GB936902A - Quinazolinone derivatives - Google Patents

Quinazolinone derivatives

Info

Publication number
GB936902A
GB936902A GB9836/62A GB983662A GB936902A GB 936902 A GB936902 A GB 936902A GB 9836/62 A GB9836/62 A GB 9836/62A GB 983662 A GB983662 A GB 983662A GB 936902 A GB936902 A GB 936902A
Authority
GB
United Kingdom
Prior art keywords
radical
methylphenyl
isopropyl
formula
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB9836/62A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beiersdorf AG
Original Assignee
Beiersdorf AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beiersdorf AG filed Critical Beiersdorf AG
Publication of GB936902A publication Critical patent/GB936902A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/91—Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises a quinazolinone derivative of the formula: <FORM:0936902/IV(a)/1> wherein R represents hydrogen, a methyl radical or an isopropyl radical, an R1 represents an o-methylphenyl, o-chlorophenyl, o-bromophenyl, o,o1 or o,p-dimethylphenyl radical when R is hydrogen, R1 represents an o-ethylphenyl, o-hydroxyphenyl, o-S-methylphenyl, or o,o1-chloro-methylphenyl radical when R is methyl and R1 represents an o-methylphenyl radical when R is isopropyl, or acid addition salts thereof which have therapeutically acceptable anions, and a process for the preparation thereof by condensing a compound of the formula: <FORM:0936902/IV(a)/2> in the presence of an acid condensing agent with a compound of the formula R1NH2. The condensation may be effected in the presence of phosphorus pentachloride in nitrobenzene as solvent. Specifications 642,134 and 843,073 are referred to.ALSO:Quinazolinone compounds having the formula <FORM:0936902/VI/1> wherein R represents hydrogen, a methyl radical or an isopropyl radical, and R1 represents o-methylphenyl, o-chlorophenyl, o-bromophenyl, o,o1- or o,p-dimethylphenyl radical, when R is hydrogen, R1 represents an o-ethylphenyl, o-hydroxyphenyl, o-S-methylphenyl, or o,o1-chloro-methylphenyl radical, when R is methyl and R1 represents an o-methylphenyl radical, when R is isopropyl or acid addition salts thereof which haved therapeutically acceptable anions, are employed as spasmolytics and hypnotics and may be used to intensify the analgesic action of weak analgesics, e.g. phenacetin, isopropyl phenazone and codeine, or the activity of known antitussive agents. Specifications 642,134 and 843,073 are referred to.
GB9836/62A 1961-03-18 1962-03-14 Quinazolinone derivatives Expired GB936902A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEB61759A DE1224316B (en) 1961-03-18 1961-03-18 Process for the preparation of 2-methyl-3- (o-aethylphenyl) -4-oxo-3, 4-dihydroquinazoline and its salts

Publications (1)

Publication Number Publication Date
GB936902A true GB936902A (en) 1963-09-18

Family

ID=6973320

Family Applications (1)

Application Number Title Priority Date Filing Date
GB9836/62A Expired GB936902A (en) 1961-03-18 1962-03-14 Quinazolinone derivatives

Country Status (4)

Country Link
BE (1) BE615282A (en)
CH (1) CH416653A (en)
DE (1) DE1224316B (en)
GB (1) GB936902A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3462434A (en) * 1965-05-05 1969-08-19 Boehringer Sohn Ingelheim 2-isopropyl-3-(p-amino-phenyl)-3h-4-quinazolone
US7960399B2 (en) 2004-06-08 2011-06-14 Novartis Ag Quinazolinone derivatives useful as vanilloid antagonists

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB642134A (en) * 1945-04-07 1950-08-30 Gen Aniline & Film Corp Preparation of quinazolones
GB843073A (en) * 1958-05-09 1960-08-04 Toraude Lab 2-methyl-3-orthotolyl-4-quinazolone and acid addition salts thereof

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3462434A (en) * 1965-05-05 1969-08-19 Boehringer Sohn Ingelheim 2-isopropyl-3-(p-amino-phenyl)-3h-4-quinazolone
US7960399B2 (en) 2004-06-08 2011-06-14 Novartis Ag Quinazolinone derivatives useful as vanilloid antagonists
US8211902B2 (en) 2004-06-08 2012-07-03 Novartis Ag Quinazolinone derivatives useful as vanilloid antagonists
US8809528B2 (en) 2004-06-08 2014-08-19 Novartis Ag Quinazolinone derivatives useful as vanilloid antagonists
US9102653B2 (en) 2004-06-08 2015-08-11 Novartis Ag Substituted quinazolinones as vanilloid antagonists

Also Published As

Publication number Publication date
DE1224316B (en) 1966-09-08
BE615282A (en) 1962-09-19
CH416653A (en) 1966-07-15

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