GB793558A - Improvements in or relating to tetracycline preparations - Google Patents
Improvements in or relating to tetracycline preparationsInfo
- Publication number
- GB793558A GB793558A GB19657/55A GB1965755A GB793558A GB 793558 A GB793558 A GB 793558A GB 19657/55 A GB19657/55 A GB 19657/55A GB 1965755 A GB1965755 A GB 1965755A GB 793558 A GB793558 A GB 793558A
- Authority
- GB
- United Kingdom
- Prior art keywords
- acid
- water
- tetracycline
- chlortetracycline
- acid addition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Mineral and strong organic acid addition salts of tetracycline or chlortetracycline are prepared by dissolving the amphoteric antibiotic in methyl "Cellosolve" (Registered Trade Mark), and adding one equivalent of the acid dissolved in water. Specified are salts with hydrochloric, hydrobromic, hydriodic, sulphuric and nitric acids.ALSO:A therapeutically effective composition useful for the preparation of intramuscularly injectable liquid preparations comprises a mixture of an acid addition salt of tetracycline or chlortetracycline (see Group IV (b)) and magnesium chloride. It is preferred to use two molecules of magnesium chloride to one molecule of the antibiotic. Specified acid addition salts are the hydrochloride, hydrobromide, hydroiodide, sulphate and nitrate. The injectable vehicle may be water, propylene glycol or oils such as sesame and peanut oils. Optional ingredients for aqueous injections are (a) a non-toxic, water-soluble organic acid, e.g. citric, gluconic, lactic, ascorbic, maleic, malic, malonic and nicotinic acids, an hydroxy acid, or a compound which on addition of water forms such an acid, e.g. glucurono-lactone; and (b) a water-soluble local anaesthetic, e.g. procaine hydrochloride and other dialkylamino alkanol esters of p-aminobenzoic acid.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US793558XA | 1954-07-07 | 1954-07-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB793558A true GB793558A (en) | 1958-04-16 |
Family
ID=22150009
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB19657/55A Expired GB793558A (en) | 1954-07-07 | 1955-07-07 | Improvements in or relating to tetracycline preparations |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB793558A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3004894A (en) * | 1959-04-07 | 1961-10-17 | Upjohn Co | Therapeutic composition comprising tetracycline and a dioxolane |
US9084802B2 (en) | 2010-05-12 | 2015-07-21 | Rempex Pharmaceuticals, Inc. | Tetracycline compositions |
-
1955
- 1955-07-07 GB GB19657/55A patent/GB793558A/en not_active Expired
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3004894A (en) * | 1959-04-07 | 1961-10-17 | Upjohn Co | Therapeutic composition comprising tetracycline and a dioxolane |
US9084802B2 (en) | 2010-05-12 | 2015-07-21 | Rempex Pharmaceuticals, Inc. | Tetracycline compositions |
US9278105B2 (en) | 2010-05-12 | 2016-03-08 | Rempex Pharmaceuticals, Inc. | Tetracycline compositions |
US9744179B2 (en) | 2010-05-12 | 2017-08-29 | Rempex Pharmaceuticals, Inc. | Tetracycline compositions |
US11944634B2 (en) | 2010-05-12 | 2024-04-02 | Melinta Subsidiary Corp. | Tetracycline compositions |
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