GB827580A - Injectable tetracycline compositions - Google Patents

Abstract

An injectable formulation comprises a dry mixture containing tetracycline sodium (or potassium) hexametaphosphate, a non-toxic alpha-hydroxy carboxylic acid containing only carbon, hydrogen and oxygen, and a non-toxic, water soluble, polyvalent metal salt. The alpha-hydroxy acid may be citric, gluconic, tartaric, malic, ascorbic, or mandelic acid. The metal salt may be one of Mg, Ca, Al, or Fe. Examples given of such salts are the chlorides, sulphates, and ascorbates of the above metals, magnesium hydroxide and oxide, calcium hydroxide. The alpha-hydroxy acid is present in of from 0.25 to 1 (preferably 0.45 to 0.9) parts by weight of that of the tetracycline complex, and the metal salt in amounts of at least 0.07 and preferably 0.075 to 0.15 parts. The formulation may be intimately mixed, screened and sealed into sterile vials in predetermined dosage amounts and may be subsequently prepared for administration by the addition of sterile water or saline. Local an sthetics, for example, procaine hydrochloride, and ingredients to prevent discoloration, for example, sodium or calcium bisulphite, sodium formaldehyde sulphate, acetone sodium bisulphite in amounts of from 0.01 to 0.5% by weight of the total dry weight may also be present.