GB719295A - Improvements in or relating to therapeutic procaine penicillin compositions - Google Patents
Improvements in or relating to therapeutic procaine penicillin compositionsInfo
- Publication number
- GB719295A GB719295A GB30966/50A GB3096650A GB719295A GB 719295 A GB719295 A GB 719295A GB 30966/50 A GB30966/50 A GB 30966/50A GB 3096650 A GB3096650 A GB 3096650A GB 719295 A GB719295 A GB 719295A
- Authority
- GB
- United Kingdom
- Prior art keywords
- penicillin
- milled
- micronized
- procaine
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
Abstract
An aqueous injectable procaine penicillin preparation of high potency i.e. up to 1,000,000 units per e.c. which may be in the form of a dry powder for dilution with sterile water immediately prior to use, is characterized in that the procaine penicillin is (a) "micronized" i.e. has an average particle size of 5 microns (b) "milled" i.e. has average particle size of 50 microns, or (c) a mixture of the "micronized" and "milled" forms. The preparation may be fluidized by the addition of a non-toxic water-soluble penicillin salt such as the potassium, sodium, calcium and ammonium salt. The penicillin is preferably penicillin G, but other penicillins such as penicillin F and X may be used. Optional ingredients are (a) substances for rendering the suspension isotonic e.g. sodium citrate (b) dispersing agents such as polyethylene oxide derivatives e.g. polyoxyethylene sorbitan monooleate (c) preservatives e.g. methyl or propyl p-hydroxy benzoate (d) thickening agents such as sodium carboxymethyl-cellulose, natural gums e.g. tragacanth, acacia and agar agar, gelatin, polyvinyl alcohol, polyvinyl pyrrolidone and pectin. Compositions containing the procaine penicillin either in the "micronized" or "milled" form, necessarily contain the fluidizing water-soluble penicillin salt. In addition, preparations containing the "milled" form alone, preferably contain a thickening agent.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US719295XA | 1949-12-20 | 1949-12-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB719295A true GB719295A (en) | 1954-12-01 |
Family
ID=22104492
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB30966/50A Expired GB719295A (en) | 1949-12-20 | 1950-12-19 | Improvements in or relating to therapeutic procaine penicillin compositions |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB719295A (en) |
-
1950
- 1950-12-19 GB GB30966/50A patent/GB719295A/en not_active Expired
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