載の内因性非ヒト遺伝子座。
  7. 前記オルソログコード配列を持つ遺伝子セグメントが少なくとも95kbである、請求項6に記載の内因性非ヒト遺伝子座。
  8. 前記オルソログコード配列を持つ遺伝子セグメントが少なくとも120kbである、請求項7に記載の内因性非ヒト遺伝子座。
  9. げっ歯類遺伝子座である請求項1に記載の内因性非ヒト遺伝子座であって、前記オルソログコード配列を持つ遺伝子セグメントがヒトである、内因性非ヒト遺伝子座。
  10. 前記オルソログコード配列を持つ遺伝子セグメントがヒトであり、かつ少なくとも70kbである、請求項9に記載の内因性非ヒト遺伝子座。
JP2013247817A 2000-10-31 2013-11-29 真核生物細胞を改変する方法 Expired - Lifetime JP5945263B2 (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US24466500P 2000-10-31 2000-10-31
US60/244,665 2000-10-31
US09/732,234 2000-12-07
US09/732,234 US6586251B2 (en) 2000-10-31 2000-12-07 Methods of modifying eukaryotic cells

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JP2013108631A Division JP5892975B2 (ja) 2000-10-31 2013-05-23 真核生物細胞を改変する方法

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JP2014039567A JP2014039567A (ja) 2014-03-06
JP2014039567A5 true JP2014039567A5 (ja) 2015-02-19
JP5945263B2 JP5945263B2 (ja) 2016-07-05

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JP2002539535A Expired - Lifetime JP5339566B2 (ja) 2000-10-31 2001-10-31 真核生物細胞を改変する方法
JP2010136321A Pending JP2010220628A (ja) 2000-10-31 2010-06-15 真核生物細胞を改変する方法
JP2013108631A Expired - Lifetime JP5892975B2 (ja) 2000-10-31 2013-05-23 真核生物細胞を改変する方法
JP2013247817A Expired - Lifetime JP5945263B2 (ja) 2000-10-31 2013-11-29 真核生物細胞を改変する方法
JP2014265082A Withdrawn JP2015062432A (ja) 2000-10-31 2014-12-26 真核生物細胞を改変する方法
JP2017024803A Expired - Lifetime JP6486979B2 (ja) 2000-10-31 2017-02-14 真核生物細胞を改変する方法
JP2017024802A Withdrawn JP2017123855A (ja) 2000-10-31 2017-02-14 真核生物細胞を改変する方法

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JP2002539535A Expired - Lifetime JP5339566B2 (ja) 2000-10-31 2001-10-31 真核生物細胞を改変する方法
JP2010136321A Pending JP2010220628A (ja) 2000-10-31 2010-06-15 真核生物細胞を改変する方法
JP2013108631A Expired - Lifetime JP5892975B2 (ja) 2000-10-31 2013-05-23 真核生物細胞を改変する方法

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JP2014265082A Withdrawn JP2015062432A (ja) 2000-10-31 2014-12-26 真核生物細胞を改変する方法
JP2017024803A Expired - Lifetime JP6486979B2 (ja) 2000-10-31 2017-02-14 真核生物細胞を改変する方法
JP2017024802A Withdrawn JP2017123855A (ja) 2000-10-31 2017-02-14 真核生物細胞を改変する方法

Country Status (19)

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US (1) US6586251B2 (ja)
EP (1) EP1399575B1 (ja)
JP (7) JP5339566B2 (ja)
KR (1) KR100833136B1 (ja)
CN (1) CN100497642C (ja)
AT (1) ATE332388T1 (ja)
AU (2) AU2002220048B2 (ja)
BR (1) BRPI0115096B1 (ja)
CA (1) CA2426398C (ja)
CZ (1) CZ304856B6 (ja)
DE (1) DE60121372T2 (ja)
HK (1) HK1059802A1 (ja)
HU (1) HU227639B1 (ja)
MX (1) MXPA03003797A (ja)
NO (1) NO332300B1 (ja)
NZ (1) NZ525511A (ja)
PL (1) PL204759B1 (ja)
RU (1) RU2290441C2 (ja)
WO (1) WO2002036789A2 (ja)

Families Citing this family (198)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6908744B1 (en) * 2000-03-14 2005-06-21 Regeneron Pharmaceuticals, Inc. Methods of stimulating cartilage formation
ES2394877T3 (es) * 2000-08-14 2013-02-06 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Recombinación homóloga mejorada mediada por proteínas de recombinación de lambda
US6586251B2 (en) * 2000-10-31 2003-07-01 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
US20050144655A1 (en) 2000-10-31 2005-06-30 Economides Aris N. Methods of modifying eukaryotic cells
US6596541B2 (en) 2000-10-31 2003-07-22 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
GB0110029D0 (en) 2001-04-24 2001-06-13 Grosveld Frank Transgenic animal
WO2004098490A2 (en) 2002-05-17 2004-11-18 Mount Sinai School Of Medicine Of New York University Mesoderm and definitive endoderm cell populations
USRE47770E1 (en) 2002-07-18 2019-12-17 Merus N.V. Recombinant production of mixtures of antibodies
DK2314629T4 (da) 2002-07-18 2023-02-06 Merus Nv Rekombinant produktion af blandinger af antistoffer
EP1539946A4 (en) * 2002-09-09 2006-03-15 California Inst Of Techn METHOD AND COMPOSITIONS FOR PRODUCING HUMANIZED MICE
WO2004067725A2 (en) * 2003-01-30 2004-08-12 Regeneron Pharmaceuticals, Inc. Methods of identifying modulators of nmur2-mediated activity
US20100069614A1 (en) 2008-06-27 2010-03-18 Merus B.V. Antibody producing non-human mammals
ES2408582T3 (es) 2003-05-30 2013-06-21 Merus B.V. Biblioteca de Fab para la preparación de una mezcla de anticuerpos
CA2583750C (en) 2004-10-19 2015-11-24 Regeneron Pharmaceuticals, Inc. Methods for generating a rodent having a genetic modification
US20060117396A1 (en) * 2004-11-30 2006-06-01 Murphy Andrew J Assay methods for identifying modulators of OPSDL3 and transgenic knockouts
US20090263900A1 (en) * 2008-04-14 2009-10-22 Sangamo Biosciences, Inc. Linear donor constructs for targeted integration
PL2125894T3 (pl) 2007-03-22 2019-08-30 Biogen Ma Inc. Białka wiążące, w tym przeciwciała, pochodne przeciwciał i fragmenty przeciwciał, które swoiście wiążą się z CD154 i ich zastosowania
EP3382022A1 (en) 2007-06-01 2018-10-03 Open Monoclonal Technology, Inc. Compositions and methods for inhibiting endogenous immunoglobulin genes and producing transgenic human idiotype antibodies
EP2245155A4 (en) * 2007-12-10 2011-05-25 Aliva Biopharmaceuticals Inc METHODS FOR SEQUENTIALLY REPLACING A TARGETED AREA BY HOMOLOGOUS RECOMBINATION
US20090328240A1 (en) * 2008-06-24 2009-12-31 Sing George L Genetically modified mice as predictors of immune response
DE102008002715A1 (de) * 2008-06-27 2009-12-31 Evonik Röhm Gmbh 2-Hydroxyisobuttersäure produzierende rekombinante Zelle
EP3889265A1 (en) * 2008-09-30 2021-10-06 Ablexis, LLC Transgenic mice for the production of chimeric antibodies
US20120204278A1 (en) 2009-07-08 2012-08-09 Kymab Limited Animal models and therapeutic molecules
EP2564695B1 (en) 2009-07-08 2015-04-15 Kymab Limited Animal models and therapeutic molecules
US9445581B2 (en) 2012-03-28 2016-09-20 Kymab Limited Animal models and therapeutic molecules
PT3417701T (pt) 2009-10-06 2022-03-16 Univ Yale Ratinhos modificados geneticamente e enxerto
AU2010319894B2 (en) 2009-10-29 2015-03-05 Regeneron Pharmaceuticals, Inc. Multifunctional alleles
HUE030208T2 (en) 2009-12-10 2017-04-28 Regeneron Pharma Heavy-chain antibody-producing mice
KR102178064B1 (ko) 2009-12-21 2020-11-12 리제너론 파마슈티칼스 인코포레이티드 인간화된 FcγR 마우스
US20130045492A1 (en) 2010-02-08 2013-02-21 Regeneron Pharmaceuticals, Inc. Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain
US20120021409A1 (en) 2010-02-08 2012-01-26 Regeneron Pharmaceuticals, Inc. Common Light Chain Mouse
US9796788B2 (en) 2010-02-08 2017-10-24 Regeneron Pharmaceuticals, Inc. Mice expressing a limited immunoglobulin light chain repertoire
EP2501817B2 (en) * 2010-02-08 2021-04-21 Regeneron Pharmaceuticals, Inc. Common light chain mouse
CA3006800C (en) 2010-03-31 2022-10-04 Ablexis, Llc Genetic engineering of non-human animals for the production of chimeric antibodies
US9242014B2 (en) 2010-06-15 2016-01-26 The Regents Of The University Of California Receptor tyrosine kinase-like orphan receptor 1 (ROR1) single chain Fv antibody fragment conjugates and methods of use thereof
CN103068993B (zh) 2010-06-22 2016-01-06 瑞泽恩制药公司 杂交轻链小鼠
US10662256B2 (en) 2010-07-26 2020-05-26 Trianni, Inc. Transgenic mammals and methods of use thereof
US10793829B2 (en) 2010-07-26 2020-10-06 Trianni, Inc. Transgenic mammals and methods of use thereof
EP2597945B1 (en) 2010-07-26 2020-07-22 Trianni, Inc. Transgenic animals and methods of use
ES2612459T3 (es) 2010-08-02 2017-05-17 Regeneron Pharmaceuticals, Inc. Ratones que producen proteínas de unión que comprenden dominios VL
WO2012063048A1 (en) 2010-11-08 2012-05-18 Kymab Limited Cells & vertebrates for enhanced somatic hypermutation and class switch recombination
ES2634098T3 (es) 2011-01-14 2017-09-26 The Regents Of The University Of California Anticuerpos terapéuticos contra la proteína ROR-1 y procedimientos para el uso de los mismos.
FI3375284T3 (fi) 2011-02-15 2023-06-15 Regeneron Pharma Humanisoituja m-csf-hiiriä ja niiden käyttötapoja
SG10201913160QA (en) 2011-02-25 2020-03-30 Regeneron Pharma Adam6 mice
US10920242B2 (en) 2011-02-25 2021-02-16 Recombinetics, Inc. Non-meiotic allele introgression
EP2527842B1 (en) 2011-05-12 2013-06-05 Regeneron Pharmaceuticals, Inc. Neuropeptide release assay for sodium channels
NZ781020A (en) 2011-08-05 2023-01-27 Regeneron Pharma Humanized universal light chain mice
CN106995822B (zh) 2011-09-19 2021-06-29 科马布有限公司 定制供人类使用的抗体、可变结构域和链
JP2014531452A (ja) 2011-09-19 2014-11-27 カイマブ・リミテッド 動物、レパートリーおよび方法
EP2761008A1 (en) 2011-09-26 2014-08-06 Kymab Limited Chimaeric surrogate light chains (slc) comprising human vpreb
HUE057680T2 (hu) 2011-10-17 2022-06-28 Regeneron Pharma Korlátozott immunglobulin-nehézlánccal rendelkezõ egerek
US9043996B2 (en) 2011-10-28 2015-06-02 Regeneron Pharmaceuticals, Inc. Genetically modified major histocompatibility complex animals
US9591835B2 (en) 2011-10-28 2017-03-14 Regeneron Pharmaceuticals, Inc. Genetically modified major histocompatibility complex animals
ES2651517T3 (es) 2011-10-28 2018-01-26 Regeneron Pharmaceuticals, Inc. Ratones con complejo mayor de histocompatibilidad modificado genéticamente
GB2496375A (en) 2011-10-28 2013-05-15 Kymab Ltd A non-human assay vertebrate comprising human antibody loci and human epitope knock-in, and uses thereof
RS57893B1 (sr) 2011-10-28 2019-01-31 Regeneron Pharma Miševi sa genetski modifikovanim receptorom t ćelija
EP4052572A1 (en) 2011-10-28 2022-09-07 Regeneron Pharmaceuticals, Inc. Genetically modified mice expressing chimeric major histocompatibility complex (mhc) ii molecules
AU2012332894A1 (en) 2011-10-31 2014-05-08 Merck Sharp & Dohme Corp. Nano-suspension process
US9253965B2 (en) 2012-03-28 2016-02-09 Kymab Limited Animal models and therapeutic molecules
GB201122047D0 (en) 2011-12-21 2012-02-01 Kymab Ltd Transgenic animals
KR102186822B1 (ko) 2011-12-20 2020-12-04 리제너론 파마슈티칼스 인코포레이티드 인간화 경쇄 마우스
CA2863175A1 (en) 2012-02-01 2013-08-08 Regeneron Pharamaceuticals, Inc. Humanized rodents that express heavy chains containing vl domains
RU2683514C2 (ru) 2012-03-06 2019-03-28 Регенерон Фармасьютикалз, Инк. Мышь с общей легкой цепью
US20140013456A1 (en) 2012-03-16 2014-01-09 Regeneron Pharmaceuticals, Inc. Histidine Engineered Light Chain Antibodies and Genetically Modified Non-Human Animals for Generating the Same
EP2825035A1 (en) 2012-03-16 2015-01-21 Regeneron Pharmaceuticals, Inc. Mice that produce antigen-binding proteins with ph-dependent binding characteristics
WO2013138712A1 (en) 2012-03-16 2013-09-19 Regeneron Pharmaceuticals, Inc. Non-human animals expressing ph-sensitive immunoglobulin sequences
KR102228296B1 (ko) 2012-03-16 2021-03-17 리제너론 파마슈티칼스 인코포레이티드 히스티딘 공학처리된 경쇄 항체 및 그것을 생성하기 위한 유전자 변형된 비-사람 동물
US10251377B2 (en) 2012-03-28 2019-04-09 Kymab Limited Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies
JP2015512635A (ja) 2012-03-28 2015-04-30 カイマブ・リミテッド クラススイッチした完全ヒト抗体の発現のためのトランスジェニック非−ヒト脊椎動物
GB2502127A (en) 2012-05-17 2013-11-20 Kymab Ltd Multivalent antibodies and in vivo methods for their production
DK2847335T3 (en) 2012-04-25 2018-08-13 Regeneron Pharma NUCLEASED MEDIUM TARGETING WITH LARGE TARGET VECTORS
RS62121B1 (sr) 2012-06-12 2021-08-31 Regeneron Pharma Humanizovane nehumane životinje sa ograničenim lokusima imunoglobulinskog teškog lanca
AR091482A1 (es) * 2012-06-21 2015-02-04 Recombinetics Inc Celulas modificadas geneticamente y metodos par su obtencion
KR102355959B1 (ko) 2012-08-23 2022-01-27 어젠시스 인코포레이티드 158p1d7 단백질에 결합하는 항체 약물 컨쥬게이트(adc)
KR102134088B1 (ko) 2012-08-24 2020-07-14 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 Ror1 암을 치료하고 전이를 저해하는데 이용을 위한 항체와 백신
UA118090C2 (uk) * 2012-09-07 2018-11-26 ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі Спосіб інтегрування послідовності нуклеїнової кислоти, що представляє інтерес, у ген fad2 у клітині сої та специфічний для локусу fad2 білок, що зв'язується, здатний індукувати спрямований розрив
KR102340059B1 (ko) 2012-09-07 2021-12-17 예일 유니버시티 유전적으로 변형된 비-인간 동물 및 이것들의 사용 방법
ES2748662T3 (es) 2012-11-05 2020-03-17 Institute For Res In Biomedicine Irb Roedores inmunodeficientes modificados genéticamente y métodos de uso de los mismos
EP2958938B1 (en) 2013-02-20 2019-04-17 Regeneron Pharmaceuticals, Inc. Mice expressing humanized t-cell co-receptors
SG10201706741VA (en) 2013-02-20 2017-10-30 Regeneron Pharma Genetic modification of rats
BR112015019350A2 (pt) 2013-02-20 2017-08-22 Regeneron Pharma Animal não humano, locus de imunoglobulina, e, métodos de fabricação de um animal não humano, para a obtenção de uma sequência de ácido nucleico e de fabricação de uma proteína de ligação ao antígeno
US20150342163A1 (en) 2013-02-22 2015-12-03 Regeneron Pharmaceuticals, Inc. Genetically modified major histocompatibility complex mice
CA2900824A1 (en) 2013-02-22 2014-08-28 Regeneron Pharmaceuticals, Inc. Mice expressing humanized major histocompatibility complex
CN108464278B (zh) 2013-03-11 2021-05-04 瑞泽恩制药公司 表达嵌合的主要组织相容性复合物(mhc)ii类分子的转基因小鼠
CN105188358B (zh) 2013-03-11 2018-01-26 瑞泽恩制药公司 表达嵌合的主要组织相容性复合物(mhc)i类分子的转基因小鼠
JP2016519568A (ja) 2013-03-13 2016-07-07 リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. 共通軽鎖のマウス
TR201901668T4 (tr) 2013-03-13 2019-02-21 Regeneron Pharma Sınırlı bir immünoglobulin hafif zincir repertuvarını eksprese eden fareler.
US9788534B2 (en) 2013-03-18 2017-10-17 Kymab Limited Animal models and therapeutic molecules
PL3456831T3 (pl) * 2013-04-16 2021-12-06 Regeneron Pharmaceuticals, Inc. Ukierunkowana modyfikacja genomu szczura
US9783618B2 (en) 2013-05-01 2017-10-10 Kymab Limited Manipulation of immunoglobulin gene diversity and multi-antibody therapeutics
US11707056B2 (en) 2013-05-02 2023-07-25 Kymab Limited Animals, repertoires and methods
US9783593B2 (en) 2013-05-02 2017-10-10 Kymab Limited Antibodies, variable domains and chains tailored for human use
TWI646108B (zh) 2013-08-01 2019-01-01 艾澤西公司 結合至cd37蛋白質之抗體藥物結合物(adc)
JP6998656B2 (ja) 2013-08-07 2022-02-04 リジェネロン・ファーマシューティカルズ・インコーポレイテッド lincRNA欠失非ヒト動物
HUE044747T2 (hu) 2013-09-18 2019-11-28 Regeneron Pharma Hisztidinmódosított könnyûláncú antitestek és genetikailag módosított nem humán állati élõlények ugyanennek az elõállítására
SI3175706T1 (sl) 2013-09-23 2019-03-29 Regeneron Pharmaceuticals, Inc. Nehumane živali s humaniziranim genom signal-regulatornega proteina
NL2013554B1 (en) 2013-10-01 2016-01-08 Kymab Ltd Animal models and therapeutic molecules.
WO2015077071A1 (en) 2013-11-19 2015-05-28 Regeneron Pharmaceuticals, Inc. Non-human animals having a humanized b-cell activating factor gene
AU2014353347B2 (en) 2013-11-19 2020-07-02 Regeneron Pharmaceuticals, Inc. Non-human animals having a humanized a proliferation-inducing ligand gene
RU2685914C1 (ru) 2013-12-11 2019-04-23 Регенерон Фармасьютикалс, Инк. Способы и композиции для направленной модификации генома
EP3080279B1 (en) 2013-12-11 2018-09-26 Regeneron Pharmaceuticals, Inc. Methods and compositions for the targeted modification of a genome
JP6593595B2 (ja) 2014-01-15 2019-10-23 正道 山本 Atp可視化動物およびその用途
SG11201607015VA (en) 2014-03-21 2016-09-29 Regeneron Pharma V<sb>L</sb> ANTIGEN BINDING PROTEINS EXHIBITING DISTINCT BINDING CHARACTERISTICS
SG11201607203XA (en) 2014-03-21 2016-09-29 Regeneron Pharma Non-human animals that make single domain binding proteins
FI3841877T3 (fi) 2014-05-19 2023-12-01 Regeneron Pharma Ihmisen epo:a ilmentäviä geneettisesti muunneltuja hiiriä
ES2877275T3 (es) 2014-05-30 2021-11-16 Regeneron Pharma Animales con dipeptidil peptidasa IV (DPP4) humanizada
KR102374379B1 (ko) 2014-06-06 2022-03-17 리제너론 파마슈티칼스 인코포레이티드 표적화된 좌를 변형시키는 방법 및 조성물
PT3157956T (pt) * 2014-06-19 2020-04-09 Regeneron Pharma Animais não humanos com um gene 1 de morte programada humanizada em células
HUE049405T2 (hu) 2014-06-23 2020-09-28 Regeneron Pharma Nukleáz-közvetített DNS-összeállítás
PT3161128T (pt) 2014-06-26 2018-11-21 Regeneron Pharma Métodos e composições para modificações genéticas alvejadas e métodos de utilização
SG11201701040XA (en) 2014-09-19 2017-03-30 Regeneron Pharma Chimeric antigen receptors
AU2015332451A1 (en) 2014-10-15 2017-04-20 Regeneron Pharmaceuticals, Inc. Methods and compositions for generating or maintaining pluripotent cells
PL3221457T3 (pl) * 2014-11-21 2019-09-30 Regeneron Pharmaceuticals, Inc. Sposoby i kompozycje do celowanej modyfikacji genetycznej z zastosowaniem sparowanych przewodników RNA
RS61080B1 (sr) 2014-11-24 2020-12-31 Regeneron Pharma Ne-humane životinje koje eksprimiraju humanizovani cd3 kompleks
HUE043132T2 (hu) 2014-12-05 2019-07-29 Regeneron Pharma Nem-humán állatok, amelyek egy humanizált differenciáció klaszter 47 gént tartalmazzák
MX2017007636A (es) 2014-12-09 2018-03-28 Regeneron Pharma Animales no humanos que tienen un gen del grupo de diferenciacion 274 humanizado.
WO2016100819A1 (en) * 2014-12-19 2016-06-23 Regeneron Pharmaceuticals, Inc. Methods and compositions for targeted genetic modification through single-step multiple targeting
MX2017011380A (es) 2015-03-09 2018-04-26 Agensys Inc Conjugados anticuerpo-farmaco (adc) que se ligan a proteinas flt3.
SG11201706809WA (en) 2015-03-16 2017-09-28 Regeneron Pharma Non-human animal exhibiting diminished upper and lower motor neuron function and sensory perception
AU2016232715A1 (en) 2015-03-19 2017-09-28 Regeneron Pharmaceuticals, Inc. Non-human animals that select for light chain variable regions that bind antigen
CN113349159B (zh) 2015-04-06 2022-11-11 瑞泽恩制药公司 非人动物中的人源化t细胞介导的免疫应答
CN113424798B (zh) 2015-04-13 2023-01-13 再生元制药公司 人源化SIRPα-IL15敲入小鼠及其使用方法
US10395759B2 (en) 2015-05-18 2019-08-27 Regeneron Pharmaceuticals, Inc. Methods and systems for copy number variant detection
BR112017025507A2 (pt) 2015-05-29 2018-08-07 Regeneron Pharmaceuticals, Inc. roedor, célula isolada de roedor ou tecido isolado de roedor, célula-tronco embrionária de roedor, embrião de roedor, e, métodos para preparação de um roedor e para identificação de um candidato terapêutico.
JP2018526005A (ja) 2015-09-02 2018-09-13 リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. 前立腺がんのげっ歯類モデル
RU2745403C2 (ru) 2015-11-20 2021-03-24 Регенерон Фармасьютикалз, Инк. Животные, отличные от человека, имеющие гуманизированный ген активации лимфоцитов-3
DE102016122317A1 (de) * 2015-11-24 2017-05-24 Glaxosmithkline Intellectual Property Development Limited Transientes transfektionsverfahren für retrovirale produktion
ES2939617T3 (es) * 2015-11-24 2023-04-25 Glaxosmithkline Ip Dev Ltd Líneas celulares estables para producción retroviral
WO2017095939A1 (en) 2015-12-03 2017-06-08 Trianni, Inc. Enhanced immunoglobulin diversity
MX2018008701A (es) 2016-01-13 2019-06-06 Regeneron Pharma Roedores que tienen una region de diversidad de cadena pesada modificada geneticamente.
US20170218398A1 (en) * 2016-01-30 2017-08-03 Markus Alexander Brown Method to selectively target cancerous cells for genetic manipulation
IL260743B2 (en) 2016-02-04 2024-03-01 Trianni Inc Advanced production of antibodies
WO2017136712A1 (en) * 2016-02-04 2017-08-10 Regeneron Pharmaceuticals, Inc. Non-human animals having an engineered angptl8 gene
KR20180110107A (ko) 2016-02-16 2018-10-08 리제너론 파마슈티칼스 인코포레이티드 돌연변이 키뉴레니나아제 유전자를 갖는 비인간 동물
CN109068621B (zh) 2016-02-29 2021-07-20 再生元制药公司 具有人源化的tmprss基因的啮齿类动物
WO2017172958A1 (en) 2016-03-29 2017-10-05 Regeneron Pharmaceuticals, Inc. Genetic variant-phenotype analysis system and methods of use
EP4368637A2 (en) 2016-05-20 2024-05-15 Regeneron Pharmaceuticals, Inc. Methods for breaking immunological tolerance using multiple guide rnas
CN109640644B (zh) 2016-06-03 2021-10-26 瑞泽恩制药公司 表达外源末端脱氧核苷酸转移酶的非人动物
IL299099A (en) 2016-06-27 2023-02-01 Univ California Combinations of cancer treatments
WO2018001241A1 (zh) 2016-06-28 2018-01-04 北京百奥赛图基因生物技术有限公司 一种pd-1基因修饰人源化动物模型的构建方法及其应用
MX2019001211A (es) 2016-07-29 2019-09-16 Regeneron Pharma Ratones que comprenden mutaciones que dan lugar a la expresión de la fibrilina-1 truncada en c.
SG10202102997UA (en) * 2016-09-30 2021-04-29 Regeneron Pharma Non-human animals having a hexanucleotide repeat expansion in a c9orf72 locus
SG11201903344XA (en) 2016-11-04 2019-05-30 Regeneron Pharma Non-human animals having an engineered immunoglobulin lambda light chain locus
US11064685B2 (en) 2017-02-27 2021-07-20 Regeneron Pharmaceuticals, Inc. Non-human animal models of retinoschisis
SG11201912236YA (en) 2017-07-31 2020-01-30 Regeneron Pharma Crispr reporter non-human animals and uses thereof
JP7359753B2 (ja) 2017-07-31 2023-10-11 リジェネロン・ファーマシューティカルズ・インコーポレイテッド Casトランスジェニックマウスの胚性幹細胞およびマウスならびにその使用
PT3687287T (pt) 2017-09-29 2023-11-03 Regeneron Pharma Roedores que expressam complexo c1q humanizado
WO2019072241A1 (en) 2017-10-13 2019-04-18 Beijing Biocytogen Co., Ltd NON-HUMAN ANIMAL GENETICALLY MODIFIED WITH PD-1 HUMAN OR CHIMERIC
CN109666701B (zh) * 2017-10-13 2021-08-24 百奥赛图(北京)医药科技股份有限公司 一种pd-1基因修饰人源化动物模型的构建方法及其应用
EP3585164B1 (en) 2017-11-30 2023-12-27 Regeneron Pharmaceuticals, Inc. Rats comprising a humanized trkb locus
CA3084049A1 (en) 2017-12-05 2019-06-13 Regeneron Pharmaceuticals, Inc. Non-human animals having an engineered immunoglobulin lambda light chain and uses thereof
CA3089331A1 (en) 2018-03-19 2019-09-26 Regeneron Pharmaceuticals, Inc. Transcription modulation in animals using crispr/cas systems
MA52177A (fr) 2018-03-26 2021-02-17 Regeneron Pharma Rongeurs humanisés pour tester des agents thérapeutiques
EP3811364A1 (en) 2018-06-01 2021-04-28 Regeneron Pharmaceuticals, Inc. Methods and systems for sparse vector-based matrix transformations
CA3103646C (en) 2018-06-14 2023-06-27 Regeneron Pharmaceuticals, Inc. Non-human animals capable of engineered dh-dh rearrangement and uses thereof
AU2019308205A1 (en) 2018-07-16 2020-11-19 Regeneron Pharmaceuticals, Inc. Non-human animal models of DITRA disease and uses thereof
CN109504708A (zh) * 2018-12-03 2019-03-22 江苏集萃药康生物科技有限公司 一种筛选标记自我删除的基因打靶载体及方法
CN116064550A (zh) 2018-12-20 2023-05-05 瑞泽恩制药公司 核酸酶介导的重复扩增
US20220104468A1 (en) 2019-01-22 2022-04-07 St. Jude Children's Research Hospital Modulation of lc3-associated endocytosis pathway and genetically modified non-human animals as a model of neuroinflammation and neurodegeneration
JP2022521358A (ja) 2019-02-18 2022-04-06 バイオサイトジェン ファーマシューティカルズ (ベイジン) カンパニー リミテッド ヒト化免疫グロブリン遺伝子座を有する遺伝子改変非ヒト動物
US11464217B2 (en) 2019-02-22 2022-10-11 Regeneron Pharmaceuticals, Inc. Rodents having genetically modified sodium channels and methods of use thereof
US11111504B2 (en) 2019-04-04 2021-09-07 Regeneron Pharmaceuticals, Inc. Methods for scarless introduction of targeted modifications into targeting vectors
AU2020253532A1 (en) 2019-04-04 2021-09-02 Regeneron Pharmaceuticals, Inc. Non-human animals comprising a humanized coagulation factor 12 locus
US11136353B2 (en) 2019-04-15 2021-10-05 Qwixel Therapeutics Llc Fusion protein composition(s) comprising masked type I interferons (IFNA and IFNB) for use in the treatment of cancer and methods thereof
KR20220016869A (ko) 2019-06-04 2022-02-10 리제너론 파마슈티칼스 인코포레이티드 베타-슬립 돌연변이를 갖는 인간화 ttr 좌위를 포함하는 비-인간 동물 및 사용 방법
BR112021023683A2 (pt) 2019-06-05 2022-02-01 Regeneron Pharma Roedor e camundongo geneticamente modificado, embrião de roedor, célula b do roedor ou camundongo geneticamente modificado, hibridoma, população de células b, célula-tronco embrionária, célula de mamífero, métodos de produção de um anticorpo, de uma cadeia pesada, de um domínio variável, de uma coleção de domínios variáveis, de uma cadeia leve, de uma sequência nucleotídica, de um roedor geneticamente modificado e de células es, de geração de um domínio variável e in vitro para gerar uma célula recombinante de roedor, e, vetor de direcionamento
JP2022534560A (ja) 2019-06-07 2022-08-02 リジェネロン・ファーマシューティカルズ・インコーポレイテッド ヒト化アルブミン遺伝子座を含む非ヒト動物
CN114008193A (zh) 2019-06-27 2022-02-01 瑞泽恩制药公司 Tdp-43蛋白病的建模
MX2022000133A (es) 2019-07-01 2022-04-27 Tonix Pharma Ltd Anticuerpos anti-cd154 y usos de los mismos.
JP2022550434A (ja) 2019-10-04 2022-12-01 ティーエーイー ライフ サイエンシーズ Fc変異および部位特異的コンジュゲーション特性を含む抗体組成物
WO2021108363A1 (en) 2019-11-25 2021-06-03 Regeneron Pharmaceuticals, Inc. Crispr/cas-mediated upregulation of humanized ttr allele
AU2021212668A1 (en) 2020-01-28 2022-08-18 Regeneron Pharmaceuticals, Inc. Non-human animals comprising a humanized PNPLA3 locus and methods of use
US20230081547A1 (en) 2020-02-07 2023-03-16 Regeneron Pharmaceuticals, Inc. Non-human animals comprising a humanized klkb1 locus and methods of use
US20230102342A1 (en) 2020-03-23 2023-03-30 Regeneron Pharmaceuticals, Inc. Non-human animals comprising a humanized ttr locus comprising a v30m mutation and methods of use
JP2023523174A (ja) 2020-04-21 2023-06-02 リジェネロン・ファーマシューティカルズ・インコーポレイテッド ヒト化cxcl13遺伝子を有する非ヒト動物
RU2751237C1 (ru) * 2020-06-10 2021-07-12 Регенерон Фармасьютикалс, Инк. Способы и композиции для направленной модификации генома
CN115988960A (zh) 2020-06-25 2023-04-18 株式会社湖美宝 杂合转基因动物
KR20230066386A (ko) 2020-09-11 2023-05-15 리제너론 파마슈티칼스 인코포레이티드 항원 특이적 항체의 확인 및 제조
CA3191836A1 (en) 2020-10-01 2022-04-07 Andrew J. Murphy Rodent animals expressing human cr1
CN116848254A (zh) 2020-12-16 2023-10-03 瑞泽恩制药公司 表达人源化Fcα受体的小鼠
KR20230124973A (ko) 2020-12-21 2023-08-28 리제너론 파마슈티칼스 인코포레이티드 인간화 tslp 유전자, 인간화 tslp 수용체 유전자, 및/또는인간화 il7ra 유전자를 갖는 비인간 동물
WO2022140219A1 (en) 2020-12-23 2022-06-30 Regeneron Pharmaceuticals, Inc. Nucleic acids encoding anchor modified antibodies and uses thereof
US20240059781A1 (en) 2021-01-06 2024-02-22 Tonix Pharma Limited Methods of inducing immune tolerance with modified anti-cd154 antibodies
CA3213460A1 (en) 2021-03-31 2022-10-06 Regeneron Pharmaceuticals, Inc. Genetically modified mice comprising humanized cellular immune system components with improved diversity of tcrb repertoire
WO2022220603A1 (ko) 2021-04-16 2022-10-20 고려대학교 산학협력단 코로나-19 바이러스 표적 인간 항체
CA3221878A1 (en) 2021-06-18 2022-12-22 David Stover Fusion protein composition(s) comprising masked type i interferons (ifna and ifnb) for use in the treatment of cancer and methods thereof
WO2023077053A2 (en) 2021-10-28 2023-05-04 Regeneron Pharmaceuticals, Inc. Crispr/cas-related methods and compositions for knocking out c5
WO2023108047A1 (en) 2021-12-08 2023-06-15 Regeneron Pharmaceuticals, Inc. Mutant myocilin disease model and uses thereof
WO2023122506A1 (en) 2021-12-20 2023-06-29 Regeneron Pharmaceuticals, Inc. Non-human animals comprising humanized ace2 and tmprss loci
WO2023150798A1 (en) 2022-02-07 2023-08-10 Regeneron Pharmaceuticals, Inc. Compositions and methods for defining optimal treatment timeframes in lysosomal disease
WO2023154861A1 (en) 2022-02-11 2023-08-17 Regeneron Pharmaceuticals, Inc. Compositions and methods for screening 4r tau targeting agents
WO2023212560A1 (en) 2022-04-26 2023-11-02 Regeneron Pharmaceuticals, Inc. A rodent model of fibrodysplasia ossificans progressiva
WO2023235677A1 (en) 2022-05-31 2023-12-07 Regeneron Pharmaceuticals, Inc. Animal model of tdp-43 proteinopathy
WO2023235725A2 (en) 2022-05-31 2023-12-07 Regeneron Pharmaceuticals, Inc. Crispr-based therapeutics for c9orf72 repeat expansion disease
US20230417899A1 (en) 2022-06-27 2023-12-28 Oshkosh Corporation Position tracking for a lift device
US20240102045A1 (en) 2022-07-19 2024-03-28 Regeneron Pharmaceuticals, Inc. Vectors, genetically modified cells, and genetically modified non-human animals comprising the same
US20240099279A1 (en) 2022-09-22 2024-03-28 Regeneron Pharmaceuticals, Inc. Genetically modified mice expressing components of human cellular immune system
US20240130341A1 (en) 2022-09-29 2024-04-25 Regeneron Pharmaceuticals, Inc. Correction of hepatosteatosis in humanized liver animals through restoration of il6/il6r/gp130 signaling in human hepatocytes

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5770429A (en) * 1990-08-29 1998-06-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
AU2515992A (en) 1991-08-20 1993-03-16 Genpharm International, Inc. Gene targeting in animal cells using isogenic dna constructs
AU675661B2 (en) * 1992-07-24 1997-02-13 Abgenix, Inc. Generation of xenogeneic antibodies
DE4228162C1 (de) * 1992-08-25 1994-01-13 Rajewsky Klaus Dr Verfahren zum Ersetzen homologer Genabschnitte aus Säugern in der Keimbahn von nicht-menschlichen Säugern
US5436149A (en) 1993-02-19 1995-07-25 Barnes; Wayne M. Thermostable DNA polymerase with enhanced thermostability and enhanced length and efficiency of primer extension
EP0754225A4 (en) * 1993-04-26 2001-01-31 Genpharm Int HETEROLOGIC ANTIBODY-PRODUCING TRANSGENIC NON-HUMAN ANIMALS
CA2362098C (en) * 1999-02-05 2011-10-11 Jens-Ulrich Bulow Human polyclonal antibodies from genetically engineered animals
US6586251B2 (en) * 2000-10-31 2003-07-01 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells

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