JP2013510885A5 - - Google Patents

Download PDF

Info

Publication number
JP2013510885A5
JP2013510885A5 JP2012539065A JP2012539065A JP2013510885A5 JP 2013510885 A5 JP2013510885 A5 JP 2013510885A5 JP 2012539065 A JP2012539065 A JP 2012539065A JP 2012539065 A JP2012539065 A JP 2012539065A JP 2013510885 A5 JP2013510885 A5 JP 2013510885A5
Authority
JP
Japan
Prior art keywords
formula
composition
compound
nhch
optical isomer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2012539065A
Other languages
English (en)
Japanese (ja)
Other versions
JP2013510885A (ja
JP5650233B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2010/056760 external-priority patent/WO2011060392A1/en
Publication of JP2013510885A publication Critical patent/JP2013510885A/ja
Publication of JP2013510885A5 publication Critical patent/JP2013510885A5/ja
Application granted granted Critical
Publication of JP5650233B2 publication Critical patent/JP5650233B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2012539065A 2009-11-13 2010-11-15 選択的スフィンゴシン−1−リン酸受容体変調因子および不斉合成方法 Active JP5650233B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US26130109P 2009-11-13 2009-11-13
US61/261,301 2009-11-13
US26247409P 2009-11-18 2009-11-18
US61/262,474 2009-11-18
PCT/US2010/056760 WO2011060392A1 (en) 2009-11-13 2010-11-15 Selective sphingosine 1 phosphate receptor modulators and methods of chiral synthesis

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2013235966A Division JP5982705B2 (ja) 2009-11-13 2013-11-14 選択的スフィンゴシン−1−リン酸受容体変調因子および不斉合成方法
JP2014229895A Division JP2015038145A (ja) 2009-11-13 2014-11-12 選択的スフィンゴシン−1−リン酸受容体変調因子および不斉合成方法

Publications (3)

Publication Number Publication Date
JP2013510885A JP2013510885A (ja) 2013-03-28
JP2013510885A5 true JP2013510885A5 (https=) 2014-01-09
JP5650233B2 JP5650233B2 (ja) 2015-01-07

Family

ID=43992106

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2012539065A Active JP5650233B2 (ja) 2009-11-13 2010-11-15 選択的スフィンゴシン−1−リン酸受容体変調因子および不斉合成方法
JP2013235966A Active JP5982705B2 (ja) 2009-11-13 2013-11-14 選択的スフィンゴシン−1−リン酸受容体変調因子および不斉合成方法
JP2014229895A Pending JP2015038145A (ja) 2009-11-13 2014-11-12 選択的スフィンゴシン−1−リン酸受容体変調因子および不斉合成方法

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2013235966A Active JP5982705B2 (ja) 2009-11-13 2013-11-14 選択的スフィンゴシン−1−リン酸受容体変調因子および不斉合成方法
JP2014229895A Pending JP2015038145A (ja) 2009-11-13 2014-11-12 選択的スフィンゴシン−1−リン酸受容体変調因子および不斉合成方法

Country Status (32)

Country Link
US (4) US8362048B2 (https=)
EP (3) EP3868377A1 (https=)
JP (3) JP5650233B2 (https=)
KR (2) KR101721716B1 (https=)
CN (2) CN102762100B (https=)
AU (1) AU2010319983B2 (https=)
BR (2) BR122018077504B8 (https=)
CA (2) CA2780772C (https=)
CY (3) CY1120338T1 (https=)
DK (2) DK2498610T4 (https=)
EA (2) EA024801B1 (https=)
ES (2) ES2673160T5 (https=)
FI (2) FIC20200044I1 (https=)
FR (1) FR20C1059I2 (https=)
HR (2) HRP20180874T4 (https=)
HU (3) HUE037535T2 (https=)
IL (2) IL219691B (https=)
LT (3) LT3406142T (https=)
LU (1) LUC00184I2 (https=)
MX (1) MX2012005560A (https=)
MY (2) MY161854A (https=)
NO (2) NO2498610T3 (https=)
NZ (1) NZ599915A (https=)
PH (2) PH12012500939A1 (https=)
PL (2) PL3406142T3 (https=)
PT (2) PT2498610T (https=)
RS (2) RS61829B1 (https=)
SG (1) SG10201407357PA (https=)
SI (2) SI3406142T1 (https=)
SM (2) SMT201800288T1 (https=)
TR (1) TR201807912T4 (https=)
WO (1) WO2011060392A1 (https=)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ599913A (en) * 2009-11-13 2014-08-29 Receptos Inc Sphingosine 1 phosphate receptor modulators and methods of chiral synthesis
EA024801B1 (ru) 2009-11-13 2016-10-31 Рецептос Ллк Селективные модуляторы рецептора сфингозин-1-фосфата
EP2706999B1 (en) 2011-05-13 2019-08-28 Celgene International II Sàrl Selective heterocyclic sphingosine 1 phosphate receptor modulators
MY169073A (en) * 2012-06-21 2019-02-13 Eisai R&D Man Co Ltd Indanesulfamide derivative
WO2014158302A1 (en) * 2013-03-25 2014-10-02 Swenson Rolf Eric Novel sphingosine 1-phosphate receptor antagonists
US20170165236A1 (en) * 2013-11-01 2017-06-15 Celgene International Ii Sàrl Selective sphingosine 1 phosphate receptor modulators and combination therapy therewith
EP3280703A1 (en) 2015-04-06 2018-02-14 Auspex Pharmaceuticals, Inc. Deuterium-substituted oxadiazoles
CN114957157A (zh) * 2016-06-14 2022-08-30 瑞塞普托斯有限责任公司 奥扎莫德盐酸盐的晶型及其制备方法
ES2877686T3 (es) 2016-07-22 2021-11-17 Shijiazhuang Sagacity New Drug Dev Co Ltd Agonista S1P1 y aplicación del mismo
WO2018033149A1 (zh) * 2016-08-19 2018-02-22 苏州科睿思制药有限公司 奥扎莫德的晶型及其制备方法
CN108137516A (zh) * 2016-09-14 2018-06-08 杭州领业医药科技有限公司 奥扎莫德的晶型、其制备方法及药物组合物
US10882830B2 (en) * 2016-09-14 2021-01-05 Receptos Llc Crystal form of ozanimod hydrochloride and processes for preparation therefor
KR102408814B1 (ko) 2016-09-29 2022-06-14 리셉토스 엘엘씨 루푸스를 치료하기 위한 화합물 및 방법
JP7123956B2 (ja) * 2017-02-28 2022-08-23 ヘリオイースト・ファーマシューティカル・カンパニー・リミテッド スピロ化合物およびその使用
WO2018184185A1 (zh) * 2017-04-07 2018-10-11 杭州领业医药科技有限公司 奥扎莫德加成盐晶型、制备方法及药物组合物和用途
CN108727291A (zh) * 2017-04-21 2018-11-02 宁波爱诺医药科技有限公司 奥扎莫德及其中间体的制备方法
CN108727292A (zh) * 2017-04-21 2018-11-02 宁波爱诺医药科技有限公司 一种奥扎莫德及其中间体的制备方法
US11207301B2 (en) 2017-05-08 2021-12-28 Receptos Llc Sphingosine 1 phosphate receptor agonists for neuroprotection
EP3630738B1 (en) * 2017-05-22 2023-07-19 Egis Gyógyszergyár Zrt. Process for the production of ozanimod
WO2018237379A2 (en) 2017-06-23 2018-12-27 Enzo Biochem, Inc. Sphingosine pathway modulating compounds for the treatment of cancers
US10660879B2 (en) 2017-06-23 2020-05-26 Enzo Biochem, Inc. Sphingosine pathway modulating compounds for the treatment of cancers
CN109280035B (zh) * 2017-07-19 2023-06-09 广东东阳光药业有限公司 奥扎莫德的多晶型及其制备方法
EP3677575A4 (en) * 2017-08-31 2020-07-15 Crystal Pharmaceutical (Suzhou) Co., Ltd. CRYSTALLINE FORM OF OZANIMODHYDROCHLORIDE AND PRODUCTION METHOD THEREFOR
WO2019058290A1 (en) * 2017-09-20 2019-03-28 Suven Life Sciences Limited IMPROVED PROCESS FOR THE PREPARATION OF AZANIMOD A-AMINO COMPOUND
WO2019094409A1 (en) 2017-11-07 2019-05-16 Teva Pharmaceuticals International Gmbh Salts and solid state forms of ozanimod
CN107857760A (zh) * 2017-11-21 2018-03-30 南京天翔医药科技有限公司 鞘氨醇‑1‑磷酸受体调节剂及其应用
KR20200128386A (ko) * 2018-01-18 2020-11-12 스자좡 서개시티 뉴 드러그 디벨롭먼트 컴퍼니, 엘티디. 트리사이클릭 화합물의 결정형 및 염 형태, 및 이의 제조방법
KR20200132858A (ko) 2018-03-20 2020-11-25 에자이 알앤드디 매니지먼트 가부시키가이샤 간질 치료제
CN110615747A (zh) * 2018-06-20 2019-12-27 广东东阳光药业有限公司 一种二氢茚中间体的制备方法
EP3810285B1 (en) 2018-06-25 2025-02-12 Enzo Biochem, Inc. Sphingosine pathway modulating compounds for the treatment of cancers
AU2019338657A1 (en) 2018-09-12 2021-03-18 Pharmazell Gmbh A process for the preparation of Ozanimod and its intermediate (S)-1-amino-2,3-dihydro-1H-indene-4-carbonitrile
AR116479A1 (es) 2018-09-25 2021-05-12 Quim Sintetica S A Intermediarios para la síntesis de ozanimod y procedimiento para la preparación del mencionado agonista del receptor de esfingosina-1-fosfato y de dichos intermediarios
WO2020115200A1 (en) * 2018-12-07 2020-06-11 Synthon B.V. Improved process for preparing ozanimod
WO2020205483A1 (en) * 2019-03-29 2020-10-08 Celgene International Ii Sarl Sphingosine 1 phosphate receptor modulators
EP3947363A4 (en) * 2019-03-29 2023-01-04 Receptos Llc SPHINGOSINE-1-PHOSPHATE RECEPTOR MODULATORS
KR20210151068A (ko) * 2019-03-29 2021-12-13 리셉토스 엘엘씨 스핑고신 1 포스페이트 수용체 조절제
JP2022529845A (ja) * 2019-04-26 2022-06-24 レセプトス・リミテッド・ライアビリティ・カンパニー スフィンゴシン1リン酸受容体調節因子
CN112062785B (zh) * 2019-06-11 2023-06-27 广东东阳光药业有限公司 奥扎莫德及其中间体的制备方法
EP3999495A1 (en) 2019-07-16 2022-05-25 Synthon B.V. Improved process for preparing ozanimod
AU2020372647B2 (en) 2019-10-31 2026-02-05 Idorsia Pharmaceuticals Ltd Combination of a CXCR7 antagonist with an S1P1 receptor modulator
EP4087562A4 (en) * 2020-01-06 2024-01-10 Arena Pharmaceuticals, Inc. Methods of treating conditions related to the s1p1 receptor
WO2021175223A1 (zh) * 2020-03-04 2021-09-10 南京明德新药研发有限公司 苯并2-氮杂螺[4.4]壬烷类化合物及其应用
WO2021175225A1 (zh) * 2020-03-04 2021-09-10 南京明德新药研发有限公司 三环类化合物及其应用
EP4121025A4 (en) 2020-03-17 2024-03-27 Enzo Biochem, Inc. Sphingosine pathway modulating compounds for the treatment of coronavirus infection
FI4126829T3 (fi) * 2020-03-27 2026-04-01 Receptos Llc Sfingosiini 1 -fosfaattireseptorin modulaattoreita
WO2021195397A1 (en) * 2020-03-27 2021-09-30 Receptos Llc Sphingosine 1 phosphate receptor modulators
WO2021197852A1 (en) 2020-04-02 2021-10-07 Synthon B.V. Crystalline form of ozanimod hydrochloride
CN111620788B (zh) * 2020-04-20 2022-09-30 广东莱佛士制药技术有限公司 一种制备(2s,3s)-3-氨基-二环[2.2.2]辛烷-2-甲酸酯的方法
CN116867771B (zh) * 2021-04-09 2025-08-26 南昌弘益药业有限公司 噁二唑取代的螺环类化合物及其应用
EP4212156A1 (en) 2022-01-13 2023-07-19 Abivax Combination of 8-chloro-n-(4-(trifluoromethoxy)phenyl)quinolin-2-amine and its derivatives with a s1p receptor modulator
WO2023152767A1 (en) 2022-02-11 2023-08-17 Mylan Laboratories Limited Polymorphic forms of ozanimod hydrochloride
CN121194965A (zh) 2023-05-31 2025-12-23 奎米卡新特缇卡股份有限公司 盐酸奥扎莫德的无定形形式和晶型
TW202535949A (zh) 2023-12-20 2025-09-16 美商必治妥美雅史谷比公司 靶向IL-18受體β(IL-18RB)之抗體及相關方法
US12565492B2 (en) 2024-08-09 2026-03-03 Triana Biomedicines, Inc. Anaplastic Lymphoma Kinase (ALK) degraders and uses thereof
CN119462405B (zh) * 2025-01-10 2025-05-27 天津阿尔塔科技有限公司 一种氘标记鞘氨醇类化合物和氘标记神经酰胺类化合物的制备方法和应用

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1479544A (en) 1974-02-07 1977-07-13 American Cyanamid Co 1,2,3,4-tetrahydro-1-naphthylurea derivatives their preparation and their use
FR2628103B1 (fr) * 1988-03-03 1991-06-14 Roussel Uclaf Nouveaux esters pyrethrinoides portant un noyau indanyle, leur procede de preparation et leur application comme pesticides
US5039802A (en) 1990-04-18 1991-08-13 Merck & Co., Inc. Arylation process for preparation of chiral catalysts for ketone reduction
EP0508425A1 (en) 1991-04-12 1992-10-14 Schering Corporation Bicyclic amides as inhibitors of acyl-coenzyme a: cholesterol acyl transferase
GB2290790A (en) 1994-06-30 1996-01-10 Merck & Co Inc Asymmetric synthesis of 6-substituted 2-amino-1,2,3,4-tetrahydronaphthalenes
IL137295A (en) * 1998-01-23 2005-12-18 Sankyo Co History of spiropipridine and pharmaceutical preparations containing them
AR035585A1 (es) 2000-09-15 2004-06-16 Pharmacia Corp Derivados del acido 2-amino-2-alquil-4-heptenoico, composicion farmaceutica y su uso en la fabricacion de medicamentos
US20040058894A1 (en) 2002-01-18 2004-03-25 Doherty George A. Selective S1P1/Edg1 receptor agonists
JP4516430B2 (ja) 2002-12-20 2010-08-04 メルク・シャープ・エンド・ドーム・コーポレイション 1−(アミノ)インダン並びに(1,2−ジヒドロ−3−アミノ)−ベンゾフラン、ベンゾチオフェン及びインドール
EP4101846B1 (en) 2003-04-11 2023-08-02 PTC Therapeutics, Inc. 1,2,4-oxadiazole benzoic acid compounds and their use for nonsense suppression and the treatment of disease
CN1859908A (zh) * 2003-10-01 2006-11-08 默克公司 作为s1p受体激动剂的3,5-芳基、杂芳基或环烷基取代的-1,2,4-噁二唑类化合物
US7605171B2 (en) * 2003-12-17 2009-10-20 Merck & Co., Inc. (3,4-disubstituted)propanoic carboxylates as S1P (Edg) receptor agonists
US7585881B2 (en) * 2004-02-18 2009-09-08 Astrazeneca Ab Additional heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
US20060173183A1 (en) 2004-12-31 2006-08-03 Alantos Pharmaceuticals, Inc., Multicyclic bis-amide MMP inhibitors
AU2006245349A1 (en) 2005-02-22 2006-11-16 Teva Pharmaceutical Industries Ltd. Improved process for the synthesis of enantiomeric indanylamine derivatives
KR100667075B1 (ko) 2005-07-22 2007-01-10 삼성에스디아이 주식회사 주사 구동부 및 이를 포함하는 유기 전계발광 표시장치
AU2006278718B2 (en) 2005-08-03 2010-10-07 Secura Bio Inc. Use of HDAC inhibitors for the treatment of myeloma
WO2007033002A1 (en) 2005-09-14 2007-03-22 Amgen Inc. Conformationally constrained 3- (4-hydroxy-phenyl) - substituted-propanoic acids useful for treating metabolic disorders
PE20070705A1 (es) * 2005-11-25 2007-08-23 Basf Ag Compuestos de indanil - y tetrahidronaftil-amino-azolina para combatir pestes animales
CA2634488C (en) 2005-12-21 2016-10-04 Joseph Gabriele Catecholamine regulated protein
WO2007105053A2 (en) 2006-03-13 2007-09-20 Pfizer Products Inc. Tetralines antagonists of the h-3 receptor
US20080009534A1 (en) * 2006-07-07 2008-01-10 Bristol-Myers Squibb Company Substituted acid derivatives useful as antidiabetic and antiobesity agents and method
MX2009002915A (es) * 2006-09-21 2009-03-31 Actelion Pharmaceuticals Ltd Derivados de fenilo y su uso como inmunomoduladores.
CA2669104A1 (en) 2006-11-21 2008-05-29 University Of Virginia Patent Foundation Hydrindane analogs having sphingosine 1-phosphate receptor agonist activity
SG177221A1 (en) * 2006-12-15 2012-01-30 Abbott Lab Novel oxadiazole compounds
JO2701B1 (en) 2006-12-21 2013-03-03 جلاكسو جروب ليميتد Vehicles
WO2008106224A1 (en) 2007-02-28 2008-09-04 Rib-X Pharmaceuticals, Inc. Macrolide compounds and methods of making and using the same
GB0725104D0 (en) 2007-12-21 2008-01-30 Glaxo Group Ltd Compounds
US20090298894A1 (en) 2008-04-21 2009-12-03 Asahi Kasei Pharma Corporation Amino acid compounds
SI2291080T1 (sl) * 2008-05-14 2015-11-30 The Scripps Research Institute Novi modulatorji sfingosinskih fosfatnih receptorjev
CN102066752B (zh) * 2008-06-13 2014-02-19 (学)斗源学院 具有回转阀的往复式压缩机
GB0910674D0 (en) 2009-06-19 2009-08-05 Glaxo Group Ltd Novel compounds
WO2011005290A1 (en) 2009-06-23 2011-01-13 Arena Pharmaceuticals, Inc. Disubstituted oxadiazole derivatives useful in the treatment of autoimmune and inflammatory disorders
GB0911130D0 (en) 2009-06-26 2009-08-12 Glaxo Group Ltd Novel compounds
NZ599913A (en) * 2009-11-13 2014-08-29 Receptos Inc Sphingosine 1 phosphate receptor modulators and methods of chiral synthesis
NZ599914A (en) 2009-11-13 2014-08-29 Receptos Inc Selective heterocyclic sphingosine 1 phosphate receptor modulators
EA024801B1 (ru) 2009-11-13 2016-10-31 Рецептос Ллк Селективные модуляторы рецептора сфингозин-1-фосфата
EP2706999B1 (en) 2011-05-13 2019-08-28 Celgene International II Sàrl Selective heterocyclic sphingosine 1 phosphate receptor modulators
CN106344576A (zh) 2011-10-12 2017-01-25 泰华制药工业有限公司 以拉喹莫德和芬戈莫德的组合治疗多发性硬化症

Similar Documents

Publication Publication Date Title
JP2013510885A5 (https=)
JP2015505296A5 (https=)
JP2014506907A5 (https=)
SI2498610T1 (en) Selective sphingosine 1 phosphate receptor modulators and methods of chiral synthesis
JP2016534063A5 (https=)
JP2011527691A5 (https=)
JP2013032389A5 (https=)
JP2013537203A5 (https=)
JP2012092103A5 (https=)
JP2009242409A5 (https=)
JP2012532883A5 (https=)
JP2009535358A5 (https=)
AR047972A1 (es) Derivado de bencimidazol, proceso de obtencion y composiciones farmaceuticas.
JP2018537535A5 (https=)
JP2020507589A5 (https=)
JP2010536766A5 (https=)
JP2007302689A5 (https=)
JP2013542992A5 (https=)
JP2015535847A5 (https=)
JP2010529994A5 (https=)
JP2009543795A5 (https=)
JP2013533253A5 (https=)
JP2019516739A5 (https=)
JP2013514980A5 (https=)
JP2020505354A5 (https=)