GB812138A - Improvements relating to antibiotic composition - Google Patents
Improvements relating to antibiotic compositionInfo
- Publication number
- GB812138A GB812138A GB17539/55A GB1753955A GB812138A GB 812138 A GB812138 A GB 812138A GB 17539/55 A GB17539/55 A GB 17539/55A GB 1753955 A GB1753955 A GB 1753955A GB 812138 A GB812138 A GB 812138A
- Authority
- GB
- United Kingdom
- Prior art keywords
- magnesium
- antibiotic
- ions
- source
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
An intramuscularly acceptable antibiotic composition comprises tetracycline or oxytetracycline or their acid or basic salts, a soluble source of magnesium ions, a soluble source of absorption-enhancing non-toxic acid ions which source is solid in the dry state, and a non-toxic local an sthetic. The source of absorption-enhancing ions may be a water-soluble non-toxic carboxylic or thiocarboxylic acid or a lactone of such acids including citric, ascorbic, gluconic and thioglycollic acids or may be a soluble mineral acid salt of an amino acid. The antibiotic may be used in salt form as the hydrochloride, hydrobromide, sulphate, nitrate, citrate, ascorbate or gluconate, or as the sodium, potassium, ammonium, calcium, or magnesium salts as well as in the neutral form. The magnesium source may be a soluble ionizable salt such as the halides and their hydrates, e.g. magnesium chloride hexahydrate, or magnesium sulphate, nitrate, bromide, acetate, glycinate or as the magnesium salt of one of the absorption enhancing acids such as magnesium citrate or ascorbate. Specified local an sthetics include procaine, xylocaine, hydroxy-procaine, 2-chloroprocaine, piperocaine, hexylcaine, diethoxin, tetracaine and larocaine. They may be used as the free base or more conveniently as the hydrochlorides. The compositions may be prepared as a sterile, dry powder to which water may be added immediately prior to use, or alternatively one or more of the storage stable constituents may be present in the aqueous diluent. The components may be mixed and sterilized by ethylene oxide or if desired by high frequency radiation or by neutrons. The final composition should preferably contain 10 to 100 milligrams/millilitre of antibiotic calculated as antibiotic hydrochloride, an amount of an sthetic equivalent in effect to that obtained from 0.5 to 40 milligrams/millilitre, from 1 to 15 milligrams/millilitre of magnesium ions and the absorption-enhancing ions in an amount equal to up to three times that of the antibiotic. In an example, tetracycline hydrochloride, anhydrous citric acid and procaine hydrochloride are ground together and sterilized by exposure to ethylene oxide. Heated ground magnesium chloride hexahydrate is added and the mixture filled into glass vials. Reference has been directed by the Comptroller to Specification 739,736.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US812138XA | 1954-06-17 | 1954-06-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB812138A true GB812138A (en) | 1959-04-22 |
Family
ID=22162786
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB17539/55A Expired GB812138A (en) | 1954-06-17 | 1955-06-17 | Improvements relating to antibiotic composition |
Country Status (2)
Country | Link |
---|---|
GB (1) | GB812138A (en) |
MY (1) | MY6100085A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9084802B2 (en) | 2010-05-12 | 2015-07-21 | Rempex Pharmaceuticals, Inc. | Tetracycline compositions |
-
1955
- 1955-06-17 GB GB17539/55A patent/GB812138A/en not_active Expired
-
1961
- 1961-12-31 MY MY196185A patent/MY6100085A/en unknown
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9084802B2 (en) | 2010-05-12 | 2015-07-21 | Rempex Pharmaceuticals, Inc. | Tetracycline compositions |
US9278105B2 (en) | 2010-05-12 | 2016-03-08 | Rempex Pharmaceuticals, Inc. | Tetracycline compositions |
US9744179B2 (en) | 2010-05-12 | 2017-08-29 | Rempex Pharmaceuticals, Inc. | Tetracycline compositions |
US11944634B2 (en) | 2010-05-12 | 2024-04-02 | Melinta Subsidiary Corp. | Tetracycline compositions |
Also Published As
Publication number | Publication date |
---|---|
MY6100085A (en) | 1961-12-31 |
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