JP2013514337A - 甲状腺ホルモンおよびその塩の製造方法 - Google Patents
甲状腺ホルモンおよびその塩の製造方法 Download PDFInfo
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- 238000004519 manufacturing process Methods 0.000 title claims abstract description 9
- AUYYCJSJGJYCDS-LBPRGKRZSA-N Thyrolar Chemical class IC1=CC(C[C@H](N)C(O)=O)=CC(I)=C1OC1=CC=C(O)C(I)=C1 AUYYCJSJGJYCDS-LBPRGKRZSA-N 0.000 title claims description 7
- 150000003839 salts Chemical class 0.000 title description 3
- 239000005495 thyroid hormone Substances 0.000 title description 2
- 229940036555 thyroid hormone Drugs 0.000 title description 2
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical class [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 claims abstract description 19
- 150000001875 compounds Chemical class 0.000 claims abstract description 16
- 239000012336 iodinating agent Substances 0.000 claims abstract description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical group O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 37
- 238000000034 method Methods 0.000 claims description 35
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 24
- 239000000243 solution Substances 0.000 claims description 23
- 239000007864 aqueous solution Substances 0.000 claims description 19
- 239000002253 acid Substances 0.000 claims description 13
- QUSNBJAOOMFDIB-UHFFFAOYSA-N Ethylamine Chemical group CCN QUSNBJAOOMFDIB-UHFFFAOYSA-N 0.000 claims description 12
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical class [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 claims description 9
- 239000012670 alkaline solution Substances 0.000 claims description 9
- 150000007524 organic acids Chemical class 0.000 claims description 9
- 239000012153 distilled water Substances 0.000 claims description 7
- 239000007787 solid Substances 0.000 claims description 6
- 150000007522 mineralic acids Chemical class 0.000 claims description 5
- 238000001816 cooling Methods 0.000 claims description 4
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims description 3
- 238000010438 heat treatment Methods 0.000 claims description 2
- ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 claims 4
- HTSGKJQDMSTCGS-UHFFFAOYSA-N 1,4-bis(4-chlorophenyl)-2-(4-methylphenyl)sulfonylbutane-1,4-dione Chemical compound C1=CC(C)=CC=C1S(=O)(=O)C(C(=O)C=1C=CC(Cl)=CC=1)CC(=O)C1=CC=C(Cl)C=C1 HTSGKJQDMSTCGS-UHFFFAOYSA-N 0.000 claims 1
- FZZMTSNZRBFGGU-UHFFFAOYSA-N 2-chloro-7-fluoroquinazolin-4-amine Chemical compound FC1=CC=C2C(N)=NC(Cl)=NC2=C1 FZZMTSNZRBFGGU-UHFFFAOYSA-N 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- YDTFRJLNMPSCFM-YDALLXLXSA-M levothyroxine sodium anhydrous Chemical compound [Na+].IC1=CC(C[C@H](N)C([O-])=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 YDTFRJLNMPSCFM-YDALLXLXSA-M 0.000 abstract description 10
- XUIIKFGFIJCVMT-LBPRGKRZSA-N L-thyroxine Chemical class IC1=CC(C[C@H]([NH3+])C([O-])=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-LBPRGKRZSA-N 0.000 abstract description 7
- 238000006192 iodination reaction Methods 0.000 abstract description 6
- 239000000543 intermediate Substances 0.000 abstract description 5
- 125000003118 aryl group Chemical group 0.000 abstract description 2
- 230000015572 biosynthetic process Effects 0.000 abstract description 2
- 238000003786 synthesis reaction Methods 0.000 abstract description 2
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 21
- DRSHXJFUUPIBHX-UHFFFAOYSA-N COc1ccc(cc1)N1N=CC2C=NC(Nc3cc(OC)c(OC)c(OCCCN4CCN(C)CC4)c3)=NC12 Chemical compound COc1ccc(cc1)N1N=CC2C=NC(Nc3cc(OC)c(OC)c(OCCCN4CCN(C)CC4)c3)=NC12 DRSHXJFUUPIBHX-UHFFFAOYSA-N 0.000 description 13
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 13
- ZHSOTLOTTDYIIK-UHFFFAOYSA-N 3,5-Diiodothyronine Chemical compound IC1=CC(CC(N)C(O)=O)=CC(I)=C1OC1=CC=C(O)C=C1 ZHSOTLOTTDYIIK-UHFFFAOYSA-N 0.000 description 12
- HWDXNEYBINJXFP-XOCLESOZSA-L disodium (2S)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoate Chemical compound [Na+].[Na+].N[C@@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C([O-])=O.N[C@@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C([O-])=O HWDXNEYBINJXFP-XOCLESOZSA-L 0.000 description 11
- 239000000203 mixture Substances 0.000 description 11
- 239000011734 sodium Substances 0.000 description 11
- 238000006243 chemical reaction Methods 0.000 description 10
- 239000002244 precipitate Substances 0.000 description 9
- 238000002360 preparation method Methods 0.000 description 8
- 150000001412 amines Chemical class 0.000 description 7
- 239000002585 base Substances 0.000 description 6
- 238000004128 high performance liquid chromatography Methods 0.000 description 6
- 229950008325 levothyroxine Drugs 0.000 description 6
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 4
- 230000020477 pH reduction Effects 0.000 description 4
- 239000011541 reaction mixture Substances 0.000 description 4
- 239000000725 suspension Substances 0.000 description 4
- MRGXYNUASWENPL-LTCKWSDVSA-N (2s)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic acid;sodium Chemical compound [Na].[Na].IC1=CC(C[C@H](N)C(O)=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 MRGXYNUASWENPL-LTCKWSDVSA-N 0.000 description 3
- XUIIKFGFIJCVMT-GFCCVEGCSA-N D-thyroxine Chemical compound IC1=CC(C[C@@H](N)C(O)=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-GFCCVEGCSA-N 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 3
- 239000012736 aqueous medium Substances 0.000 description 3
- NLFBCYMMUAKCPC-KQQUZDAGSA-N ethyl (e)-3-[3-amino-2-cyano-1-[(e)-3-ethoxy-3-oxoprop-1-enyl]sulfanyl-3-oxoprop-1-enyl]sulfanylprop-2-enoate Chemical compound CCOC(=O)\C=C\SC(=C(C#N)C(N)=O)S\C=C\C(=O)OCC NLFBCYMMUAKCPC-KQQUZDAGSA-N 0.000 description 3
- 238000001914 filtration Methods 0.000 description 3
- 238000010979 pH adjustment Methods 0.000 description 3
- 238000001556 precipitation Methods 0.000 description 3
- 239000012429 reaction media Substances 0.000 description 3
- 159000000000 sodium salts Chemical class 0.000 description 3
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 2
- BAVYZALUXZFZLV-UHFFFAOYSA-N Methylamine Chemical compound NC BAVYZALUXZFZLV-UHFFFAOYSA-N 0.000 description 2
- 239000003513 alkali Substances 0.000 description 2
- 150000008044 alkali metal hydroxides Chemical class 0.000 description 2
- 239000003125 aqueous solvent Substances 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 239000012065 filter cake Substances 0.000 description 2
- -1 hydrochloric acid Chemical class 0.000 description 2
- 150000007529 inorganic bases Chemical class 0.000 description 2
- 230000026045 iodination Effects 0.000 description 2
- 235000005985 organic acids Nutrition 0.000 description 2
- 159000000001 potassium salts Chemical class 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- WGYKZJWCGVVSQN-UHFFFAOYSA-N propylamine Chemical compound CCCN WGYKZJWCGVVSQN-UHFFFAOYSA-N 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 239000007858 starting material Substances 0.000 description 2
- 229940034208 thyroxine Drugs 0.000 description 2
- XUIIKFGFIJCVMT-UHFFFAOYSA-N thyroxine-binding globulin Natural products IC1=CC(CC([NH3+])C([O-])=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-UHFFFAOYSA-N 0.000 description 2
- ZHSOTLOTTDYIIK-ZDUSSCGKSA-N (2S)-2-amino-3-[4-(4-hydroxyphenoxy)-3,5-diiodophenyl]propanoic acid Chemical class IC1=CC(C[C@H](N)C(O)=O)=CC(I)=C1OC1=CC=C(O)C=C1 ZHSOTLOTTDYIIK-ZDUSSCGKSA-N 0.000 description 1
- ZQKNYJRYGNGYOT-YDALLXLXSA-N (2s)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic acid;hydrochloride Chemical class Cl.IC1=CC(C[C@H](N)C(O)=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 ZQKNYJRYGNGYOT-YDALLXLXSA-N 0.000 description 1
- BRLSOHUOWVCKNI-YDALLXLXSA-N (2s)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic acid;sodium Chemical class [Na].IC1=CC(C[C@H](N)C(O)=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 BRLSOHUOWVCKNI-YDALLXLXSA-N 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 0 NC(Cc(cc1I)cc(I)c1Oc(cc1I)cc(I)c1O)*C[N+] Chemical compound NC(Cc(cc1I)cc(I)c1Oc(cc1I)cc(I)c1O)*C[N+] 0.000 description 1
- 239000003929 acidic solution Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- 229910001854 alkali hydroxide Inorganic materials 0.000 description 1
- 230000003592 biomimetic effect Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000013058 crude material Substances 0.000 description 1
- 239000012043 crude product Substances 0.000 description 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 1
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical class C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 description 1
- 238000010494 dissociation reaction Methods 0.000 description 1
- 230000005593 dissociations Effects 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 239000003688 hormone derivative Substances 0.000 description 1
- SBXXSUDPJJJJLC-YDALLXLXSA-M liothyronine sodium Chemical compound [Na+].IC1=CC(C[C@H](N)C([O-])=O)=CC(I)=C1OC1=CC=C(O)C(I)=C1 SBXXSUDPJJJJLC-YDALLXLXSA-M 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- DUWWHGPELOTTOE-UHFFFAOYSA-N n-(5-chloro-2,4-dimethoxyphenyl)-3-oxobutanamide Chemical compound COC1=CC(OC)=C(NC(=O)CC(C)=O)C=C1Cl DUWWHGPELOTTOE-UHFFFAOYSA-N 0.000 description 1
- 239000012299 nitrogen atmosphere Substances 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 125000002524 organometallic group Chemical group 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 238000005691 oxidative coupling reaction Methods 0.000 description 1
- 239000003002 pH adjusting agent Substances 0.000 description 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 239000011833 salt mixture Substances 0.000 description 1
- 238000005063 solubilization Methods 0.000 description 1
- 230000007928 solubilization Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 238000001308 synthesis method Methods 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 230000006016 thyroid dysfunction Effects 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 238000000844 transformation Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B61/00—Other general methods
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
反応式I
反応式II
(a) 有機酸の添加;
(b) 得られた「遊離型」の分離(沈殿物として);および
(c) 最後に過剰の水酸化ナトリウムを加えて式IIのL-チロキシン2ナトリウム塩を得る。
本発明は、NaIおよびI2の存在下で式Iの3,5-ジヨード-チロニンを直接ヨウ素化することによる甲状腺ホルモン誘導体チロキシン(T4)のナトリウム塩およびその遊離型の新規製造方法に関する。
で示される化合物を、NaIおよびI2を含むヨウ素化剤と反応させて、式II:
で示される2ナトリウム誘導体を得ることを含む甲状腺ホルモン誘導体の製造方法に関する。
本発明は、脂肪族アミンの存在下で、式I:
で示される化合物を、NaIおよびI2を含むか、好ましくはそれらからなるヨウ素化剤と反応させて、式II:
で示される2ナトリウム誘導体を得ることを含む甲状腺ホルモン誘導体の製造方法に関する。
反応式III
(実験の部)
式Iの3,5-ジヨードチロニン(1.0 kg、Sigma、cat Nr D0629)とNaI (0.3 kg)を、窒素雰囲気下で水(8.5 kg)に懸濁させ、70%水性エチルアミン (5.6 kg)を約1時間で加え、約22℃の温度に維持し、溶液を得る。
実施例1に従って得られた式IIのL-チロキシン2ナトリウム誘導体を、約25〜30℃の温度で表1に従ってNaOHの水性溶液に溶解した。Na2SO3 (0.03kg)および活性炭(3g)を加えた後、混合物を約0.25〜0.30時間撹拌し、次いでMillipore(0.45μm)で濾過した。
実施例1に従って得られる乾燥、式IIのL-チロキシン2ナトリウム塩(1.0 kg)を水(14 kg)に懸濁し、pH約12〜13になるまで30% NaOH (100 g)を加えた(必要ならば混合物を25〜30℃に加熱した)。
Claims (15)
- 該脂肪族アミンが直鎖状モノC1-C4アミンである請求項1記載の方法。
- 該脂肪族アミンがエチルアミンである請求項2記載の方法。
- ヨウ素化剤中のNaIとI2のモル比が1〜4である請求項1〜3のいずれかに記載の方法。
- ヨウ素化剤中のNaIとI2のモル比が2〜3である請求項4記載の方法。
- ヨウ素化剤を25℃以下の温度で化合物Iと脂肪族アミンを含む溶液に加える請求項1〜5のいずれかに記載の方法。
- 溶媒が蒸留水である請求項1〜6のいずれかに記載の方法。
- さらに少なくともpH11の、式IIの化合物の含水アルコールアルカリ溶液を製造し、40℃〜80℃の温度に加熱し、5℃〜20℃の温度に冷却し、化合物IIを純粋な固体として単離することを含む請求項1〜7のいずれかに記載の方法。
- 該酸が酢酸である請求項9記載の方法。
- 該酸をIIの水性溶液に加え、70℃〜95℃の温度に加熱し、得られる溶液を10℃〜15℃の温度に冷却することを含む請求項9〜10のいずれかに記載の方法。
- 該酸を82℃〜85℃の温度でIIの水性溶液に加える請求項11記載の方法。
- IIの水性溶液の水含有量が11w/w〜25w/wである請求項9〜12のいずれかに記載の方法。
- IIの水性溶液の水含有量が11w/w〜15w/wである請求項13に記載の方法。
- 該酸を75℃〜85℃の温度でIIの水性溶液に加え、該溶液の水含有量が11〜15w/wである請求項11〜14のいずれかに記載の方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP09179805.8 | 2009-12-18 | ||
EP09179805A EP2338875A1 (en) | 2009-12-18 | 2009-12-18 | Process for the preparation of thyroid hormones and derivatives thereof |
PCT/EP2010/070118 WO2011073409A1 (en) | 2009-12-18 | 2010-12-17 | Process for the preparation of thyroid hormones and salts thereof |
Publications (2)
Publication Number | Publication Date |
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JP2013514337A true JP2013514337A (ja) | 2013-04-25 |
JP5694367B2 JP5694367B2 (ja) | 2015-04-01 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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JP2012543799A Active JP5694367B2 (ja) | 2009-12-18 | 2010-12-17 | 甲状腺ホルモンおよびその塩の製造方法 |
Country Status (16)
Country | Link |
---|---|
US (1) | US8759572B2 (ja) |
EP (2) | EP2338875A1 (ja) |
JP (1) | JP5694367B2 (ja) |
KR (1) | KR101755291B1 (ja) |
CN (1) | CN102781907B (ja) |
AU (1) | AU2010332798B2 (ja) |
BR (1) | BR112012014893B1 (ja) |
CA (1) | CA2784544C (ja) |
DK (1) | DK2513044T3 (ja) |
ES (1) | ES2640774T3 (ja) |
IL (1) | IL220452A (ja) |
MX (1) | MX2012007069A (ja) |
NZ (1) | NZ600908A (ja) |
RU (1) | RU2561125C2 (ja) |
SI (1) | SI2513044T1 (ja) |
WO (1) | WO2011073409A1 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2017510593A (ja) * | 2014-03-31 | 2017-04-13 | ルピン・リミテッド | レボチロキシンおよびレボチロキシンの塩の調製方法 |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9782376B1 (en) | 2016-12-01 | 2017-10-10 | Fresenius Kabi Usa Llc | Levothyroxine liquid formulations |
CN109761830B (zh) * | 2019-02-22 | 2021-12-17 | 珐玛赫(天津)科技有限公司 | 一种左甲状腺素钠的制备方法 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS62153237A (ja) * | 1985-12-26 | 1987-07-08 | Asahi Chem Ind Co Ltd | ヨウ素化ジフエニルエ−テルの製造法 |
WO2009136249A1 (en) * | 2008-05-09 | 2009-11-12 | Cadila Pharmaceuticals Ltd. | An improved process for the preparation of levothyroxine sodium with reduced levels of impurities |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2889363A (en) | 1955-12-09 | 1959-06-02 | Baxter Laboratories Inc | Process for producing thyroxine |
US2993928A (en) | 1957-01-15 | 1961-07-25 | Glaxo Lab Ltd | Preparation of triiodothyronine |
US2889364A (en) | 1957-05-03 | 1959-06-02 | Baxter Laboratories Inc | Process for producing thyroxine |
GB9420705D0 (en) | 1994-10-14 | 1994-11-30 | Boots Co Plc | Process |
IT1302201B1 (it) * | 1998-09-11 | 2000-07-31 | Bracco Spa | Processo per la produzione di ormoni tiroidei. |
PA8626701A1 (es) * | 2004-03-26 | 2006-05-16 | Wyeth Corp | Procedimientos para la preparacion de compuestos aminoarilos yodados |
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JPS62153237A (ja) * | 1985-12-26 | 1987-07-08 | Asahi Chem Ind Co Ltd | ヨウ素化ジフエニルエ−テルの製造法 |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2017510593A (ja) * | 2014-03-31 | 2017-04-13 | ルピン・リミテッド | レボチロキシンおよびレボチロキシンの塩の調製方法 |
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ES2640774T3 (es) | 2017-11-06 |
RU2012130404A (ru) | 2014-01-27 |
SI2513044T1 (sl) | 2017-11-30 |
BR112012014893B1 (pt) | 2021-06-22 |
EP2513044B1 (en) | 2017-07-12 |
DK2513044T3 (en) | 2017-10-16 |
IL220452A (en) | 2015-05-31 |
CN102781907B (zh) | 2015-11-25 |
MX2012007069A (es) | 2012-07-30 |
WO2011073409A1 (en) | 2011-06-23 |
US20120296113A1 (en) | 2012-11-22 |
KR20120101553A (ko) | 2012-09-13 |
US8759572B2 (en) | 2014-06-24 |
NZ600908A (en) | 2014-07-25 |
JP5694367B2 (ja) | 2015-04-01 |
AU2010332798A1 (en) | 2012-07-19 |
IL220452A0 (en) | 2012-08-30 |
BR112012014893A2 (pt) | 2017-03-14 |
BR112012014893A8 (pt) | 2021-06-08 |
KR101755291B1 (ko) | 2017-07-10 |
EP2513044A1 (en) | 2012-10-24 |
EP2338875A1 (en) | 2011-06-29 |
CA2784544A1 (en) | 2011-06-23 |
CN102781907A (zh) | 2012-11-14 |
CA2784544C (en) | 2016-02-02 |
AU2010332798B2 (en) | 2014-09-18 |
RU2561125C2 (ru) | 2015-08-20 |
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