BR112012014893A2 - processo para a separação de hormônios da tireóide e seus sais - Google Patents
processo para a separação de hormônios da tireóide e seus saisInfo
- Publication number
- BR112012014893A2 BR112012014893A2 BR112012014893A BR112012014893A BR112012014893A2 BR 112012014893 A2 BR112012014893 A2 BR 112012014893A2 BR 112012014893 A BR112012014893 A BR 112012014893A BR 112012014893 A BR112012014893 A BR 112012014893A BR 112012014893 A2 BR112012014893 A2 BR 112012014893A2
- Authority
- BR
- Brazil
- Prior art keywords
- salts
- thyroid hormones
- separation
- preparation
- thyroxine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B61/00—Other general methods
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
processo para a preparação de hormônios da tireóide e seus sais a presente invenção refere-se geralmente a um processo para a preparação de derivados de l-tiroxina. mais em particular, a presente invenção refere-se a uma reação de iodação de um derivado aromático com um agente apropriado iodação, de modo a proporcionar o composto relacionado iodado como sal dissódico, o que pode representar um intermediário útil para a síntese do l-tiroxina de sódio mono-sal , e a forma livre do mesmo.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09179805.8 | 2009-12-18 | ||
| EP09179805A EP2338875A1 (en) | 2009-12-18 | 2009-12-18 | Process for the preparation of thyroid hormones and derivatives thereof |
| PCT/EP2010/070118 WO2011073409A1 (en) | 2009-12-18 | 2010-12-17 | Process for the preparation of thyroid hormones and salts thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BR112012014893A2 true BR112012014893A2 (pt) | 2017-03-14 |
| BR112012014893A8 BR112012014893A8 (pt) | 2021-06-08 |
| BR112012014893B1 BR112012014893B1 (pt) | 2021-06-22 |
Family
ID=41809153
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112012014893-1A BR112012014893B1 (pt) | 2009-12-18 | 2010-12-17 | Processo para a preparação de hormônios da tireoide e sais dos mesmos |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US8759572B2 (pt) |
| EP (2) | EP2338875A1 (pt) |
| JP (1) | JP5694367B2 (pt) |
| KR (1) | KR101755291B1 (pt) |
| CN (1) | CN102781907B (pt) |
| AU (1) | AU2010332798B2 (pt) |
| BR (1) | BR112012014893B1 (pt) |
| CA (1) | CA2784544C (pt) |
| DK (1) | DK2513044T3 (pt) |
| ES (1) | ES2640774T3 (pt) |
| IL (1) | IL220452A (pt) |
| MX (1) | MX2012007069A (pt) |
| NZ (1) | NZ600908A (pt) |
| RU (1) | RU2561125C2 (pt) |
| SI (1) | SI2513044T1 (pt) |
| WO (1) | WO2011073409A1 (pt) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IN2014MU01233A (pt) * | 2014-03-31 | 2015-10-02 | Lupin Ltd | |
| US9782376B1 (en) | 2016-12-01 | 2017-10-10 | Fresenius Kabi Usa Llc | Levothyroxine liquid formulations |
| CN109761830B (zh) * | 2019-02-22 | 2021-12-17 | 珐玛赫(天津)科技有限公司 | 一种左甲状腺素钠的制备方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2889363A (en) | 1955-12-09 | 1959-06-02 | Baxter Laboratories Inc | Process for producing thyroxine |
| US2993928A (en) | 1957-01-15 | 1961-07-25 | Glaxo Lab Ltd | Preparation of triiodothyronine |
| US2889364A (en) | 1957-05-03 | 1959-06-02 | Baxter Laboratories Inc | Process for producing thyroxine |
| JPS62153237A (ja) * | 1985-12-26 | 1987-07-08 | Asahi Chem Ind Co Ltd | ヨウ素化ジフエニルエ−テルの製造法 |
| GB9420705D0 (en) | 1994-10-14 | 1994-11-30 | Boots Co Plc | Process |
| IT1302201B1 (it) * | 1998-09-11 | 2000-07-31 | Bracco Spa | Processo per la produzione di ormoni tiroidei. |
| PA8626701A1 (es) * | 2004-03-26 | 2006-05-16 | Wyeth Corp | Procedimientos para la preparacion de compuestos aminoarilos yodados |
| WO2009136249A1 (en) * | 2008-05-09 | 2009-11-12 | Cadila Pharmaceuticals Ltd. | An improved process for the preparation of levothyroxine sodium with reduced levels of impurities |
-
2009
- 2009-12-18 EP EP09179805A patent/EP2338875A1/en not_active Withdrawn
-
2010
- 2010-12-17 RU RU2012130404/04A patent/RU2561125C2/ru active
- 2010-12-17 AU AU2010332798A patent/AU2010332798B2/en active Active
- 2010-12-17 BR BR112012014893-1A patent/BR112012014893B1/pt active IP Right Grant
- 2010-12-17 NZ NZ600908A patent/NZ600908A/en unknown
- 2010-12-17 MX MX2012007069A patent/MX2012007069A/es active IP Right Grant
- 2010-12-17 ES ES10795681.5T patent/ES2640774T3/es active Active
- 2010-12-17 CN CN201080057949.5A patent/CN102781907B/zh active Active
- 2010-12-17 JP JP2012543799A patent/JP5694367B2/ja active Active
- 2010-12-17 WO PCT/EP2010/070118 patent/WO2011073409A1/en active Application Filing
- 2010-12-17 CA CA2784544A patent/CA2784544C/en active Active
- 2010-12-17 KR KR1020127018781A patent/KR101755291B1/ko active IP Right Grant
- 2010-12-17 EP EP10795681.5A patent/EP2513044B1/en active Active
- 2010-12-17 US US13/515,712 patent/US8759572B2/en active Active
- 2010-12-17 DK DK10795681.5T patent/DK2513044T3/en active
- 2010-12-17 SI SI201031551T patent/SI2513044T1/sl unknown
-
2012
- 2012-06-17 IL IL220452A patent/IL220452A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| ES2640774T3 (es) | 2017-11-06 |
| RU2012130404A (ru) | 2014-01-27 |
| SI2513044T1 (sl) | 2017-11-30 |
| JP2013514337A (ja) | 2013-04-25 |
| BR112012014893B1 (pt) | 2021-06-22 |
| EP2513044B1 (en) | 2017-07-12 |
| DK2513044T3 (en) | 2017-10-16 |
| IL220452A (en) | 2015-05-31 |
| CN102781907B (zh) | 2015-11-25 |
| MX2012007069A (es) | 2012-07-30 |
| WO2011073409A1 (en) | 2011-06-23 |
| US20120296113A1 (en) | 2012-11-22 |
| KR20120101553A (ko) | 2012-09-13 |
| US8759572B2 (en) | 2014-06-24 |
| NZ600908A (en) | 2014-07-25 |
| JP5694367B2 (ja) | 2015-04-01 |
| AU2010332798A1 (en) | 2012-07-19 |
| IL220452A0 (en) | 2012-08-30 |
| BR112012014893A8 (pt) | 2021-06-08 |
| KR101755291B1 (ko) | 2017-07-10 |
| EP2513044A1 (en) | 2012-10-24 |
| EP2338875A1 (en) | 2011-06-29 |
| CA2784544A1 (en) | 2011-06-23 |
| CN102781907A (zh) | 2012-11-14 |
| CA2784544C (en) | 2016-02-02 |
| AU2010332798B2 (en) | 2014-09-18 |
| RU2561125C2 (ru) | 2015-08-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
|
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 17/12/2010, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, , QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO. |