JP2013534809A5 - - Google Patents
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- JP2013534809A5 JP2013534809A5 JP2013511701A JP2013511701A JP2013534809A5 JP 2013534809 A5 JP2013534809 A5 JP 2013534809A5 JP 2013511701 A JP2013511701 A JP 2013511701A JP 2013511701 A JP2013511701 A JP 2013511701A JP 2013534809 A5 JP2013534809 A5 JP 2013534809A5
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| CN106029696B (zh) | 2013-12-17 | 2020-07-28 | 基因泰克公司 | 抗cd3抗体及使用方法 |
| JP6510532B2 (ja) * | 2013-12-20 | 2019-05-08 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | 二重特異性her2抗体及び使用方法 |
| PT2948184T (pt) * | 2014-01-10 | 2016-07-08 | Synthon Biopharmaceuticals Bv | Conjugados de anticorpo-fármaco de duocarmicina apresentando uma melhor atividade antitumoral in vivo. |
| AU2015222757B2 (en) | 2014-02-28 | 2020-10-08 | Allakos Inc. | Methods and compositions for treating Siglec-8 associated diseases |
| CN105017421B (zh) * | 2014-04-16 | 2017-12-26 | 中国人民解放军海军总医院 | 一种抗her2双特异性抗体及其制备方法与应用 |
| BR112016027888A2 (pt) | 2014-05-28 | 2017-10-24 | Zymeworks Inc | construto de polipeptídeo de ligação ao antígeno isolado, polinucleotídeo isolado ou um conjunto de polinucleotídeos isolados, vetor ou conjunto de vetores, célula isolada, composição farmacêutica, uso do construto, método para tratar um sujeito com uma doença ou distúrbio, método para obter um construto, método para preparar um construto, meio de armazenamento legível por computador, método para produzir um construto de polipeptídeo de ligação com antígeno bi-específico e método para preparar um construto de polipeptídeo de ligação com antígeno isolado |
| TWI695011B (zh) * | 2014-06-18 | 2020-06-01 | 美商梅爾莎納醫療公司 | 抗her2表位之單株抗體及其使用之方法 |
| CN110642952B (zh) * | 2014-08-14 | 2021-05-25 | 上海生物制品研究所有限责任公司 | 抗her3抗体、其制法及其应用 |
| WO2016082044A1 (en) | 2014-11-27 | 2016-06-02 | Zymeworks Inc. | Methods of using bispecific antigen-binding constructs targeting her2 |
| CN105985435B (zh) | 2015-01-30 | 2019-10-15 | 嘉和生物药业有限公司 | 全人源her2抗体的突变抗体及其编码基因和应用 |
| CN104689335B (zh) * | 2015-02-12 | 2017-12-01 | 中国科学院上海高等研究院 | 烯基磺酰胺基作为连接子的抗体药物偶联物及其应用 |
| CA2984458A1 (en) | 2015-05-13 | 2016-11-17 | Zymeworks Inc. | Antigen-binding constructs targeting her2 |
| WO2016191246A2 (en) * | 2015-05-22 | 2016-12-01 | Memorial Sloan-Kettering Cancer Center | T cell receptor-like antibodies specific for a prame peptide |
| PE20240218A1 (es) | 2015-06-16 | 2024-02-16 | Genentech Inc | Anticuerpos madurados por afinidad y humanizados para fcrh5 |
| EP3322735A4 (en) | 2015-07-15 | 2019-03-13 | Zymeworks Inc. | ACTIVE CONJUGATED BIS-SPECIFIC ANTIGEN-BONDING CONSTRUCTS |
| PL3359576T3 (pl) | 2015-10-08 | 2025-04-14 | Zymeworks Bc Inc. | Konstrukty polipeptydowe wiążące antygen zawierające łańcuchy lekkie kappa i lambda oraz ich zastosowania |
| US10604577B2 (en) | 2015-10-22 | 2020-03-31 | Allakos Inc. | Methods and compositions for treating systemic mastocytosis |
| ITUA20162242A1 (it) * | 2016-04-01 | 2017-10-01 | St Biochimico Italiano Giovanni Lorenzini Spa | Un nuovo anticorpo anti-erbb2 |
| EP3241847A1 (en) | 2016-05-06 | 2017-11-08 | MAB Discovery GmbH | Her-2 binding antibodies |
| CA3040913A1 (en) * | 2016-11-04 | 2018-05-11 | Genentech, Inc. | Treatment of her2-positive breast cancer |
| US11466094B2 (en) | 2016-11-15 | 2022-10-11 | Genentech, Inc. | Dosing for treatment with anti-CD20/anti-CD3 bispecific antibodies |
| CN108610419B (zh) * | 2016-12-09 | 2020-08-18 | 泰州迈博太科药业有限公司 | 一种人源化抗her2单克隆抗体 |
| CA3061898A1 (en) | 2016-12-28 | 2019-10-29 | Green Cross Lab Cell Corporation | Chimeric antigen receptor and natural killer cells expressing same |
| CA3053803A1 (en) * | 2017-02-24 | 2018-08-30 | Macrogenics, Inc. | Bispecific binding molecules that are capable of binding cd137 and tumor antigens, and uses thereof |
| CN110831628A (zh) | 2017-05-05 | 2020-02-21 | 爱乐科斯公司 | 用于治疗过敏性眼病的方法和组合物 |
| AU2018275359C1 (en) | 2017-06-02 | 2022-02-03 | Pfizer Inc. | Antibodies specific for FLT3 and their uses |
| US11517632B2 (en) * | 2017-06-20 | 2022-12-06 | Nanomab Technology Limited | Anti-Her2 single chain antibody and coding sequence and use thereof |
| US12116417B2 (en) | 2017-11-14 | 2024-10-15 | GC Cell Corporation | Anti-HER2 antibody or antigen-binding fragment thereof, and chimeric antigen receptor comprising same |
| US11649294B2 (en) | 2017-11-14 | 2023-05-16 | GC Cell Corporation | Anti-HER2 antibody or antigen-binding fragment thereof, and chimeric antigen receptor comprising same |
| CN118772288A (zh) | 2018-02-08 | 2024-10-15 | 豪夫迈·罗氏有限公司 | 双特异性抗原结合分子和使用方法 |
| EP3752196A4 (en) | 2018-02-15 | 2022-03-23 | MacroGenics, Inc. | CD3-BINDING DOMAIN VARIANTS AND THEIR USE IN COMBINATION THERAPIES FOR THE TREATMENT OF DISEASES |
| CN108484772A (zh) * | 2018-04-11 | 2018-09-04 | 中国人民解放军军事科学院军事医学研究院 | 抗her2抗原的人源化抗体h5l5及其应用 |
| CA3104390A1 (en) | 2018-06-22 | 2019-12-26 | Genmab A/S | Method for producing a controlled mixture of two or more different antibodies |
| CN110790840A (zh) * | 2018-08-01 | 2020-02-14 | 三生国健药业(上海)股份有限公司 | 结合人her2的抗体、其制备方法和用途 |
| CA3112043A1 (en) | 2018-09-10 | 2020-03-19 | Mirati Therapeutics, Inc. | Combination therapies |
| US20220204644A1 (en) * | 2019-05-02 | 2022-06-30 | Mab Discovery Gmbh | Combination of her2 antibodies |
| CA3218578A1 (en) | 2021-05-14 | 2022-11-17 | Carol Elaine O'hear | Methods for treatment of cd20-positive proliferative disorder with mosunetuzumab and polatuzumab vedotin |
| WO2024183623A1 (zh) * | 2023-03-03 | 2024-09-12 | 盛禾(中国)生物制药有限公司 | 一种抗her2抗体在制备治疗癌症的药物中的用途 |
Family Cites Families (111)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| JPS5896026A (ja) | 1981-10-30 | 1983-06-07 | Nippon Chemiphar Co Ltd | 新規ウロキナ−ゼ誘導体およびその製造法ならびにそれを含有する血栓溶解剤 |
| DE3380726D1 (en) | 1982-06-24 | 1989-11-23 | Japan Chem Res | Long-acting composition |
| US4766106A (en) | 1985-06-26 | 1988-08-23 | Cetus Corporation | Solubilization of proteins for pharmaceutical compositions using polymer conjugation |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| JP3040121B2 (ja) | 1988-01-12 | 2000-05-08 | ジェネンテク,インコーポレイテッド | 増殖因子レセプターの機能を阻害することにより腫瘍細胞を処置する方法 |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| US5705157A (en) | 1989-07-27 | 1998-01-06 | The Trustees Of The University Of Pennsylvania | Methods of treating cancerous cells with anti-receptor antibodies |
| US6884418B1 (en) | 1989-08-04 | 2005-04-26 | Berlex Laboratories, Inc. | Use of ligand-mimicking agents and anti-neoplastic drugs in cancer therapy |
| US5877397A (en) | 1990-08-29 | 1999-03-02 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US5874299A (en) | 1990-08-29 | 1999-02-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US6300129B1 (en) | 1990-08-29 | 2001-10-09 | Genpharm International | Transgenic non-human animals for producing heterologous antibodies |
| US5814318A (en) | 1990-08-29 | 1998-09-29 | Genpharm International Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| US5789650A (en) | 1990-08-29 | 1998-08-04 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5770429A (en) | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| WO1992003918A1 (en) | 1990-08-29 | 1992-03-19 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| WO1992022645A1 (en) | 1991-06-14 | 1992-12-23 | Genpharm International, Inc. | Transgenic immunodeficient non-human animals |
| EP0593592B1 (en) | 1991-07-08 | 1998-03-25 | The University Of Massachusetts At Amherst | Thermotropic liquid crystal segmented block copolymer |
| US5733743A (en) | 1992-03-24 | 1998-03-31 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
| AU6819494A (en) | 1993-04-26 | 1994-11-21 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US6077835A (en) | 1994-03-23 | 2000-06-20 | Case Western Reserve University | Delivery of compacted nucleic acid to cells |
| US6410690B1 (en) | 1995-06-07 | 2002-06-25 | Medarex, Inc. | Therapeutic compounds comprised of anti-Fc receptor antibodies |
| KR970029803A (ko) | 1995-11-03 | 1997-06-26 | 김광호 | 반도체 메모리장치의 프리차지 회로 |
| PT896586E (pt) | 1996-03-27 | 2007-01-31 | Genentech Inc | Anticorpos de erbb3 |
| CN101412758A (zh) | 1996-10-18 | 2009-04-22 | 基因技术股份有限公司 | 抗ErbB2抗体 |
| ZA9811162B (en) | 1997-12-12 | 2000-06-07 | Genentech Inc | Treatment with anti-ERBB2 antibodies. |
| US6417168B1 (en) | 1998-03-04 | 2002-07-09 | The Trustees Of The University Of Pennsylvania | Compositions and methods of treating tumors |
| WO1999048527A1 (en) | 1998-03-27 | 1999-09-30 | Genentech, Inc. | Apo-2 ligand-anti-her-2 antibody synergism |
| CA2347067C (en) | 1998-03-31 | 2013-09-17 | Geron Corporation | Dendritic cell vaccine containing telomerase reverse transcriptase for the treatment of cancer |
| US7244826B1 (en) | 1998-04-24 | 2007-07-17 | The Regents Of The University Of California | Internalizing ERB2 antibodies |
| IL144084A0 (en) | 1999-02-03 | 2002-05-23 | Biosante Pharmaceuticals Inc | Therapeutic calcium phosphate particles and methods of manufacture and use |
| AU782325B2 (en) | 1999-05-14 | 2005-07-21 | Genentech Inc. | Treatment with anti-ErbB2 antibodies |
| US6281005B1 (en) | 1999-05-14 | 2001-08-28 | Copernicus Therapeutics, Inc. | Automated nucleic acid compaction device |
| US6949245B1 (en) | 1999-06-25 | 2005-09-27 | Genentech, Inc. | Humanized anti-ErbB2 antibodies and treatment with anti-ErbB2 antibodies |
| MXPA01013395A (es) | 1999-06-25 | 2003-09-04 | Genentech Inc | Tratamiento de cancer de prostata con anticuerpos anti-erbb2. |
| BRPI0012198B8 (pt) | 1999-06-25 | 2021-05-25 | Genentech Inc | anticorpos humanizados, composição e imunoconjugado |
| KR20020012292A (ko) | 1999-06-25 | 2002-02-15 | 제넨테크, 인크. | 항-ErbB 항체-메이탄시노이드 결합체를 사용한 치료방법 |
| CA2380813A1 (en) | 1999-07-29 | 2001-02-08 | Medarex, Inc. | Human monoclonal antibodies to her2/neu |
| WO2001014424A2 (en) | 1999-08-24 | 2001-03-01 | Medarex, Inc. | Human ctla-4 antibodies and their uses |
| AU2001264696B2 (en) | 2000-05-19 | 2007-01-04 | Genentech, Inc. | Gene detection assay for improving the likelihood of an effective response to an ErbB antagonist cancer therapy |
| WO2002042468A2 (en) | 2000-11-27 | 2002-05-30 | Geron Corporation | Glycosyltransferase vectors for treating cancer |
| DE60131456T2 (de) | 2000-11-30 | 2008-07-10 | Medarex, Inc., Milpitas | Transchromosomale transgen-nagetiere zur herstellung von humanen antikörpern |
| EP1243276A1 (en) | 2001-03-23 | 2002-09-25 | Franciscus Marinus Hendrikus De Groot | Elongated and multiple spacers containing activatible prodrugs |
| US7087600B2 (en) | 2001-05-31 | 2006-08-08 | Medarex, Inc. | Peptidyl prodrugs and linkers and stabilizers useful therefor |
| US7452539B2 (en) | 2001-12-19 | 2008-11-18 | Genentech, Inc. | Stabilizing polypeptides which have been exposed to urea |
| US7332585B2 (en) | 2002-04-05 | 2008-02-19 | The Regents Of The California University | Bispecific single chain Fv antibody molecules and methods of use thereof |
| US20050148607A1 (en) | 2002-06-03 | 2005-07-07 | Tsuyoshi Suzuki | Preventives and/or remedies for subjects with the expression or activation of her2 and/or egfr |
| PL210545B1 (pl) | 2002-10-10 | 2012-01-31 | Merck Patent Gmbh | Kompozycja farmaceutyczna i zestaw farmaceutyczny zawierające przeciwciała ukierunkowane na receptory ERB-B1 oraz ich zastosowanie do otrzymywania leku do leczenia nowotworów |
| US7705045B2 (en) | 2002-11-14 | 2010-04-27 | Syntarga, B.V. | Prodrugs built as multiple self-elimination-release spacers |
| US7309486B1 (en) | 2002-11-15 | 2007-12-18 | Mark Zamoyski | HER cancer protocols |
| CA2541360A1 (en) | 2003-10-08 | 2005-04-21 | Bradley T. Messmer | Methods and compositions for diagnosis and treatment of b cell chronic lymphocytic leukemia |
| AU2004309347B2 (en) | 2003-12-19 | 2010-03-04 | Genentech, Inc. | Monovalent antibody fragments useful as therapeutics |
| BRPI0511782B8 (pt) * | 2004-06-03 | 2021-05-25 | Novimmune Sa | anticorpos anti-cd3, uso e método de produção dos mesmos, composição farmacêutica, molécula de ácido nucleico isolada e vetor |
| CA2568952C (en) | 2004-06-18 | 2019-05-21 | Ambrx, Inc. | Novel antigen-binding polypeptides and their uses |
| ZA200701234B (en) | 2004-07-22 | 2008-12-31 | Genentech Inc | HER2 antibody composition |
| US8911726B2 (en) | 2004-09-22 | 2014-12-16 | Kyowa Hakko Kirin Co., Ltd | Stabilized human Igg4 antibodies |
| JP2008523073A (ja) | 2004-12-07 | 2008-07-03 | ジェネンテック・インコーポレーテッド | Her阻害剤を用いた治療のための患者の選択 |
| GB0503546D0 (en) * | 2005-02-21 | 2005-03-30 | Hellenic Pasteur Inst | Antibody |
| CA2596133C (en) | 2005-02-23 | 2016-11-15 | Genentech, Inc. | Extending time to disease progression or survival in cancer patients |
| US8604174B2 (en) * | 2005-04-20 | 2013-12-10 | Amgen Inc. | High affinity fully human monoclonal antibodies to interleukin-8 |
| CA2605560A1 (en) | 2005-04-22 | 2006-11-02 | Kristen Hjortsvang | Immunoliposome composition for targeting to a her2 cell receptor |
| WO2007018431A2 (en) | 2005-08-05 | 2007-02-15 | Syntarga B.V. | Triazole-containing releasable linkers and conjugates comprising the same |
| AR056142A1 (es) | 2005-10-21 | 2007-09-19 | Amgen Inc | Metodos para generar el anticuerpo igg monovalente |
| EA016609B1 (ru) | 2005-11-28 | 2012-06-29 | Генмаб А/С | Рекомбинантные моновалентные антитела и способы их получения |
| RU2489423C2 (ru) | 2006-02-02 | 2013-08-10 | Синтарга Б.В. | Водорастворимые аналоги сс-1065 и их конъюгаты |
| EP2078732B1 (en) * | 2006-07-10 | 2015-09-16 | Fujita Health University | Method of identifying a candidate diagnostic or therapeutic antibody using flow cytometry |
| LT2511301T (lt) * | 2006-08-04 | 2018-04-10 | Medimmune Limited | Žmogaus antikūnas prieš erbb2 |
| EP2441472B1 (en) | 2006-08-21 | 2015-06-10 | F. Hoffmann-La Roche AG | Tumor therapy with an anti-VEGF antibody |
| WO2008031531A1 (en) | 2006-09-15 | 2008-03-20 | F. Hoffmann-La Roche Ag | Tumor therapy with a combination of anti-her2 antibodies |
| EP2126117A2 (en) | 2007-01-18 | 2009-12-02 | University Of Southern California | Gene polymorphisms predictive for dual tki therapy |
| WO2008097229A1 (en) | 2007-02-09 | 2008-08-14 | The Government Of The Usa As Represented By The Secretary Of The Dept. Of Health And Human Services | Method for spectroscopic quantitation of her-2 in biological samples |
| CA2677108A1 (en) | 2007-03-02 | 2008-09-12 | Genentech, Inc. | Predicting response to a her inhibitor |
| CA2681790A1 (en) | 2007-03-30 | 2008-10-09 | F. Hoffmann-La Roche Ag | Composition of labeled and non-labeled monoclonal antibodies |
| AU2008239594B2 (en) | 2007-04-13 | 2013-10-24 | Beth Israel Deaconess Medical Center | Methods for treating cancer resistant to ErbB therapeutics |
| EP1980626A1 (en) | 2007-04-13 | 2008-10-15 | Het Nederlands Kanker Instituut | Involvement of lipid kinase, and signal transduction pathway comprising said lipid kinase, in resistance to HER2-targeting therapy |
| WO2008130910A1 (en) | 2007-04-19 | 2008-10-30 | Wellstat Biologics Corporation | Detection her-2/neu protein from non-isolated circulating cancer cells and treatment |
| US20090258005A1 (en) | 2007-05-29 | 2009-10-15 | Trubion Pharmaceuticals Inc. | Therapeutic compositions and methods |
| AU2008255352B2 (en) | 2007-05-31 | 2014-05-22 | Genmab A/S | Stable IgG4 antibodies |
| BRPI0812777A2 (pt) | 2007-06-06 | 2014-12-02 | Hoffmann La Roche | Composição de um primeiro anticorpo monoclonal não-marcado que se liga a um antígeno de tumor e de um segundo anticorpo monoclonal que não sofre reação cruzada marcado com um marcador fluorescente nir |
| EP2592156B1 (en) | 2007-06-08 | 2016-04-20 | Genentech, Inc. | Gene expression markers of tumor resistance to HER2 inhibitor treatment |
| DE102007031818A1 (de) | 2007-07-07 | 2009-01-08 | Daimler Ag | Windschutzeinrichtung |
| CA2695297C (en) | 2007-08-01 | 2017-03-21 | Syntarga B.V. | Substituted cc-1065 analogs and their conjugates |
| EP2185692A4 (en) | 2007-08-10 | 2012-05-02 | Medarex Inc | HCO32 AND HCO27 AND RELATED EXAMPLES |
| EP2192919A1 (en) | 2007-08-24 | 2010-06-09 | University Health Network | Methods of inhibiting tumor growth using beta 5 integrin antagonists |
| WO2009030239A1 (en) | 2007-09-06 | 2009-03-12 | Genmab A/S | Novel methods and antibodies for treating cancer |
| WO2009055074A2 (en) | 2007-10-25 | 2009-04-30 | Wyeth | Erbb2 binding proteins and use thereof |
| GB0722704D0 (en) | 2007-11-20 | 2007-12-27 | Cadbury Schweppes Plc | Confectionery product |
| MX2010005783A (es) | 2007-11-27 | 2010-08-10 | Ablynx Nv | Secuencias de aminoacidos dirigidas contra citoquinas heterodimericas y/o sus receptores y polipeptidos que comprenden las mismas. |
| TW200930407A (en) | 2007-11-30 | 2009-07-16 | Medarex Inc | Conjugates of anti-RG-1 antibodies |
| TWI472339B (zh) | 2008-01-30 | 2015-02-11 | Genentech Inc | 包含結合至her2結構域ii之抗體及其酸性變異體的組合物 |
| RU2528736C2 (ru) | 2008-02-05 | 2014-09-20 | Бристоль-Мейерз Сквибб Компани | Антитела против альфа5-бета 1 и их применение |
| US8394377B2 (en) | 2008-02-21 | 2013-03-12 | The Regents Of The University Of Colorado | Methods for treating cancer using combination therapy |
| EP2282773B2 (en) | 2008-05-02 | 2025-03-05 | Seagen Inc. | Methods and compositions for making antibodies and antibody derivatives with reduced core fucosylation |
| JP2010006705A (ja) * | 2008-06-13 | 2010-01-14 | Atlas Antibodies Ab | Her2サブセット |
| BRPI0812682A2 (pt) | 2008-06-16 | 2010-06-22 | Genentech Inc | tratamento de cáncer de mama metastático |
| AU2009288167B2 (en) | 2008-09-03 | 2015-10-22 | Genentech, Inc. | Multispecific antibodies |
| CN101721700A (zh) | 2008-10-15 | 2010-06-09 | 哈药集团生物工程有限公司 | 一种抗人Her2抗体的冻干制剂 |
| WO2010070117A1 (en) | 2008-12-18 | 2010-06-24 | Universite Libre De Bruxelles | Treatment method by the administration of anti-her2 targeted active compounds to patients with early breast cancer and her2-negative primary tumor |
| CN101633695B (zh) | 2009-04-15 | 2012-12-12 | 北京天广实生物技术股份有限公司 | 基于erbB2蛋白胞外区C-端功能表位特征设计抗erbB2功能抗体 |
| US8446101B2 (en) | 2009-07-20 | 2013-05-21 | Gallen Ka Leung Tsui | Control switch |
| CA2796181C (en) * | 2010-04-20 | 2023-01-03 | Genmab A/S | Heterodimeric antibody fc-containing proteins and methods for production thereof |
| CN107253992B (zh) | 2010-05-27 | 2022-03-11 | 根马布股份公司 | 针对her2的单克隆抗体 |
| CA2800769C (en) | 2010-05-27 | 2021-11-02 | Genmab A/S | Monoclonal antibodies against her2 epitope |
| CN103796677B (zh) * | 2011-04-20 | 2019-08-16 | 健玛保 | 针对her2和cd3的双特异性抗体 |
| US20140170148A1 (en) * | 2011-04-20 | 2014-06-19 | Genmab A/S | Bispecific antibodies against her2 |
| JP6177231B2 (ja) * | 2011-04-20 | 2017-08-09 | ゲンマブ エー/エス | Her2に対する二重特異性抗体 |
-
2011
- 2011-05-27 CA CA2800769A patent/CA2800769C/en active Active
- 2011-05-27 EP EP11723427.8A patent/EP2575880B1/en active Active
- 2011-05-27 NZ NZ60400711A patent/NZ604007A/en not_active IP Right Cessation
- 2011-05-27 US US13/700,246 patent/US9714294B2/en active Active
- 2011-05-27 WO PCT/EP2011/058772 patent/WO2011147982A2/en not_active Ceased
- 2011-05-27 JP JP2013511701A patent/JP6082344B2/ja active Active
- 2011-05-27 CN CN201180036931.1A patent/CN103153339B/zh active Active
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- 2012-11-20 IL IL223163A patent/IL223163A0/en unknown
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- 2016-04-21 IL IL245274A patent/IL245274B/en active IP Right Grant
- 2016-09-12 JP JP2016177734A patent/JP6438442B2/ja active Active
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- 2020-08-26 US US17/003,442 patent/US20210122830A1/en not_active Abandoned
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