JP2013525335A5 - - Google Patents

Info

Publication number

JP2013525335A5

JP2013525335A5 JP2013505489A JP2013505489A JP2013525335A5 JP 2013525335 A5 JP2013525335 A5 JP 2013525335A5 JP 2013505489 A JP2013505489 A JP 2013505489A JP 2013505489 A JP2013505489 A JP 2013505489A JP 2013525335 A5 JP2013525335 A5 JP 2013525335A5

Authority

JP

Japan

Prior art keywords

emulsion

emulsion according

phospholipid

polymer

cellulose

Prior art date

2011-04-21

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 239000000839 emulsion Substances 0.000 claims 21
• 150000003904 phospholipids Chemical class 0.000 claims 9
• 229920000642 polymer Polymers 0.000 claims 8
• 150000002632 lipids Chemical class 0.000 claims 4
• 238000000034 method Methods 0.000 claims 3
• 230000000087 stabilizing effect Effects 0.000 claims 3
• 239000008346 aqueous phase Substances 0.000 claims 2
• 239000001913 cellulose Substances 0.000 claims 2
• 229920002678 cellulose Polymers 0.000 claims 2
• 239000000203 mixture Substances 0.000 claims 2
• 239000007764 o/w emulsion Substances 0.000 claims 2
• 230000003204 osmotic effect Effects 0.000 claims 2
• 230000002265 prevention Effects 0.000 claims 2
• KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 1
• LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical group CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 claims 1
• IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims 1
• 229920002134 Carboxymethyl cellulose Polymers 0.000 claims 1
• 208000003556 Dry Eye Syndromes Diseases 0.000 claims 1
• 206010013774 Dry eye Diseases 0.000 claims 1
• 239000001856 Ethyl cellulose Substances 0.000 claims 1
• ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims 1
• 229920002683 Glycosaminoglycan Polymers 0.000 claims 1
• 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 1
• 206010020751 Hypersensitivity Diseases 0.000 claims 1
• 206010061218 Inflammation Diseases 0.000 claims 1
• 239000002253 acid Substances 0.000 claims 1
• 239000013543 active substance Substances 0.000 claims 1
• 230000007815 allergy Effects 0.000 claims 1
• 239000001768 carboxy methyl cellulose Substances 0.000 claims 1
• 235000010948 carboxy methyl cellulose Nutrition 0.000 claims 1
• 239000008112 carboxymethyl-cellulose Substances 0.000 claims 1
• 235000019325 ethyl cellulose Nutrition 0.000 claims 1
• 229920001249 ethyl cellulose Polymers 0.000 claims 1
• 208000030533 eye disease Diseases 0.000 claims 1
• 125000005456 glyceride group Chemical group 0.000 claims 1
• 229920002674 hyaluronan Polymers 0.000 claims 1
• 229960003160 hyaluronic acid Drugs 0.000 claims 1
• 239000001863 hydroxypropyl cellulose Substances 0.000 claims 1
• 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 1
• 230000004054 inflammatory process Effects 0.000 claims 1
• 235000010445 lecithin Nutrition 0.000 claims 1
• 239000000787 lecithin Substances 0.000 claims 1
• 229940067606 lecithin Drugs 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 229920000609 methyl cellulose Polymers 0.000 claims 1
• 239000001923 methylcellulose Substances 0.000 claims 1
• 235000010981 methylcellulose Nutrition 0.000 claims 1
• 239000012071 phase Substances 0.000 claims 1
• 150000003010 phosphonosphingolipids Chemical class 0.000 claims 1
• 150000003019 phosphosphingolipids Chemical class 0.000 claims 1
• 229920000136 polysorbate Polymers 0.000 claims 1
• 229940068965 polysorbates Drugs 0.000 claims 1
• 229920002451 polyvinyl alcohol Polymers 0.000 claims 1
• 239000003755 preservative agent Substances 0.000 claims 1
• 230000002335 preservative effect Effects 0.000 claims 1
• 230000001954 sterilising effect Effects 0.000 claims 1
• 239000004094 surface-active agent Substances 0.000 claims 1
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1