DE869486C - Process for the production of ferrocalcium citrate - Google Patents
Process for the production of ferrocalcium citrateInfo
- Publication number
- DE869486C DE869486C DEO1297A DEO0001297A DE869486C DE 869486 C DE869486 C DE 869486C DE O1297 A DEO1297 A DE O1297A DE O0001297 A DEO0001297 A DE O0001297A DE 869486 C DE869486 C DE 869486C
- Authority
- DE
- Germany
- Prior art keywords
- citrate
- ferrocalcium
- production
- calcium
- citric acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/41—Preparation of salts of carboxylic acids
- C07C51/418—Preparation of metal complexes containing carboxylic acid moieties
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
Verfahren zur Herstellung von Ferrocalciumcitrat In der Patentschrift 857 363 ist ein Verfahren zur Herstellung eines für therapeutische Zwecke bestimmten Ferrocalciumcitrats der Formel Ca Fe. (C, H;, 0-,), durch Umsetzung von vorzugsweise stöchiometrischen Mengen Citronensäure, Ferrum reductum, Calciumcarbonat oder Calciumcitrat in Anwesenheit eines Schutzgases und Abtreibung des Wassers nach erfolgter Umsetzung vorzugsweise ebenfalls in Gegenwart eines Schutzgases beschrieben.Process for the preparation of ferrocalcium citrate In the patent specification 857 363 there is a process for the preparation of a ferrocalcium citrate of the formula Ca Fe intended for therapeutic purposes. (C, H ;, 0-,), by reacting preferably stoichiometric amounts of citric acid, Ferrum reductum, calcium carbonate or calcium citrate in the presence of a protective gas and aborting the water after the reaction, preferably also in the presence of a protective gas.
Es wurde nun gefunden, daß man das gleiche Diferromonocalciumcitrat auch durch Umsetzung von Citronensäure und Calciumcarbonat oder Calciumcitrat mit Ferrohydroxyd oder Ferrosalzen flüchtiger Säuren, insbesondere Ferrocarbonat, herstellen kann. Als weitere geeignete Eisensalze kommen Ferroformiat, -acetat und -lactat in Frage. Diese Eisenverbindungen sind im allgemeinen leichter herstellbar als das Ferrum reductum, außerdem verläuft die Reaktion sehr viel leichter und schneller.It has now been found that one can use the same Diferromonocalciumcitrat also by reacting citric acid and calcium carbonate or calcium citrate with Ferrohydroxyd or ferrous salts of volatile acids, especially ferrocarbonate, produce can. Other suitable iron salts are ferroformate, acetate and lactate in question. These iron compounds are generally easier to make than that Ferrum reductum, in addition, the reaction is much easier and faster.
Beispiel Eine Lösung von 2 Mol Citronensäure in destilliertem Wasser
wird nach Vertreiben der gelösten Luft durch Auskochen und Durchleiten von Stickstoff
mit 2 Mol Eisenhydroxyd versetzt. Hierauf wird i Mol Cälciumcarbonat zugesetzt,
wobei unter Kohlensäureentwicklung das Calciumferrocitrat gebildet wird.
Während
beider-Umsetzungen- wird weiterhin- Stickstoff durchgeleitet. Hierauf- wird das
Wasser durch. Erhitzen bis auf 2oo° unter weiterem Durchleiten des Schutzgases abgetrieben.
-Die--Analyse-des erhaltenen gelblichen Kristallpulvers ergäb` fölgeride Daten
Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DEO1297A DE869486C (en) | 1950-11-22 | 1950-11-22 | Process for the production of ferrocalcium citrate |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DEO1297A DE869486C (en) | 1950-11-22 | 1950-11-22 | Process for the production of ferrocalcium citrate |
Publications (1)
Publication Number | Publication Date |
---|---|
DE869486C true DE869486C (en) | 1953-03-05 |
Family
ID=7349495
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DEO1297A Expired DE869486C (en) | 1950-11-22 | 1950-11-22 | Process for the production of ferrocalcium citrate |
Country Status (1)
Country | Link |
---|---|
DE (1) | DE869486C (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1270540B (en) * | 1959-08-10 | 1968-06-20 | Beecham Group Ltd | Process for the preparation of water-soluble complex compounds of aliphatic oxycarboxylic acids |
-
1950
- 1950-11-22 DE DEO1297A patent/DE869486C/en not_active Expired
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1270540B (en) * | 1959-08-10 | 1968-06-20 | Beecham Group Ltd | Process for the preparation of water-soluble complex compounds of aliphatic oxycarboxylic acids |
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