GB948090A - Improvements in or relating to tetracycline complexes - Google Patents
Improvements in or relating to tetracycline complexesInfo
- Publication number
- GB948090A GB948090A GB13299/61A GB1329961A GB948090A GB 948090 A GB948090 A GB 948090A GB 13299/61 A GB13299/61 A GB 13299/61A GB 1329961 A GB1329961 A GB 1329961A GB 948090 A GB948090 A GB 948090A
- Authority
- GB
- United Kingdom
- Prior art keywords
- aluminium
- cation
- calcium
- antibiotic
- magnesium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The invention relates to complexes of 6-demethyl tetracycline or 7-chloro- -6-demethyl tetracycline, aluminium, a cation selected from the cations of hydrogen, calcium and magnesium, and gluconic acid in the molar ratio of antibiotic to aluminium to cation to acid of not less than 1:1:1:1 and not greater than 1:6:9:28 save that when the cation is hydrogen the ratio of antibiotic to cation may be 1:28. These complexes are prepared by reacting the antibiotic or a salt thereof, an aluminium compound which furnishes aluminium ions in aqueous solution, gluconic acid or glucono-delta-lactone and, when the cation is not hydrogen, a calcium or magnesium compound which furnishes calcium or magnesium ions in aqueous solution so as to form said complex. Specified antibiotic salts are the hydrochloride, hydrobromide, nitrate, sulphate or an alkali or alkaline earth metal salt. The aluminium may be added as the ethoxide, isopropoxide, citrate, nitrate, lactrate, formate, chloride, sulphate or as potassium aluminium sulphate. The complex forming cations of calcium and magnesium may be added in the form of their oxides, hydroxides or water soluble salts. The complexes may be administered parenterally in aqueous solution.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2376360A | 1960-04-21 | 1960-04-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB948090A true GB948090A (en) | 1964-01-29 |
Family
ID=21817061
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB13299/61A Expired GB948090A (en) | 1960-04-21 | 1961-04-13 | Improvements in or relating to tetracycline complexes |
Country Status (3)
| Country | Link |
|---|---|
| BE (1) | BE602878A (en) |
| FR (1) | FR1077M (en) |
| GB (1) | GB948090A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9084802B2 (en) | 2010-05-12 | 2015-07-21 | Rempex Pharmaceuticals, Inc. | Tetracycline compositions |
-
1961
- 1961-04-13 GB GB13299/61A patent/GB948090A/en not_active Expired
- 1961-04-18 FR FR859028A patent/FR1077M/en active Active
- 1961-04-21 BE BE602878A patent/BE602878A/en unknown
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9084802B2 (en) | 2010-05-12 | 2015-07-21 | Rempex Pharmaceuticals, Inc. | Tetracycline compositions |
| US9278105B2 (en) | 2010-05-12 | 2016-03-08 | Rempex Pharmaceuticals, Inc. | Tetracycline compositions |
| US9744179B2 (en) | 2010-05-12 | 2017-08-29 | Rempex Pharmaceuticals, Inc. | Tetracycline compositions |
| US11944634B2 (en) | 2010-05-12 | 2024-04-02 | Melinta Subsidiary Corp. | Tetracycline compositions |
Also Published As
| Publication number | Publication date |
|---|---|
| FR1077M (en) | 1962-01-22 |
| BE602878A (en) | 1961-10-23 |
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