SG10201811204RA - Bicyclic heterocyclyl derivatives as irak4 inhibitors - Google Patents

Bicyclic heterocyclyl derivatives as irak4 inhibitors

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Publication number
SG10201811204RA
SG10201811204RA SG10201811204RA SG10201811204RA SG10201811204RA SG 10201811204R A SG10201811204R A SG 10201811204RA SG 10201811204R A SG10201811204R A SG 10201811204RA SG 10201811204R A SG10201811204R A SG 10201811204RA SG 10201811204R A SG10201811204R A SG 10201811204RA
Authority
SG
Singapore
Prior art keywords
bicyclic heterocyclyl
inhibitors
irak4
irak4 inhibitors
diseases
Prior art date
Application number
SG10201811204RA
Inventor
Venkateshwar Gummadi
Susanta Samajdar
Original Assignee
Aurigene Discovery Tech Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aurigene Discovery Tech Ltd filed Critical Aurigene Discovery Tech Ltd
Publication of SG10201811204RA publication Critical patent/SG10201811204RA/en

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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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Abstract

BICYCLIC HETEROCYCLYL DERIVATIVES AS IRAK4 INHIBITORS The present invention provides bicyclic heterocyclyl kinase enzyme inhibitor compounds of formula (I), which are therapeutically useful as kinase inhibitors, particularly IRAK4 inhibitors. wherein A, Y, Z, X1, X2, X3, R1, R3, 'm', 'n' and 'p' have the meanings given in the specification and pharmaceutically acceptable salt or stereoisomer thereof that are useful in the treatment and prevention of diseases or disorder, in particular their use in diseases or disorder mediated by kinase enzyme, particularly IRAK4 enzyme. The present invention also provides pharmaceutical composition comprising at least one of the compounds of compound of formula (I) together with a pharmaceutically acceptable carrier, diluent or excipient therefor. FIGURE: NONE
SG10201811204RA 2014-01-13 2015-01-12 Bicyclic heterocyclyl derivatives as irak4 inhibitors SG10201811204RA (en)

Applications Claiming Priority (2)

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IN158CH2014 2014-01-13
IN3000CH2014 2014-06-20

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