JP2013532139A5 - - Google Patents

Info

Publication number

JP2013532139A5

JP2013532139A5 JP2013512891A JP2013512891A JP2013532139A5 JP 2013532139 A5 JP2013532139 A5 JP 2013532139A5 JP 2013512891 A JP2013512891 A JP 2013512891A JP 2013512891 A JP2013512891 A JP 2013512891A JP 2013532139 A5 JP2013532139 A5 JP 2013532139A5

Authority

JP

Japan

Prior art keywords

component

process according

final container

hemostatic composition

hemostasis

Prior art date

2011-06-01

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

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• 239000000203 mixture Substances 0.000 claims description 29
• 230000002439 hemostatic effect Effects 0.000 claims description 23
• 229920000249 biocompatible polymer Polymers 0.000 claims description 15
• 230000023597 hemostasis Effects 0.000 claims description 15
• 238000002360 preparation method Methods 0.000 claims description 11
• 239000003085 diluting agent Substances 0.000 claims description 10
• CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 8
• 229920000642 polymer Polymers 0.000 claims description 6
• 108090000190 Thrombin Proteins 0.000 claims description 5
• 239000003795 chemical substances by application Substances 0.000 claims description 5
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• 108010010803 Gelatin Proteins 0.000 claims description 4
• 235000010323 ascorbic acid Nutrition 0.000 claims description 4
• 239000011668 ascorbic acid Substances 0.000 claims description 4
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• 229920000159 gelatin Polymers 0.000 claims description 4
• 239000008273 gelatin Substances 0.000 claims description 4
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• 235000018102 proteins Nutrition 0.000 claims description 4
• 102000004169 proteins and genes Human genes 0.000 claims description 4
• 108090000623 proteins and genes Proteins 0.000 claims description 4
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• FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims description 2
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• BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 claims description 2
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• BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 claims description 2
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• 229920002678 cellulose Polymers 0.000 claims description 2
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• 229920000193 polymethacrylate Polymers 0.000 claims description 2
• -1 polyoxyethylene Polymers 0.000 claims description 2
• 229920000915 polyvinyl chloride Polymers 0.000 claims description 2
• 239000000843 powder Substances 0.000 claims description 2
• 230000005855 radiation Effects 0.000 claims description 2
• 108010015680 recombinant human thrombin Proteins 0.000 claims description 2
• 150000003839 salts Chemical class 0.000 claims description 2
• 235000010378 sodium ascorbate Nutrition 0.000 claims description 2
• PPASLZSBLFJQEF-RKJRWTFHSA-M sodium ascorbate Substances [Na+].OC[C@@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RKJRWTFHSA-M 0.000 claims description 2
• 229960005055 sodium ascorbate Drugs 0.000 claims description 2
• PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical compound [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 claims description 2
• 239000003381 stabilizer Substances 0.000 claims description 2
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• 229920001221 xylan Polymers 0.000 claims description 2
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