MX359909B - Derivados de heterociclilo biciclicos como inhibores de cinasa-4 asociada al receptor de interleucina-1 (irak4). - Google Patents

Derivados de heterociclilo biciclicos como inhibores de cinasa-4 asociada al receptor de interleucina-1 (irak4).

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Publication number
MX359909B
MX359909B MX2016009013A MX2016009013A MX359909B MX 359909 B MX359909 B MX 359909B MX 2016009013 A MX2016009013 A MX 2016009013A MX 2016009013 A MX2016009013 A MX 2016009013A MX 359909 B MX359909 B MX 359909B
Authority
MX
Mexico
Prior art keywords
bicyclic heterocyclyl
inhibitors
irak4 inhibitors
diseases
pharmaceutically acceptable
Prior art date
Application number
MX2016009013A
Other languages
English (en)
Other versions
MX2016009013A (es
Inventor
Rao Gummadi Venkateshwar
Samajdar Susanta
Original Assignee
Aurigene Discovery Tech Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aurigene Discovery Tech Ltd filed Critical Aurigene Discovery Tech Ltd
Publication of MX2016009013A publication Critical patent/MX2016009013A/es
Publication of MX359909B publication Critical patent/MX359909B/es

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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Abstract

La presente invención se refiere a compuestos biciclicos inhibidores de enzimas heterociclil cinasa de la formula (I), los cuales son terapéuticamente útiles como inhibidores de cinasa, particularmente inhibidores de IRAK4, en donde A, Y, Z, X1, X2, X3, R1, R3, "m", "n", y "p" tienen los significados proporcionados en la especificación y una sal o estereoisómero farmacéuticamente aceptable de los mismos que son útiles en el tratamiento y prevención de enfermedades o trastornos, en particular su uso en enfermedades o trastornos mediados por una enzima cinasa, particularmente la enzima IRAK4. La presente invención también proporciona una composición farmacéutica que comprende por lo menos uno de los compuestos de la formula (I) junto con un portador, diluyente o excipiente farmacéuticamente aceptable para los mismos.
MX2016009013A 2014-01-13 2015-01-12 Derivados de heterociclilo biciclicos como inhibores de cinasa-4 asociada al receptor de interleucina-1 (irak4). MX359909B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN158CH2014 2014-01-13
IN3000CH2014 2014-06-20
PCT/IB2015/050217 WO2015104688A1 (en) 2014-01-13 2015-01-12 Bicyclic heterocyclyl derivatives as irak4 inhibitors

Publications (2)

Publication Number Publication Date
MX2016009013A MX2016009013A (es) 2017-01-23
MX359909B true MX359909B (es) 2018-10-16

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MX2016009013A MX359909B (es) 2014-01-13 2015-01-12 Derivados de heterociclilo biciclicos como inhibores de cinasa-4 asociada al receptor de interleucina-1 (irak4).

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Families Citing this family (42)

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Publication number Priority date Publication date Assignee Title
GB201311888D0 (en) 2013-07-03 2013-08-14 Glaxosmithkline Ip Dev Ltd Novel compounds
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