JP2013517281A - 化合物及び方法 - Google Patents

化合物及び方法 Download PDF

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Publication number
JP2013517281A
JP2013517281A JP2012549068A JP2012549068A JP2013517281A JP 2013517281 A JP2013517281 A JP 2013517281A JP 2012549068 A JP2012549068 A JP 2012549068A JP 2012549068 A JP2012549068 A JP 2012549068A JP 2013517281 A JP2013517281 A JP 2013517281A
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Japan
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alkyl
phenyl
membered heteroaryl
alkoxy
optionally substituted
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Japanese (ja)
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JP2013517281A5 (enExample
Inventor
エルカン、バログル
ショミール、ゴーシュ
メルセデス、ロベラ
ダービー、シュミット
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Tempero Pharmaceuticals Inc
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Tempero Pharmaceuticals Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P11/06—Antiasthmatics
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    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
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    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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    • C07D495/04—Ortho-condensed systems

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  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Neurology (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
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  • Obesity (AREA)
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JP2012549068A 2010-01-13 2011-01-13 化合物及び方法 Ceased JP2013517281A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US29462610P 2010-01-13 2010-01-13
US61/294,626 2010-01-13
PCT/US2011/021104 WO2011088192A1 (en) 2010-01-13 2011-01-13 Compounds and methods

Publications (2)

Publication Number Publication Date
JP2013517281A true JP2013517281A (ja) 2013-05-16
JP2013517281A5 JP2013517281A5 (enExample) 2014-02-27

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US (1) US8981084B2 (enExample)
EP (1) EP2523664A4 (enExample)
JP (1) JP2013517281A (enExample)
WO (1) WO2011088192A1 (enExample)

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014520794A (ja) * 2011-07-08 2014-08-25 ノバルティス アーゲー 新規トリフルオロメチル−オキサジアゾール誘導体および疾患の治療におけるその使用
JP2016534124A (ja) * 2013-08-29 2016-11-04 ベイラー カレッジ オブ メディスンＢａｙｌｏｒ Ｃｏｌｌｅｇｅ Ｏｆ Ｍｅｄｉｃｉｎｅ 代謝並びに体重関連疾患の処置のための組成物および方法
WO2017014170A1 (ja) * 2015-07-17 2017-01-26 武田薬品工業株式会社 複素環化合物
WO2017033946A1 (ja) * 2015-08-25 2017-03-02 武田薬品工業株式会社 複素環化合物
JP2017507976A (ja) * 2014-03-12 2017-03-23 チョン クン ダン ファーマシューティカル コーポレーション ヒストン脱アセチル化酵素６阻害剤としての新規化合物およびこれを含む薬剤学的組成物
JPWO2016031815A1 (ja) * 2014-08-26 2017-06-15 武田薬品工業株式会社 複素環化合物
JP2018515492A (ja) * 2015-05-07 2018-06-14 シーエイチディーアイ ファウンデーション，インコーポレーテッド ヒストンデアセチラーゼ阻害薬及び組成物並びにそれらの使用の方法
JP2018521092A (ja) * 2015-07-27 2018-08-02 チョン クン ダン ファーマシューティカル コーポレーション ヒストン脱アセチル化酵素６阻害剤としての１，３，４−オキサジアゾールスルファミド誘導体化合物及びこれを含有する薬剤学的組成物（１，３，４−Ｏｘａｄｉａｚｏｌｅ Ｓｕｌｆａｍｉｄｅ Ｄｅｒｉｖａｔｉｖｅ Ｃｏｍｐｏｕｎｄｓ ａｓ Ｈｉｓｔｏｎｅ Ｄｅａｃｅｔｙｌａｓｅ ６ Ｉｎｈｉｂｉｔｏｒ， ａｎｄ ｔｈｅ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｃｏｍｐｏｓｉｔｉｏｎ Ｃｏｍｐｒｉｓｉｎｇ ｔｈｅ ｓａｍｅ）
US10308643B2 (en) 2015-07-17 2019-06-04 Takeda Pharmaceutical Company Limited Heterocyclic compound
US10435399B2 (en) 2017-07-31 2019-10-08 Takeda Pharmaceutical Company Limited HDAC6 inhibitory heterocyclic compound
US10494355B2 (en) 2015-10-12 2019-12-03 Chong Kun Dang Pharmaceutical Corp. Oxadiazole amine derivative compounds as histone deacetylase 6 inhibitor, and the pharmaceutical composition comprising the same
US10538498B2 (en) 2015-07-27 2020-01-21 Chong Kun Dang Pharmaceutical Corp. 1,3,4-oxadiazole sulfonamide derivative compounds as histone deacetylase 6 inhibitor, and the pharmaceutical composition comprising the same
WO2020032071A1 (ja) * 2018-08-08 2020-02-13 日本農薬株式会社 オキサジアゾリン化合物又はその塩類及び該化合物を含有する農園芸用殺菌剤並びにその使用方法
US10584117B2 (en) 2015-07-27 2020-03-10 Chong Kun Dang Pharmaceutical Corp. 1,3,4-oxadiazole amide derivative compound as histone deacetylase 6 inhibitor, and pharmaceutical composition containing same
US10717716B2 (en) 2015-08-04 2020-07-21 Chong Kun Dang Pharmaceutical Corp. 1,3,4-oxadiazole derivative compounds as histone deacetylase 6 inhibitor, and the pharmaceutical composition comprising the same
JP2021532130A (ja) * 2018-07-26 2021-11-25 チョン クン ダン ファーマシューティカル コーポレーション ヒストン脱アセチル化酵素６阻害剤としての１，３，４−オキサジアゾール誘導体化合物およびそれを含む薬剤学的組成物
US12440484B2 (en) 2019-05-31 2025-10-14 Chong Kun Dang Pharmaceutical Corporation 1,3,4-oxadiazole homophthalimide derivative compounds as histone deacetylase 6 inhibitor, and the pharmaceutical composition comprising the same

Families Citing this family (36)

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US8173666B2 (en) 2007-03-12 2012-05-08 Nektar Therapeutics Oligomer-opioid agonist conjugates
US10512644B2 (en) 2007-03-12 2019-12-24 Inheris Pharmaceuticals, Inc. Oligomer-opioid agonist conjugates
WO2011088181A1 (en) 2010-01-13 2011-07-21 Tempero Pharmaceuticals, Inc. Compounds and methods
WO2013066833A1 (en) * 2011-10-31 2013-05-10 Glaxosmithkline Llc Compounds and methods to inhibit histone deacetylase (hdac) enzymes
WO2013066839A2 (en) * 2011-10-31 2013-05-10 Glaxosmithkline Llc Compounds and methods
KR20140097459A (ko) 2011-11-28 2014-08-06 노파르티스 아게 신규 트리플루오로메틸-옥사디아졸 유도체 및 질환의 치료에서의 그의 용도
CN103360343B (zh) * 2012-03-30 2017-04-19 凯惠药业(上海)有限公司 一种哌嗪酰胺类化合物的制备方法
JO3407B1 (ar) 2012-05-31 2019-10-20 Eisai R&D Man Co Ltd مركبات رباعي هيدرو بيرازولو بيريميدين
CN103664930B (zh) * 2012-09-20 2016-02-10 天津药物研究院有限公司 一类含噻唑结构的化合物、其制备方法和用途
EP3626717A1 (en) 2013-10-14 2020-03-25 Eisai R&D Management Co., Ltd. Selectively substituted quinoline compounds
US9663486B2 (en) 2013-10-14 2017-05-30 Eisai R&D Management Co., Ltd. Selectively substituted quinoline compounds
SG11201608303QA (en) 2014-04-04 2016-11-29 Del Mar Pharmaceuticals Use of dianhydrogalactitol and analogs or derivatives thereof to treat non-small-cell carcinoma of the lung and ovarian cancer
EP3151669B1 (en) 2014-06-06 2020-10-28 Basf Se Use of substituted oxadiazoles for combating phytopathogenic fungi
CN104262218B (zh) * 2014-09-30 2016-08-24 江苏强盛功能化学股份有限公司 一种2-硫氰基苯乙酮衍生物的制备方法
WO2016164770A1 (en) 2015-04-10 2016-10-13 Bioresponse, L.L.C. Self-emulsifying formulations of dim-related indoles
US10501425B2 (en) 2015-10-02 2019-12-10 Syngenta Participations Ag Microbiocidal oxadiazole derivatives
EP3356358B1 (en) 2015-10-02 2020-05-06 Syngenta Participations AG Microbiocidal oxadiazole derivatives
AR106679A1 (es) 2015-11-13 2018-02-07 Basf Se Oxadiazoles sustituidos para combatir hongos fitopatógenos
WO2017081309A1 (en) 2015-11-13 2017-05-18 Basf Se Substituted oxadiazoles for combating phytopathogenic fungi
BR112018008449B1 (pt) 2015-11-19 2021-07-06 Basf Se Compostos de fórmula i, mistura, composição agroquímica e método para combater fungos nocivos fitopatogênicos
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