GB914451A - Chelate complexes of ª--hydroxy acids with magnesium and other metals - Google Patents

Chelate complexes of ª--hydroxy acids with magnesium and other metals

Info

Publication number
GB914451A
GB914451A GB27330/59A GB2733059A GB914451A GB 914451 A GB914451 A GB 914451A GB 27330/59 A GB27330/59 A GB 27330/59A GB 2733059 A GB2733059 A GB 2733059A GB 914451 A GB914451 A GB 914451A
Authority
GB
United Kingdom
Prior art keywords
metal
precipitate
hydroxy acid
magnesium
iron
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB27330/59A
Inventor
Frederick Grossmith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Research Laboratories Ltd
Original Assignee
Beecham Research Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to NL254744D priority Critical patent/NL254744A/xx
Application filed by Beecham Research Laboratories Ltd filed Critical Beecham Research Laboratories Ltd
Priority to GB27330/59A priority patent/GB914451A/en
Priority to DEP1270A priority patent/DE1270540B/en
Priority to FR835371A priority patent/FR159M/en
Publication of GB914451A publication Critical patent/GB914451A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
    • C07C65/03—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups monocyclic and having all hydroxy or O-metal groups bound to the ring
    • C07C65/05—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups monocyclic and having all hydroxy or O-metal groups bound to the ring o-Hydroxy carboxylic acids
    • C07C65/10—Salicylic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/41—Preparation of salts of carboxylic acids
    • C07C51/418—Preparation of metal complexes containing carboxylic acid moieties
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/01—Saturated compounds having only one carboxyl group and containing hydroxy or O-metal groups
    • C07C59/06—Glycolic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/01—Saturated compounds having only one carboxyl group and containing hydroxy or O-metal groups
    • C07C59/08—Lactic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/01—Saturated compounds having only one carboxyl group and containing hydroxy or O-metal groups
    • C07C59/10—Polyhydroxy carboxylic acids
    • C07C59/105—Polyhydroxy carboxylic acids having five or more carbon atoms, e.g. aldonic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
    • C07C59/255—Tartaric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/02—Iron compounds
    • C07F15/025—Iron compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/06—Aluminium compounds
    • C07F5/069—Aluminium compounds without C-aluminium linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Compounds Of Alkaline-Earth Elements, Aluminum Or Rare-Earth Metals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises complexes of the general formula: Mx[M12(OH)yAz] where M is magnesium, aluminium, iron, sodium, potassium or the ammonium radical, M1 is magnesium, aluminium or iron, A is an a -hydroxy acid ion in chelated form, x is an integer from 1 to 5, y is zero or an integer from 1 to 8 and z is an integer from 1 to 4 and the preparation thereof either by dissolving the stoichiometric amounts of chlorides or sulphates of the metal or metals represented by M and M1 and the a -hydroxy acid or a salt thereof in water and slowly adding thereto the stoichiometric amount of an alkali metal hydroxide, e.g. sodium hydroxide, or by precipitating the hydroxides or carbonates of the metal or metals represented by M and M1, washing the precipitate free from the soluble salts and dissolving the precipitate in the stoichiometric amount of the a -hydroxy acid. Alternatively, in the latter process, one or more of the metal hydroxides or carbonates may be replaced by the corresponding oxide or a co-precipitate of the metal salts is formed with sodium hydroxide or sodium carbonate with the optional inclusion of ammonium hydroxide or ammonium chloride, and the co-precipitate dissolved in the a -hydroxy acid. The metal carbonates may be dissolved in the a -hydroxy acid under pressure of the carbon dioxide generated in the reaction as in the case of the formation of magnesium or magnesium-iron chelates or in the case of ironII precipitates the reaction is carried out in an inert atmosphere to avoid oxidation. Compounds of the invention wherein M is iron are also prepared by forming the alkali metal hydroxoferrate, adding thereto a solution of the salt of the cation metal to precipitate the required ferrate and thereafter dissolving the precipitate in the a -hydroxy acid. a -Hydroxy acids which may be used include citric, tartaric, lactic, glycolic, gluconic and salicylic acids. Specification 905,427 is referred to.
GB27330/59A 1959-08-10 1959-08-10 Chelate complexes of ª--hydroxy acids with magnesium and other metals Expired GB914451A (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
NL254744D NL254744A (en) 1959-08-10
GB27330/59A GB914451A (en) 1959-08-10 1959-08-10 Chelate complexes of ª--hydroxy acids with magnesium and other metals
DEP1270A DE1270540B (en) 1959-08-10 1960-08-08 Process for the preparation of water-soluble complex compounds of aliphatic oxycarboxylic acids
FR835371A FR159M (en) 1959-08-10 1960-08-09 Pharmaceutical composition consisting of a chelated complex of alpha-hydroxy acids with magnesium.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB27330/59A GB914451A (en) 1959-08-10 1959-08-10 Chelate complexes of ª--hydroxy acids with magnesium and other metals

Publications (1)

Publication Number Publication Date
GB914451A true GB914451A (en) 1963-01-02

Family

ID=10257819

Family Applications (1)

Application Number Title Priority Date Filing Date
GB27330/59A Expired GB914451A (en) 1959-08-10 1959-08-10 Chelate complexes of ª--hydroxy acids with magnesium and other metals

Country Status (4)

Country Link
DE (1) DE1270540B (en)
FR (1) FR159M (en)
GB (1) GB914451A (en)
NL (1) NL254744A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0380829A1 (en) * 1988-01-05 1990-08-08 Mission Pharmacal Company, Inc. Magnesium potassium citrate
JP2006036699A (en) * 2004-07-28 2006-02-09 Komatsuya Kagaku Kk alpha-HYDROXYCARBOXYLIC ACID ALUMINUM SALT, ITS COMPLEX SALT AND METHOD FOR PRODUCING THE SAME
JP2006036698A (en) * 2004-07-28 2006-02-09 Komatsuya Kagaku Kk Citric acid aluminum salt and complex salt, and method for producing the same

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE335475C (en) * 1919-11-28 1921-04-02 K A Hofmann Dr Process for the preparation of iron-alkali lactates
DE825402C (en) * 1948-12-18 1951-12-17 Rhein Chemie G M B H Process for the production of highly basic carboxylic or sulphonic acid salts
DE857363C (en) * 1949-09-13 1952-11-27 Johann G W Opfermann & Sohn Process for the production of ferrocalcium citrate
DE874305C (en) * 1950-11-22 1953-04-23 Johann G W Opfermann & Sohn Process for the production of ferrocalcium citrate
DE869486C (en) * 1950-11-22 1953-03-05 Johann G W Opfermann & Sohn Process for the production of ferrocalcium citrate
GB827521A (en) * 1957-03-27 1960-02-03 Director Of Technical Services New organic copper compounds and solutions and mixtures containing the same, and processes for the preparation of such compounds
GB827523A (en) * 1957-03-27 1960-02-03 Director Of Technical Services New organic copper compounds and solutions and mixtures containing the same, and processes for the preparation of such compounds

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0380829A1 (en) * 1988-01-05 1990-08-08 Mission Pharmacal Company, Inc. Magnesium potassium citrate
JP2006036699A (en) * 2004-07-28 2006-02-09 Komatsuya Kagaku Kk alpha-HYDROXYCARBOXYLIC ACID ALUMINUM SALT, ITS COMPLEX SALT AND METHOD FOR PRODUCING THE SAME
JP2006036698A (en) * 2004-07-28 2006-02-09 Komatsuya Kagaku Kk Citric acid aluminum salt and complex salt, and method for producing the same

Also Published As

Publication number Publication date
FR159M (en) 1961-02-13
NL254744A (en)
DE1270540B (en) 1968-06-20

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