LT3094329T - Bicikliniai heterociklilo dariniai kaip irak4 inhibitoriai - Google Patents
Bicikliniai heterociklilo dariniai kaip irak4 inhibitoriaiInfo
- Publication number
- LT3094329T LT3094329T LTEP15735499.4T LT15735499T LT3094329T LT 3094329 T LT3094329 T LT 3094329T LT 15735499 T LT15735499 T LT 15735499T LT 3094329 T LT3094329 T LT 3094329T
- Authority
- LT
- Lithuania
- Prior art keywords
- bicyclic heterocyclyl
- irak4 inhibitors
- heterocyclyl derivatives
- derivatives
- irak4
- Prior art date
Links
- 229940127590 IRAK4 inhibitor Drugs 0.000 title 1
- 125000002618 bicyclic heterocycle group Chemical group 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Ophthalmology & Optometry (AREA)
- Neurology (AREA)
- Dermatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Obesity (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Endocrinology (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Reproductive Health (AREA)
- Otolaryngology (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Communicable Diseases (AREA)
- Vascular Medicine (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN158CH2014 | 2014-01-13 | ||
IN3000CH2014 | 2014-06-20 | ||
PCT/IB2015/050217 WO2015104688A1 (en) | 2014-01-13 | 2015-01-12 | Bicyclic heterocyclyl derivatives as irak4 inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
LT3094329T true LT3094329T (lt) | 2018-11-26 |
Family
ID=53523587
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
LTEP20211096.1T LT3805233T (lt) | 2014-01-13 | 2015-01-12 | N-(5-(3-hidroksipirolidin-1-il)-2-morfolinooksazolo[4,5-b]piridin-6-il)-2-(2- metilpiridin-4-il)oksazol-karboksamido (r) ir (s) enantiomerai, kaip irak4 inhibitoriai, skirti vėžio gydymui |
LTEP18190333.7T LT3466955T (lt) | 2014-01-13 | 2015-01-12 | Oksazol[4,5-b]piridino ir tiazol[4,5-b]piridino darinių, kaip irak4 inhibitorių, skirtų vėžio gydymui, gamybos būdas |
LTEP15735499.4T LT3094329T (lt) | 2014-01-13 | 2015-01-12 | Bicikliniai heterociklilo dariniai kaip irak4 inhibitoriai |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
LTEP20211096.1T LT3805233T (lt) | 2014-01-13 | 2015-01-12 | N-(5-(3-hidroksipirolidin-1-il)-2-morfolinooksazolo[4,5-b]piridin-6-il)-2-(2- metilpiridin-4-il)oksazol-karboksamido (r) ir (s) enantiomerai, kaip irak4 inhibitoriai, skirti vėžio gydymui |
LTEP18190333.7T LT3466955T (lt) | 2014-01-13 | 2015-01-12 | Oksazol[4,5-b]piridino ir tiazol[4,5-b]piridino darinių, kaip irak4 inhibitorių, skirtų vėžio gydymui, gamybos būdas |
Country Status (31)
Country | Link |
---|---|
US (7) | US9732095B2 (lt) |
EP (4) | EP3466955B1 (lt) |
JP (5) | JP6479850B2 (lt) |
KR (3) | KR102392684B1 (lt) |
CN (2) | CN106456619B (lt) |
AU (5) | AU2015205374B2 (lt) |
BR (1) | BR112016016158B1 (lt) |
CA (1) | CA2935887A1 (lt) |
CU (1) | CU24389B1 (lt) |
CY (2) | CY1121433T1 (lt) |
DK (3) | DK3805233T3 (lt) |
EA (2) | EA038748B1 (lt) |
ES (3) | ES2846678T3 (lt) |
FI (1) | FI3805233T3 (lt) |
HK (1) | HK1231410A1 (lt) |
HR (3) | HRP20240489T1 (lt) |
HU (3) | HUE066261T2 (lt) |
IL (6) | IL284952B (lt) |
LT (3) | LT3805233T (lt) |
MX (1) | MX359909B (lt) |
MY (1) | MY197116A (lt) |
NZ (2) | NZ722019A (lt) |
PH (2) | PH12016501344A1 (lt) |
PL (3) | PL3094329T3 (lt) |
PT (3) | PT3466955T (lt) |
RS (3) | RS61448B1 (lt) |
SG (2) | SG11201605486WA (lt) |
SI (3) | SI3805233T1 (lt) |
TR (1) | TR201815683T4 (lt) |
WO (1) | WO2015104688A1 (lt) |
ZA (2) | ZA202007274B (lt) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB201311891D0 (en) | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compound |
GB201311888D0 (en) | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
JP2017505337A (ja) | 2014-01-10 | 2017-02-16 | アウリジーン ディスカバリー テクノロジーズ リミテッド | Irak4阻害剤としてのインダゾール化合物 |
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