DE335475C - Process for the preparation of iron-alkali lactates - Google Patents
Process for the preparation of iron-alkali lactatesInfo
- Publication number
- DE335475C DE335475C DE1919335475D DE335475DD DE335475C DE 335475 C DE335475 C DE 335475C DE 1919335475 D DE1919335475 D DE 1919335475D DE 335475D D DE335475D D DE 335475DD DE 335475 C DE335475 C DE 335475C
- Authority
- DE
- Germany
- Prior art keywords
- iron
- preparation
- alkali
- lactic acid
- lactates
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000002360 preparation method Methods 0.000 title claims description 5
- 239000003513 alkali Substances 0.000 title claims description 4
- 150000003893 lactate salts Chemical class 0.000 title claims description 3
- 238000000034 method Methods 0.000 title claims description 3
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 14
- 239000004310 lactic acid Substances 0.000 claims description 7
- 235000014655 lactic acid Nutrition 0.000 claims description 7
- 230000002378 acidificating effect Effects 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 claims description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N iron Substances [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 239000000203 mixture Substances 0.000 description 4
- 229910052742 iron Inorganic materials 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- CYDQOEWLBCCFJZ-UHFFFAOYSA-N 4-(4-fluorophenyl)oxane-4-carboxylic acid Chemical compound C=1C=C(F)C=CC=1C1(C(=O)O)CCOCC1 CYDQOEWLBCCFJZ-UHFFFAOYSA-N 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 238000000855 fermentation Methods 0.000 description 2
- 230000004151 fermentation Effects 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000001540 sodium lactate Substances 0.000 description 2
- 229940005581 sodium lactate Drugs 0.000 description 2
- 235000011088 sodium lactate Nutrition 0.000 description 2
- VPKDTEBBNJPGBH-UHFFFAOYSA-L 2-hydroxypropanoate;iron(2+);trihydrate Chemical compound O.O.O.[Fe+2].CC(O)C([O-])=O.CC(O)C([O-])=O VPKDTEBBNJPGBH-UHFFFAOYSA-L 0.000 description 1
- YNVZDODIHZTHOZ-UHFFFAOYSA-K 2-hydroxypropanoate;iron(3+) Chemical compound [Fe+3].CC(O)C([O-])=O.CC(O)C([O-])=O.CC(O)C([O-])=O YNVZDODIHZTHOZ-UHFFFAOYSA-K 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 206010021703 Indifference Diseases 0.000 description 1
- 229910021578 Iron(III) chloride Inorganic materials 0.000 description 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 1
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 1
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 238000007792 addition Methods 0.000 description 1
- FRHBOQMZUOWXQL-UHFFFAOYSA-L ammonium ferric citrate Chemical compound [NH4+].[Fe+3].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O FRHBOQMZUOWXQL-UHFFFAOYSA-L 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O ammonium group Chemical group [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229910052792 caesium Inorganic materials 0.000 description 1
- 238000010411 cooking Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000004043 dyeing Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 229960004642 ferric ammonium citrate Drugs 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 235000000011 iron ammonium citrate Nutrition 0.000 description 1
- 239000004313 iron ammonium citrate Substances 0.000 description 1
- RBTARNINKXHZNM-UHFFFAOYSA-K iron trichloride Chemical compound Cl[Fe](Cl)Cl RBTARNINKXHZNM-UHFFFAOYSA-K 0.000 description 1
- 229940001447 lactate Drugs 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229910052744 lithium Inorganic materials 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000000276 potassium ferrocyanide Substances 0.000 description 1
- GCAKFSUPQDLXIL-UHFFFAOYSA-N potassium rhodium Chemical compound [K].[Rh] GCAKFSUPQDLXIL-UHFFFAOYSA-N 0.000 description 1
- 229910052701 rubidium Inorganic materials 0.000 description 1
- 238000010025 steaming Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000009967 tasteless effect Effects 0.000 description 1
- XOGGUFAVLNCTRS-UHFFFAOYSA-N tetrapotassium;iron(2+);hexacyanide Chemical compound [K+].[K+].[K+].[K+].[Fe+2].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-] XOGGUFAVLNCTRS-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/02—Iron compounds
- C07F15/025—Iron compounds without a metal-carbon linkage
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
Verfahren zur Darstellung von Eisen-Alkalilaktaten. Bekanntlich dient in der Medizin als Ferrumlacticum das Ferrolaktat (C3 H5 03) 2 Fe -f- 3 H2 O ein Eisenpräparat in Form eines blaßgelben Kristallpulvers. Dagegen ist Ferri laktat bisher nur als braune amorphe zerfließliehe und durch Wasser zersetztliche Substanz von schwankender Zusammensetzung erhalten worden (s: Handwörterbuch der Chemie 4, 1886, S.453).Process for the preparation of iron-alkali lactates. As is well known, serves in medicine, ferrolactate (C3 H5 03) 2 Fe -f- 3 H2 O is used as Ferrumlacticum Iron preparation in the form of a pale yellow crystal powder. In contrast, Ferri is lactate hitherto only as a brown, amorphous substance that dissolves and is decomposed by water of fluctuating composition (see: Manual dictionary of chemistry 4, 1886, p.453).
Es wurde gefunden, daß die Milchsäure mit Eisenoxyd und Alkalien zusammen charakteristische, schwer lösliche, kristalline Verbindungen liefert von der allgemeinen Zusammensetzung Fe (C3 H4 O$) 2 M, + n H20, wo Me bedeutet: Li, Na, K, Rb, Cs bzw. NH4 und andere Ammoniumgruppen.It has been found that lactic acid is associated with iron oxide and alkalis characteristic, poorly soluble, crystalline compounds provides from the general Composition Fe (C3 H4 O $) 2 M, + n H20, where Me means: Li, Na, K, Rb, Cs resp. NH4 and other ammonium groups.
Besonders schwer löslich und beständig ist das entsprechende Natriumferrüaktat Fe (C3 H4 03) 2 Na - 2 H2 O, das ein blaßgrünes, feinkristallines Pulver bildet. Vor dem Ferrolaktat bietet das neue Präparat in medizinischer Hinsicht den Vorteil, daß es geschmacklos ist und neutral reagiert. Die Schwerlöslichkeit gestattet die Abscheidung der Milchsäure in dieser Form auch aus komplizierten Gärungsgemischen wie z. B. aus Glyzerinpech. In der Cyanotypie kann das Salz an Stelle von Ferriammoncitrat dienen, desgleichen in der Gerberei und Färberei als eine in der Wärme und beim Dämpfen entwickelbare Eisenbeize. Darstellung: Die Bildung dieses komplexen Ferrinatriumlaktates findet beim Eindampfen schwachsaurer Gemische statt, wenn man z. B. Eisenchlorid entsprechend 3o Teilen Eisen mit iio Teilen Milchsäure, =2o Teilen wasserfreie Soda unter Umrühren in etwa i ooo Teilen Wasser vermischt, allenfalls durch Milchsäure schwach ansäuert und auf dem Wasserbad fast zur Trockne einengt. Das abgeschiedene grünlichweiße Kristallpulver wird mit Wasser verrührt, abgesaugt und gewaschen. Die Ausbeute an lufttrockenem Salz beträgt 16o bis =7o Teile. An Stelle der reinen Milchsäure kann man auch milchsäurehaltige Gährungsrückstände in entsprechendem Mengenverhältnis verwenden, wobei die Trennung von den anderen Salzen oder Beimengungen keine Schwierigkeiten bietet, weil dieses Ferrinatriumlaktat in Wasser von gewöhnlicher Temperatur praktisch unlöslich ist. Auch schwache verdünnte Säuren sowie schwache Alkalien, wie z. B. Natriumbikarbonat, wirken nur sehr langsam ein. Beim Kochen mit Wasser erfolgt nur allmähliche Hydrolyse.The corresponding sodium ferric lactate is particularly sparingly soluble and stable Fe (C3 H4 03) 2 Na - 2 H2 O, which forms a pale green, finely crystalline powder. Before ferrolactate, the new preparation has the medical advantage of that it is tasteless and reacts neutrally. The poor solubility allows Lactic acid is separated in this form even from complicated fermentation mixtures such as B. from glycerine pitch. In the cyanotype, the salt can be used in place of ferric ammonium citrate serve, likewise in tannery and dyeing, as one in warmth and at Steaming developable iron stain. Presentation: The formation of this complex ferric sodium lactate takes place in the evaporation of weakly acidic mixtures, if you z. B. ferric chloride corresponding to 30 parts of iron with 10 parts of lactic acid, = 20 parts of anhydrous soda mixed with stirring in about 1,000 parts of water, if necessary with lactic acid weakly acidified and concentrated almost to dryness on the water bath. The secluded Greenish white crystal powder is stirred with water, filtered off with suction and washed. The yield of air-dry salt is 16o to 7o parts. Instead of the pure Lactic acid can also contain lactic acid-containing fermentation residues in the same way Use quantitative ratio, separating it from the other salts or additions does not present any difficulties because this ferric sodium lactate is more common in water Temperature is practically insoluble. Also weak diluted acids as well as weak ones Alkalis, such as B. sodium bicarbonate, act very slowly. While cooking hydrolysis is gradual with water.
Der komplexe Charakter der neuen Verbindung folgt aus der Indifferenz gegen Ferrocyankalium und Rhodankalium in neutraler Flüssigkeit.The complex character of the new connection follows from the indifference against potassium ferrocyanide and potassium rhodium in neutral liquid.
Claims (1)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE335475T | 1919-11-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE335475C true DE335475C (en) | 1921-04-02 |
Family
ID=6219326
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE1919335475D Expired DE335475C (en) | 1919-11-28 | 1919-11-28 | Process for the preparation of iron-alkali lactates |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE335475C (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2503781A (en) * | 1946-04-09 | 1950-04-11 | Reed & Carnrick | Organic iron alkali metal complexes |
| DE1270540B (en) * | 1959-08-10 | 1968-06-20 | Beecham Group Ltd | Process for the preparation of water-soluble complex compounds of aliphatic oxycarboxylic acids |
-
1919
- 1919-11-28 DE DE1919335475D patent/DE335475C/en not_active Expired
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2503781A (en) * | 1946-04-09 | 1950-04-11 | Reed & Carnrick | Organic iron alkali metal complexes |
| DE1270540B (en) * | 1959-08-10 | 1968-06-20 | Beecham Group Ltd | Process for the preparation of water-soluble complex compounds of aliphatic oxycarboxylic acids |
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