JP2013529201A5 - - Google Patents
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- Publication number
- JP2013529201A5 JP2013529201A5 JP2013510322A JP2013510322A JP2013529201A5 JP 2013529201 A5 JP2013529201 A5 JP 2013529201A5 JP 2013510322 A JP2013510322 A JP 2013510322A JP 2013510322 A JP2013510322 A JP 2013510322A JP 2013529201 A5 JP2013529201 A5 JP 2013529201A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- dimethylamino
- divalent
- molar ratio
- trivalent cation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 31
- 150000001768 cations Chemical class 0.000 claims 27
- 229940072172 tetracycline antibiotic Drugs 0.000 claims 22
- 239000000203 mixture Substances 0.000 claims 21
- 239000000243 solution Substances 0.000 claims 17
- 229960004089 tigecycline Drugs 0.000 claims 16
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims 15
- FFTVPQUHLQBXQZ-KVUCHLLUSA-N (4s,4as,5ar,12ar)-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1C2=C(N(C)C)C=CC(O)=C2C(O)=C2[C@@H]1C[C@H]1[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]1(O)C2=O FFTVPQUHLQBXQZ-KVUCHLLUSA-N 0.000 claims 12
- 229960004023 minocycline Drugs 0.000 claims 12
- SOVUOXKZCCAWOJ-HJYUBDRYSA-N (4s,4as,5ar,12ar)-9-[[2-(tert-butylamino)acetyl]amino]-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical group C1C2=C(N(C)C)C=C(NC(=O)CNC(C)(C)C)C(O)=C2C(O)=C2[C@@H]1C[C@H]1[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]1(O)C2=O SOVUOXKZCCAWOJ-HJYUBDRYSA-N 0.000 claims 10
- 238000000034 method Methods 0.000 claims 10
- 239000011777 magnesium Substances 0.000 claims 9
- KFTLBUWBQDMTSQ-JNCWMXRTSA-N (4s,4as,5ar,12ar)-4-(dimethylamino)-n-[2-(dimethylamino)acetyl]-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1C2=CC=CC(O)=C2C(O)=C(C2=O)[C@@H]1C[C@@H]1[C@@]2(O)C(O)=C(C(=O)NC(=O)CN(C)C)C(=O)[C@H]1N(C)C KFTLBUWBQDMTSQ-JNCWMXRTSA-N 0.000 claims 6
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 claims 6
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims 6
- 238000001990 intravenous administration Methods 0.000 claims 6
- 239000004098 Tetracycline Substances 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 229960002180 tetracycline Drugs 0.000 claims 5
- 208000035143 Bacterial infection Diseases 0.000 claims 4
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 4
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 claims 4
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 claims 4
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 claims 4
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 4
- 208000022362 bacterial infectious disease Diseases 0.000 claims 4
- 239000003085 diluting agent Substances 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- -1 polyoxyethylene Polymers 0.000 claims 4
- 239000008247 solid mixture Substances 0.000 claims 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 3
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims 3
- 239000007864 aqueous solution Substances 0.000 claims 3
- 239000002585 base Substances 0.000 claims 3
- 239000000872 buffer Substances 0.000 claims 3
- 239000011575 calcium Substances 0.000 claims 3
- 229910052791 calcium Inorganic materials 0.000 claims 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 3
- 229910052749 magnesium Inorganic materials 0.000 claims 3
- 239000011701 zinc Substances 0.000 claims 3
- 229910052725 zinc Inorganic materials 0.000 claims 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 2
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims 2
- RGHNJXZEOKUKBD-SQOUGZDYSA-M D-gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O RGHNJXZEOKUKBD-SQOUGZDYSA-M 0.000 claims 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- GYHNNYVSQQEPJS-UHFFFAOYSA-N Gallium Chemical compound [Ga] GYHNNYVSQQEPJS-UHFFFAOYSA-N 0.000 claims 2
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims 2
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims 2
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 claims 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 229910052782 aluminium Inorganic materials 0.000 claims 2
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims 2
- 239000003963 antioxidant agent Substances 0.000 claims 2
- 230000003078 antioxidant effect Effects 0.000 claims 2
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 claims 2
- 229910017052 cobalt Inorganic materials 0.000 claims 2
- 239000010941 cobalt Substances 0.000 claims 2
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 229910052802 copper Inorganic materials 0.000 claims 2
- 239000010949 copper Substances 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229910052733 gallium Inorganic materials 0.000 claims 2
- 229940050410 gluconate Drugs 0.000 claims 2
- 239000004615 ingredient Substances 0.000 claims 2
- 229910052742 iron Inorganic materials 0.000 claims 2
- UEGPKNKPLBYCNK-UHFFFAOYSA-L magnesium acetate Chemical compound [Mg+2].CC([O-])=O.CC([O-])=O UEGPKNKPLBYCNK-UHFFFAOYSA-L 0.000 claims 2
- 239000011654 magnesium acetate Substances 0.000 claims 2
- 235000011285 magnesium acetate Nutrition 0.000 claims 2
- 229940069446 magnesium acetate Drugs 0.000 claims 2
- 229910001629 magnesium chloride Inorganic materials 0.000 claims 2
- 235000011147 magnesium chloride Nutrition 0.000 claims 2
- 229910052943 magnesium sulfate Inorganic materials 0.000 claims 2
- 235000019341 magnesium sulphate Nutrition 0.000 claims 2
- 229940091250 magnesium supplement Drugs 0.000 claims 2
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 claims 2
- 229910052759 nickel Inorganic materials 0.000 claims 2
- 239000003921 oil Substances 0.000 claims 2
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 2
- 239000001632 sodium acetate Substances 0.000 claims 2
- 235000017281 sodium acetate Nutrition 0.000 claims 2
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 claims 2
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 claims 1
- ZOIORXHNWRGPMV-UHFFFAOYSA-N acetic acid;zinc Chemical compound [Zn].CC(O)=O.CC(O)=O ZOIORXHNWRGPMV-UHFFFAOYSA-N 0.000 claims 1
- 150000007513 acids Chemical class 0.000 claims 1
- 229910001622 calcium bromide Inorganic materials 0.000 claims 1
- 239000001110 calcium chloride Substances 0.000 claims 1
- 229910001628 calcium chloride Inorganic materials 0.000 claims 1
- FNAQSUUGMSOBHW-UHFFFAOYSA-H calcium citrate Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O FNAQSUUGMSOBHW-UHFFFAOYSA-H 0.000 claims 1
- 239000001354 calcium citrate Substances 0.000 claims 1
- 229960004256 calcium citrate Drugs 0.000 claims 1
- WGEFECGEFUFIQW-UHFFFAOYSA-L calcium dibromide Chemical compound [Ca+2].[Br-].[Br-] WGEFECGEFUFIQW-UHFFFAOYSA-L 0.000 claims 1
- 239000004202 carbamide Substances 0.000 claims 1
- 239000004359 castor oil Substances 0.000 claims 1
- 235000019438 castor oil Nutrition 0.000 claims 1
- 229960004106 citric acid Drugs 0.000 claims 1
- 235000015165 citric acid Nutrition 0.000 claims 1
- 239000012024 dehydrating agents Substances 0.000 claims 1
- 238000004090 dissolution Methods 0.000 claims 1
- UPWPDUACHOATKO-UHFFFAOYSA-K gallium trichloride Chemical compound Cl[Ga](Cl)Cl UPWPDUACHOATKO-UHFFFAOYSA-K 0.000 claims 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims 1
- 239000008101 lactose Substances 0.000 claims 1
- 239000003589 local anesthetic agent Substances 0.000 claims 1
- OTCKOJUMXQWKQG-UHFFFAOYSA-L magnesium bromide Chemical compound [Mg+2].[Br-].[Br-] OTCKOJUMXQWKQG-UHFFFAOYSA-L 0.000 claims 1
- 229910001623 magnesium bromide Inorganic materials 0.000 claims 1
- 239000004337 magnesium citrate Substances 0.000 claims 1
- 229960005336 magnesium citrate Drugs 0.000 claims 1
- 235000002538 magnesium citrate Nutrition 0.000 claims 1
- JFQQIWNDAXACSR-UHFFFAOYSA-L magnesium malate Chemical compound [Mg+2].[O-]C(=O)C(O)CC([O-])=O JFQQIWNDAXACSR-UHFFFAOYSA-L 0.000 claims 1
- 229940096424 magnesium malate Drugs 0.000 claims 1
- 239000000395 magnesium oxide Substances 0.000 claims 1
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 claims 1
- 235000012245 magnesium oxide Nutrition 0.000 claims 1
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 claims 1
- 229960003966 nicotinamide Drugs 0.000 claims 1
- 235000005152 nicotinamide Nutrition 0.000 claims 1
- 239000011570 nicotinamide Substances 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 claims 1
- 229960004919 procaine Drugs 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 229930101283 tetracycline Natural products 0.000 claims 1
- 235000019364 tetracycline Nutrition 0.000 claims 1
- 238000011200 topical administration Methods 0.000 claims 1
- 235000013337 tricalcium citrate Nutrition 0.000 claims 1
- PLSARIKBYIPYPF-UHFFFAOYSA-H trimagnesium dicitrate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O PLSARIKBYIPYPF-UHFFFAOYSA-H 0.000 claims 1
- 239000004246 zinc acetate Substances 0.000 claims 1
- 229960000314 zinc acetate Drugs 0.000 claims 1
- 235000013904 zinc acetate Nutrition 0.000 claims 1
- 239000011592 zinc chloride Substances 0.000 claims 1
- 235000005074 zinc chloride Nutrition 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33410610P | 2010-05-12 | 2010-05-12 | |
| US61/334,106 | 2010-05-12 | ||
| US39230410P | 2010-10-12 | 2010-10-12 | |
| US61/392,304 | 2010-10-12 | ||
| PCT/US2011/036351 WO2011143503A2 (en) | 2010-05-12 | 2011-05-12 | Tetracycline compositions |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016093691A Division JP6290298B2 (ja) | 2010-05-12 | 2016-05-09 | テトラサイクリン組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013529201A JP2013529201A (ja) | 2013-07-18 |
| JP2013529201A5 true JP2013529201A5 (enExample) | 2014-06-26 |
| JP6025712B2 JP6025712B2 (ja) | 2016-11-16 |
Family
ID=44914987
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013510322A Active JP6025712B2 (ja) | 2010-05-12 | 2011-05-12 | テトラサイクリン組成物 |
| JP2016093691A Active JP6290298B2 (ja) | 2010-05-12 | 2016-05-09 | テトラサイクリン組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016093691A Active JP6290298B2 (ja) | 2010-05-12 | 2016-05-09 | テトラサイクリン組成物 |
Country Status (21)
| Country | Link |
|---|---|
| US (7) | US9278105B2 (enExample) |
| EP (2) | EP3135289B1 (enExample) |
| JP (2) | JP6025712B2 (enExample) |
| KR (1) | KR101799304B1 (enExample) |
| CN (1) | CN102970992B (enExample) |
| AU (1) | AU2011252919B2 (enExample) |
| BR (1) | BR112012028524B1 (enExample) |
| CA (1) | CA2799079C (enExample) |
| CL (1) | CL2012003168A1 (enExample) |
| CO (1) | CO6650346A2 (enExample) |
| DK (1) | DK2568987T3 (enExample) |
| ES (2) | ES2613738T3 (enExample) |
| HU (1) | HUE033161T2 (enExample) |
| IL (1) | IL222896A (enExample) |
| MX (1) | MX347919B (enExample) |
| PL (1) | PL2568987T3 (enExample) |
| PT (1) | PT2568987T (enExample) |
| RU (1) | RU2647972C2 (enExample) |
| SG (1) | SG185513A1 (enExample) |
| WO (1) | WO2011143503A2 (enExample) |
| ZA (1) | ZA201208466B (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG185513A1 (en) | 2010-05-12 | 2012-12-28 | Rempex Pharmaceuticals Inc | Tetracycline compositions |
| CN102697739B (zh) * | 2012-05-31 | 2014-10-29 | 丽珠医药集团股份有限公司 | 一种减少替加环素差向异构体化的粉针剂制备方法 |
| WO2014167575A2 (en) | 2013-03-26 | 2014-10-16 | Astron Research Limited | Stable tigecycline composition |
| IN2013MU01127A (enExample) * | 2013-03-26 | 2015-05-01 | Astron Res Ltd | |
| US20140323443A1 (en) * | 2013-04-30 | 2014-10-30 | Fresenius Kabi Usa, Llc | Tigecycline formulations |
| KR20170134514A (ko) | 2015-03-23 | 2017-12-06 | 바이오팜엑스 인코포레이티드 | 피부과 사용을 위한 약학 테트라사이클린 조성물 |
| PT108978B (pt) * | 2015-11-24 | 2020-03-09 | Hovione Farm S A | Sais de tetraciclinas |
| GB201904851D0 (en) | 2019-04-05 | 2019-05-22 | Katholieke Univ Leven | Melanoma treatment |
| WO2021063468A1 (en) * | 2019-10-02 | 2021-04-08 | Anfarm Hellas S.A. | Stable parenteral pharmaceutical composition containing tigecycline and process for the preparation thereof |
| CN113101371A (zh) * | 2021-04-07 | 2021-07-13 | 中国科学院大学温州研究院(温州生物材料与工程研究所) | 一种基于阳离子-π作用的疏水药物的增溶方法 |
| CN119157870A (zh) * | 2024-10-08 | 2024-12-20 | 宁夏大学 | 铜盐在制备缓解替加环素光解作用药物中的医药用途 |
Family Cites Families (100)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2736725A (en) | 1954-03-11 | 1956-02-28 | American Cyanamid Co | Complexes of tetracycline antibiotics and preparation of same |
| GB812138A (en) | 1954-06-17 | 1959-04-22 | American Cyanamid Co | Improvements relating to antibiotic composition |
| GB793558A (en) | 1954-07-07 | 1958-04-16 | Pfizer | Improvements in or relating to tetracycline preparations |
| DE1228252B (de) | 1956-01-16 | 1966-11-10 | Pfizer & Co C | Verfahren zur Herstellung eines in waessrigem Medium leicht resuspendierbaren und bestaendigen Mg-Tetracyclinsalzes |
| GB809015A (en) | 1956-01-16 | 1959-02-18 | Pfizer & Co C | Stable aqueous suspensions of tetracycline |
| GB845454A (en) | 1956-06-27 | 1960-08-24 | American Cyanamid Co | Preparation of improved tetracycline antibiotic compositions |
| DE1053734B (de) | 1956-06-27 | 1959-03-26 | American Cyanamid Co | Verfahren zur Loeslichmachung und Stabilisierung der Tetracyclinantibiotika |
| US3232834A (en) | 1957-06-27 | 1966-02-01 | Pfizer & Co C | Antibiotic preparations |
| US2980584A (en) | 1957-10-29 | 1961-04-18 | Pfizer & Co C | Parenteral magnesium oxytetracycline acetic or lactic acid carboxamide vehicle preparation |
| GB879629A (en) | 1958-12-05 | 1961-10-11 | American Cyanamid Co | Improvements in or relating to stable 6-demethyl-tetracycline antibiotic compositions |
| GB901107A (en) | 1959-06-29 | 1962-07-11 | Pfizer | Therapeutic composition and method of preparing same |
| DE1163318B (de) | 1960-04-12 | 1964-02-20 | Pfizer & Co C | Verfahren zur Herstellung von Tetracyclin-Verbindungen |
| GB948090A (en) | 1960-04-21 | 1964-01-29 | American Cyanamid Co | Improvements in or relating to tetracycline complexes |
| DE1144721B (de) | 1960-04-21 | 1963-03-07 | American Cyanamid Co | Verfahren zur Herstellung von Tetracyclin-Komplexverbindungen |
| FR1430859A (enExample) | 1960-05-23 | 1966-05-25 | ||
| US3166474A (en) | 1961-05-26 | 1965-01-19 | American Cyanamid Co | Stable aqueous propylene glycol solutions of aluminum gluconate complexes of certain tetracycline antibiotics |
| US3335055A (en) | 1961-08-30 | 1967-08-08 | American Cyanamid Co | More stable and more soluble tetracycline compositions suitable for parenteral use and method of preparing same |
| USRE26253E (en) | 1963-05-17 | 1967-08-15 | And z-alkylamino-g-deoxytetracycline | |
| US3275513A (en) | 1963-05-29 | 1966-09-27 | American Cyanamid Co | Stable calcium tetracycline compositions |
| GB1120821A (en) | 1965-03-09 | 1968-07-24 | Rit Rech Ind Therapeut | Derivatives of tetracycline antibiotics |
| ES324597A1 (es) | 1966-03-23 | 1967-02-01 | Gallardo Antonio Sa | Procedimiento para la obtencion de complejos estables de 4-dimetilamino-1,4,4a,5,5a,6,11,12a-octahidro-3,6,10,12,12a-pentahidroxi-6-metil-1,11-dioxo-2-naftacen carboxamida. |
| DE1767891C3 (de) | 1968-06-28 | 1980-10-30 | Pfizer | Verfahren zur Herstellung von wäßrigen arzneilichen Lösungen für die parenterale, perorale und lokale Anwendung mit einem Gehalt an einem Tetracyclinderivat |
| BE786427A (fr) | 1971-07-19 | 1973-01-18 | Pfizer | Compositions aqueuses de doxycycline |
| US4038315A (en) * | 1972-05-11 | 1977-07-26 | American Cyanamid Company | Isolation and recovery of calcium chloride complex of 7-dimethylamino-6-dimethyl l-6-deoxytetracycline hydrochloride |
| US3957980A (en) * | 1972-10-26 | 1976-05-18 | Pfizer Inc. | Doxycycline parenteral compositions |
| US4060605A (en) | 1973-09-28 | 1977-11-29 | Ankerfarm, S.P.A. | Water-soluble derivative of 6-deoxy-tetracyclines |
| US4018889A (en) | 1976-01-02 | 1977-04-19 | Pfizer Inc. | Oxytetracycline compositions |
| JPS61130228A (ja) * | 1984-11-29 | 1986-06-18 | Sunstar Inc | ミノサイクリンを安定に配合した組成物 |
| US4701320A (en) | 1984-11-29 | 1987-10-20 | Lederle (Japan), Ltd. | Composition stably containing minocycline for treating periodontal diseases |
| IE74244B1 (en) | 1985-10-01 | 1997-07-16 | Bimeda Res Dev Ltd | A process for preparing an antibiotic composition |
| FR2608044B1 (fr) | 1986-12-10 | 1992-09-11 | Sogeval | Composition antibiotique aqueuse a usage veterinaire |
| US4999194A (en) | 1988-01-14 | 1991-03-12 | Collaborative Research, Inc. | Two-chain urokinase plasminogen activators for treatment of thrombotic disease |
| IL89894A0 (en) | 1988-04-13 | 1989-12-15 | Pfizer | Single dose intramuscular treatment of chlamydia trachomatis infections |
| US5075295A (en) * | 1989-12-12 | 1991-12-24 | Boehringer Ingelheim Animal Health, Inc. | Novel oxytetracycline compositions |
| ES2168254T3 (es) | 1991-10-04 | 2002-06-16 | American Cyanamid Co | Nuevas 7-sustituidas-9-(amino sustituido)-6-desmetil-6-desoxitetraciclinas. |
| US5494903A (en) | 1991-10-04 | 1996-02-27 | American Cyanamid Company | 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines |
| GB9413873D0 (en) | 1994-07-09 | 1994-08-31 | Norbrook Lab Ltd | Long-acting oxytetracycline composition |
| JP3759640B2 (ja) * | 1995-06-30 | 2006-03-29 | 日本原子力研究所 | 単一縦モード周波数可変レーザー発振器の発振周波数安定化装置及び方法と周波数掃引可能なレーザー発振装置及び方法 |
| US6310053B1 (en) * | 1995-07-05 | 2001-10-30 | Norbrook Laboratories Limited | Long-acting oxytetracycline composition |
| FR2740686B1 (fr) * | 1995-11-03 | 1998-01-16 | Sanofi Sa | Formulation pharmaceutique lyophilisee stable |
| CN1126537C (zh) | 1996-05-23 | 2003-11-05 | 株式会社三养社 | 可局部给药,可生物降解和持续释放的用于治疗牙周炎的药物组合物及其制备方法 |
| US6245735B1 (en) | 1996-07-29 | 2001-06-12 | The Brigham And Women's Hospital, Inc. | Methods and products for treating pseudomonas infection |
| KR100252699B1 (ko) * | 1998-03-17 | 2000-12-01 | 강재헌 | 치주염 치료용 미노사이클린 조성물 |
| JPH11286448A (ja) | 1998-04-01 | 1999-10-19 | Showa Yakuhin Kako Kk | ミノサイクリン含有組成物 |
| IN183807B (enExample) | 1998-04-22 | 2000-04-22 | Hindustan Antibiotics Ltd | |
| US6432934B1 (en) | 1998-08-06 | 2002-08-13 | Advanced Vision Research | Methods and compositions for topical treatment of eye surface inflammation and related dry eye disease |
| BR9804395A (pt) | 1998-11-04 | 2000-06-06 | Hoechst Roussel Vet S A Brasil | Composição farmacêutica injejetável, de longa ação, à base de uma tetraciclina. |
| US20040131628A1 (en) | 2000-03-08 | 2004-07-08 | Bratzler Robert L. | Nucleic acids for the treatment of disorders associated with microorganisms |
| AU2001272935A1 (en) | 2000-05-31 | 2001-12-11 | Mayo Foundation For Medical Education And Research | Cobalamin compounds useful as antibiotic agents and as imaging agents |
| WO2002002081A1 (en) | 2000-07-05 | 2002-01-10 | Capricorn Pharma, Inc. | Rapid-melt semi-solid compositions, methods of making same and methods of using same |
| US6375982B1 (en) | 2000-07-05 | 2002-04-23 | Capricorn Pharma, Inc. | Rapid-melt semi-solid compositions, methods of making same and method of using same |
| US20100010101A1 (en) | 2000-07-05 | 2010-01-14 | Capricorn Pharma, Inc. | Rapid-Melt Compositions and Methods of Making Same |
| AU2001287198A1 (en) | 2000-08-22 | 2002-03-04 | Jeneric/Pentron, Incorporated | Dental restorative compositions and method of use thereof |
| IL145751A (en) | 2001-10-04 | 2010-12-30 | Avi Dascalu | Use of aluminum fluoride for the preparation of compositions for the treatment of acne vulgaris and folliculitis |
| EP1438019A1 (en) | 2001-10-24 | 2004-07-21 | PARI GmbH Spezialisten für effektive Inhalation | Kit for the preparation of a pharmaceutical composition |
| US20030083318A1 (en) | 2001-10-25 | 2003-05-01 | Jean-Pierre Julien | Therapy for neurodegenerative diseases |
| US20040235801A1 (en) | 2001-10-25 | 2004-11-25 | Jean-Pierre Julien | Therapy for stroke |
| US20030171340A1 (en) | 2002-02-07 | 2003-09-11 | Jenefir Isbister | Methods of disease treatment using metal-complexed tetracycline antibiotics |
| WO2003079984A2 (en) * | 2002-03-21 | 2003-10-02 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
| AU2003256284A1 (en) * | 2002-06-20 | 2004-01-06 | Orapharma, Inc. | Rapidly disintegrating formulations for treating or preventing mucositis |
| JP2006506442A (ja) | 2002-07-09 | 2006-02-23 | ポイント セラピューティクス， インコーポレイテッド | ボロプロリン化合物併用療法 |
| CN1390550A (zh) * | 2002-07-25 | 2003-01-15 | 于航 | 盐酸米诺环素冻干粉针剂及其制备方法 |
| RU2273232C2 (ru) | 2003-07-21 | 2006-04-10 | Олег Иванович Квасенков | Способ получения желейного мармелада |
| WO2005009416A1 (en) | 2003-07-24 | 2005-02-03 | Ranbaxy Laboratories Limited | Modified release compositions for minocycline |
| AU2004261143B2 (en) | 2003-07-25 | 2009-11-05 | Allergan Pharmaceuticals International Limited | A doxycycline metal complex in a solid dosage form |
| CN1562045A (zh) | 2004-04-02 | 2005-01-12 | 北京正大绿洲医药科技有限公司 | 强力霉素滴丸 |
| WO2006002868A1 (en) | 2004-06-30 | 2006-01-12 | Omega Bio-Pharma (I.P.1) Limited | Materials and methods for improving shellfish health, immunity and growth |
| US7799937B2 (en) | 2004-10-25 | 2010-09-21 | Synthonics, Inc. | Metal coordinated compositions |
| US20060141054A1 (en) | 2004-10-25 | 2006-06-29 | Thomas Piccariello | Metal coordinated compositions |
| EP1855690B1 (en) * | 2005-01-21 | 2016-06-01 | Warner Chilcott Company, LLC | A tetracycline metal complex in a solid dosage form |
| KR20130122988A (ko) * | 2005-03-14 | 2013-11-11 | 와이어쓰 엘엘씨 | 티게사이클린 조성물 및 이의 제조방법 |
| AR057033A1 (es) | 2005-05-27 | 2007-11-14 | Wyeth Corp | Tigeciclina y metodos para preparar 9-nitrominociclina |
| JP2009521456A (ja) * | 2005-12-22 | 2009-06-04 | ワイス | チゲサイクリンでの胃腸管感染症の治療法 |
| CN101340895A (zh) | 2005-12-22 | 2009-01-07 | 惠氏公司 | 包含替加环素的口服制剂 |
| HUE029222T2 (en) | 2006-01-27 | 2017-02-28 | Univ Yale | Fast acting gastric acid secretion inhibitor |
| ES2315123B1 (es) | 2006-09-25 | 2009-12-30 | Divasa-Farmavic, S.A. | Composiciones farmaceuticas estables de tetraciclinas en solucion, procedimiento para su obtencion y sus usos. |
| WO2008097850A1 (en) | 2007-02-02 | 2008-08-14 | Warner Chilcott Company, Inc. | Tretracycline compositions for topical administration |
| CN101254156B (zh) | 2007-03-01 | 2011-05-25 | 段亚东 | 一种化妆品组合物及其制备化妆品的用途 |
| JP5395052B2 (ja) * | 2007-03-23 | 2014-01-22 | モレキュラー リサーチ センター インコーポレイテッド | 炎症を処置するための組成物および方法 |
| WO2008121107A1 (en) | 2007-04-02 | 2008-10-09 | Medicis Pharmaceutical Corporation | Minocycline oral dosage forms for the treatment of acne |
| US20080248124A1 (en) | 2007-04-03 | 2008-10-09 | Sunstar Kabushiki Kaisha | Process for producing pharmaceutical composition |
| US8828363B2 (en) | 2007-08-03 | 2014-09-09 | Gary H. EIREW | Pharmaceutical composition for improving oral hygiene and methods thereof |
| CA2699157A1 (en) | 2007-09-10 | 2009-03-19 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
| US20090111780A1 (en) | 2007-10-31 | 2009-04-30 | Everett Laboratories, Inc. | Compositions and methods for treatment of ear canal infection and inflammation |
| WO2009076454A2 (en) | 2007-12-12 | 2009-06-18 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
| BRPI0908181A2 (pt) | 2008-02-15 | 2015-08-18 | Harvard College | Solução de cardioplegia para cirurgia cardíaca |
| PT2271348T (pt) | 2008-03-28 | 2018-04-16 | Paratek Pharm Innc | Formulação de comprimido oral de composto de tetraciclina |
| US9107929B2 (en) | 2008-05-01 | 2015-08-18 | Ranbaxy Laboratories Limited | Stable parenteral formulations of tigecycline |
| CN101301268A (zh) | 2008-06-11 | 2008-11-12 | 成都乾坤动物药业有限公司 | 一种兽用盐酸多西环素注射液的组成及其制备工艺 |
| US20110245148A1 (en) * | 2008-06-23 | 2011-10-06 | Danmarks Tekniske Universitet | Acetic acid and a buffer |
| AU2009282659A1 (en) | 2008-08-18 | 2010-02-25 | Nanotherapeutics, Inc. | Topical hydrogel composition |
| WO2010033800A2 (en) * | 2008-09-19 | 2010-03-25 | Alacrity Biosciences, Inc. | Tetracycline stabilizing formulations |
| WO2010034011A2 (en) | 2008-09-22 | 2010-03-25 | Calcimedica, Inc. | Phenylthiophenyldihydrobenzothiazepine inhibitors of store operated calcium release |
| WO2010034003A2 (en) | 2008-09-22 | 2010-03-25 | Calcimedica, Inc. | Benzylthiotetrazole inhibitors of store operated calcium release |
| WO2010046932A2 (en) | 2008-10-21 | 2010-04-29 | Jubilant Organosys Limited | Extended release pharmaceutical composition of minocycline and process thereof |
| AU2010210620B2 (en) | 2009-02-03 | 2016-02-25 | Microbion Corporation | Bismuth-thiols as antiseptics for epithelial tissues, acute and chronic wounds, bacterial biofilms and other indications |
| CN101607086B (zh) | 2009-07-21 | 2011-11-02 | 山西安特生物制药股份有限公司 | 一种复方铋剂组合物及其制备方法 |
| CN101822650B (zh) | 2010-04-28 | 2012-06-20 | 中国科学院上海生命科学研究院湖州营养与健康产业创新中心 | 一种盐酸米诺环素缓释片及其制备方法 |
| SG185513A1 (en) | 2010-05-12 | 2012-12-28 | Rempex Pharmaceuticals Inc | Tetracycline compositions |
| CN101940560A (zh) | 2010-09-16 | 2011-01-12 | 孙卫东 | 一种盐酸米诺环素缓释片及其不同规格的制备方法 |
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