RS58024B1 - Biciklični heterociklični derivati kao irak4 inhibitori - Google Patents
Biciklični heterociklični derivati kao irak4 inhibitoriInfo
- Publication number
- RS58024B1 RS58024B1 RS20181355A RSP20181355A RS58024B1 RS 58024 B1 RS58024 B1 RS 58024B1 RS 20181355 A RS20181355 A RS 20181355A RS P20181355 A RSP20181355 A RS P20181355A RS 58024 B1 RS58024 B1 RS 58024B1
- Authority
- RS
- Serbia
- Prior art keywords
- bicyclic heterocyclyl
- irak4 inhibitors
- heterocyclyl derivatives
- derivatives
- irak4
- Prior art date
Links
- 229940127590 IRAK4 inhibitor Drugs 0.000 title 1
- 125000002618 bicyclic heterocycle group Chemical group 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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- C—CHEMISTRY; METALLURGY
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
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- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Ophthalmology & Optometry (AREA)
- Neurology (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Neurosurgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Reproductive Health (AREA)
- Otolaryngology (AREA)
- Epidemiology (AREA)
- Vascular Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Pregnancy & Childbirth (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN158CH2014 | 2014-01-13 | ||
IN3000CH2014 | 2014-06-20 | ||
PCT/IB2015/050217 WO2015104688A1 (en) | 2014-01-13 | 2015-01-12 | Bicyclic heterocyclyl derivatives as irak4 inhibitors |
EP15735499.4A EP3094329B1 (en) | 2014-01-13 | 2015-01-12 | Bicyclic heterocyclyl derivatives as irak4 inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
RS58024B1 true RS58024B1 (sr) | 2019-02-28 |
Family
ID=53523587
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RS20210039A RS61448B1 (sr) | 2014-01-13 | 2015-01-12 | Način pripreme derivata oksazolo [4,5-b] piridina i tiazolo [4,5-b] piridina kao irak4 inhibitora za lečenje raka |
RS20181355A RS58024B1 (sr) | 2014-01-13 | 2015-01-12 | Biciklični heterociklični derivati kao irak4 inhibitori |
RS20240415A RS65437B1 (sr) | 2014-01-13 | 2015-01-12 | (r) i (s) enantiomeri n-(5-(3-hidroksipirolidin-1-il)-2-morfolinooksazolo[4,5-b]piridin-6-il)-2-(2-metilpiridin-4-il)oksazol-karboksamida kao inhibitori irak4 za lečenje kancera |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RS20210039A RS61448B1 (sr) | 2014-01-13 | 2015-01-12 | Način pripreme derivata oksazolo [4,5-b] piridina i tiazolo [4,5-b] piridina kao irak4 inhibitora za lečenje raka |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RS20240415A RS65437B1 (sr) | 2014-01-13 | 2015-01-12 | (r) i (s) enantiomeri n-(5-(3-hidroksipirolidin-1-il)-2-morfolinooksazolo[4,5-b]piridin-6-il)-2-(2-metilpiridin-4-il)oksazol-karboksamida kao inhibitori irak4 za lečenje kancera |
Country Status (31)
Country | Link |
---|---|
US (6) | US9732095B2 (sr) |
EP (4) | EP4353324A3 (sr) |
JP (5) | JP6479850B2 (sr) |
KR (3) | KR102392684B1 (sr) |
CN (2) | CN106456619B (sr) |
AU (5) | AU2015205374B2 (sr) |
BR (1) | BR112016016158B1 (sr) |
CA (1) | CA2935887A1 (sr) |
CU (1) | CU24389B1 (sr) |
CY (2) | CY1121433T1 (sr) |
DK (3) | DK3466955T3 (sr) |
EA (2) | EA038748B1 (sr) |
ES (3) | ES2692852T3 (sr) |
FI (1) | FI3805233T3 (sr) |
HK (1) | HK1231410A1 (sr) |
HR (3) | HRP20240489T1 (sr) |
HU (2) | HUE052252T2 (sr) |
IL (6) | IL302878B1 (sr) |
LT (3) | LT3094329T (sr) |
MX (1) | MX359909B (sr) |
MY (1) | MY197116A (sr) |
NZ (2) | NZ760657A (sr) |
PH (2) | PH12016501344A1 (sr) |
PL (3) | PL3466955T3 (sr) |
PT (3) | PT3466955T (sr) |
RS (3) | RS61448B1 (sr) |
SG (2) | SG11201605486WA (sr) |
SI (2) | SI3466955T1 (sr) |
TR (1) | TR201815683T4 (sr) |
WO (1) | WO2015104688A1 (sr) |
ZA (2) | ZA202007273B (sr) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB201311891D0 (en) | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compound |
GB201311888D0 (en) | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
US10160753B2 (en) | 2014-01-10 | 2018-12-25 | Aurigene Discovery Technologies Limited | Indazole compounds as IRAK4 inhibitors |
PT3466955T (pt) * | 2014-01-13 | 2021-01-29 | Aurigene Discovery Tech Ltd | Método de preparação de derivados de oxazolo[4,5-b] piridina e tiazolo[4,5-b] piridina como inibidores de irak-4 para o tratamento do cancro |
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2021
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2023
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