CL2012003168A1 - Composicion farmaceutica que comprende una solucion acuosa de minociclina y un cation divalente o trivalente en una proporcion mayor de 2:1 con respecto a la minociclina; metodo de preparacion; kit y uso en el tratamiento de infecciones bacterianas. - Google Patents

Composicion farmaceutica que comprende una solucion acuosa de minociclina y un cation divalente o trivalente en una proporcion mayor de 2:1 con respecto a la minociclina; metodo de preparacion; kit y uso en el tratamiento de infecciones bacterianas.

Info

Publication number
CL2012003168A1
CL2012003168A1 CL2012003168A CL2012003168A CL2012003168A1 CL 2012003168 A1 CL2012003168 A1 CL 2012003168A1 CL 2012003168 A CL2012003168 A CL 2012003168A CL 2012003168 A CL2012003168 A CL 2012003168A CL 2012003168 A1 CL2012003168 A1 CL 2012003168A1
Authority
CL
Chile
Prior art keywords
minocycline
divalent
kit
preparation
treatment
Prior art date
Application number
CL2012003168A
Other languages
English (en)
Spanish (es)
Inventor
David C Griffith
Serge Boyer
Original Assignee
Remplex Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44914987&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2012003168(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Remplex Pharmaceuticals Inc filed Critical Remplex Pharmaceuticals Inc
Publication of CL2012003168A1 publication Critical patent/CL2012003168A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/04—Nitro compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/26—Iron; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/34—Copper; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
CL2012003168A 2010-05-12 2012-11-12 Composicion farmaceutica que comprende una solucion acuosa de minociclina y un cation divalente o trivalente en una proporcion mayor de 2:1 con respecto a la minociclina; metodo de preparacion; kit y uso en el tratamiento de infecciones bacterianas. CL2012003168A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33410610P 2010-05-12 2010-05-12
US39230410P 2010-10-12 2010-10-12

Publications (1)

Publication Number Publication Date
CL2012003168A1 true CL2012003168A1 (es) 2013-12-20

Family

ID=44914987

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2012003168A CL2012003168A1 (es) 2010-05-12 2012-11-12 Composicion farmaceutica que comprende una solucion acuosa de minociclina y un cation divalente o trivalente en una proporcion mayor de 2:1 con respecto a la minociclina; metodo de preparacion; kit y uso en el tratamiento de infecciones bacterianas.

Country Status (21)

Country Link
US (7) US9278105B2 (enExample)
EP (2) EP3135289B1 (enExample)
JP (2) JP6025712B2 (enExample)
KR (1) KR101799304B1 (enExample)
CN (1) CN102970992B (enExample)
AU (1) AU2011252919B2 (enExample)
BR (1) BR112012028524B1 (enExample)
CA (1) CA2799079C (enExample)
CL (1) CL2012003168A1 (enExample)
CO (1) CO6650346A2 (enExample)
DK (1) DK2568987T3 (enExample)
ES (2) ES2613738T3 (enExample)
HU (1) HUE033161T2 (enExample)
IL (1) IL222896A (enExample)
MX (1) MX347919B (enExample)
PL (1) PL2568987T3 (enExample)
PT (1) PT2568987T (enExample)
RU (1) RU2647972C2 (enExample)
SG (1) SG185513A1 (enExample)
WO (1) WO2011143503A2 (enExample)
ZA (1) ZA201208466B (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG185513A1 (en) 2010-05-12 2012-12-28 Rempex Pharmaceuticals Inc Tetracycline compositions
CN102697739B (zh) * 2012-05-31 2014-10-29 丽珠医药集团股份有限公司 一种减少替加环素差向异构体化的粉针剂制备方法
WO2014167575A2 (en) 2013-03-26 2014-10-16 Astron Research Limited Stable tigecycline composition
IN2013MU01127A (enExample) * 2013-03-26 2015-05-01 Astron Res Ltd
US20140323443A1 (en) * 2013-04-30 2014-10-30 Fresenius Kabi Usa, Llc Tigecycline formulations
KR20170134514A (ko) 2015-03-23 2017-12-06 바이오팜엑스 인코포레이티드 피부과 사용을 위한 약학 테트라사이클린 조성물
PT108978B (pt) * 2015-11-24 2020-03-09 Hovione Farm S A Sais de tetraciclinas
GB201904851D0 (en) 2019-04-05 2019-05-22 Katholieke Univ Leven Melanoma treatment
WO2021063468A1 (en) * 2019-10-02 2021-04-08 Anfarm Hellas S.A. Stable parenteral pharmaceutical composition containing tigecycline and process for the preparation thereof
CN113101371A (zh) * 2021-04-07 2021-07-13 中国科学院大学温州研究院(温州生物材料与工程研究所) 一种基于阳离子-π作用的疏水药物的增溶方法
CN119157870A (zh) * 2024-10-08 2024-12-20 宁夏大学 铜盐在制备缓解替加环素光解作用药物中的医药用途

Family Cites Families (100)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2736725A (en) 1954-03-11 1956-02-28 American Cyanamid Co Complexes of tetracycline antibiotics and preparation of same
GB812138A (en) 1954-06-17 1959-04-22 American Cyanamid Co Improvements relating to antibiotic composition
GB793558A (en) 1954-07-07 1958-04-16 Pfizer Improvements in or relating to tetracycline preparations
DE1228252B (de) 1956-01-16 1966-11-10 Pfizer & Co C Verfahren zur Herstellung eines in waessrigem Medium leicht resuspendierbaren und bestaendigen Mg-Tetracyclinsalzes
GB809015A (en) 1956-01-16 1959-02-18 Pfizer & Co C Stable aqueous suspensions of tetracycline
GB845454A (en) 1956-06-27 1960-08-24 American Cyanamid Co Preparation of improved tetracycline antibiotic compositions
DE1053734B (de) 1956-06-27 1959-03-26 American Cyanamid Co Verfahren zur Loeslichmachung und Stabilisierung der Tetracyclinantibiotika
US3232834A (en) 1957-06-27 1966-02-01 Pfizer & Co C Antibiotic preparations
US2980584A (en) 1957-10-29 1961-04-18 Pfizer & Co C Parenteral magnesium oxytetracycline acetic or lactic acid carboxamide vehicle preparation
GB879629A (en) 1958-12-05 1961-10-11 American Cyanamid Co Improvements in or relating to stable 6-demethyl-tetracycline antibiotic compositions
GB901107A (en) 1959-06-29 1962-07-11 Pfizer Therapeutic composition and method of preparing same
DE1163318B (de) 1960-04-12 1964-02-20 Pfizer & Co C Verfahren zur Herstellung von Tetracyclin-Verbindungen
GB948090A (en) 1960-04-21 1964-01-29 American Cyanamid Co Improvements in or relating to tetracycline complexes
DE1144721B (de) 1960-04-21 1963-03-07 American Cyanamid Co Verfahren zur Herstellung von Tetracyclin-Komplexverbindungen
FR1430859A (enExample) 1960-05-23 1966-05-25
US3166474A (en) 1961-05-26 1965-01-19 American Cyanamid Co Stable aqueous propylene glycol solutions of aluminum gluconate complexes of certain tetracycline antibiotics
US3335055A (en) 1961-08-30 1967-08-08 American Cyanamid Co More stable and more soluble tetracycline compositions suitable for parenteral use and method of preparing same
USRE26253E (en) 1963-05-17 1967-08-15 And z-alkylamino-g-deoxytetracycline
US3275513A (en) 1963-05-29 1966-09-27 American Cyanamid Co Stable calcium tetracycline compositions
GB1120821A (en) 1965-03-09 1968-07-24 Rit Rech Ind Therapeut Derivatives of tetracycline antibiotics
ES324597A1 (es) 1966-03-23 1967-02-01 Gallardo Antonio Sa Procedimiento para la obtencion de complejos estables de 4-dimetilamino-1,4,4a,5,5a,6,11,12a-octahidro-3,6,10,12,12a-pentahidroxi-6-metil-1,11-dioxo-2-naftacen carboxamida.
DE1767891C3 (de) 1968-06-28 1980-10-30 Pfizer Verfahren zur Herstellung von wäßrigen arzneilichen Lösungen für die parenterale, perorale und lokale Anwendung mit einem Gehalt an einem Tetracyclinderivat
BE786427A (fr) 1971-07-19 1973-01-18 Pfizer Compositions aqueuses de doxycycline
US4038315A (en) * 1972-05-11 1977-07-26 American Cyanamid Company Isolation and recovery of calcium chloride complex of 7-dimethylamino-6-dimethyl l-6-deoxytetracycline hydrochloride
US3957980A (en) * 1972-10-26 1976-05-18 Pfizer Inc. Doxycycline parenteral compositions
US4060605A (en) 1973-09-28 1977-11-29 Ankerfarm, S.P.A. Water-soluble derivative of 6-deoxy-tetracyclines
US4018889A (en) 1976-01-02 1977-04-19 Pfizer Inc. Oxytetracycline compositions
JPS61130228A (ja) * 1984-11-29 1986-06-18 Sunstar Inc ミノサイクリンを安定に配合した組成物
US4701320A (en) 1984-11-29 1987-10-20 Lederle (Japan), Ltd. Composition stably containing minocycline for treating periodontal diseases
IE74244B1 (en) 1985-10-01 1997-07-16 Bimeda Res Dev Ltd A process for preparing an antibiotic composition
FR2608044B1 (fr) 1986-12-10 1992-09-11 Sogeval Composition antibiotique aqueuse a usage veterinaire
US4999194A (en) 1988-01-14 1991-03-12 Collaborative Research, Inc. Two-chain urokinase plasminogen activators for treatment of thrombotic disease
IL89894A0 (en) 1988-04-13 1989-12-15 Pfizer Single dose intramuscular treatment of chlamydia trachomatis infections
US5075295A (en) * 1989-12-12 1991-12-24 Boehringer Ingelheim Animal Health, Inc. Novel oxytetracycline compositions
ES2168254T3 (es) 1991-10-04 2002-06-16 American Cyanamid Co Nuevas 7-sustituidas-9-(amino sustituido)-6-desmetil-6-desoxitetraciclinas.
US5494903A (en) 1991-10-04 1996-02-27 American Cyanamid Company 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
GB9413873D0 (en) 1994-07-09 1994-08-31 Norbrook Lab Ltd Long-acting oxytetracycline composition
JP3759640B2 (ja) * 1995-06-30 2006-03-29 日本原子力研究所 単一縦モード周波数可変レーザー発振器の発振周波数安定化装置及び方法と周波数掃引可能なレーザー発振装置及び方法
US6310053B1 (en) * 1995-07-05 2001-10-30 Norbrook Laboratories Limited Long-acting oxytetracycline composition
FR2740686B1 (fr) * 1995-11-03 1998-01-16 Sanofi Sa Formulation pharmaceutique lyophilisee stable
CN1126537C (zh) 1996-05-23 2003-11-05 株式会社三养社 可局部给药,可生物降解和持续释放的用于治疗牙周炎的药物组合物及其制备方法
US6245735B1 (en) 1996-07-29 2001-06-12 The Brigham And Women's Hospital, Inc. Methods and products for treating pseudomonas infection
KR100252699B1 (ko) * 1998-03-17 2000-12-01 강재헌 치주염 치료용 미노사이클린 조성물
JPH11286448A (ja) 1998-04-01 1999-10-19 Showa Yakuhin Kako Kk ミノサイクリン含有組成物
IN183807B (enExample) 1998-04-22 2000-04-22 Hindustan Antibiotics Ltd
US6432934B1 (en) 1998-08-06 2002-08-13 Advanced Vision Research Methods and compositions for topical treatment of eye surface inflammation and related dry eye disease
BR9804395A (pt) 1998-11-04 2000-06-06 Hoechst Roussel Vet S A Brasil Composição farmacêutica injejetável, de longa ação, à base de uma tetraciclina.
US20040131628A1 (en) 2000-03-08 2004-07-08 Bratzler Robert L. Nucleic acids for the treatment of disorders associated with microorganisms
AU2001272935A1 (en) 2000-05-31 2001-12-11 Mayo Foundation For Medical Education And Research Cobalamin compounds useful as antibiotic agents and as imaging agents
WO2002002081A1 (en) 2000-07-05 2002-01-10 Capricorn Pharma, Inc. Rapid-melt semi-solid compositions, methods of making same and methods of using same
US6375982B1 (en) 2000-07-05 2002-04-23 Capricorn Pharma, Inc. Rapid-melt semi-solid compositions, methods of making same and method of using same
US20100010101A1 (en) 2000-07-05 2010-01-14 Capricorn Pharma, Inc. Rapid-Melt Compositions and Methods of Making Same
AU2001287198A1 (en) 2000-08-22 2002-03-04 Jeneric/Pentron, Incorporated Dental restorative compositions and method of use thereof
IL145751A (en) 2001-10-04 2010-12-30 Avi Dascalu Use of aluminum fluoride for the preparation of compositions for the treatment of acne vulgaris and folliculitis
EP1438019A1 (en) 2001-10-24 2004-07-21 PARI GmbH Spezialisten für effektive Inhalation Kit for the preparation of a pharmaceutical composition
US20030083318A1 (en) 2001-10-25 2003-05-01 Jean-Pierre Julien Therapy for neurodegenerative diseases
US20040235801A1 (en) 2001-10-25 2004-11-25 Jean-Pierre Julien Therapy for stroke
US20030171340A1 (en) 2002-02-07 2003-09-11 Jenefir Isbister Methods of disease treatment using metal-complexed tetracycline antibiotics
WO2003079984A2 (en) * 2002-03-21 2003-10-02 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
AU2003256284A1 (en) * 2002-06-20 2004-01-06 Orapharma, Inc. Rapidly disintegrating formulations for treating or preventing mucositis
JP2006506442A (ja) 2002-07-09 2006-02-23 ポイント セラピューティクス， インコーポレイテッド ボロプロリン化合物併用療法
CN1390550A (zh) * 2002-07-25 2003-01-15 于航 盐酸米诺环素冻干粉针剂及其制备方法
RU2273232C2 (ru) 2003-07-21 2006-04-10 Олег Иванович Квасенков Способ получения желейного мармелада
WO2005009416A1 (en) 2003-07-24 2005-02-03 Ranbaxy Laboratories Limited Modified release compositions for minocycline
AU2004261143B2 (en) 2003-07-25 2009-11-05 Allergan Pharmaceuticals International Limited A doxycycline metal complex in a solid dosage form
CN1562045A (zh) 2004-04-02 2005-01-12 北京正大绿洲医药科技有限公司 强力霉素滴丸
WO2006002868A1 (en) 2004-06-30 2006-01-12 Omega Bio-Pharma (I.P.1) Limited Materials and methods for improving shellfish health, immunity and growth
US7799937B2 (en) 2004-10-25 2010-09-21 Synthonics, Inc. Metal coordinated compositions
US20060141054A1 (en) 2004-10-25 2006-06-29 Thomas Piccariello Metal coordinated compositions
EP1855690B1 (en) * 2005-01-21 2016-06-01 Warner Chilcott Company, LLC A tetracycline metal complex in a solid dosage form
KR20130122988A (ko) * 2005-03-14 2013-11-11 와이어쓰 엘엘씨 티게사이클린 조성물 및 이의 제조방법
AR057033A1 (es) 2005-05-27 2007-11-14 Wyeth Corp Tigeciclina y metodos para preparar 9-nitrominociclina
JP2009521456A (ja) * 2005-12-22 2009-06-04 ワイス チゲサイクリンでの胃腸管感染症の治療法
CN101340895A (zh) 2005-12-22 2009-01-07 惠氏公司 包含替加环素的口服制剂
HUE029222T2 (en) 2006-01-27 2017-02-28 Univ Yale Fast acting gastric acid secretion inhibitor
ES2315123B1 (es) 2006-09-25 2009-12-30 Divasa-Farmavic, S.A. Composiciones farmaceuticas estables de tetraciclinas en solucion, procedimiento para su obtencion y sus usos.
WO2008097850A1 (en) 2007-02-02 2008-08-14 Warner Chilcott Company, Inc. Tretracycline compositions for topical administration
CN101254156B (zh) 2007-03-01 2011-05-25 段亚东 一种化妆品组合物及其制备化妆品的用途
JP5395052B2 (ja) * 2007-03-23 2014-01-22 モレキュラー リサーチ センター インコーポレイテッド 炎症を処置するための組成物および方法
WO2008121107A1 (en) 2007-04-02 2008-10-09 Medicis Pharmaceutical Corporation Minocycline oral dosage forms for the treatment of acne
US20080248124A1 (en) 2007-04-03 2008-10-09 Sunstar Kabushiki Kaisha Process for producing pharmaceutical composition
US8828363B2 (en) 2007-08-03 2014-09-09 Gary H. EIREW Pharmaceutical composition for improving oral hygiene and methods thereof
CA2699157A1 (en) 2007-09-10 2009-03-19 Calcimedica, Inc. Compounds that modulate intracellular calcium
US20090111780A1 (en) 2007-10-31 2009-04-30 Everett Laboratories, Inc. Compositions and methods for treatment of ear canal infection and inflammation
WO2009076454A2 (en) 2007-12-12 2009-06-18 Calcimedica, Inc. Compounds that modulate intracellular calcium
BRPI0908181A2 (pt) 2008-02-15 2015-08-18 Harvard College Solução de cardioplegia para cirurgia cardíaca
PT2271348T (pt) 2008-03-28 2018-04-16 Paratek Pharm Innc Formulação de comprimido oral de composto de tetraciclina
US9107929B2 (en) 2008-05-01 2015-08-18 Ranbaxy Laboratories Limited Stable parenteral formulations of tigecycline
CN101301268A (zh) 2008-06-11 2008-11-12 成都乾坤动物药业有限公司 一种兽用盐酸多西环素注射液的组成及其制备工艺
US20110245148A1 (en) * 2008-06-23 2011-10-06 Danmarks Tekniske Universitet Acetic acid and a buffer
AU2009282659A1 (en) 2008-08-18 2010-02-25 Nanotherapeutics, Inc. Topical hydrogel composition
WO2010033800A2 (en) * 2008-09-19 2010-03-25 Alacrity Biosciences, Inc. Tetracycline stabilizing formulations
WO2010034011A2 (en) 2008-09-22 2010-03-25 Calcimedica, Inc. Phenylthiophenyldihydrobenzothiazepine inhibitors of store operated calcium release
WO2010034003A2 (en) 2008-09-22 2010-03-25 Calcimedica, Inc. Benzylthiotetrazole inhibitors of store operated calcium release
WO2010046932A2 (en) 2008-10-21 2010-04-29 Jubilant Organosys Limited Extended release pharmaceutical composition of minocycline and process thereof
AU2010210620B2 (en) 2009-02-03 2016-02-25 Microbion Corporation Bismuth-thiols as antiseptics for epithelial tissues, acute and chronic wounds, bacterial biofilms and other indications
CN101607086B (zh) 2009-07-21 2011-11-02 山西安特生物制药股份有限公司 一种复方铋剂组合物及其制备方法
CN101822650B (zh) 2010-04-28 2012-06-20 中国科学院上海生命科学研究院湖州营养与健康产业创新中心 一种盐酸米诺环素缓释片及其制备方法
SG185513A1 (en) 2010-05-12 2012-12-28 Rempex Pharmaceuticals Inc Tetracycline compositions
CN101940560A (zh) 2010-09-16 2011-01-12 孙卫东 一种盐酸米诺环素缓释片及其不同规格的制备方法

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US20140194393A1 (en) 2014-07-10
US20240189326A1 (en) 2024-06-13
ES2715551T3 (es) 2019-06-04
ZA201208466B (en) 2018-12-19
EP2568987A4 (en) 2014-05-21
KR101799304B1 (ko) 2017-11-20
RU2012147527A (ru) 2014-06-20
HK1180586A1 (zh) 2013-10-25
CO6650346A2 (es) 2013-04-15
RU2647972C2 (ru) 2018-03-21
US20180078570A1 (en) 2018-03-22
JP6025712B2 (ja) 2016-11-16
CA2799079C (en) 2019-01-15
US9278105B2 (en) 2016-03-08
US20250049820A1 (en) 2025-02-13
MX347919B (es) 2017-05-17
CA2799079A1 (en) 2011-11-17
US11944634B2 (en) 2024-04-02
HUE033161T2 (en) 2017-11-28
WO2011143503A3 (en) 2012-01-19
AU2011252919B2 (en) 2017-01-19
BR112012028524A2 (pt) 2016-07-19
EP2568987B1 (en) 2016-11-16
US12161656B2 (en) 2024-12-10
EP3135289A1 (en) 2017-03-01
JP6290298B2 (ja) 2018-03-07
JP2013529201A (ja) 2013-07-18
CN102970992A (zh) 2013-03-13
US9084802B2 (en) 2015-07-21
MX2012012993A (es) 2013-08-27
DK2568987T3 (en) 2017-02-20
US9744179B2 (en) 2017-08-29
AU2011252919A2 (en) 2012-12-06
BR112012028524B1 (pt) 2022-03-15
ES2613738T3 (es) 2017-05-25
JP2016145253A (ja) 2016-08-12
US20150094282A1 (en) 2015-04-02
PT2568987T (pt) 2017-02-03
EP2568987A2 (en) 2013-03-20
IL222896A (en) 2017-03-30
IL222896A0 (en) 2012-12-31
EP3135289B1 (en) 2018-12-12
AU2011252919A1 (en) 2012-12-06
KR20130080797A (ko) 2013-07-15
WO2011143503A2 (en) 2011-11-17
SG185513A1 (en) 2012-12-28
US20130040918A1 (en) 2013-02-14
CN102970992B (zh) 2016-07-06
US20200000828A1 (en) 2020-01-02
PL2568987T3 (pl) 2017-06-30

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