GB700774A - Stabilised aqueous solutions of sodium p-aminosalicylate and production of the same - Google Patents
Stabilised aqueous solutions of sodium p-aminosalicylate and production of the sameInfo
- Publication number
- GB700774A GB700774A GB6840/51A GB684051A GB700774A GB 700774 A GB700774 A GB 700774A GB 6840/51 A GB6840/51 A GB 6840/51A GB 684051 A GB684051 A GB 684051A GB 700774 A GB700774 A GB 700774A
- Authority
- GB
- United Kingdom
- Prior art keywords
- sodium
- per cent
- aminosalicylate
- weight
- stabilized
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
Abstract
Solutions of sodium p-aminosalicylate are stabilized for heat sterilization by adding sodium formaldehyde-sulphoxylate. Compositions may contain 0.5 to 20 per cent. by weight of the former, with 0.01 to 2 per cent. by weight of the latter reckoned on the weight of water present with or without 0.1 to 0.6 per cent. of sodium bicarbonate. In an example, portions of the solution from one litre of water containing 30 gms. of sodium p-aminosalicylate, stabilized with 1 gm. of sodium formaldehyde sulphoxylate stood sterilization at 100-120 DEG without deterioration. Decarboxylation was lessened by the addition of sodium bicarbonate to the solution.ALSO:Aqueous solutions of sodium para-amino-salicylate are stabilized for heat sterilization for use in intravenous injection by the addition of 0.01-2.0 per cent by weight of sodium formaldehyde sulphoxylate to 0.5-20 per cent by weight of the above compound in water with or without 0.1-0.6 per cent of sodium bicarbonate. The solution containing 30 gms. sodium p-aminosalicylate in 1 litre, stabilized with 1 gm. of sodium formaldehyde sulphoxylate could be sterilized at 100-120 DEG C, without deterioration, decarboxylation being lessened by the addition of sodium bicrabonate.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR700774X | 1950-03-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB700774A true GB700774A (en) | 1953-12-09 |
Family
ID=9051658
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB6840/51A Expired GB700774A (en) | 1950-03-25 | 1951-03-22 | Stabilised aqueous solutions of sodium p-aminosalicylate and production of the same |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB700774A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE964169C (en) * | 1955-05-12 | 1957-05-16 | Hoechst Ag | Process for the stabilization of p-aminosalicylic acid salts |
| US4036951A (en) * | 1973-03-12 | 1977-07-19 | Synergistics, Inc. | Ultra-violet filtration with certain aminosalicylic acid esters |
-
1951
- 1951-03-22 GB GB6840/51A patent/GB700774A/en not_active Expired
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE964169C (en) * | 1955-05-12 | 1957-05-16 | Hoechst Ag | Process for the stabilization of p-aminosalicylic acid salts |
| US4036951A (en) * | 1973-03-12 | 1977-07-19 | Synergistics, Inc. | Ultra-violet filtration with certain aminosalicylic acid esters |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB1052537A (en) | ||
| GB700774A (en) | Stabilised aqueous solutions of sodium p-aminosalicylate and production of the same | |
| GB672459A (en) | Improvements in or relating to alkali metal pentachlorophenate pellets and process for making the same | |
| GB1019461A (en) | Improvements in or relating to chromone derivatives | |
| GB1063541A (en) | Stable aqueous formaldehyde solutions | |
| GB816592A (en) | A method for the preparation of stable magnesium solutions of high concentration | |
| GB932988A (en) | Improvements in or relating to tobacco products | |
| GB1033736A (en) | Stable injectable protamine-active compositions | |
| GB616456A (en) | Improvements in or relating to the production of normal lead dinitroresorcinate | |
| GB713720A (en) | Improvements in or relating to the preparation of stabilized liquid catalase | |
| GB790605A (en) | Antiseptic preparations | |
| ES338996A1 (en) | 3'-desdimethylamino-delta3', 4'-erythromycin derivatives | |
| GB818248A (en) | Improvements in and relating to the production of adrenocorticotrophin preparation of enhanced stability | |
| GB780330A (en) | Process for the preservation of meat | |
| GB657512A (en) | Prevention of sprouting of stored potatoes | |
| GB705657A (en) | Cleansing beer handling equipment | |
| GB902609A (en) | Process for the preparation of gluconic acid monohydrate | |
| GB1235053A (en) | New organic acid and process for its preparation | |
| GB1042894A (en) | 3-cyanopyrrolidines | |
| GB835453A (en) | Improvements in or relating to stabilized aliphatic chlorohydrocarbons | |
| GB942876A (en) | Improvements in or relating to piperidylidene-thiaxanthene | |
| GB668502A (en) | Improvements in or relating to anesthetic compositions | |
| GB621934A (en) | Preparation of 2-alkyl-1:4 naphthaquinone-4-carboxy-alkoximes | |
| GB1292503A (en) | Formulation for treatment of psoriasis | |
| GB692449A (en) | Improvements in caustic alkali composition of matter and its use as a poly-valent metal precipitation inhibitor |